Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 8, 2000, Pages 2966-2969

  Simoncini, T ^a,b   Genazzani, A R ^a  

^a UNIVERSITY OF PISA   (Italy)

^b SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FULVESTRANT; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; UMBILICAL VEIN;

EID: 0034456567     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.85.8.6853     Document Type: Article

References (25)

1. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease
2. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
3. The protective effects of estrogen on the cardiovascular system
4. Therapeutic potential of selective estrogen receptor modulators
5. Hormone replacement therapy: The perspectives for the 21st century
6. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women
7. Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women
8. Raloxifene inhibits aortic accumulation of cholesterol in ovariectomized, cholesterol-fed rabbits
9. Selective estrogen receptor modulators: Different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells
10. Endothelial nitric oxide and vascular inflammation
11. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
12. Raloxifene Acutely Relaxes Rabbit Coronary Arteries In Vitro by an Estrogen Receptor-Dependent and Nitric Oxide-Dependent Mechanism
13. Human umbilical vein endothelial cells: A new source and potential target for corticotropin-releasing factor
14. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
15. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells
16. Vascular endothelial cells synthesize nitric oxide from L-arginine
17. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women
18. Molecular basis of agonism and antagonism in the oestrogen receptor
19. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
20. Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene
21. Estrogen and selective estrogen receptor modulator LY117018 enhance release of nitric oxide in rat aorta
22. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
23. Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium
24. 17 Beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization