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Volumn 126, Issue 1, 1996, Pages 65-75

Inhibition of LDL oxidation and myeloperoxidase dependent tyrosyl radical formation by the selective estrogen receptor modulator raloxifene (LY139481 HCL)

Author keywords

Lipoperoxides; Low density lipoproteins; Macrophages; Oxidation; Phagocytosis

Indexed keywords

DEXAMETHASONE; ESTRADIOL; ESTROGEN RECEPTOR; HORSERADISH PEROXIDASE; LOW DENSITY LIPOPROTEIN; MYELOPEROXIDASE; RALOXIFENE;

EID: 0030604022     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(96)05894-7     Document Type: Article
Times cited : (87)

References (50)
  • 1
    • 0028970042 scopus 로고
    • Cell biology of atherosclerosis
    • [1] Ross R. Cell biology of atherosclerosis. Annu Rev Physiol 1995;57:791.
    • (1995) Annu Rev Physiol , vol.57 , pp. 791
    • Ross, R.1
  • 2
    • 0028923856 scopus 로고
    • Lipoprotein oxidation as a mediator of atherogenesis: Insights from pharmacological studies
    • [2] Daugherty A, Roselaar SE. Lipoprotein oxidation as a mediator of atherogenesis: insights from pharmacological studies. Cardiovasc Res 1995;29:297.
    • (1995) Cardiovasc Res , vol.29 , pp. 297
    • Daugherty, A.1    Roselaar, S.E.2
  • 3
    • 0026072558 scopus 로고
    • Effects of post-menopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins
    • [3] Walsh RW, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of post-menopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991;325:1196.
    • (1991) N Engl J Med , vol.325 , pp. 1196
    • Walsh, R.W.1    Schiff, I.2    Rosner, B.3    Greenberg, L.4    Ravnikar, V.5    Sacks, F.M.6
  • 6
    • 0028282823 scopus 로고
    • Effect of postmenopausal estrogen replacement on plasma Lp(a) lipoprotein concentrations
    • [6] Sacks FM, McPherson R, Walsh BW. Effect of postmenopausal estrogen replacement on plasma Lp(a) lipoprotein concentrations. Arch Intern Med 1994;154:1106.
    • (1994) Arch Intern Med , vol.154 , pp. 1106
    • Sacks, F.M.1    McPherson, R.2    Walsh, B.W.3
  • 8
    • 0024956983 scopus 로고
    • Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology
    • [8] Gey KF, Puska P. Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology. Ann NY Acad Sci 1989;570:268.
    • (1989) Ann NY Acad Sci , vol.570 , pp. 268
    • Gey, K.F.1    Puska, P.2
  • 9
    • 0024461584 scopus 로고
    • Probucol attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits
    • [9] Daugherty A, Zweifel BS, Schonfeld G. Probucol attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Br J Pharmacol 1989;98:612.
    • (1989) Br J Pharmacol , vol.98 , pp. 612
    • Daugherty, A.1    Zweifel, B.S.2    Schonfeld, G.3
  • 10
    • 0013693531 scopus 로고
    • Anti-atherogenic effects of probucol unrelated to its hypocholesterolemic effect: Evidence that anti-oxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit
    • [10] Carew TE, Schwenke DC, Steinberg D. Anti-atherogenic effects of probucol unrelated to its hypocholesterolemic effect: evidence that anti-oxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 1987;84:7725.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7725
    • Carew, T.E.1    Schwenke, D.C.2    Steinberg, D.3
  • 11
    • 0025907448 scopus 로고
    • Oestrogen-induced enhancement of myeloperoxidase activity in human PMN leukocytes; a possible cause of oxidative stress in inflammatory cells
    • [11] Jansson G. Oestrogen-induced enhancement of myeloperoxidase activity in human PMN leukocytes; a possible cause of oxidative stress in inflammatory cells. Free Rad Res Comm 1991;14:195.
    • (1991) Free Rad Res Comm , vol.14 , pp. 195
    • Jansson, G.1
  • 12
    • 0025240069 scopus 로고
    • 17β-Estradiol inhibits LDL oxidation and cholesteryl ester formation in cultured macrophages
    • [12] Huber LA, Scheffler E, Poll KT, Ziegler R, Dresel HA. 17β-estradiol inhibits LDL oxidation and cholesteryl ester formation in cultured macrophages. Free Rad Res Comm 1990;8:167.
    • (1990) Free Rad Res Comm , vol.8 , pp. 167
    • Huber, L.A.1    Scheffler, E.2    Poll, K.T.3    Ziegler, R.4    Dresel, H.A.5
  • 15
    • 0028919243 scopus 로고
    • Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro
