Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: Clinical and pharmacological implications in atherosclerosis

Pharmacological Reviews

Volumn 48, Issue 1, 1996, Pages 3-19

  Cox, David A ^a   Cohen, Marlene L ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ARGININE; CELL ADHESION MOLECULE; CHOLESTEROL; CYTOKINE; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDYLCHOLINE; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PENTAERYTHRITYL TETRANITRATE; PROBUCOL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SUPEROXIDE;

ARTERY CONSTRICTION; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; ENZYME ACTIVATION; HUMAN; HYPERCHOLESTEROLEMIA; LIPID OXIDATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; VASODILATATION;

ARTERIOSCLEROSIS; ENDOTHELIUM, VASCULAR; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; OXIDATION-REDUCTION;

EID: 0029877542     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (182)

1. AMBROSE, J. A., WINTERS, S. L., ARORA, R. R., ENG, A., RICCIO, A., GORLIN, R., AND FUSTER, V.: Angiographic evolution of coronary artery morphology in unstable angina. J. Am. Coll. Cardiol. 7: 472-478, 1986.
2. ANDERSON, T. J., MEREDITH, I. T., YEUNG, A. C., FREI, B., SELWYN, A. P., GANZ, P.: The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N. Engl. J. Med. 332: 488-493, 1995a.
3. ANDERSON, T. J, GERHARD, M. D., MEREDITH, I. T., CHARBONNEAU, F., DELAGRANGE, D., CHEAGER, M. A., SELWYN, A. P., AND GANZ, P.: Systemic nature of endothelial dysfunction in atherosclerosis. Am. J. Cardiol. 75: 71B-74B, 1995b.
4. ARCARO, G., ZENERE, B. M., TRAVIA, D., ZENTI, M. G., Covi, G., LECHI, A., AND MUGGEO, M.: Non-invasive detection of early endothelial dysfunction in hypercholesterolemic subjects. Atherosclerosis 114: 247-254, 1995.
5. BERLINER, J. A., TERRITO, M. C., SEVANIAN, A., RAMIN, S., KIM, J. A., BAMSHAD, B., ESTERSON, M., AND FOGELMAN, A, M.: Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J. Clin. Invest. 85: 1260-1266, 1990.
6. BOSSALLER, C., HABIB, G. B., YAMAMOTO, H., WILLIAMS, C., WELLS, S., AND HENRY P. D.: Impaired musearinic endothelium-dependent relaxation and cyclic guanosine 5-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J. Clin. Invest. 79: 170-174, 1987.
7. BOULANGER, C. M., TANNER, F. C., BEA, M.-L., HAHN, A. W. A., WERNER, A., AND LUSCHER, T. F.: Oxidized low density lipoprotein induce mRNA expression and release of endothelin from human and porcine endothelium. Circ. Res. 70: 1191-1197, 1992.
8. BREDT, D. S., FERRIS, C. D., SNYDER, S. H.: Nitric oxide synthase regulatory sites: phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase - identification of flavin and calmodulin binding sites. J. Biol. Chem. 267: 10976-10981, 1992.
9. BREUGNOT, C., PRIVAT, S., GUILLONNEAU, C., REGNIER, G., BOUZOM, F., VILAINE, J.-P., AND LENAERS, A.: S 12340: a potent inhibitor of the oxidative modification of low-density lipoprotein in vitro and ex vivo in WHHL rabbits. J. Pharmacol. Exp. Ther. 269: 515-520, 1994.
10. BROCK, T. A., AND CAPASSO, E. A.: Thrombin and histamine activate phospholipase C in human endothelium cells via a phorbol ester-sensitive pathway. J. Cell Physiol. 136: 54-62, 1988.
11. BROWN, G., ALBERS, J. J., FISHER, L. D., SCHAEFER, S. M., LIN, J. T., KAPLAN, C., ZHAO, X. Q., BISSON, B. D., FITZPATRICK, V. F., AND DODGE, H. T.: Regression of coronary artery disease as a result of intensive lipid lowering therapy in men with high levels of apolipoprotein B. N. Engl. J. Med. 323: 1289-1298, 1990.
12. BHOWN, M. S., AND GOLDSTELN, J. L.: A receptor-mediated pathway for cholesterol homeostasis. Science (Wash. DC) 232: 34-47, 1986.
13. BUCKLEY, M. M.-T., GOA, K. L., PRICE, A. H., AND BROGDEN, R. N.: Probucol: a reappraisal of its pharmacological properties and therapeutic use in hypercholesterolemia. Drugs 37: 761-800, 1989.
14. BULT, H., DEMEYER, G. R. Y., AND HERMAN, A. G.: Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta. Br. J. Pharmacol. 114: 1371-1382, 1995.
15. BUSSE, R. AND MULSCH, A.: Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett. 275: 87-90, 1990.
16. CAREW, T. E., SCHWENKE, D. C., AND STEINBERG, D.: Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc. Natl. Acad. Sci. USA 84: 7725-7729, 1987.
17. CASINO, P. R., KILCOYNE, C. M., CANNON, R. O., III, QUYYUMI, A. A., AND PANZA, J. A.: Impaired endothelium-dependent vascular relaxation in patients with hypercholesterolemia extends beyond the musearinie receptor. Am. J. Cardiol. 75: 40-44, 1995.
18. CAZZOLATO, G., AVOGARO, P., AND BITTOLO-BON, G.: Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radical Biol. & Med. 11: 247-253, 1991.
