메뉴 건너뛰기




Volumn 47, Issue , 2001, Pages 159-190

Therapeutic angiogenesis inhibitors in the treatment of cancer

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; 2-METHOXYESTRADIOL; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; COLLAGEN; DRUG DERIVATIVE; ENDOSTATIN; ENDOTHELIAL CELL GROWTH FACTOR; ENZYME INHIBITOR; ESTRADIOL; HYDROXAMIC ACID; LYMPHOKINE; MARIMASTAT; MATRIX METALLOPROTEINASE; MONOCLONAL ANTIBODY; ORGANIC COMPOUND; PEPTIDE FRAGMENT; PRINOMASTAT; PROTEIN TYROSINE KINASE; THALIDOMIDE; VASCULOTROPIN; VASCULOTROPIN A;

EID: 0035748883     PISSN: 00652822     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (193)
  • 1
    • 0000009898 scopus 로고
    • Tumor angiogenesis: Therapeutic applications. N
    • Folkman J: Tumor angiogenesis: Therapeutic applications. N Engl J Med 285:82-86, 1971.
    • (1971) Engl J Med , vol.285 , pp. 82-86
    • Folkman, J.1
  • 2
    • 0002501771 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • in DeVita VT, Hellman S, Rosenberg SA (eds): Philadelphia, Lippincott-Raven
    • Folkman J: Tumor angiogenesis, in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Philadelphia, Lippincott-Raven, 1997, pp 3075-3085.
    • Cancer: Principles and Practice of Oncology. , vol.1997 , pp. 3075-3085
    • Folkman, J.1
  • 3
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • Bergers G, Javaherian K, Kin-Ming L, et al: Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 284:808-812, 1999.
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Kin-Ming, L.3
  • 4
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis.
    • Chambers AF, Matrisian L: Changing views of the role of matrix metalloproteinases in metastasis. / Natl Cancer Inst 89:1260-1270, 1997.
    • (1997) Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.2
  • 5
    • 0033014166 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors in tumour growth and invasion
    • Kahari VM, Saarialho-Kere U: Matrix metalloproteinases and their inhibitors in tumour growth and invasion. Ann Med 31:34-45, 1999.
    • (1999) Ann Med , vol.31 , pp. 34-45
    • Kahari, V.M.1    Saarialho-Kere, U.2
  • 6
    • 0028948844 scopus 로고
    • Gelatinase a activity directly modulates melanoma cell adhesion and spreading
    • Ray JM, Stetler-Stevenson WG: Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J 14:908-917, 1995.
    • (1995) EMBO J , vol.14 , pp. 908-917
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 8
    • 0030723230 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: Present achievements and future prospects
    • Denis LJ, Verweij J: Matrix metalloproteinase inhibitors: Present achievements and future prospects. Invest New Drugs 15:175-185, 1997.
    • (1997) Invest New Drugs , vol.15 , pp. 175-185
    • Denis, L.J.1    Verweij, J.2
  • 9
    • 0003089209 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase gene expression
    • in Parks W, Mechan R (eds): San Diego, Academic Press
    • Fini ME, Cook JR, Mohan R, et al: Regulation of matrix metalloproteinase gene expression, in Parks W, Mechan R (eds): Matrix Metalloproteinases. San Diego, Academic Press, 1998, pp 300-356.
    • Matrix Metalloproteinases. , vol.1998 , pp. 300-356
    • Fini, M.E.1    Cook, J.R.2    Mohan, R.3
  • 10
    • 0031671855 scopus 로고    scopus 로고
    • Matrix metalloproteinase degradation of extracellular matrix: Biological consequences
    • Shapiro SD: Matrix metalloproteinase degradation of extracellular matrix: Biological consequences. Curr Opin Cell Biol 10:602-608,1998.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 602-608
    • Shapiro, S.D.1
  • 11
    • 0029876809 scopus 로고    scopus 로고
    • Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in coculture of human osteosarcoma cells and human fibroblasts: Gelatinase B production was stimulated via upregulation of fibroblast growth factor (FGF) receptor
    • Kurogi T, Nabeshima K, Kataoka H, et al: Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in coculture of human osteosarcoma cells and human fibroblasts: Gelatinase B production was stimulated via upregulation of fibroblast growth factor (FGF) receptor. Int J Cancer 66:82-90, 1996.