    • [15] Lacort M, Leal AM, Liza M, Martin C, Martinez R, Ruiz-Larrea MB. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids 1995;30:141.
    • (1995) Lipids , vol.30 , pp. 141
    • Lacort, M.1    Leal, A.M.2    Liza, M.3    Martin, C.4    Martinez, R.5    Ruiz-Larrea, M.B.6
  • 16
    • 0026657363 scopus 로고
    • The role of lipid peroxidation and anti-oxidants in oxidative modification of LDL
    • [16] Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and anti-oxidants in oxidative modification of LDL. Free Rad Biol Med 1992;13:341.
    • (1992) Free Rad Biol Med , vol.13 , pp. 341
    • Esterbauer, H.1    Gebicki, J.2    Puhl, H.3    Jurgens, G.4
  • 17
    • 0028176129 scopus 로고
    • 17β-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine
    • [17] Keaney JF, Shwaery GT, Xu A, Nicolosi RJ, Loscalzo, J, Foxall TL, Vita JA. 17β-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation 1994;89:2251.
    • (1994) Circulation , vol.89 , pp. 2251
    • Keaney, J.F.1    Shwaery, G.T.2    Xu, A.3    Nicolosi, R.J.4    Loscalzo, J.5    Foxall, T.L.6    Vita, J.A.7
  • 19
    • 0002658633 scopus 로고
    • Effects of raloxifene (LY139481 HCL) on biochemical markers of bone and lipid metabolism in healthy post-menopausal women
    • Hong Kong
    • [19] Draper MW, Flowers DE, Huster WJ, Neild JA. Effects of raloxifene (LY139481 HCL) on biochemical markers of bone and lipid metabolism in healthy post-menopausal women. 1993;119 (Abstract). Proc 4th Int. Symp. Osteoporosis, Hong Kong.
    • (1993) Proc 4th Int. Symp. Osteoporosis , pp. 119
    • Draper, M.W.1    Flowers, D.E.2    Huster, W.J.3    Neild, J.A.4
  • 20
    • 0028263965 scopus 로고
    • Methods to determine oxidation of low density lipoproteins
    • [20] Puhl H, Waeg G, Esterbauer H. Methods to determine oxidation of low density lipoproteins. Methods Enzymol 1994;233:425.
    • (1994) Methods Enzymol , vol.233 , pp. 425
    • Puhl, H.1    Waeg, G.2    Esterbauer, H.3
  • 21
    • 0024423945 scopus 로고
    • An improved spectrofluorometric assay for quantitating yeast phagocytosis in cultures of murine peritoneal macrophages
    • [21] Ragsdale RL, Grasso RJ. An improved spectrofluorometric assay for quantitating yeast phagocytosis in cultures of murine peritoneal macrophages. J lmmunol Meth 1989;123:259.
    • (1989) J Lmmunol Meth , vol.123 , pp. 259
    • Ragsdale, R.L.1    Grasso, R.J.2
  • 22
    • 0021117853 scopus 로고
    • Dityrosine: In vitro production and characterization
    • [22] Amado R, Aeschbach R, Neukom H. Dityrosine: In vitro production and characterization. Methods Enzymol 1984;107:377.
    • (1984) Methods Enzymol , vol.107 , pp. 377
    • Amado, R.1    Aeschbach, R.2    Neukom, H.3
  • 23
    • 0027267487 scopus 로고
    • Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells
    • [23] Francis GA, Mendez AJ, Bierman EL, Heinecke JW. Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells. Proc Natl Acad Sci USA 1993;90:6631.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6631
    • Francis, G.A.1    Mendez, A.J.2    Bierman, E.L.3    Heinecke, J.W.4
  • 24
    • 0027292790 scopus 로고
    • Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins
    • [24] Heinecke JW, Li W, Francis GA, Goldstein JA. Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins. J Clin Invest 1993;91:2866.
    • (1993) J Clin Invest , vol.91 , pp. 2866
    • Heinecke, J.W.1    Li, W.2    Francis, G.A.3    Goldstein, J.A.4
  • 25
    • 0023192020 scopus 로고
    • Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/ macrophages during atherogenesis
    • [25] Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/ macrophages during atherogenesis. Proc Natl Acad Sci USA 1987;84:2995.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2995
    • Quinn, M.T.1    Parthasarathy, S.2    Fong, L.G.3    Steinberg, D.4
  • 27
    • 0026028139 scopus 로고
    • Minimally oxidized low density lipoprotein induces tissue factor expression in cultured human endothelial cells
    • [27] Drake TA, Hannani K, Fei HH, Lavi S, Berliner JA. Minimally oxidized low density lipoprotein induces tissue factor expression in cultured human endothelial cells. Am J Pathol 1991;138:601.
    • (1991) Am J Pathol , vol.138 , pp. 601