19. CELERMAJER, D. S, SORENSEN, K. E., GOOCH, V. M., SPIEGELHALTER, D. J., MILLER, O. I., SULLIVAN, I. D, LLOYD, J. K., AND DEANFIELD, J. E.: Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340: 1111-1115, 1992.
20. CHIN, J. H., AZHAR, S., AND HUFFMAN, B. B.: Inactivation of endothelialdependent relaxing factor by oxidized lipoproteine. J. Clin. Invest. 89: 10-18, 1992.
21. CIAMPRICOTTI, R., EL GAMAL, M., RELIK, T., TAVERNE, R., PANIS, J., DEWART, J., VAN GELDER, B., AND RELIK-VAN WELY, L.: Clinical characteristics and coronary angiographic findings of patients with unstable angina, acute myocardial infarction, and survivors of sudden ischemie death occurring during and after sport Am. Heart J. 120: 1267-1278, 1990.
22. COHEN, R. A., ZITNAY, K. M., HAUDENSCHILD, C. C., AND CUNNINGHAM, L. D.: Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ. Res 63: 903-910, 1988.
23. κB and cytokine-inducible enhancers. FASEB J. 9: 899-909, 1995.
24. COX, D. A., SUSENUCHEL, A. D , AND COHEN, M L.: Selective endothelial dysfunction in porcine coronary artery produced by incubation in cell culture medium in vitro. Endothelium, 3: 171-179, 1995.
25. COX, R. H., AND TULENKO, T. N.: Altered contractile and ion channel function in rabbit portal vein with dietary atherosclerosis. Am. J. Physiol. 268: H2522-H2530, 1995.
26. CREAGER, M. A., COOKE, J. P., MENDELSOHN, M E., GALLAGHER, S. J., COLEMAN, S. M., LOSCALZO, J , AND DZAU, V. J.: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J. Clin. Invest. 86: 228-234, 1990.
27. CREAGER, M. A., GALLAGHEB, S. J., GIRERD, X. J., COLEMAN, S. M., DZAU, V. J., AND COOKE, J. P.: L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 90: 1248-1253, 1992.
28. CUSHING, S. D., BERLINER, J. A., VALENTINE, A. J., TERRITO, M. C., NAVAB, M., PARHAMI, F , GERRITY, R., SCHWARTZ, C J., AND FOGELMAN, A. M.: Minimally-modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and vascular smooth muscle cells. Proc. Natl. Acad. Sci. USA 87: 5134-5138, 1990
29. DAUGHERTY, A., ZWEIFEL, B. S., SOBEL, B. E., AND SCHONFELD, G : Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits. Arteriosclerosis 8: 768-777, 1988.
30. EGASHIRA, K., HIROOKA, Y., KAI, H , SUOIMACHI, M., SUZUKI, S., INOU, T., AND TAKESHITA, A., Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation 89: 2519-2524, 1994.
31. ENOEMANN, G., STANTON, L. W., MADDEN, K. S., BRYANT, C. M., TYLER WHITE, R., AND PROTTER, A. A : CD36 is a receptor for oxidized low density lipoprotein. J. Biol. Chem. 268: 11811-11816, 1993.
32. FEELISCH, M, TE POEL, M., ZAMORA, R., DEUSSEN, A., AND MONCADA, S.: Understanding the controversy over the identity of EDRF. Nature (Lond.) 368: 62-65, 1994.
33. FLAVAHAN, N. A.: Atherosclerosis or lipoprotein-induced endothelial dysfunction: potential mechanisms underlying reduction of EDRF/nitric oxide activity. Circulation 85: 1927-1938, 1992.
34. FLAVAHAN, N. A.: Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells. Am. J Physiol. 264: H722-H727, 1993.
35. FLAVAHAN, N. A., SHIMOKAWA, H., AND VANHOUTTE, P. M.: Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries. J. Physiol. 408: 549-560, 1989.
36. FOWLER, S., SHIO, H., AND HALEY, N. J.: Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. IV. Investigation of macrophage-like properties of aortic cell populations. Lab. Invest. 41: 372-378, 1979.
37. FRUEDIS, J., PARTHARSARATHY, S., AND STEINBERG, D.: Evidence for a concerted reaction between lipid hydroperoxides and polypeptides. Proc. Natl. Acad. Sci. USA 89: 10588-10592, 1992.
38. FUSTER, V, STEIN, B., AMBROSE, J. A., BADIMON, L., BADIMON, J. J., AND CHESEBRO, J. H.: Atherosclerotic plaque rupture and thrombosis: evolving concepts. Circulation 82 (suppl. II) : 47-59, 1990.
39. GAGE, J. E., HESS, O M., MURAKAMI, T., RITTER, M., GRIMM, J., AND KRAYENBUEHL, H. P.: Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin. Circulation 73: 865-876, 1986.
40. GALLE, J., BASSENGE, E., AND BUSSE, R.: Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle. Circ. Res. 66: 1287-1293, 1990.
41. GALLE, J., MULSCH, A., BUSSE, R., AND BASSENGE, E.: Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor. Arterioscler Thrornb. 11: 198-203, 1991.
42. GEY, K. F., PUSKA, P., JORDAN, P., AND MOSER, U. K.: Inverse correlation between plasma vitamin E and mortality from ischemie heart disease in cross-cultural epidemiology. Am. J. Clin. Nutr. 53: 326S-334S, 1991.
43. GILLIGAN, D. M., SACK, M. N., GUETTA, V., CASINO, P. R., QUYYUMI, A, A., RADER, D. J., PANZA, J. A., AND CANNON, R. O.: Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation. in patients with hypercholesterolemia. J. Am. Coll. Cardiol. 24: 1611-1617, 1994a.
