메뉴 건너뛰기




Volumn 15, Issue 2, 1997, Pages 840-852

Clinical potential of new antiestrogens

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; DROLOXIFENE; ESTRADIOL; FULVESTRANT; IDOXIFENE; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; RALOXIFENE; TAMOXIFEN; TOREMIFENE;

EID: 0031026744     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.2.840     Document Type: Review
Times cited : (128)

References (138)
  • 1
    • 0021618186 scopus 로고
    • The pharmacology and clinical uses of tamoxifen
    • Furr BJA, Jordan VC: The pharmacology and clinical uses of tamoxifen. Pharmacol Ther 25:127-205, 1984
    • (1984) Pharmacol Ther , vol.25 , pp. 127-205
    • Furr, B.J.A.1    Jordan, V.C.2
  • 2
    • 0023773272 scopus 로고
    • The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole
    • Jordan VC: The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole. Breast Cancer Res Treat 11:197-209, 1988
    • (1988) Breast Cancer Res Treat , vol.11 , pp. 197-209
    • Jordan, V.C.1
  • 3
    • 0025338591 scopus 로고
    • Development of antiestrogens and their use in breast cancer. Eighth Cain Memorial Lecture
    • Lerner LJ, Jordan VC: Development of antiestrogens and their use in breast cancer. Eighth Cain Memorial Lecture. Cancer Res 50:4177-4189, 1990
    • (1990) Cancer Res , vol.50 , pp. 4177-4189
    • Lerner, L.J.1    Jordan, V.C.2
  • 4
    • 0028861586 scopus 로고
    • Use of tamoxifen for breast cancer twenty eight years later
    • Jaiyesimi IA, Buzdar AU, Decker DA, et al.: Use of tamoxifen for breast cancer twenty eight years later. J Clin Oncol 13:513-529, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 513-529
    • Jaiyesimi, I.A.1    Buzdar, A.U.2    Decker, D.A.3
  • 6
    • 0027172047 scopus 로고
    • Current view of the use of tamoxifen for the treatment and prevention of breast cancer. Gaddum Memorial Lecture
    • Jordan VC: Current view of the use of tamoxifen for the treatment and prevention of breast cancer. Gaddum Memorial Lecture. Br J Pharmacol 110: 507-517, 1993
    • (1993) Br J Pharmacol , vol.110 , pp. 507-517
    • Jordan, V.C.1
  • 7
    • 0000396336 scopus 로고    scopus 로고
    • Should adjuvant tamoxifen therapy be stopped at 5 years?
    • Bilimoria MM, Assikis VJ, Jordan VC: Should adjuvant tamoxifen therapy be stopped at 5 years? Cancer J Sci Am 2:140-150, 1996
    • (1996) Cancer J Sci Am , vol.2 , pp. 140-150
    • Bilimoria, M.M.1    Assikis, V.J.2    Jordan, V.C.3
  • 8
    • 0027361914 scopus 로고
    • Molecular mechanism of resistance to tamoxifen therapy in breast cancer
    • Morrow M, Jordan VC: Molecular mechanism of resistance to tamoxifen therapy in breast cancer. Arch Surg 128:1187-1191, 1993
    • (1993) Arch Surg , vol.128 , pp. 1187-1191
    • Morrow, M.1    Jordan, V.C.2
  • 9
    • 0029144331 scopus 로고
    • Possible mechanisms in the emergence of tamoxifen-resistant breast cancer
    • Tonetti DA, Jordan VC: Possible mechanisms in the emergence of tamoxifen-resistant breast cancer. Anticancer Drugs 9:498-507, 1995
    • (1995) Anticancer Drugs , vol.9 , pp. 498-507
    • Tonetti, D.A.1    Jordan, V.C.2
  • 10
    • 0028796491 scopus 로고
    • What if tamoxifen had been found to produce rat liver tumors in 1973?
    • Jordan VC: What if tamoxifen had been found to produce rat liver tumors in 1973? Ann Oncol 6:29-33,1995
    • (1995) Ann Oncol , vol.6 , pp. 29-33
    • Jordan, V.C.1
  • 11
    • 0027942428 scopus 로고
    • Should clinicians be concerned about the carcinogenic potential of tamoxifen?
    • Jordan VC, Morrow M: Should clinicians be concerned about the carcinogenic potential of tamoxifen? Eur J Cancer 30A: 1714-1721, 1994
    • (1994) Eur J Cancer , vol.30 A , pp. 1714-1721
    • Jordan, V.C.1    Morrow, M.2
  • 12
    • 0029048753 scopus 로고
    • Gynecological effects of tamoxifen and the association with endometrial cancer
    • Assikis VJ, Jordan VC: Gynecological effects of tamoxifen and the association with endometrial cancer. Int J Gynecol Obstet 49:241-257, 1995
    • (1995) Int J Gynecol Obstet , vol.49 , pp. 241-257
    • Assikis, V.J.1    Jordan, V.C.2
  • 13
    • 33748456978 scopus 로고    scopus 로고
    • A realistic clinical perspective of tamoxifen and endometrial carcinogenesis
    • Assikis VJ, Neven P, Jordan VC, et al. A realistic clinical perspective of tamoxifen and endometrial carcinogenesis. Eur J Cancer 32:1464-1476, 1996
    • (1996) Eur J Cancer , vol.32 , pp. 1464-1476
    • Assikis, V.J.1    Neven, P.2    Jordan, V.C.3
  • 14
    • 0028936687 scopus 로고
    • Tamoxifen and tumorigencity: A predictable cancer
    • Jordan VC: Tamoxifen and tumorigencity: A predictable cancer. J Natl Cancer Inst 87:623-626, 1995
    • (1995) J Natl Cancer Inst , vol.87 , pp. 623-626
    • Jordan, V.C.1
  • 15
    • 0021709492 scopus 로고
    • Biochemical pharmacology of antiestrogen action
    • Jordan VC: Biochemical pharmacology of antiestrogen action. Pharmacol Rev 36:245-276, 1984
    • (1984) Pharmacol Rev , vol.36 , pp. 245-276
    • Jordan, V.C.1
  • 16
    • 0017665570 scopus 로고
    • A monohydroxyiated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan VC, Collins MM, Rowsby L, et al.: A monohydroxyiated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75:305-316, 1977
    • (1977) J Endocrinol , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3
  • 17
    • 0026440014 scopus 로고
    • Interaction of DP-TAT-59 an active metabolite of new triphenylethylene derivative (TAT- 59) with estrogen receptors
    • Toko T, Maksuo KI, Shibata J, et al.: Interaction of DP-TAT-59 an active metabolite of new triphenylethylene derivative (TAT- 59) with estrogen receptors. J Steroid Biochem Mol Biol 43:507-514, 1992
    • (1992) J Steroid Biochem Mol Biol , vol.43 , pp. 507-514
    • Toko, T.1    Maksuo, K.I.2    Shibata, J.3
  • 18
    • 0018138311 scopus 로고
    • Non-steroidal antiestrogens: Their biological effects and potential mechanisms of action
    • Jordan VC, Dix CJ, Naylor KE, et al.: Non-steroidal antiestrogens: Their biological effects and potential mechanisms of action. J Toxicol Environ Health 4:364-390, 1978
    • (1978) J Toxicol Environ Health , vol.4 , pp. 364-390
    • Jordan, V.C.1    Dix, C.J.2    Naylor, K.E.3
  • 19
    • 0021735339 scopus 로고
    • Structural requirements for the pharmacological activity of non-steroidal antiestrogens in vitro
    • Jordan VC, Lieberman ME, Cormier E, et al.:. Structural requirements for the pharmacological activity of non-steroidal antiestrogens in vitro. Mol Pharmacol 226:272-278, 1984
    • (1984) Mol Pharmacol , vol.226 , pp. 272-278
    • Jordan, V.C.1    Lieberman, M.E.2    Cormier, E.3
  • 20
    • 0020506431 scopus 로고
    • Antiestrogen action of 3-hydroxy-tamoxifen in the human breast cancer cell line MCF-7