    • Drake, T.A.1    Hannani, K.2    Fei, H.H.3    Lavi, S.4    Berliner, J.A.5
  • 28
    • 0026781978 scopus 로고
    • Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells
    • [28] Kume N, Cybulsky MI, Gimbrone MA. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 1992;90:1138.
    • (1992) J Clin Invest , vol.90 , pp. 1138
    • Kume, N.1    Cybulsky, M.I.2    Gimbrone, M.A.3
  • 29
    • 0020972414 scopus 로고
    • Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
    • [29] Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Ann Rev Biochem 1983;52:223.
    • (1983) Ann Rev Biochem , vol.52 , pp. 223
    • Brown, M.S.1    Goldstein, J.L.2
  • 30
    • 0021933648 scopus 로고
    • Monocytes and neutrophils oxidize low density lipoprotein, making it cytotoxic
    • [30] Cathcart MK, Morel DW, Chisolm GM. Monocytes and neutrophils oxidize low density lipoprotein, making it cytotoxic. J Leukocyte Biol 1985;38:341.
    • (1985) J Leukocyte Biol , vol.38 , pp. 341
    • Cathcart, M.K.1    Morel, D.W.2    Chisolm, G.M.3
  • 31
    • 0022538758 scopus 로고
    • Superoxide mediated modification of low density lipoprotein by arterial smooth muscle cells
    • [31] Heinecke JW, Baker L, Rosen H, Chait A. Superoxide mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest 1986;77:757.
    • (1986) J Clin Invest , vol.77 , pp. 757
    • Heinecke, J.W.1    Baker, L.2    Rosen, H.3    Chait, A.4
  • 32
    • 0000061171 scopus 로고
    • Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
    • [32] Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984;81:3883.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3883
    • Steinbrecher, U.P.1    Parthasarathy, S.2    Leake, D.S.3    Witztum, J.L.4    Steinberg, D.5
  • 34
    • 0026515759 scopus 로고
    • Cellular oxidative modifications of low density lipoprotein does not require lipoxygenases
    • [34] Sparrow CP, Olszewski J. Cellular oxidative modifications of low density lipoprotein does not require lipoxygenases. Proc Natl Acad Sci USA 1992;89:128.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 128
    • Sparrow, C.P.1    Olszewski, J.2
  • 35
    • 0029010630 scopus 로고
    • Paradoxical actions of anti-oxidants in the oxidation of low density lipoprotein by peroxidases
    • [35] Santanam N, Parthasarathy S. Paradoxical actions of anti-oxidants in the oxidation of low density lipoprotein by peroxidases. J Clin Invest 1995;95:2594.
    • (1995) J Clin Invest , vol.95 , pp. 2594
    • Santanam, N.1    Parthasarathy, S.2
  • 36
    • 0028076845 scopus 로고
    • Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein
    • [36] Savenkova MI, Mueller DM, Heinecke JW. Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein. J Biol Chem 1994;269:20394.
    • (1994) J Biol Chem , vol.269 , pp. 20394
    • Savenkova, M.I.1    Mueller, D.M.2    Heinecke, J.W.3
  • 37
    • 0025076921 scopus 로고
    • Co-localization of 15-lipoxygenase messenger RNA and protein epitopes of oxidized low density lipoprotein in macrophage rich areas of atherosclerotic lesions
    • [37] Yla-Herttuala S, Rosenfeld ME, Parthasarathy S, Glass CK, Sigal E, Witztum JL, Steinberg D. Co-localization of 15-lipoxygenase messenger RNA and protein epitopes of oxidized low density lipoprotein in macrophage rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA 1990;87:6959.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6959
    • Yla-Herttuala, S.1    Rosenfeld, M.E.2    Parthasarathy, S.3    Glass, C.K.4    Sigal, E.5    Witztum, J.L.6    Steinberg, D.7
  • 38
    • 0023717222 scopus 로고
    • DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions
    • [38] Mowri H, Ohkuma S, Takano T. DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions. Biochim Biophys Acta 1988;963:208.
    • (1988) Biochim Biophys Acta , vol.963 , pp. 208
    • Mowri, H.1    Ohkuma, S.2    Takano, T.3
  • 40
    • 0025353845 scopus 로고
    • Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits
    • [40] Rosenfeld ME, Palinski W, Yla-Herttuala S, Butler S, Witztum JL. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. Arteriosclerosis 1990;10:336.
    • (1990) Arteriosclerosis , vol.10 , pp. 336
    • Rosenfeld, M.E.1    Palinski, W.2    Yla-Herttuala, S.3    Butler, S.4    Witztum, J.L.5