44. GILLIGAN, D. M., GUETTA, V., PANZA, J. A., GARCIA, C. E., QUYYUMI, A. A., CANNON, R. O.: Selective loss of microvascular endothelial function in human hypercholesterolemia. Circulation 90: 35-41, 1994b.
45. GOLDSTEIN, J. L., Ho, Y. K., BASU, S. K., AND BROWN, M. S.: Binding site on macrophages that mediated uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA 76: 333-337, 1979.
46. GOLINO, P., PISCIONE, F., WILLERSON, J. T., CAPPELLI-BIGAZZI, M., FOCACCIO, A., VILLARI, B., INDOLFI, C., RUSSOLILLO, E., CONDORELLI, M., AND CHIARIELLO, M.: Divergent effects of serotonin on coronary-artery dimensions and ood flow in patients with coronary atherosclerosis and control patients. N. Engl. J. Med. 324: 641-648, 1991.
47. GBYGLEWSKI, R. J., PALMER, R. M. J., AND MONCADA, S.: Superoxide anion is involved in the breakdown of endothelium-derived relaxing factor. Nature (Lond.) 320: 454-456, 1986.
48. HABERLAND, M. E., FONG, D., AND CHENG, L.: Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science (Wash. DC) 241: 215-218, 1988.
49. HABIB, J B., BOSSALLER, C., WELLS, S., WILLIAMS, C., MORRISETT, J. D , AND HENEY, P. D.: Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110. Circ. Res. 58: 305-309, 1986.
50. HAMILTON, C A., THORIN, E., MCCULLOCK, J., DOMINICZAK, M. H., AND REID, J. L.: Chronic exposure of bovine aortic endothelial cells to native and oxidized LDL modifies phosphatidylinositol metabolism. Atheroslcerosis 107: 55-63, 1994.
51. HARRISON, D. G., ARMSTRONG, M. L., FREIMAN, P. C., AND HEISTAD, D. D.: Restoration of endothehum-dependent relaxation by dietary treatment of atherosclerosis. J. Clin. Invest. 80: 1808-1811, 1987.
52. HARRISON, D. G.: Endothelial function in atherosclerosis. Basic Res. Cardiol. 89 (suppl. 1) : 87-102, 1994.
53. HATTORI, R., SASE, K., EIZAWA, H, KOSUGA, K., AOYAMA, T., INOUE, R., SASAYAMA, S., KAWAI, C., AND YUI, Y.: Structure and function of nitric oxide syntheses. Int. J. Cardiol. 47(suppl.): 71S-75S, 1994.
54. HAYASHI, T., ISHIKAWA, T., KUZUYA, M., NAITO, M., YAMADA, K., ASAI, K., HIDAKA, H., AND IGUCHI, A.: Chelation of copper reduces inhibition by oxidized lipoproteins of endothehum-dependent relaxation in porcine coronary arteries. Heart Vessels 9: 283-291, 1994.
55. HAYNES, W. G., NOON, J. P., WALKER, B. R., AND WEBB, D. J.: Inhibition of nitric oxide synthesis increases blood pressure in healthy humans, J. Hypertens. 11: 1375-1380, 1993.
56. HECKER, M., BARA, A. T , BAUERSACHS, J., AND BUSSE, R.: Characterization of endothelium-derived hyperpolarizing factor as a cytoehrome P450-derived arachidonic acid metabolite in mammals. J Physiol. 481: 407-414, 1994.
57. HENRICKSON, T., MAHONEY, E. M., AND STEINBERG, D.: Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc. Natl. Acad. Sci. USA 78: 6499-6503, 1981.
58. HESSLER, J. R., ROBERTSON, A. L., JR., AND CHISOLM, G. M.: LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture. Atherosclerosis 32: 213, 1979.
59. HIBBS, J. B., TAINTOR, R. R., AND VAVRIN, Z.: Macrophage cytotoxicity: role of L-arginine deiminase and imino nitrogen oxidation to nitrite. Science (Wash. DC) 235: 473-476, 1987.
60. HIRATA, K., KURODA, R., SAKODA, T., KATAYAMA, M., INOUE, N., SUEMATSU, M., KAWASHIMA, S., AND YOKOYAMA, M : Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Hypertension 25: 180-185, 1995a.
61. HIRATA, K., MIKI, N, KURODA, Y., SAKODA, T., KAWASHIMA, S., AND YOKOHAMA, M.: Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells. Circ. Res. 76: 958-962, 1995b.
62. HODIS, H. N., KRAMSCH, D M , AVOGARO, P., BITTOLO-BON, G., CAZZOLATO, G., HWANG, J., PETERSON, H., AND SEVANIAN, A.: Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). J. Lipid Res. 35: 669-677, 1994.
63. HOFF, H. F., AND O'NEIL, J.: Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation. Arterioscler. Thromb. 11: 1209-1222, 1991.
64. HOLVOET, P., AND COLLEN, D.: Oxidized lipoproteins in atherosclerosis and thrombosis. FASEB J. 8: 1279-1284, 1995.
65. HOLZMANN, S., KUKOVETZ, W. R., WINDISCHHOFER, W., PASCHKE, E., AND GRAIER, W. F.: Pharmacological differentiation between endothelium-dependent relaxations sensitive and resistant to nitro-L-arginine in coronary arteries. J. Cardiovasc. Pharmacol. 23: 747-756, 1994.