    • Roos WK, Oeze L, Loser R, et al.: Antiestrogen action of 3-hydroxy-tamoxifen in the human breast cancer cell line MCF-7. J Natl Cancer Inst 71: 55-59, 1983
    • (1983) J Natl Cancer Inst , vol.71 , pp. 55-59
    • Roos, W.K.1    Oeze, L.2    Loser, R.3
  • 21
    • 0018721780 scopus 로고
    • Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthenyl] [4-2-(1-p-pyrrolidinyl ethoxy) - phenyl] methanone methane sulfonic acid
    • Jones CD, Suarez T, Mossey EH, et al.: Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthenyl] [4-(2-(1-p-pyrrolidinyl ethoxy) - phenyl] methanone methane sulfonic acid. J Med Chem 22:962-966, 1979
    • (1979) J Med Chem , vol.22 , pp. 962-966
    • Jones, C.D.1    Suarez, T.2    Mossey, E.H.3
  • 22
    • 0019416798 scopus 로고
    • Activity of the antiestrogen trioxifene against N-nitrosomethylurea- induced rat mammary carcinomas
    • Rose DP, Fischer AH, Jordan VC: Activity of the antiestrogen trioxifene against N-nitrosomethylurea- induced rat mammary carcinomas. Eur J Cancer Clin Oncol 17:893-898, 1981
    • (1981) Eur J Cancer Clin Oncol , vol.17 , pp. 893-898
    • Rose, D.P.1    Fischer, A.H.2    Jordan, V.C.3
  • 23
    • 84913734164 scopus 로고
    • Changes in endocrine status following antiestrogen administration to premenopausal and postmenopausal women
    • Sutherland RL, Jordan VC (eds): Syndney, Australia, Academic
    • Manni A, Arafah B, Pearson OH: Changes in endocrine status following antiestrogen administration to premenopausal and postmenopausal women, in Sutherland RL, Jordan VC (eds): Non-steroidal Antioestrogens. Molecular Pharmacology and Antitumour Activity. Syndney, Australia, Academic, 1981, pp 435-452
    • (1981) Non-steroidal Antioestrogens. Molecular Pharmacology and Antitumour Activity , pp. 435-452
    • Manni, A.1    Arafah, B.2    Pearson, O.H.3
  • 24
    • 0022638821 scopus 로고
    • A phase I/II investigation of trioxifene mesylate in advanced breast cancer. Clinical and endocrinological effects
    • Witte RS, Pruitt B, Tormey DC, et al.: A phase I/II investigation of trioxifene mesylate in advanced breast cancer. Clinical and endocrinological effects. Cancer 57:34-39, 1986
    • (1986) Cancer , vol.57 , pp. 34-39
    • Witte, R.S.1    Pruitt, B.2    Tormey, D.C.3
  • 25
    • 0022655909 scopus 로고
    • Trioxifene mesylate in the treatment of advanced breast cancer
    • Lee RW, Buzdar AU, Blumenschein GR, et al.: Trioxifene mesylate in the treatment of advanced breast cancer. Cancer 57:40-43, 1986
    • (1986) Cancer , vol.57 , pp. 40-43
    • Lee, R.W.1    Buzdar, A.U.2    Blumenschein, G.R.3
  • 26
    • 0021201213 scopus 로고
    • Antiestrogens 2, structure activity studies in a series of 3-aroyl-2-(4-hydroxyphenyl)-benzo [b] thiene - 3-yl [4-[2- (1-piperidinyl) ethoxy] phenyl] methanone hydrochloride (LY156,758) a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity
    • Jones CD, Jevnikar MG, Pike AJ, et al.: Antiestrogens 2, structure activity studies in a series of 3-aroyl-2-(4-hydroxyphenyl)-benzo [b] thiene - 3-yl] [4-[2- (1-piperidinyl) ethoxy] phenyl] methanone hydrochloride (LY156,758) a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity. J Med Chem 27:1057-1066, 1984
    • (1984) J Med Chem , vol.27 , pp. 1057-1066
    • Jones, C.D.1    Jevnikar, M.G.2    Pike, A.J.3
  • 27
    • 0020694796 scopus 로고
    • Antagonism of estrogen action with a new benzothiophene-derived antiestrogen
    • Black LJ, Jones CD, Falcone JF: Antagonism of estrogen action with a new benzothiophene-derived antiestrogen Life Sci 32:1031-1036, 1983
    • (1983) Life Sci , vol.32 , pp. 1031-1036
    • Black, L.J.1    Jones, C.D.2    Falcone, J.F.3
  • 28
    • 0020636027 scopus 로고
    • Inhibition of the uterotrophic activity of estrogens and antiestrogens by the short acting antiestrogen LY 117 018
    • Jordan VC, Gosden B: Inhibition of the uterotrophic activity of estrogens and antiestrogens by the short acting antiestrogen LY 117 018. Endocrinology 113:463-468, 1983
    • (1983) Endocrinology , vol.113 , pp. 463-468
    • Jordan, V.C.1    Gosden, B.2
  • 29
    • 0020825481 scopus 로고
    • Differential antiestrogen actions in the immature rat uterus: A comparision of hydroxylated antiestrogens with high affinity for the estrogen receptor
    • Jordan VC, Gosden B: Differential antiestrogen actions in the immature rat uterus: A comparision of hydroxylated antiestrogens with high affinity for the estrogen receptor. J Steroid Biochem 19:1249-1258, 1983
    • (1983) J Steroid Biochem , vol.19 , pp. 1249-1258
    • Jordan, V.C.1    Gosden, B.2
  • 30
    • 0020587401 scopus 로고
    • An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro
    • Lieberman ME, Gorski J, Jordan VC: An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro. J Biol Chem 258:4741-4745, 1983
    • (1983) J Biol Chem , vol.258 , pp. 4741-4745
    • Lieberman, M.E.1    Gorski, J.2    Jordan, V.C.3
  • 31
    • 0020516248 scopus 로고
    • Antiestrogenic effects of LY117018 in MCF-7 cells
    • Schull M, Huff KK, Lippman ME: Antiestrogenic effects of LY117018 in MCF-7 cells. Endocrinology 113:611-617, 1983
    • (1983) Endocrinology , vol.113 , pp. 611-617
    • Schull, M.1    Huff, K.K.2    Lippman, M.E.3
  • 32
    • 0024788816 scopus 로고
    • Antiestrogenic properties of keoxifene, trans 4-hydroxy tamoxifen and ICI 164,384, a new steroidal antiestrogen in ZR-75-1 human breast cancer cells
    • Poulin R, Merand Y, Poirier D, et al.: Antiestrogenic properties of keoxifene, trans 4-hydroxy tamoxifen and ICI 164,384, a new steroidal antiestrogen in ZR-75-1 human breast cancer cells. Breast Cancer Res Treat 14: 655-667, 1989
    • (1989) Breast Cancer Res Treat , vol.14 , pp. 655-667
    • Poulin, R.1    Merand, Y.2    Poirier, D.3
  • 33
    • 0020582094 scopus 로고
    • Effects of a new antiestrogen keoxifene (LY156758) on growth of carcinogen induced mammary tumors and on LH and prolactin levels
    • Clemens JA, Bennet DR, Black LJ, et al.: Effects of a new antiestrogen keoxifene (LY156758) on growth of carcinogen induced mammary tumors and on LH and prolactin levels. Life Sci 32:2869-2875, 1983
    • (1983) Life Sci , vol.32 , pp. 2869-2875
    • Clemens, J.A.1    Bennet, D.R.2    Black, L.J.3
  • 34
    • 0021038981 scopus 로고
    • Antioestrogenic and antitumour activities of a series of non-steriodal antioestrogens
    • Wakeling AE, Valcaccia B: Antioestrogenic and antitumour activities of a series of non-steriodal antioestrogens. J Endocrinol 99:455-464, 1983
    • (1983) J Endocrinol , vol.99 , pp. 455-464
    • Wakeling, A.E.1    Valcaccia, B.2
  • 35
    • 0023229345 scopus 로고
    • The antitumor action of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model