    • (1996) Int J Cancer , vol.66 , pp. 82-90
    • Kurogi, T.1    Nabeshima, K.2    Kataoka, H.3
  • 12
    • 0030888746 scopus 로고    scopus 로고
    • Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells
    • Kondapaka SB, Fridman R, Reddy KB: Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells. Int J Cancer 70:722-726, 1997.
    • (1997) Int J Cancer , vol.70 , pp. 722-726
    • Kondapaka, S.B.1    Fridman, R.2    Reddy, K.B.3
  • 13
    • 0030917658 scopus 로고    scopus 로고
    • In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines
    • Nuovo GJ: In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines. Int J Cancer 71:1056-1060, 1997.
    • (1997) Int J Cancer , vol.71 , pp. 1056-1060
    • Nuovo, G.J.1
  • 14
    • 0031471249 scopus 로고    scopus 로고
    • In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.
    • Panek RL, Lu GH, Klutchko SR, et al: In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. / Pharmacol Exp Ther 283: 1433-1444, 1997.
    • (1997) Pharmacol Exp Ther , vol.283 , pp. 1433-1444
    • Panek, R.L.1    Lu, G.H.2    Klutchko, S.R.3
  • 15
    • 0033053127 scopus 로고    scopus 로고
    • Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9
    • Mira E, Manes S, Lacalle RA, et al: Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9. Endocrinology 140:1657-1664, 1999.
    • (1999) Endocrinology , vol.140 , pp. 1657-1664
    • Mira, E.1    Manes, S.2    Lacalle, R.A.3
  • 16
    • 0032533511 scopus 로고    scopus 로고
    • Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- And scatter factor-stimulated invasion of carcinoma cells
    • Rosenthal EL, Johnson TM, Allen ED, et al: Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells. Cancer Res 58:5221-5230, 1998.
    • (1998) Cancer Res , vol.58 , pp. 5221-5230
    • Rosenthal, E.L.1    Johnson, T.M.2    Allen, E.D.3
  • 17
    • 0032578691 scopus 로고    scopus 로고
    • : Proteinase requirements of epidermal growth factor-induced ovarian cancer cell invasion
    • Ellerbroek SM, Hudson LG, Stack MS: Proteinase requirements of epidermal growth factor-induced ovarian cancer cell invasion. Int J Cancer 78:331-337, 1998.
    • (1998) Int J Cancer , vol.78 , pp. 331-337
    • Ellerbroek, S.M.1    Hudson, L.G.2    Stack, M.S.3
  • 18
    • 0032807991 scopus 로고    scopus 로고
    • : EGF induces the expression of matrilysin in the human prostate adenocarcinoma cell line, LNCaP
    • Sundareshan P, Nagle RB, Bowden GT: EGF induces the expression of matrilysin in the human prostate adenocarcinoma cell line, LNCaP. Prostate 40:159-166, 1999.
    • (1999) Prostate , vol.40 , pp. 159-166
    • Sundareshan, P.1    Nagle, R.B.2    Bowden, G.T.3
  • 19
    • 0032983385 scopus 로고    scopus 로고
    • : Transforming growth factor a acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells
    • Duivenvoorden WC, Hirte HW, Singh G: Transforming growth factor a acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. Clin Exp Metastasis 17:2734, 1999.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 2734
    • Duivenvoorden, W.C.1    Hirte, H.W.2    Singh, G.3
  • 20
    • 0027530706 scopus 로고
    • Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice
    • Powel W, Knox J, Navre M, et al: Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice. Cancer Res 53:417-422, 1993.
    • (1993) Cancer Res , vol.53 , pp. 417-422
    • Powel, W.1    Knox, J.2    Navre, M.3
  • 21
    • 65749308863 scopus 로고    scopus 로고
    • The matrix metalloproteinases and their inhibitors in pancreatic cancer. from molecular science to a clinical application
    • Bramhall SR: The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application. Int J Pancreatol 21:1-12, 1997.
