Induction of Endothelial Nitric-oxide Synthase Phosphorylation by the Raloxifene Analog LY117018 Is Differentially Mediated by Akt and Extracellular Signal-regulated Protein Kinase in Vascular Endothelial Cells

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47642-47649

  Hisamoto, Koji ^a   Ohmichi, Masahide ^a   Kanda, Yuki ^a   Adachi, Kazushige ^a   Nishio, Yukihiro ^a   Hayakawa, Jun ^a   Mabuchi, Seiji ^a   Takahashi, Kazuhiro ^a   Tasaka, Keiichi ^a   Miyamoto, Yasuhide ^a   Taniguchi, Naoyuki ^a   Murata, Yuji ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; ENZYMES; NITROGEN OXIDES; TISSUE; VIRUSES;

PHOSPHORYLATION;

CELLS;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; DACTINOMYCIN; ESTRADIOL; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; RALOXIFENE; WORTMANNIN; ANTIESTROGEN; DRUG DERIVATIVE; ENDOTHELIAL CONSTITUTIVE NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; ESTRADIOL RECEPTOR; ESTROGEN; FLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASES; ONCOPROTEIN; PROTO ONCOGENE PROTEIN AKT; PROTO ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEIN AKT; PYRROLIDINE DERIVATIVE; THIOPHENE DERIVATIVE;

ARTICLE; BLOOD VESSEL WALL; CARDIOVASCULAR DISEASE; CHO CELL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVATION; DRUG ACTIVITY; DRUG BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; EXTRACELLULAR SPACE; GENETIC ANALYSIS; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LUNG PARENCHYMA; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RECEPTOR BINDING; REGULATORY MECHANISM; SIMIAN VIRUS 40; TISSUE SPECIFICITY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; ANIMAL; CELL CULTURE; CELL LINE; CYTOLOGY; HAMSTER; LUNG; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; RAT; TIME;

CRICETINAE; CRICETULUS GRISEUS; SIMIAE; SIMIAN VIRUS 40; SIMIAN VIRUS;

ANIMAL; CELL LINE, TRANSFORMED; CELLS, CULTURED; CHO CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS; FLAVONES; HAMSTERS; HUMAN; LUNG; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC-OXIDE SYNTHASE; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PYRROLIDINES; RALOXIFENE; RATS; RECEPTORS, ESTRADIOL; THIOPHENES; TIME FACTORS; UMBILICAL VEINS;

EID: 0035861543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103853200     Document Type: Article

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