    • Gottardis MM, Jordan VC: The antitumor action of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res 47:4020-4024, 1987
    • (1987) Cancer Res , vol.47 , pp. 4020-4024
    • Gottardis, M.M.1    Jordan, V.C.2
  • 36
    • 0023547257 scopus 로고
    • Effects of antiestrogens on bone in castrated and intact female rate
    • Jordan VC, Phelps E, Lindgren JU: Effects of antiestrogens on bone in castrated and intact female rate. Breast Cancer Res Treat 10:31-35, 1987
    • (1987) Breast Cancer Res Treat , vol.10 , pp. 31-35
    • Jordan, V.C.1    Phelps, E.2    Lindgren, J.U.3
  • 37
    • 0028212448 scopus 로고
    • The effects of raloxifene on tibia histomorphometry in ovariectomized rats
    • Evans GL, Bryant HU, Magee D, et al.: The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology 134:2283-2288, 1994
    • (1994) Endocrinology , vol.134 , pp. 2283-2288
    • Evans, G.L.1    Bryant, H.U.2    Magee, D.3
  • 38
    • 0028167482 scopus 로고
    • Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypotrophy in ovariectomized rats
    • Black LJ, Sato M, Rowley ER, et al.: Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypotrophy in ovariectomized rats. J Clin Invest 93:63-69, 1994
    • (1994) J Clin Invest , vol.93 , pp. 63-69
    • Black, L.J.1    Sato, M.2    Rowley, E.R.3
  • 39
    • 0028951607 scopus 로고
    • Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized rats
    • Stao M, Kim J, Short LL, et al.: Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized rats. J Pharmacol Exp Ther 272:1251-1259, 1995
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 1251-1259
    • Stao, M.1    Kim, J.2    Short, L.L.3
  • 40
    • 70449221678 scopus 로고
    • A non-steroidal estrogen antagonist 1-(p-2-diethylaminoethoxyphenyl)-1 -phenyl-2-p-methoxyphenyl-ethanol
    • Lerner LJ, Holthaus JF, Thompson CR: A non-steroidal estrogen antagonist 1-(p-2-diethylaminoethoxyphenyl)-1 -phenyl-2-p-methoxyphenyl-ethanol. Endocrinology 63:295-318, 1958
    • (1958) Endocrinology , vol.63 , pp. 295-318
    • Lerner, L.J.1    Holthaus, J.F.2    Thompson, C.R.3
  • 41
    • 0001559063 scopus 로고
    • A new approach to breast cancer therapy - Total estrogen ablation with pure antiestrogens
    • Jordan VC (ed): Madison, WI, University of Wisconsin
    • Wakeling AE: A new approach to breast cancer therapy - Total estrogen ablation with pure antiestrogens, in Jordan VC (ed): Long-Term Tamoxifen Treatment for Breast Cancer. Madison, WI, University of Wisconsin, 1994, pp 219-234
    • (1994) Long-Term Tamoxifen Treatment for Breast Cancer , pp. 219-234
    • Wakeling, A.E.1
  • 42
    • 0026040217 scopus 로고
    • The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue
    • Gibson MK, Nemmas LA, Beckman WC, et al.: The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology 129:2000-2010, 1991
    • (1991) Endocrinology , vol.129 , pp. 2000-2010
    • Gibson, M.K.1    Nemmas, L.A.2    Beckman, W.C.3
  • 43
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182 780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Davois S, White R, Parker MG, et al.: The antiestrogen ICI 182 780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 106:1377-1388, 1993
    • (1993) J Cell Sci , vol.106 , pp. 1377-1388
    • Davois, S.1    White, R.2    Parker, M.G.3
  • 44
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling AE, Dukes M, Bowler J: A potent specific pure antiestrogen with clinical potential. Cancer Res 51:3867-3873, 1991
    • (1991) Cancer Res , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 45
    • 0028861402 scopus 로고
    • Response to a specific antioestrogen (ICI 182,780) in tamoxifen-resistant breast cancer
    • Howell A, DeFriend D, Robertson J, et al.: Response to a specific antioestrogen (ICI 182,780) in tamoxifen-resistant breast cancer. Lancet 345:29-30, 1995
    • (1995) Lancet , vol.345 , pp. 29-30
    • Howell, A.1    DeFriend, D.2    Robertson, J.3
  • 46
    • 0022468280 scopus 로고
    • A new triphenyl-ethylene compound Fc-1157a. II antitumor effects
    • Kangas L, Nieminen A-L, Blanco G, et al.: A new triphenyl-ethylene compound Fc-1157a. II antitumor effects. Cancer Chemother Pharmacol 17:109-113, 1986
    • (1986) Cancer Chemother Pharmacol , vol.17 , pp. 109-113
    • Kangas, L.1    Nieminen, A.-L.2    Blanco, G.3
  • 47
    • 0025292192 scopus 로고
    • Review of the pharmacological properties of toremifene
    • Kangas L: Review of the pharmacological properties of toremifene. J Steroid Biochem 36:191-195, 1990
    • (1990) J Steroid Biochem , vol.36 , pp. 191-195
    • Kangas, L.1
  • 48
    • 0025301011 scopus 로고
    • Antioestrogenic and antitumour properties of the new triphenylethylene derivative toremifene in the rat
    • DiSalle E, Zaccheo T, Ornati G: Antioestrogenic and antitumour properties of the new triphenylethylene derivative toremifene in the rat. J Steroid Biochem 36:203-206, 1990
    • (1990) J Steroid Biochem , vol.36 , pp. 203-206
    • DiSalle, E.1    Zaccheo, T.2    Ornati, G.3
  • 49
    • 0024241588 scopus 로고
    • Antitumor actions of toremifene in the 7, 12 dimethylbenzanthracene (DMBA)-induced rat mammary tumor model
    • Robinson SP, Mauel DA, Jordan VC: Antitumor actions of toremifene in the 7, 12 dimethylbenzanthracene (DMBA)-induced rat mammary tumor model. Eur J Cancer 24:1817-1821, 1988
    • (1988) Eur J Cancer , vol.24 , pp. 1817-1821
    • Robinson, S.P.1    Mauel, D.A.2    Jordan, V.C.3
  • 50
    • 0029084658 scopus 로고
    • Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastic breast cancer
    • Hayes DF, Van Zyl JA, Hacking A, et al.: Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastic breast cancer. J Clin Oncol 113:2556-2566, 1995
    • (1995) J Clin Oncol , vol.113 , pp. 2556-2566
    • Hayes, D.F.1    Van Zyl, J.A.2    Hacking, A.3
  • 51
    • 0027428568 scopus 로고
    • Major differences in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl;CD (BR) rats
    • Hard GC, Iatropoulos MJ, Jordan K et al.: Major differences in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl;CD (BR) rats. Cancer Res 53:4534-4541, 1993
    • (1993) Cancer Res , vol.53 , pp. 4534-4541
    • Hard, G.C.1    Iatropoulos, M.J.2    Jordan, K.3
  • 52
    • 0027397629 scopus 로고
    • Tamoxifen induces hepatocellular carcinoma in rat liver: A 1 year study with 2 antiestrogens
    • Hirsimaki P, Hirsimaki Y, Nieminen L, et al.: Tamoxifen induces hepatocellular carcinoma in rat liver: A 1 year study with 2 antiestrogens. Arch Toxicol 67:49-59, 1993
    • (1993) Arch Toxicol , vol.67 , pp. 49-59
    • Hirsimaki, P.1    Hirsimaki, Y.2    Nieminen, L.3
  • 53
    • 0019132163 scopus 로고