66. INOUE, N., HIRATA, K., YAMADA, M., HAMAMORI, Y., MATSUDA, Y., AKITA, H., AND YOKOYAMA, M.: Lysophosphatidylcholine inhibits bradykimn-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells. Circ. Res. 71: 1410-1421, 1992.
67. JIALAL, I., FULLER, C. J., AND HUET, B. A.: The effect of α-tocopherol supplementation on LDL oxidation: a dose-response study. Arterioscler. Thromb. Vase. Biol. 15: 190-198, 1995
68. KALSNER, S.: Coronary artery spasm: multiple causes and multiple roles in heart disease. Biochem. Pharmacol. 49: 859-871, 1995.
69. KANNEL, W. B., CASTELLI, W. P., GORDON, T. AND MCNAMARA, P. M.: Serum cholesterol, lipoproteins, and the risk of coronary heart disease. Ann. Intern. Med. 74: 1-12, 1971.
70. KASKI, J. C., TOUSOULIS, D., MCFADDEN, E., CREA, F., PEREIRA, W. I , AND MASERI, A.: Variant angina pectoris: role of coronary spasm in the development of fixed coronary obstructions. Circulation 85: 619-626, 1992.
71. KASTEN, T. P., SETTLE, S. L., MISKO, T. P , RILEY, D. P., WEISS, R. H., CURRIE, M. G., AND NICKOLS, G. A.: Potentiation of nitric oxide-mediated vascular relaxation by SC52608, a Superoxide dismutase mimic. Proc. Soc. Exp. Biol. Med. 208: 170-177, 1995.
72. KATADA, T., GILMAN, A. G., WATANABE, Y., BAUES, S., AND JAKOBS, K. H.: Protein kinase C phosphorylates the inhibitory guanine-nucleotide binding regulatory component and apparently supresses its function in hormonal stimulation of adenylate cyelase. Eur. J. Biochem. 151: 431-437, 1985.
73. KEANEY, J. F., JR., GAZIANO, J. M., XU, A., FREI, B., CURRAN-CELENTANO, J., SHWAERY, G. T., LOSOALZO, J., AND VITA, J. A.: Low-dose a-tocopherol improves and high-dose a-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J. Clin. Invest. 93: 844-851, 1994.
74. KEANEY, J. F., JR., Xu, A., CUNNINGHAM, D., JACKSON, T., FREI, B., AND VITA, J A.: Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. J. Clin. Invest. 95: 2520-2529, 1995.
75. KILPATRICK, E. V., AND COCKS, T. M.: Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery. Br. J. Pharmacol. 112: 557-565, 1994.
76. KOJDA, G., STEIN, D., KOTTENBERG, E., SCHNAITH, E. M., AND NOACK, E.: In vivo effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits. J. Cardiovasc. Pharmacol. 25: 763-773, 1995.
77. KUGIYAMA, K., KERNS, S. A., MORRISETT, J. D., ROBERTS, R., AND HENRY, P. D.: Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteine. Nature (Lond.) 344: 160-162, 1990.
78. KUGIYAMA, K., OHGUSHI, M., SUGIYAMA, S., MUROHARA, T., FUKUNAGA, K., MIYAMOTO, E., AND YASUE, H.: Lysophosphatidylcholine inhibits surface receptor-mediated intracellular signals in endothelial cells by a pathway involving protein kinase C activation. Circ. Res. 71: 1422-1428, 1992.
79. KUME, N., CYBULSKY, M. I., AND GIMBRONE, M. A., JR.: Lysophosphatidylcholine, a component of atherogenic lipoproteine, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J. Clin. Invest. 90: 1138-1144, 1993.
80. ΚB p65 (ReIA) and NF-IL-6. J. Immunol. 153: 153-164, 1994.
81. LAMPING, K G., PIEGORS, D. J., BENZULY, K. H., ARMSTRONG, M. L., AND HEISTAD, D. D.: Enhanced coronary vasoconstrictive response to serotonin subsides after removal of dietary cholesterol in atherosclerotic monkeys. Arterioslcer Thromb. 14: 951-957, 1994.
82. LEARY, T.: Coronary spasm as a possible factor in producing sudden death. Am. Heart J. 10: 214-218, 1934.
83. LEUNG, W. H., LAU, C. P., AND WONG, C. K.: Beneficial effect of cholesterollowering therapy on coronary endothelium-dependent relaxation in hypercholesterolemic patients. Lancet 341: 1496-1500, 1993.
84. LEVINE, G. N., KEANEY, J. F., AND VITA, J. A.: Cholesterol reduction in cardiovascular disease: clinical benefits and possible mechanisms. N. Engl. J. Med. 332: 512-521, 1995.
85. LI, Q., AND CATHCART, M. K: Protein kinase C activity is required for lipid oxidation of low density lipoprotein by activated human monocytes. J. Biol. Chem. 269: 17508-17515, 1994.
86. LIAO, J. K., SHLN, W. S., LEE, W. Y., AND CLARK, S. L.: Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J. Biol. Chem. 270: 319-324, 1995.
87. 12subunit expression by oxidized low-density lipoprotein. J. Clm. Invest. 95: 1457-1463, 1995.
88. LIN, C. S., PENHA, P. D., ZAK, F. G., AND LIN, J. C.: Morphodynamic interpretation of acute coronary thrombosis, with special reference to volcano-like eruption of atheromatous plaque caused by coronary artery spasm. Angiology 39: 535-547, 1988.