    • (1997) Int J Pancreatol , vol.21 , pp. 1-12
    • Bramhall, S.R.1
  • 22
    • 0032836427 scopus 로고    scopus 로고
    • Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications
    • Zucker S, Hymowitz M, Conner C, et al: Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. Ann N Y Acad Sei 878:212-227, 1999.
    • (1999) Ann N Y Acad Sei , vol.878 , pp. 212-227
    • Zucker, S.1    Hymowitz, M.2    Conner, C.3
  • 23
    • 0001071353 scopus 로고    scopus 로고
    • Cancer invasion and tissue remodeling-cooperation of protease systems and cell types
    • Dano K, Romer J, Nielsen B, et al: Cancer invasion and tissue remodeling-cooperation of protease systems and cell types. APMIS 107:120-127, 1999.
    • (1999) APMIS , vol.107 , pp. 120-127
    • Dano, K.1    Romer, J.2    Nielsen, B.3
  • 24
    • 0000683771 scopus 로고    scopus 로고
    • Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response
    • Johansonn N, Airola K, Grenman R, et al: Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol 151:273-289, 1997.
    • (1997) Am J Pathol , vol.151 , pp. 273-289
    • Johansonn, N.1    Airola, K.2    Grenman, R.3
  • 25
    • 0040351696 scopus 로고    scopus 로고
    • Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal epithelial cell interactions
    • Uria A, Stahle-Backdahl M, Seiki M, et al: Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal epithelial cell interactions. Cancer Res 57:4882-4888, 1997.
    • (1997) Cancer Res , vol.57 , pp. 4882-4888
    • Uria, A.1    Stahle-Backdahl, M.2    Seiki, M.3
  • 26
    • 0029946569 scopus 로고    scopus 로고
    • Expression of most matrix metalloproteinases family members in breast cancer represents a tumor-induced host response
    • Heppner KJ, Matrisian LM, Jensen RA, et al: Expression of most matrix metalloproteinases family members in breast cancer represents a tumor-induced host response. Am J Pathol 149:273-282, 1996.
    • (1996) Am J Pathol , vol.149 , pp. 273-282
    • Heppner, K.J.1    Matrisian, L.M.2    Jensen, R.A.3
  • 27
    • 0032895321 scopus 로고    scopus 로고
    • Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas
    • Airola K, Karonen T, Vaalamo M, et al: Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas. Br J Cancer 80:733-743, 1999.
    • (1999) Br J Cancer , vol.80 , pp. 733-743
    • Airola, K.1    Karonen, T.2    Vaalamo, M.3
  • 28
    • 0032867683 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas.
    • Ozdemir E, Kakehi Y, Okuno H, et al: Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas. / Urol 161:1359-1363, 1999.
    • (1999) Urol , vol.161 , pp. 1359-1363
    • Ozdemir, E.1    Kakehi, Y.2    Okuno, H.3
  • 29
    • 0028129494 scopus 로고
    • Overexpression of metalloproteinase inhibitor in B16F10 melanoma cells does not affect extravasation but reduces tumor growth
    • Koop S, Khokha R, Schmidt EE, et al: Overexpression of metalloproteinase inhibitor in B16F10 melanoma cells does not affect extravasation but reduces tumor growth. Cancer Res 54:4791-4797, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4791-4797
    • Koop, S.1    Khokha, R.2    Schmidt, E.E.3
  • 30
    • 0030801093 scopus 로고    scopus 로고
    • Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma.
    • Bramhall SR, Neoptolemos JP, Stamp GW, et al: Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. / Pathol 182:347-355, 1997.
    • (1997) Pathol , vol.182 , pp. 347-355
    • Bramhall, S.R.1    Neoptolemos, J.P.2    Stamp, G.W.3
  • 31
    • 0029965059 scopus 로고    scopus 로고
    • High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer
    • Grignon DJ, Sakr W, Toth M, et al: High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer. Cancer Res 56:1654-1659, 1996.