    • Evidence for the metabolic activation of nonsteroidal antiestrogens: A study of structure activity relationships
    • Allen KE, Clark ER, Jordan VC: Evidence for the metabolic activation of nonsteroidal antiestrogens: A study of structure activity relationships. Br J Pharmacol 71:87-91, 1980
    • (1980) Br J Pharmacol , vol.71 , pp. 87-91
    • Allen, K.E.1    Clark, E.R.2    Jordan, V.C.3
  • 54
    • 0020585962 scopus 로고
    • Direct and reversible inhibitors of estradiol-stimulated prolactin synthesis by antiestrogens in vitro
    • Lieberman ME, Jordan VC, Fritsch M, et al.: Direct and reversible inhibitors of estradiol-stimulated prolactin synthesis by antiestrogens in vitro. J Biol Chem 258:4734-4740, 1983
    • (1983) J Biol Chem , vol.258 , pp. 4734-4740
    • Lieberman, M.E.1    Jordan, V.C.2    Fritsch, M.3
  • 55
    • 0024395769 scopus 로고
    • Derivatives of tamoxifen. Dependency of estrogenicity on the 4 substituent
    • McCague R, LeClercq G, Legros N, et al.: Derivatives of tamoxifen. Dependency of estrogenicity on the 4 substituent. J Med Chem 32:2527-2533, 1989
    • (1989) J Med Chem , vol.32 , pp. 2527-2533
    • McCague, R.1    LeClercq, G.2    Legros, N.3
  • 56
    • 0025010197 scopus 로고
    • Metabolism of the 4 iodo derivative of tamoxifen by isolated rat hepatocytes. Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites
    • McCague R, Parr IB, Haynes BP: Metabolism of the 4 iodo derivative of tamoxifen by isolated rat hepatocytes. Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites. Biochem Pharmcol 40:2277-2283, 1990
    • (1990) Biochem Pharmcol , vol.40 , pp. 2277-2283
    • McCague, R.1    Parr, I.B.2    Haynes, B.P.3
  • 57
    • 0025767637 scopus 로고
    • Effect of the antiestrogen toremifene on growth of the human mammary carcinoma cell line MCF-7
    • Grenman RL, Laine KM, Klemi PJ, et al.: Effect of the antiestrogen toremifene on growth of the human mammary carcinoma cell line MCF-7. J Cancer Res Clin Oncol 117:223-226, 1991
    • (1991) J Cancer Res Clin Oncol , vol.117 , pp. 223-226
    • Grenman, R.L.1    Laine, K.M.2    Klemi, P.J.3
  • 58
    • 0025113699 scopus 로고
    • Antiestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts
    • Colletta AA, Wakefield LM, Howell FV, et al.: Antiestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br J Cancer 62:405-409, 1990
    • (1990) Br J Cancer , vol.62 , pp. 405-409
    • Colletta, A.A.1    Wakefield, L.M.2    Howell, F.V.3
  • 59
    • 0027425753 scopus 로고
    • Mitotic activity, apoptosis and TRPM-2 messenger RNA expression in DMBA-induced rat mammary carcinoma treated with antiestrogen toremifene
    • Huovinen R, Warn A, Collan Y: Mitotic activity, apoptosis and TRPM-2 messenger RNA expression in DMBA-induced rat mammary carcinoma treated with antiestrogen toremifene. Int J Cancer 55:685-691, 1993
    • (1993) Int J Cancer , vol.55 , pp. 685-691
    • Huovinen, R.1    Warn, A.2    Collan, Y.3
  • 60
    • 0024509832 scopus 로고
    • Antiestrogen action of toremifene on hormone-dependent, independent and heterogeneous breast tumor growth in the athymic mouse
    • Robinson SP, Jordan VC: Antiestrogen action of toremifene on hormone-dependent, independent and heterogeneous breast tumor growth in the athymic mouse. Cancer Res 49:1758-1762, 1989
    • (1989) Cancer Res , vol.49 , pp. 1758-1762
    • Robinson, S.P.1    Jordan, V.C.2
  • 61
    • 0028246412 scopus 로고
    • The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth
    • Osborne CK, Jarman M, McCague R, et al.: The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth. Cancer Chemother Pharmacol 34:89-95, 1994
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 89-95
    • Osborne, C.K.1    Jarman, M.2    McCague, R.3
  • 62
    • 0028035492 scopus 로고
    • Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450's
    • Styles JA, Davis A, Lim CK, et al.: Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450's. Carcinogenesis 15:5-9, 1994
    • (1994) Carcinogenesis , vol.15 , pp. 5-9
    • Styles, J.A.1    Davis, A.2    Lim, C.K.3
  • 63
    • 0028810502 scopus 로고
    • Comparison of tamoxifen and toremifene on liver and kidney tumor promotion in female rats
    • Dragan YP, Vaughn J, Jordan VC, et al.: Comparison of tamoxifen and toremifene on liver and kidney tumor promotion in female rats. Carcinogenesis 16: 2733-2741, 1995
    • (1995) Carcinogenesis , vol.16 , pp. 2733-2741
    • Dragan, Y.P.1    Vaughn, J.2    Jordan, V.C.3
  • 65
    • 0025608019 scopus 로고
    • Biochemical and pharmacological effects of toremifene metabolites
    • Kangas L: Biochemical and pharmacological effects of toremifene metabolites. Cancer Chemother Pharmacol 27:8-12, 1990
    • (1990) Cancer Chemother Pharmacol , vol.27 , pp. 8-12
    • Kangas, L.1
  • 66
    • 0025136713 scopus 로고
    • Pharmacokinetics of toremifene and its metabolites in patients with advanced breast cancer
    • Wiebe VJ, Benz C, Shermano I: Pharmacokinetics of toremifene and its metabolites in patients with advanced breast cancer. Cancer Chemother Phamacol 25:247-251, 1990
    • (1990) Cancer Chemother Phamacol , vol.25 , pp. 247-251
    • Wiebe, V.J.1    Benz, C.2    Shermano, I.3
  • 67
    • 0025793178 scopus 로고
    • High performance liquid chromatographic method for the determination of toremifene and its major human metabolites
    • Webster LK, Crinis NA, Stokes KH, et al.: High performance liquid chromatographic method for the determination of toremifene and its major human metabolites. J Chromatogr B Biomed Appl 565:482-487, 1991
    • (1991) J Chromatogr B Biomed Appl , vol.565 , pp. 482-487
    • Webster, L.K.1    Crinis, N.A.2    Stokes, K.H.3
  • 68
    • 0027195827 scopus 로고
    • High Performance liquid chromatographic analysis of tamoxifen, toremifene and their major human metabolites
    • Berthou F, Dreano Y: High Performance liquid chromatographic analysis of tamoxifen, toremifene and their major human metabolites. J Chromatogr B Biomed Appl 616:117-127, 1993
    • (1993) J Chromatogr B Biomed Appl , vol.616 , pp. 117-127
    • Berthou, F.1    Dreano, Y.2
  • 69
    • 0026724239 scopus 로고
    • Phase I clinical and pharmacokinetics study of high dose toremifene in postmenopausal patients with advanced breast cancer
    • Bishop J, Muray R, Webster L, et al.: Phase I clinical and pharmacokinetics study of high dose toremifene in postmenopausal patients with advanced breast cancer. Cancer Chemother Pharmacol 30:174-178, 1992
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 174-178
    • Bishop, J.1    Muray, R.2    Webster, L.3
  • 70
    • 0025612040 scopus 로고
    • Phase I study of the tolerance and pharmacokinetics of tormifene in patients with cancer