89. LITTLE, W. C., CONSTANTINESCU, M., APPLEGATE, R. J., KUTCHER, M. A., BURROWS, M. T., KAHL, F. R., AND SANTAMORE, W. P., Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 78: 1157-1166, 1988.
90. LOREE, H. M., KAMM, R. D., STRINGFELLOW, R. G., AND LEE, R. T.: Effects of fibrous cap thickness on peak circumferential stress in model athersclerotic vessels. Circ. Res. 71: 850-858, 1992.
91. LUDMER, P. L., SELWYN, A. P., SHOOK, T. L., WAYNE, R. R., MUDGE, G. H., ALEXANDER, R. W , AND GANZ, P.: Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N. Engl. J. Med. 315: 1046-1051, 1986
92. MCFADDEN, E. P., CLARKE, J. G., DAVIES, G. J., KASKI, J. C., HAIDER, A. W., AND MASERI, A.: Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. N. Engl. J. Med. 324: 648-654, 1991.
93. 2+ mobilization causes supersensitivity of contractile responses to serotonin in atherosclerotic arteries. Circ. Res. 75: 1096-1102, 1994.
94. MONCADA, S., REES, D D., SCHULZ, R., AND PALMER, R. M. J.: Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc. Natl. Acad. Sci. USA 88: 2166-2170, 1991.
95. MOREL, D. W., DICORLETO, P. E., AND CHISOLM, G. M.: Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis 4: 357-364, 1984.
96. MUGGE, A., ELWELL, J. H., PETERSON, T. E., HOFMEYER, T. G., HEISTED, D. D., AND HARRISON, D. G.: Chromc treatment with polyethylene glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ. Res. 69: 1293-1300, 1991.
97. HOHARA, T., KUGIYAMA, K., OHGUSHI, M., SUGIYAMA, S., OHTA, Y., AND YASUE, H.: LPC in oxidized LDL elicits vasoconstraction and inhibits endothelium-dependent relaxation. Am. J. Physiol. 267: H2441-H2449, 1994.
98. MYERS, P. R., WRIGHT, T. F., TANNER, M. A., AND OSTLUND, R. E., JR.: The effects of native LDL and oxidized LDL on EDRF bioactivity and nitric oxide production in vascular endothelium. J. Lab. Clin. Med. 124: 672-683, 1994.
99. NABEL, E. G., GANZ, P., GORDON, J. B , ALEXANDER, R. W., AND SELWYN, A. P.: Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Circulation 77: 43-52, 1988.
100. NAGAO, T., VANHOUTTE, P. M.: Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery. J. Physiol. 445: 355-367, 1992.
101. NATARAJAN, V., SCRIBNER, W. M., HART, C. M., AND PARTHASARATHY, S : Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: a possible role in cell proliferation and atherogenesis. J. Lipid Res. 36: 2005-2016, 1995.
102. NICHOLSON, A. C., FRIEDA, S., PEARCE, A., AND SILVERSTBIN, R. L.: Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell unes: evidence implicating the lipid moiety of the hpoprotein as the binding site. Arterioscler. Thromb. Vase. Biol. 15: 269-275, 1995.
103. NIU, X. L., LIU, L.-Y., HU, M.-L., AND CHEN, X.: Some similarities in vascular effects of oleic acid and oxidized low-density lipoproteine on rabbit aorta. J. Mol. Cell Cardiol. 27: 531-539, 1995.
104. OHARA, Y., PETERSON, T. E., AND HARRISON, D. G.: Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 91: 2546-2551, 1993.
105. OHARA, Y., PETERSON, T. E., ZHENG, B., Kuo, J. P., AND HARRISON, D. G.: Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation. Arterioscler. Thromb. 14: 1007-1013, 1994.
106. OHARA, Y., SAYEGH, H. S., YAMIN, J. J., AND HARRISON, D. G.: Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension 25: 415-420, 1995a.
107. OHARA, Y., PETERSON, T. E., HASSAN, S. S., SUBRAMANIAN, R. R., WILCOX, J. N., AND HARRISON, D. G.: Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation 92: 898-903, 1995b.
108. OHGUSHI, M., KUGIYAMA, K., FUKUNAGA, K., MUROHARA, T., SUGIYAMA, S., MIYAMOTO, E., AND YASUE, H.: Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL. Artenoscler. Thromb. 13: 1525-1532, 1993.
109. OISHI, K., ZHENG, B., AND Kuo, J. F.: Inhibition of Na, K-ATPase and sodium pump by protein kinase C regulators: sphingosine, lysophosphatidylcholine, and oleic acid. J. Biol. Chem. 285: 70-75, 1990.
110. OMAR, H. A., CHERRY, P. D., MORTELLITI, M. P., BURKE-WOLIN, T., AND WOLIN, M. S.: Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation. Circ. Res. 69: 601-608, 1991.
111. OTTNAD, E., PARTHASARATHY, S., SAMBRANO, G. R., RAMPRASAD, M. P., QUEHENBERGEH, O., KONDRATENKO, N , GREEN, S., AND STEINBERG, D.: A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells. Proc. Natl. Acad. Sci. USA 92: 1391-1395, 1995.
112. PALINSKI, W , ROSENFELD, M. E., YLA-HERTTUALA, S., GURTNER, G. C., SOCHER, S. S., BUTLER, S. W, PARTHASARATHY, S., CAREW, T. E., STEINBERG, D., AND WITZTUM, J. L.: Low density lipoprotein undergoes oxidative modification in vivo. Proc. Natl. Acad. Sci. USA 86: 1372-1376, 1989.
113. PALMER, R. M. J., FERRIGE, A. G., AND MONCADA, S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond.) 327: 524-526, 1987.