  • 41
    • 0025261423 scopus 로고
    • Napthalenes as inhibitors of myeloperoxidase: Direct and indirect mechanisms of inhibition
    • [41] Egan RW, Hagmann WK, Gale PH. Napthalenes as inhibitors of myeloperoxidase: direct and indirect mechanisms of inhibition. Agents Action 1990;29:265.
    • (1990) Agents Action , vol.29 , pp. 265
    • Egan, R.W.1    Hagmann, W.K.2    Gale, P.H.3
  • 42
    • 0027157319 scopus 로고
    • 2-receptor antagonists. Effects on myeloperoxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system
    • 2-receptor antagonists. Effects on myeloperoxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system. Biochem Pharmacol 1993;45:2389.
    • (1993) Biochem Pharmacol , vol.45 , pp. 2389
    • Van Zyl, J.M.1    Kriegler, A.2    Van Der Walt, B.J.3
  • 43
    • 0026079216 scopus 로고
    • Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs
    • [43] Kettle AJ, Winterbourn CC. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem Pharmacol 1991;41:1485.
    • (1991) Biochem Pharmacol , vol.41 , pp. 1485
    • Kettle, A.J.1    Winterbourn, C.C.2
  • 44
    • 0025165374 scopus 로고
    • Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase
    • [44] Zuurbier KWM, Bakkenist ARJ, Fokkens RH, Nibbering NMM, Wever R, Muijsers AO. Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase. Biochem Pharmacol 1990;40:1801.
    • (1990) Biochem Pharmacol , vol.40 , pp. 1801
    • Zuurbier, K.W.M.1    Bakkenist, A.R.J.2    Fokkens, R.H.3    Nibbering, N.M.M.4    Wever, R.5    Muijsers, A.O.6
  • 45
    • 0027492038 scopus 로고
    • Simvastatin inhibits the oxidation of low density lipoproteins by activated human monocyte-derived macrophages
    • [45] Giroux LM, Davignon J, Naruszewicz M. Simvastatin inhibits the oxidation of low density lipoproteins by activated human monocyte-derived macrophages. Biochim Biophys Acta 1993;1165:335.
    • (1993) Biochim Biophys Acta , vol.1165 , pp. 335
    • Giroux, L.M.1    Davignon, J.2    Naruszewicz, M.3
  • 46
    • 0026462553 scopus 로고
    • Carvedilol, a new anti-hypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper
    • [46] Yue T-L, McKenna PJ, Lysko PG, Ruffolo RR, Feuerstein GZ. Carvedilol, a new anti-hypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper. Atherosclerosis 1992;97:209.
    • (1992) Atherosclerosis , vol.97 , pp. 209
    • Yue, T.-L.1    McKenna, P.J.2    Lysko, P.G.3    Ruffolo, R.R.4    Feuerstein, G.Z.5
  • 47
    • 0024461584 scopus 로고
    • Probucol attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits
    • [47] Daugherty A, Zweifel BS, Schonfeld G. Probucol attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Br J Pharmacol 1989;98:612.
    • (1989) Br J Pharmacol , vol.98 , pp. 612
    • Daugherty, A.1    Zweifel, B.S.2    Schonfeld, G.3
  • 48
    • 0013693531 scopus 로고
    • Anti-atherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that anti-oxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit
    • [48] Carew TE, Schwenke DC, Steinberg D. Anti-atherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that anti-oxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 1987;84:7725.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7725
    • Carew, T.E.1    Schwenke, D.C.2    Steinberg, D.3
  • 49
    • 0003131002 scopus 로고
    • Disorders of the ovary and female reproductive tract
    • Wilson JD and Foster DW (eds). Philadelphia, PA: W.B. Saunders Co.
    • [49] Carr, BR. Disorders of the ovary and female reproductive tract. In: Wilson JD and Foster DW (eds). Williams Textbook of Endocrinology. Eighth Edition. Philadelphia, PA: W.B. Saunders Co., 1992;733.
    • (1992) Williams Textbook of Endocrinology. Eighth Edition , pp. 733
    • Carr, B.R.1
  • 50
    • 0028292033 scopus 로고
    • Myeloperoxidase, a catalyst for lipoprotein oxidation is expressed in human atherosclerotic lesions
    • [50] Daugherty A, Dunn JL, Rateri RL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation is expressed in human atherosclerotic lesions. J Clin Invest 1994;94:437.
    • (1994) J Clin Invest , vol.94 , pp. 437
    • Daugherty, A.1    Dunn, J.L.2    Rateri, R.L.3    Heinecke, J.W.4


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