    • Kohler PC, Hamm JF, Wiebe VJ, et al.: Phase I study of the tolerance and pharmacokinetics of tormifene in patients with cancer. Breast Cancer Res Treat 16:19-26, 1991
    • (1991) Breast Cancer Res Treat , vol.16 , pp. 19-26
    • Kohler, P.C.1    Hamm, J.F.2    Wiebe, V.J.3
  • 71
    • 0025991237 scopus 로고
    • Phase I study of toremifene in patients with advanced cancer
    • Hamm JT, Tormey DC, Kohler PC, et al.: Phase I study of toremifene in patients with advanced cancer. J Clin Oncol 9:2036-2041, 1991
    • (1991) J Clin Oncol , vol.9 , pp. 2036-2041
    • Hamm, J.T.1    Tormey, D.C.2    Kohler, P.C.3
  • 72
    • 0025302085 scopus 로고
    • Effect of toremifene on clinical hematological and hormonal parameters at different dose levels in healthy postmenopausal volunteers: Phase I study
    • Kivinen S, Maenpaa J: Effect of toremifene on clinical hematological and hormonal parameters at different dose levels in healthy postmenopausal volunteers: Phase I study. J Steroid Biochem 36:217-220, 1990
    • (1990) J Steroid Biochem , vol.36 , pp. 217-220
    • Kivinen, S.1    Maenpaa, J.2
  • 73
    • 0028288381 scopus 로고
    • Influence of toremifene on the endocrine regulation in breast cancer patients
    • Szamel I, Hindy I, Vincze B, et al.: Influence of toremifene on the endocrine regulation in breast cancer patients. Eur J Cancer 30A: 154-158, 1994
    • (1994) Eur J Cancer , vol.30 A , pp. 154-158
    • Szamel, I.1    Hindy, I.2    Vincze, B.3
  • 74
    • 0027418151 scopus 로고
    • Antiestrogenic potency of toremifene and tamoxifen in postmenopausal women
    • Homesley HD, Shemano I, Gamms RA, et al.: Antiestrogenic potency of toremifene and tamoxifen in postmenopausal women. Am J Clin Oncol 16:117-122, 1993
    • (1993) Am J Clin Oncol , vol.16 , pp. 117-122
    • Homesley, H.D.1    Shemano, I.2    Gamms, R.A.3
  • 75
    • 0025337501 scopus 로고
    • Effect of toremifene on estrogen primed vaginal mucosa in postmenopausal women
    • Maenpaa J, Sonderatram KO, Granroos M, et al.: Effect of toremifene on estrogen primed vaginal mucosa in postmenopausal women. J Steroid Biochem 36:221-223, 1990
    • (1990) J Steroid Biochem , vol.36 , pp. 221-223
    • Maenpaa, J.1    Sonderatram, K.O.2    Granroos, M.3
  • 76
    • 0028793801 scopus 로고
    • Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients
    • Tomas E, Kauppila A, Blanco G, et al.: Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients. Gynecol Oncol 59:261-266, 1995
    • (1995) Gynecol Oncol , vol.59 , pp. 261-266
    • Tomas, E.1    Kauppila, A.2    Blanco, G.3
  • 77
  • 78
    • 0023913406 scopus 로고
    • Toremifene, a new antiestrogenic treatment of advanced breast cancer. Phase II study
    • Valavaara R, Pyrhonen S, Heikkinen M, et al.: Toremifene, a new antiestrogenic treatment of advanced breast cancer. Phase II study. Eur J Cancer 24:785-790, 1988
    • (1988) Eur J Cancer , vol.24 , pp. 785-790
    • Valavaara, R.1    Pyrhonen, S.2    Heikkinen, M.3
  • 79
    • 0023913406 scopus 로고
    • Toremifene, a new antiestrogenic compound in the treatment of advanced breast cancer. Phase II study
    • Gunderson S: Toremifene, a new antiestrogenic compound in the treatment of advanced breast cancer. Phase II study. Eur J Cancer 24:785-790, 1990
    • (1990) Eur J Cancer , vol.24 , pp. 785-790
    • Gunderson, S.1
  • 80
    • 0025294422 scopus 로고
    • Phase II clinical study of toremifene in patients with metastatic breast cancer
    • Modig H, Borgstrom M, Nilsson I, et al.: Phase II clinical study of toremifene in patients with metastatic breast cancer. J Steroid Biochem 36:235-236, 1990
    • (1990) J Steroid Biochem , vol.36 , pp. 235-236
    • Modig, H.1    Borgstrom, M.2    Nilsson, I.3
  • 81
    • 0024313769 scopus 로고
    • Low-dose toremifene in the treatment of estrogen-receptor-positive advanced breast cancer in postmenopausal women
    • Valavaara R, Pyrhonen S: Low-dose toremifene in the treatment of estrogen-receptor-positive advanced breast cancer in postmenopausal women. Curr Ther Res 46:966-973, 1989
    • (1989) Curr Ther Res , vol.46 , pp. 966-973
    • Valavaara, R.1    Pyrhonen, S.2
  • 82
    • 0025605574 scopus 로고
    • High dose toremifene (240 mg daily) is effective as first line hormonal treatment in advanced breast cancer - An ongoing phase-11 multicenter Finnish-Latvian cooperatie study
    • Hietanen T, Baltina D, Johansson R et al.: High dose toremifene (240 mg daily) is effective as first line hormonal treatment in advanced breast cancer - An ongoing phase-11 multicenter Finnish-Latvian cooperatie study. Breast Cancer Res Treat 16:37-40, 1990 (suppl)
    • (1990) Breast Cancer Res Treat , vol.16 , Issue.SUPPL. , pp. 37-40
    • Hietanen, T.1    Baltina, D.2    Johansson, R.3
  • 83
    • 0025081706 scopus 로고
    • Phase II experience with toremifene in the treatment of ER-positive breast cancer of postmenopausal women
    • Valavaara R: Phase II experience with toremifene in the treatment of ER-positive breast cancer of postmenopausal women. Cancer Invest 8:275-276, 1990
    • (1990) Cancer Invest , vol.8 , pp. 275-276
    • Valavaara, R.1
  • 84
    • 0027516435 scopus 로고
    • Clinical evaluation of NK 22 (toremifene citrate) in advanced or recurrent breast cancer - A comparative study by a double blind method with tamoxifen
    • Nomura Y, Tominaga T, Abe O: Clinical evaluation of NK 22 (toremifene citrate) in advanced or recurrent breast cancer - A comparative study by a double blind method with tamoxifen [in Japanse]. Gan to Kagaku Ryoho 20:247-258, 1993
    • (1993) Gan to Kagaku Ryoho , vol.20 , pp. 247-258
    • Nomura, Y.1    Tominaga, T.2    Abe, O.3
  • 85
    • 0025619361 scopus 로고
    • Results of comparative clinical evaluation of antiestrogens toremifene and tamoxifen in locally advanced and disseminated breast cancer
    • Konstantinova MM, Gershanovich ML: Results of comparative clinical evaluation of antiestrogens toremifene and tamoxifen in locally advanced and disseminated breast cancer [in Russian]. Vopr Onkol 36:1182-1186, 1990
    • (1990) Vopr Onkol , vol.36 , pp. 1182-1186
    • Konstantinova, M.M.1    Gershanovich, M.L.2
  • 86
    • 0027463002 scopus 로고
    • Toremifene and tamoxifen in advanced breast cancer - A double-blind cross-over trial
    • Stenbygaard LE, Herrstedt J, Thomsen JF, et al.: Toremifene and tamoxifen in advanced breast cancer - A double-blind cross-over trial. Breast Cancer Res Treat 25:57-63, 1993
    • (1993) Breast Cancer Res Treat , vol.25 , pp. 57-63
    • Stenbygaard, L.E.1    Herrstedt, J.2    Thomsen, J.F.3
  • 87
    • 0025295506 scopus 로고
    • Response to toremifene (Fc-1157a) therapy in tamoxifen failed patients with breast cancer. Preliminary communication
    • abstr