114. PALMER, R. M. J., REES, D. D., ASHTON, D. S., AND MONCADA, S.: L-arginine is the physiological precurser for the formation of nitric oxide in endotheliumdependent relaxation, Biochem. Biophys. Res. Commun. 153: 1251-1256, 1988.
115. PARHAMI, F., FANG, Z. T., FOGELMAN, A. M , ANDALIBI, A., TERRITO, M. C., AND BERLINER, J. A.: Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J. Clin. Invest. 92: 471-478, 1993.
116. PARKER, P. J., KOUR, G., MARAIS, R. M., MITCHELL, F., PEARS, C., SCHAAP, D., STABEL, S., AND WEBSTER, C.: Protein kinase C: a family affair. Mol. Cell. Endocrinol. 65: 1-11, 1989.
117. 2 activity in endothelial cell-induced modification of low density lipoprotein. Proc. Natl. Acad. Sci. USA 82: 3000-3004, 1985.
118. PARTHASARATHY, S., YOUNG, S. G., WITZTUM, J. L., PITTMAN, R. C., AND STEINBERG, D.: Probucol inhibits oxidative modification of low density lipoprotein. J. Clin. Invest. 77: 761-800, 1986.
119. PARTHASARATHY, S., WIELAND, E., AND STEINBERG, D.: A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proc. Natl. Acad. Sci. USA 86: 1046-1050, 1989.
120. PENG, H.-B., RAJAVASHISTH, T. B., LIBBY, P., AND LIAO, J. K.: Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. J. Biol. Chem. 270: 17050-17055, 1995.
121. PENN, M. S., AND CHISOLM, G. M.: Oxidized lipoproteine, altered cell function d atherosclerosis. Atherosclerosis 108 (suppl.) : 21S-29S, 1994.
122. PLANE, F., BRUCKDORFER, K. R., KERR, P., STEUER, A., AND JACOBS, M.: Oxidative modification of low-density lipoprotein and the inhibition of relaxations mediated by endothelium-derived nitric oxide in rabbit aorta. Eur. J. Pharmacol. 105: 216-222, 1992
123. PRINCEN, H. M. G., VAN DUYVENVOORDE, W., BUYTENHEK, R., VAN DER LAAESE, A., VAN POPPEL, G., GEVERS LEUVEN, J. A., AND VAN HINSBEROH, V. W. M.: Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler. Thromb. Vase. Biol. 15: 325-333, 1995
124. QUINN, M. T., PARTHASARATHY, S., AND STEINBIRG, D.: Endothelial-cell derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein. Proc. Natl. Acad Sci. USA 82; 5949-5953, 1985.
125. QUINN, M. T., PARTHASARATHY, S., FONG, L. G., AND STEINBESG, D.: Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherosclerosis. Proc. Natl. Acad. Sci. USA 84: 2995-2998, 1987.
126. QUYYUMI, A. A., DAKAK, N., ANDREWS, N. P., HUSAIN, S., ARORA, S., GILLIGAN, D. M., PANZA, J. A., AND CANNON, R. O.: Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary artherosclerosis. J. Clin. Invest. 95: 1747-1755, 1995.
127. RADOMSKI, M. W., PALMER, R. M. J., AND MONCADA, S.: Comparative pharmacology of endothclial-denved relaxing factor, nitric oxide and prostacyclin in platelets. Br. J. Pharmacol. 92: 181-187, 1987.
128. RAJAVASHISTH, T. B., AKDALIBI, A., TERRITO, M. C., BERLINER, J. A., NAVAB, M., FOGELMAN, A. M., AND LUSIS, A. J.: Induction of endothelial expression of granulocyte and macrophage colony-stimulating factors by modified lowdensity lipoproteins. Nature (Lend.) 344: 254-257, 1990.
129. RAPOPORT, R. M., AND MURAD, F : Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through eGMP. Circ. Res. 52: 352-357, 1983.
130. REES, D. D., PALMER, R. M. J., SCHULZ, R., HUDSON, H. F., AND MONCADA, S.: Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752, 1990.
131. RIMM, E. B., STAJJPFER, M. J., ASCHERIO, A., BIOVANNUCCI, E., COLDITZ, G. A., AND WILLETT, W. C.: Vitamin E consumption and the risk of coronary artery disease in men. N. Engl J. Med. 328: 1450-1456, 1993.
132. ROSENKRANZ-WEISS, P., SESSA, W. C., MILSTIEN, S , KAUFMAN, S., WATSON, C. A., AND POSER, J. S.: Regulation of nitric oxide synthesis by proinflauimatory cytokines in human umbilical vein endothelial cells: elevations in tetrahydrobiopterin levels enhance endothelial nitnc oxide synthase specific activity. J. Clin. Invest. 93: 2236-2243, 1994
133. ROSSITCH, E., JR., ALEXANDER, E , BLACK, P. McL., AND COOKE, J. P.: L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J. Clin Invest. 87: 1295-1299, 1991.
134. RUBANYI, G. M.: Vascular effects of oxygen-derived free radicals. Free Radical Biol. & Med. 4: 107-120, 1988.
135. RUBANYI, G. M., AND VANHOUTTE, P. M.: Superoxide amons and hyperoxia inactivate endothehum-denved relaxing factor. Am. J. Physiol. 260: H822-H827, 1986a.
136. RUBANYI, G. M., AND VANOUTTE, P. M.: Oxygen derived free radicals, endothelium, and responsiveness of vascular smooth muscle. Am. J. Physiol. 250: H815-H821, 1986b.