    • Ebbs SR, Roberts J, Baum M: Response to toremifene (Fc-1157a) therapy in tamoxifen failed patients with breast cancer. Preliminary communication. J Steroid Biochem 36:239, 1990 (abstr)
    • (1990) J Steroid Biochem , vol.36 , pp. 239
    • Ebbs, S.R.1    Roberts, J.2    Baum, M.3
  • 88
    • 0025311655 scopus 로고
    • Effect of toremifene in breast cancer patients. Preliminary communication
    • Hindy I, Juhos E, Szanto J, et al.: Effect of toremifene in breast cancer patients. Preliminary communication. J Steroid Biochem 36:225-226, 1990
    • (1990) J Steroid Biochem , vol.36 , pp. 225-226
    • Hindy, I.1    Juhos, E.2    Szanto, J.3
  • 89
    • 0025786896 scopus 로고
    • Phase II study of high dose toremifene in advanced breast cancer progressing during tamoxifen treatment
    • Jonsson P-E, Malmberg M, Bergejung L, et al.: Phase II study of high dose toremifene in advanced breast cancer progressing during tamoxifen treatment. Anticancer Res 11:873-876, 1991
    • (1991) Anticancer Res , vol.11 , pp. 873-876
    • Jonsson, P.-E.1    Malmberg, M.2    Bergejung, L.3
  • 90
    • 0027476886 scopus 로고
    • Efficacy and safety of high dose NK 622 (toremifene citrate) in tamoxifen failed patients with breast cancer
    • Asaishi K, Tominaga T, Abe O: Efficacy and safety of high dose NK 622 (toremifene citrate) in tamoxifen failed patients with breast cancer [in Japanese] Gan to Kagaku Ryoho 20:91-99, 1993
    • (1993) Gan to Kagaku Ryoho , vol.20 , pp. 91-99
    • Asaishi, K.1    Tominaga, T.2    Abe, O.3
  • 91
    • 0027409546 scopus 로고
    • Multicenter phase II efficacy trial of toremifene in tamoxifen refractory patients with advanced breast cancer
    • Vogel CL, Shemano I, Schoenfelder J, et al.: Multicenter phase II efficacy trial of toremifene in tamoxifen refractory patients with advanced breast cancer. J Clin Oncol 11:345-350, 1993
    • (1993) J Clin Oncol , vol.11 , pp. 345-350
    • Vogel, C.L.1    Shemano, I.2    Schoenfelder, J.3
  • 92
    • 0028210694 scopus 로고
    • High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen treatment
    • Pyrhonen S, Valavaara R, Vuorinen J, et al.: High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen treatment. Breast Cancer Res Treat 29:223-228,1994
    • (1994) Breast Cancer Res Treat , vol.29 , pp. 223-228
    • Pyrhonen, S.1    Valavaara, R.2    Vuorinen, J.3
  • 93
    • 0029034037 scopus 로고
    • High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer. A phase II trial of the Cancer and Leukemia Group B (CALGB)
    • Perry JJ, Berry DA, Weiss RB, et al.: High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer. A phase II trial of the Cancer and Leukemia Group B (CALGB). Breast Cancer Res Treat 36:35-40, 1995
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 35-40
    • Perry, J.J.1    Berry, D.A.2    Weiss, R.B.3
  • 94
    • 0022407653 scopus 로고
    • No loss of estrogenic and antiestrogenic activity after demethylation of droloxifene (3-OH tamoxifen)
    • Loser R, Seibel K, Eppenberger U: No loss of estrogenic and antiestrogenic activity after demethylation of droloxifene (3-OH tamoxifen). Int J Cancer 36:701-703, 1985
    • (1985) Int J Cancer , vol.36 , pp. 701-703
    • Loser, R.1    Seibel, K.2    Eppenberger, U.3
  • 95
    • 0028170305 scopus 로고
    • Preclinical data for droloxifene
    • Hasman M, Rattel B, Loser R: Preclinical data for droloxifene. Cancer Lett 84:101-116, 1994
    • (1994) Cancer Lett , vol.84 , pp. 101-116
    • Hasman, M.1    Rattel, B.2    Loser, R.3
  • 96
    • 0021829829 scopus 로고
    • In vivo and in vitro antiestrogenic action of 3-hydroxy-tamoxifen, tamoxifen and 4-hydroxytamoxifen
    • Loser R, Seibel K, Roos W, et al.: In vivo and in vitro antiestrogenic action of 3-hydroxy-tamoxifen, tamoxifen and 4-hydroxytamoxifen. Eur J Cancer Clin Oncol 21:985-900, 1985
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 985-1900
    • Loser, R.1    Seibel, K.2    Roos, W.3
  • 97
    • 0026342681 scopus 로고
    • Pharmacologic and biologic properties of droloxifene, a new antiestrogen
    • Eppenberger U, Wosikowski K, Kung W: Pharmacologic and biologic properties of droloxifene, a new antiestrogen. Am J Clin Oncol 14:s5-s14, 1991 (suppl 2)
    • (1991) Am J Clin Oncol , vol.14 , Issue.2 SUPPL.
    • Eppenberger, U.1    Wosikowski, K.2    Kung, W.3
  • 98
    • 0029016173 scopus 로고
    • Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats
    • Ke HZ, Simmons HA, Pine CM, et al.: Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats. Endocrinology 136:2435-2441, 1995
    • (1995) Endocrinology , vol.136 , pp. 2435-2441
    • Ke, H.Z.1    Simmons, H.A.2    Pine, C.M.3
  • 99
    • 0026079558 scopus 로고
    • Antitumor effects of droloxifene, a new antiestrogen drug against 7,12 dimethylbenz (a) anthracene-induced mammary tumor in rats
    • Kawamura I, Mizota T, Kondo N: Antitumor effects of droloxifene, a new antiestrogen drug against 7,12 dimethylbenz (a) anthracene-induced mammary tumor in rats. Jpn J Pharmacol 57:215-224, 1991
    • (1991) Jpn J Pharmacol , vol.57 , pp. 215-224
    • Kawamura, I.1    Mizota, T.2    Kondo, N.3
  • 100
    • 0026439302 scopus 로고
    • Investigations of droloxifene and other hormonal manipulations on N-nitrosomethyl-urea-induced rat mammary tumours
    • Winterfeld G, Hauff P, Grolich M, et al.: Investigations of droloxifene and other hormonal manipulations on N-nitrosomethyl-urea-induced rat mammary tumours. J Cancer Res Clin Oncol 119:91-96, 1992
    • (1992) J Cancer Res Clin Oncol , vol.119 , pp. 91-96
    • Winterfeld, G.1    Hauff, P.2    Grolich, M.3
  • 101
    • 0027493008 scopus 로고
    • Pharmacologic and biologic properties of droloxifene, a new antiestrogen
    • Kawamura I, Mizota T, Lacey E, et al.: Pharmacologic and biologic properties of droloxifene, a new antiestrogen. Jpn J Pharmacol 63:27-34, 1993
    • (1993) Jpn J Pharmacol , vol.63 , pp. 27-34
    • Kawamura, I.1    Mizota, T.2    Lacey, E.3
  • 102
    • 0026342683 scopus 로고
    • Structural requirements for the in vitro transformation of Syrian hamster embryo cells by stilbene estrogens and triphenylethylene-type antiestrogens
    • Metzler M, Schiffmann D: Structural requirements for the in vitro transformation of Syrian hamster embryo cells by stilbene estrogens and triphenylethylene-type antiestrogens. Am J Clin Oncol 14:s30-s35, 1991 (suppl 2)
    • (1991) Am J Clin Oncol , vol.14 , Issue.2 SUPPL.
    • Metzler, M.1    Schiffmann, D.2
  • 103
    • 0026342682 scopus 로고
    • Pharmacokinetics of droloxifene and its metabolites in breast cancer patients
    • Grill HJ, Pollow K: Pharmacokinetics of droloxifene and its metabolites in breast cancer patients. Am J Clin Oncol 14:s21-s29, 1991 (suppl 2)
    • (1991) Am J Clin Oncol , vol.14 , Issue.2 SUPPL.
    • Grill, H.J.1    Pollow, K.2
  • 104
    • 0029005436 scopus 로고
    • Determination of droloxifene and two metabolites in serum by high pressure liquid chromatography
    • Lein EA, Anker G, Lonning PE, et al.: Determination of droloxifene and two metabolites in serum by high pressure liquid chromatography. Ther Drug Monit 17:259-265, 1995
    • (1995) Ther Drug Monit , vol.17 , pp. 259-265
    • Lein, E.A.1    Anker, G.2    Lonning, P.E.3
  • 105
    • 0028810645 scopus 로고
    • Influence of droloxifene (3-hydroxytamoxifen) 40 mg daily on plasma gonadotrophins, sex hormone binding globulin and estrogen levels in postmenopausal breast cancer patients
    • Geisler J, Ekse, D, Hosch S, et al.: Influence of droloxifene (3-hydroxytamoxifen) 40 mg daily on plasma gonadotrophins, sex hormone binding globulin and estrogen levels in postmenopausal breast cancer patients. J Steroid Biochem Mol Biol 55:193-195, 1995
    • (1995) J Steroid Biochem Mol Biol , vol.55 , pp. 193-195
    • Geisler, J.1    Ekse, D.2    Hosch, S.3
  • 106
    • 0023893921 scopus 로고
    • Inhibition of growth of human cancer by intermittent exposure to the antiestrogen droloxifene
    • Ahlemann LM, Staab HJ, Loser R, et al.: Inhibition of growth of human cancer by intermittent exposure to the antiestrogen droloxifene. Tumor Diag Ther 9:41-46, 1988
    • (1988) Tumor Diag Ther , vol.9 , pp. 41-46
    • Ahlemann, L.M.1    Staab, H.J.2    Loser, R.3
  • 107
    • 0004820042 scopus 로고
    • Japanese early phase II study of droloxifene in the treatment of advanced breast cancer
    • Abe O: Japanese early phase II study of droloxifene in the treatment of advanced breast cancer. Am J Clin Oncol 14:540-451, 1991
    • (1991) Am J Clin Oncol , vol.14 , pp. 540-1451
    • Abe, O.1
  • 109
    • 0026337142 scopus 로고
    • European early phase II dose finding study of droloxifene in advanced breast cancer
    • Bellmunt J, Sole L: European early phase II dose finding study of droloxifene in advanced breast cancer. Am J Clin Oncol 14:536-539, 1991
    • (1991) Am J Clin Oncol , vol.14 , pp. 536-539
    • Bellmunt, J.1    Sole, L.2
  • 110
    • 0026633520 scopus 로고
    • Droloxifene - A new anti-estrogen phase II study in advanced breast cancer
    • Haarstad H, Gundersen S, Wist E, et al.: Droloxifene - A new anti-estrogen phase II study in advanced breast cancer. Acta Oncol 31:425-428, 1992
    • (1992) Acta Oncol , vol.31 , pp. 425-428
    • Haarstad, H.1    Gundersen, S.2    Wist, E.3
  • 111
    • 0028068906 scopus 로고
    • Droloxifene, a new antiestrogen: Its role in metastatic breast cancer
    • Rausching W, Pritchard KI: Droloxifene, a new antiestrogen: Its role in metastatic breast cancer. Breast Cancer Res Treat 31:83-94, 1994
    • (1994) Breast Cancer Res Treat , vol.31 , pp. 83-94
    • Rausching, W.1    Pritchard, K.I.2
  • 112
    • 0028175068 scopus 로고
    • Phase I trial of droloxifene in patients with metastatic breast cancer
    • Buzdar AU, Kau S, Hortobagyi GN, et al.: Phase I trial of droloxifene in patients with metastatic breast cancer. Cancer Chemother Pharmacol 33:313-316, 1994
    • (1994) Cancer Chemother Pharmacol , vol.33 , pp. 313-316
    • Buzdar, A.U.1    Kau, S.2    Hortobagyi, G.N.3
  • 113
    • 0026345105 scopus 로고
    • Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer
    • Chander SK, McCague R, Lugmani Y, et al.: Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer. Cancer Res 51:5851-5858, 1991
    • (1991) Cancer Res , vol.51 , pp. 5851-5858
    • Chander, S.K.1    McCague, R.2    Lugmani, Y.3
  • 114
    • 0027054733 scopus 로고
    • Genotoxic potential of tamoxifen and analogues in female Fischer 344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
    • White INH, deMatteis F, Davis A, et al.: Genotoxic potential of tamoxifen and analogues in female Fischer 344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis 13:2197-2203, 1992
    • (1992) Carcinogenesis , vol.13 , pp. 2197-2203
    • White, I.N.H.1    DeMatteis, F.2    Davis, A.3
  • 115
    • 0026064491 scopus 로고
    • Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
    • Robinson SP, Langan-Fahey SM, Johnson DA, et al.: Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Met Disp 19:36-43, 1991
    • (1991) Drug Met Disp , vol.19 , pp. 36-43
    • Robinson, S.P.1    Langan-Fahey, S.M.2    Johnson, D.A.3
  • 116
    • 0028673007 scopus 로고
    • Biodistribution and kinetics of pyrrolidino - 4- iodo-tamoxifen: Prospects for pharmacokinetic studies using PET
    • Carnochan P, Trivedi M, Young H, et al.: Biodistribution and kinetics of pyrrolidino - 4- iodo-tamoxifen: Prospects for pharmacokinetic studies using PET. J Nucl Biol Med 38:96-98, 1994
    • (1994) J Nucl Biol Med , vol.38 , pp. 96-98
    • Carnochan, P.1    Trivedi, M.2    Young, H.3
  • 117
    • 0028935148 scopus 로고
    • Idoxifene: Report of a phase I study in patients with metastatic breast cancer
    • Coombes RC, Haynes BP, Dowsett M, et al.: Idoxifene: Report of a phase I study in patients with metastatic breast cancer. Cancer Res 55:1070-1074, 1995
    • (1995) Cancer Res , vol.55 , pp. 1070-1074
    • Coombes, R.C.1    Haynes, B.P.2    Dowsett, M.3
  • 118
    • 0025361621 scopus 로고
    • TAT-59 a new triphenylethylene derivative with antitumor activity against hormone dependent tumors
    • Toko T, Sigimoto Y, Matsuo KI, et al.: TAT-59 a new triphenylethylene derivative with antitumor activity against hormone dependent tumors. Eur J Cancer 26:397-404, 1990
    • (1990) Eur J Cancer , vol.26 , pp. 397-404
    • Toko, T.1    Sigimoto, Y.2    Matsuo, K.I.3
  • 119
    • 0026454552 scopus 로고
    • Antitumor effect of triphenylethylene derivative (TAT-59) against human breast carcinoma xenografts in nude mice
    • Koh JI, Kubota T, Asanuma F, et al.: Antitumor effect of triphenylethylene derivative (TAT-59) against human breast carcinoma xenografts in nude mice. J Surg Oncol 51:254-258, 1992
    • (1992) J Surg Oncol , vol.51 , pp. 254-258
    • Koh, J.I.1    Kubota, T.2    Asanuma, F.3
  • 120
    • 0028068127 scopus 로고
    • A new triphenylethylene derivative TAT-59: Hormone receptors, insulin-like growth factor 1 and growth supression of hormone dependent MCF-7 tumors in athymic mice
    • Iino Y, Takai Y, Ando T, et al.: A new triphenylethylene derivative TAT-59: Hormone receptors, insulin-like growth factor 1 and growth supression of hormone dependent MCF-7 tumors in athymic mice. Cancer Chemother Pharmacol 34:372-376, 1994
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 372-376
    • Iino, Y.1    Takai, Y.2    Ando, T.3
  • 121
    • 0023235522 scopus 로고
    • Human breast cancer in athymic nude mice: Cytostatic effects of long-term antiestrogenic activity