137. RUBANYI, G. M., DESIDERIO, D., LUISI, A., JOHNS, A., AND SYBERTZ, E. J.: Phorbol dibutyrate inhibits release and action of endothelium-derived relaxing factor(s) in canine blood vessels. J. Pharmacol. Exp. Ther. 249: 858-863, 1989
138. SALONEN, J. T., YLA-HERTTUALA, S., YAMAMOTO, R, BUTLER, S., KORPELA, H., SALONEN, R., NYYSSONEN, K., PALINSKI, W., AND WITZTUM, J. L.: Autoantibody against oxidized LDL and progression of carotid atherosclerosis. Lancet 339: 883-887, 1992.
139. SAMBRANO, G. R., AND STEINBERG, D.: Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine. Proc. Natl. Acad. Sci. USA 92: 1396-1400, 1995.
140. SASAHARA, M., RAINES, E. W., CHAIT, A., CAREW, T. E., STEINBERG, D., WAHL, P. W., AND ROSS, R.: Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation? J. Clin. Invest. 94: 155-164, 1994.
141. SCHMIDT, H. H. H. W., GAGNE, G. D., NAKANE, M., POLLOCK, J. S., MILLER, M. F., AND MURAD, F: Mapping of neuronal nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase, but not with soluble guanylate cyclase, and novel paraneural functions for nitrenergic signal transduction. J. Histochem. Cytochem. 40: 1439-1456, 1992.
142. SECCOMBE, J. F., PEARSON, P. J., AND SCHAFF, H. V.: Oxygen radical-mediated vascular injury selectively inhibits receptor-dependent release of nitric oxide from canine coronary arteries. J. Thorac. Cardiovasc. Surg. 107: 505-509, 1994.
143. SELLKE, F. W., ARMSTRONG, M. L., AND HARRISON, D. G.: Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 81: 1586-1593, 1990.
144. SIEGEL, G., SCHNALKE, F., STOCK, G., AND GROTE, J.: Prostacyclin, endothelin-derived relaxing factor and vasodilation. Adv. Prostaglandm Thromboxane Leukotriene Res. 19: 267-270, 1989.
145. SHIMOKAWA, H., AND VANHOUTTE, P. M.: Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ. Res. 64: 900-914, 1989.
146. SHIMOKAWA, H., FLAVAHAN, N. A., AND VANHOUTTE, P. M.: Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. Circulation 83: 652-660, 1991.
147. SIMON, B. C., CUNNINGHAM, L. D., AND COHEN, R. A.: Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J. Clin. Invest. 86: 75-79, 1990.
148. SMITH, J. A., AND LANG, D.: Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in cyclic GMP content, is inhibited by a phorhol ester. Br. J. Pharmacol. 99: 565-571, 1990.
149. SPARROW, C. P., DOEBBER, T. W., OLSZEWSKI, J., WU, M. S., VENTRE, J., STEVENS, K. A., AND CHAO, Y.: Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N, N'-diphenyl-phenylenediamine. J. Clin. Invest. 89: 1885-1891, 1992.
150. STAMPFER, M. J., HENNEKENS, C. H., MANSON, J. E., COLDITZ, G. A, ROSNER, B., AND WILLETT, W. C.: Vitamin E consumption and the risk of coronary artery disease in women. N. Engl. J. Med. 328: 1444-1449, 1993.
151. STANTON, L. W., TYLER WHITE, R., BRYANT, C. M., PROTTER, A. A., AND ENDEMANN, G.: A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein. J. Biol. Chem. 267: 22446-22451, 1992.
152. STEIN, O., AND STEIN, Y.: Bovine aortic endothelial cells display macrophagelike properties towards acetylated I-labelled low density lipoprotein. Biochem. Biophys. Acta 620: 631-635, 1980.
153. STEINBERG, D., PARTHASARATHY, S., CAREW, T. E., AND WITZTUM, J. L.: Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320: 915-924, 1989.
154. STEINBRECHER, U. P., PARTHASARATHY, S., LEAKE, D. S., WITZTUM, J. L., AND STEINBEKG, D : Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA 81: 3883-3887, 1984.
155. STEINBRECHER, U. P.: Oxidation of human low density lipoprotein results in derivatization of lysine residues of apohpoprotein B by lipid peroxide decomposition products. J. Biol. Chem. 262: 3603-3608, 1987.
156. STEPP, D W., AND TULENKO, T N.: Alterations in basal and serotonin-stimulated calcium permeability and vasoconstriction in atherosclerotic aorta. Arterioscler. Thromb. 14: 1854-1859, 1994.
157. STEWART-LEE, A. L., FORSTER, L. A., NOUROOZ-ZADEH, J., FERNS, G. A. A., ANGGARD, E. E.: Vitamin E protects against impairment of endotheliummediated relaxations in cholesterol-fed rabbits. Arterioscler. Thromb. 14: 494-499, 1994.
158. SUGIYAMA, S., KUGIYAMA, K., OHGUSHI, M., FUJIMOTO, K., AND YASUE, H.: Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries: role of protein kinase C. Circ. Res. 74: 565-575, 1994.
159. SWERLICK, R. A., LEE, K. H., WICK, T. M., AND LAWLEY, T. J.: Human dermal microvascular endothelial but not umbilical vein endothelial cells express CD36 in vivo and in vitro. J. Immunol. 148: 78-83, 1992.
160. TANNER, F. C., NOLL, G., BOULANGER, C. M., LUSCHER, T. F.: Oxidized low density lipoproteins inhibit relaxations of porcine coronary artery: role of scavenger receptor and endothelium-derived nitric oxide. Circulation 83: 2012-2020, 1991.
161. TREASURE, C. B., KLEIN, J L., WEINTRAUB, W. S., TALLEY, J. D., STILLABOWER, M, E., KOSINSKI, A. S., ZHANG, J., BOCCUZZI, S. J., CEDARHOLM, J. C., AND ALEXANDER, R. W.: Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease N. Engl. J. Med. 332: 481-487, 1995.
162. TYROLER, H. A.: Lowering blood cholesterol levels decreases risk of coronary heart disease: an overview of clinical trials. In Hypercholesterolemia and Atherosclerosis, ed. by D. Steinberg and J. M. Olefsky, pp 99-116, Churchill Livingstone, New York, 1987.
163. RBEUREN, T. J, JORDAINS, P. H., ZONNEKEYN, L. L., VAN HOVE, C. E., COENE, M. C., AND HERMAN, A. G.: Effect of hypercholesterolemia on vascular reactivity in the rabbit Circ. Res. 58: 552-564, 1986.
164. VERBEUREN, T. J.: Endothelium and coronary atherosclerosis. Coron. Artery Dis. 2: 323-337, 1991.
165. VITA, J A, TREASURE, C. B., YEUNG, A. C., VEKSHTEIN, V. I., FANTASIA, G. M., FISH, R. D., GANZ, P., AND SELWYN, A. P.: Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrates marked increase in sensitivity to constrictor effects of catecholamines. Circulation 85: 1390-1397, 1992.
166. VOYTA, J. C., VIA, D. P., BUTTERFIELD, C. E., AND ZETTER, B. R.: Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell Biol. 99: 2034-2040, 1984.
167. WATTS, G. F., LEWIS, B., BRUNT, J. N., LEWIS, E. S., COLTART, D. J., SMITH, L. D., MANN, J. I., AND SWAN, A. V.: Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St. Thomas' Atherosclerosis Regression Study (STARS). Lancet 339: 563-569, 1992.
168. WEINHEIMER, G., WAGNER, B., AND OSSWALD, H.: Interference of phorbol esters with endothelium-dependent vascular smooth muscle relaxation. Eur. J. Pharmacol. 130: 319-322, 1986.
169. XIU, R. J., FREYSCIIUSS, A., YING, X., BERGLUND, L., HENRIKSSON, P., AND BJORKHEM, I.: The antioxidant butylated hydroxytoluene prevents early cholesterol-induced microcirculatory changes in rabbits. J. Clin. Invest. 93: 2732-2737, 1994
170. YAMAMOTO, H., BOSSALLER, C., CARTWRIGHT, J., JR., AND HENRY, P. D.: Videomicroscopic demonstration of defective cholinergic arteriolar vasodilation in atherosclerotic rabbit. J. Clin. Invest. 81: 1752-1758, 1988.
171. YANG, Z., RICHARD, V., VON SEGESSER, L., BAUER, E., STULZ, P., TURINA, M., AND LUSCHER, T. F.: Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. Circulation 82: 188-195, 1990.
172. YLA-HERTTUALA, S., PALINSKI, W., ROSENFELD, M. E., PARTHASARATHY, S., CAREW, T. E., BUTLER, S, WITZTUM, J. L., STEINBERG, D.: Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest. 84: 1086-1095, 1989.
173. YOKOHAMA, M., HIRATA, K., MIYAKE, R., AKITA, H., ISHIKAWA, Y., AND FUKUZAKI, H.: Lysophosphatidylcholine: essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein. Biochem. Biophys. Res. Commun. 168: 301-308, 1990.
174. YOSHIZUMI, M., PERRELLA, M. A., BURNETT, J. C., JR., AND LEE, M.-E.: Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ. Res. 73: 205-209, 1993.
175. YOUNG, S. G., AND PARTHASARATHY, S.: Why are low-density lipoproteins atherogenic? West. J. Med. 160: 153-164, 1994.
176. YUI, Y., HATTORI, R., KOSUGA, K., EIZAWA, H., HIH, K., AND KAWAI, C.: Purification of nitric oxide synthase from rat macrophages. J. Biol. Chem. 266: 12544-12547, 1991a.
177. YUI, Y., RATTORI, R., KOSUGA, K., EIZAWA, H, HIKI, K., OHKAWA, S., OHNISHI, K, TERAO, S., AND KAWAI, C.: Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils. J. Biol. Chem. 266: 3369-3371, 1991b.
178. ZEIHER, A. M., AND SCHACHINGER, V.: Coronary endothelial vasodilator dysfunction: clinical relevance and therapeutic implications. Z. Kardiol. 83 (suppl. 3) : 7-14, 1994.
179. ZEIHER, A. M., DREXLER, H., WOLLSCHLAGER, H., AND JUST, H.: Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary athersclerosis. Circulation 83: 391-401, 1991a.
180. ZEIHER, A. M., DREXLER, H., WOLLSCHLAGER, H , AND JUST, H.: Endothelial dysfunction of the coronary microvasculature is associated with impaired coronary blood flow regulation in patients with early atherosclerosis. Circulation 84: 1984-1992, 1991b.
181. ZEMBOWICZ, A., TANG, J., AND WU, K. K.: Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine. J. Biol. Chem. 28: 17006-17010, 1995.
182. ZHANG, H., BASRA, H. J. K., AND STEINBRECHER, U. P.: Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages. J. Lipid Res. 31: 1361-1369, 1990.