    • Osborne CK, Coronado EB, Robinson JP: Human breast cancer in athymic nude mice: Cytostatic effects of long-term antiestrogenic activity. Eur J Cancer 232:1189-1196, 1987
    • (1987) Eur J Cancer , vol.232 , pp. 1189-1196
    • Osborne, C.K.1    Coronado, E.B.2    Robinson, J.P.3
  • 122
    • 0023760993 scopus 로고
    • Development of tamoxifen stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration
    • Gottardis MM, Jordan VC: Development of tamoxifen stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res 48:5183-5187, 1988
    • (1988) Cancer Res , vol.48 , pp. 5183-5187
    • Gottardis, M.M.1    Jordan, V.C.2
  • 123
    • 0021129120 scopus 로고
    • Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice
    • Satyaswaroop PG, Zaino RJ, Mortel R: Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice. Cancer Res 44:4006-4010, 1984
    • (1984) Cancer Res , vol.44 , pp. 4006-4010
    • Satyaswaroop, P.G.1    Zaino, R.J.2    Mortel, R.3
  • 124
    • 0023915865 scopus 로고
    • Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse
    • Gottardis MM, Robinson SP, Satyaswaroop PG, et al.: Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res 48:812-815, 1988
    • (1988) Cancer Res , vol.48 , pp. 812-815
    • Gottardis, M.M.1    Robinson, S.P.2    Satyaswaroop, P.G.3
  • 125
    • 0024319781 scopus 로고
    • Inhibition of tamoxifen stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens
    • Gottardis MM, Jiang SY, Jeng MH, et al.: Inhibition of tamoxifen stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Res 49:4090-4093, 1989
    • (1989) Cancer Res , vol.49 , pp. 4090-4093
    • Gottardis, M.M.1    Jiang, S.Y.2    Jeng, M.H.3
  • 126
    • 0025300620 scopus 로고
    • Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice
    • Gottardis MM, Ricchio MD, Satyaswaroop PG, et al.: Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice. Cancer Res 50:3189-3192, 1990
    • (1990) Cancer Res , vol.50 , pp. 3189-3192
    • Gottardis, M.M.1    Ricchio, M.D.2    Satyaswaroop, P.G.3
  • 127
    • 0029075872 scopus 로고
    • Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human cancer
    • Osborne CK, Coronado-Heinsohn EB, Hilsenbeck SG, et al.: Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human cancer. J Natl Cancer Inst 87:746-750, 1995
    • (1995) J Natl Cancer Inst , vol.87 , pp. 746-750
    • Osborne, C.K.1    Coronado-Heinsohn, E.B.2    Hilsenbeck, S.G.3
  • 128
    • 0025035959 scopus 로고
    • Estrogen deprivation in breast cancer. Clinical, experimental and biological aspects
    • Nicholson RI, Walker KJ, Bouzukar N, et al.: Estrogen deprivation in breast cancer. Clinical, experimental and biological aspects. Ann NY Acad Sci 595:316-327, 1990
    • (1990) Ann NY Acad Sci , vol.595 , pp. 316-327
    • Nicholson, R.I.1    Walker, K.J.2    Bouzukar, N.3
  • 129
    • 0023701360 scopus 로고
    • Novel antiestrogens without partial agonist activity
    • Wakeling AE, Bowler J: Novel antiestrogens without partial agonist activity. J Steroid Biochem 31:645-653, 1988
    • (1988) J Steroid Biochem , vol.31 , pp. 645-653
    • Wakeling, A.E.1    Bowler, J.2
  • 130
    • 0028084758 scopus 로고
    • Investigation of a pure new antiestrogen (ICI 182,780) in women with primary breast cancer
    • DeFriend DJ, Howell A, Nicholson RI, et al.: Investigation of a pure new antiestrogen (ICI 182,780) in women with primary breast cancer. Cancer Res 54:408-414, 1994
    • (1994) Cancer Res , vol.54 , pp. 408-414
    • DeFriend, D.J.1    Howell, A.2    Nicholson, R.I.3
  • 131
    • 0026776174 scopus 로고
    • Antiuterotrophic effect of a pure antioestrogen ICI 182,780: Magnetic resonance imaging of the uterus in ovariectomized monkeys
    • Dukes M, Miller D, Wakeling AE, et al.: Antiuterotrophic effect of a pure antioestrogen ICI 182,780: Magnetic resonance imaging of the uterus in ovariectomized monkeys. J Endocrinol 135:239-247, 1992
    • (1992) J Endocrinol , vol.135 , pp. 239-247
    • Dukes, M.1    Miller, D.2    Wakeling, A.E.3
  • 132
    • 0027433696 scopus 로고
    • Antiuterotropic effect of the pure antiestrogen ICI 182,780 in adult female monkeys (Macaca Nemestrina) quantitative magnetic resonance imageing
    • Dukes M, Waterton JC, Wakeling AE: Antiuterotropic effect of the pure antiestrogen ICI 182,780 in adult female monkeys (Macaca Nemestrina) quantitative magnetic resonance imageing. J Endocrinol 138:203-210, 1993
    • (1993) J Endocrinol , vol.138 , pp. 203-210
    • Dukes, M.1    Waterton, J.C.2    Wakeling, A.E.3
  • 133
    • 0030139852 scopus 로고    scopus 로고
    • The development of targeted antiestrogens to prevent diseases in women
    • Tonetti DA, Jordan VC: The development of targeted antiestrogens to prevent diseases in women. Mol Med Today 2:218-223, 1996
    • (1996) Mol Med Today , vol.2 , pp. 218-223
    • Tonetti, D.A.1    Jordan, V.C.2
  • 134
    • 0002658633 scopus 로고
    • Effects of raloxifene (LY 139481 HCL) on biochemical markers of bone and lipid metabolism in healthy postmenopausal women
    • Handelstrykkeriet Aalborg ApS, Aalborg, Denmark
    • Draper MW, Flowers DE, Hester WJ, et al.: Effects of raloxifene (LY 139481 HCL) on biochemical markers of bone and lipid metabolism in healthy postmenopausal women. Proceedings of the Fourth International Symposium on Osteoporosis. Handelstrykkeriet Aalborg ApS, Aalborg, Denmark, 1993, pp 119-121
    • (1993) Proceedings of the Fourth International Symposium on Osteoporosis , pp. 119-121
    • Draper, M.W.1    Flowers, D.E.2    Hester, W.J.3
  • 135
  • 136
    • 0023683229 scopus 로고
    • Phase II evaluation of LY156758 in metastatic breast cancer
    • Buzdar AU, Marcus C, Holmes F, et al.: Phase II evaluation of LY156758 in metastatic breast cancer. Oncology 45:344-345, 1988
    • (1988) Oncology , vol.45 , pp. 344-345
    • Buzdar, A.U.1    Marcus, C.2    Holmes, F.3
  • 137
    • 0028835120 scopus 로고
    • Tamoxifen and toremifene lower serum cholesterol by inhibition of delta 8-cholesterol conversion to lathosterol in women with breast cancer
    • Gylling H, Pyrhonen S, Mantyla E, et al.: Tamoxifen and toremifene lower serum cholesterol by inhibition of delta 8-cholesterol conversion to lathosterol in women with breast cancer. J Clin Oncol 13:2900-2905, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 2900-2905
    • Gylling, H.1    Pyrhonen, S.2    Mantyla, E.3
  • 138
    • 0027139169 scopus 로고
    • The estrogen antagonist ICI 182,780 reduces cancellous bone volumes in female rats
    • Gallagher A, Chambers TJ, Tobias JH: The estrogen antagonist ICI 182,780 reduces cancellous bone volumes in female rats. Endocrinology 133:2787-2791, 1993
    • (1993) Endocrinology , vol.133 , pp. 2787-2791
    • Gallagher, A.1    Chambers, T.J.2    Tobias, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.