    • (1996) Cancer Res , vol.56 , pp. 1654-1659
    • Grignon, D.J.1    Sakr, W.2    Toth, M.3
  • 32
    • 0030609810 scopus 로고    scopus 로고
    • 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primedside inhibitor with a distinct selectivity profile
    • Betz M, Huxley P, Davies SJ, et al: 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primedside inhibitor with a distinct selectivity profile. Eur J Biochem 247: 356-363, 1997.
    • (1997) Eur J Biochem , vol.247 , pp. 356-363
    • Betz, M.1    Huxley, P.2    Davies, S.J.3
  • 34
    • 0031776982 scopus 로고    scopus 로고
    • Phase I trial of marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer.
    • Wojtowicz-Praga S, Torri J, Johnson M, et al: Phase I trial of marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer. / Clin Oncol 16:2150-2156, 1998.
    • (1998) Clin Oncol , vol.16 , pp. 2150-2156
    • Wojtowicz-Praga, S.1    Torri, J.2    Johnson, M.3
  • 35
    • 0032934107 scopus 로고    scopus 로고
    • Marimastat in récurrent colorectal cancer: Exploratory evaluation of biological activity by measurement of carcinoembryonic antigen
    • Primrose J, Bleiberg H, Daniel F, et al: Marimastat in récurrent colorectal cancer: Exploratory evaluation of biological activity by measurement of carcinoembryonic antigen. Br J Cancer 79:509-514, 1999.
    • (1999) Br J Cancer , vol.79 , pp. 509-514
    • Primrose, J.1    Bleiberg, H.2    Daniel, F.3
  • 36
    • 0033509553 scopus 로고    scopus 로고
    • Marimastat in patients with advanced pancreatic cancer: A dose-finding study
    • Rosemurgy A, Harris J, Langleben A, et al: Marimastat in patients with advanced pancreatic cancer: a dose-finding study. Am J Clin Oncol 22:247-252, 1999.
    • (1999) Am J Clin Oncol , vol.22 , pp. 247-252
    • Rosemurgy, A.1    Harris, J.2    Langleben, A.3
  • 37
    • 33749383499 scopus 로고    scopus 로고
    • Phase I-II study of marimastat (BB2516) in patients with metastatic melanomas
    • Bourthe A, Eisenhauer E, Steward W, et al: Phase I-II study of marimastat (BB2516) in patients with metastatic melanomas. Proc Annu Meet Am Soc Clin Oncol 16:1775A, 1997.
    • (1997) Proc Annu Meet Am Soc Clin Oncol , vol.16
    • Bourthe, A.1    Eisenhauer, E.2    Steward, W.3
  • 38
    • 0000632527 scopus 로고    scopus 로고
    • Phase IB study of concurrent administration of marimastat and gemcitabine in non-resectable pancreatic cancer
    • Carmichael J, Lederman J, Woll PGT, et al: Phase IB study of concurrent administration of marimastat and gemcitabine in non-resectable pancreatic cancer. Proc Annu Meet Am Soc Clin Oncol 17:888A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.17
    • Carmichael, J.1    Lederman, J.2    Woll, P.G.T.3
  • 39
    • 0004850118 scopus 로고    scopus 로고
    • Schedules of 5-FU and the matrix metalloproteinase inhibitor marimastat (MAR): A phase I study
    • O'Reilly S, Mani S, Ratain M, et al: Schedules of 5-FU and the matrix metalloproteinase inhibitor marimastat (MAR): A phase I study. Proc Annu Meet Am Soc Clin Oncol 17:839A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.17
    • O'Reilly, S.1    Mani, S.2    Ratain, M.3
  • 40
    • 0000100112 scopus 로고    scopus 로고
    • A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer
    • Adams M, Thomas H: A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer. Proc Annu Meet Am Soc Clin Oncol 17:838A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.17
    • Adams, M.1    Thomas, H.2
  • 41
    • 0000203704 scopus 로고    scopus 로고
    • Pilot pharmacokinetic study of marimastat (MAR) in combination with carboplatin (C)/Paclitaxel (T) in patients with metastatic or locally advanced inoperable non-small cell lung cancer (NSCLC)
    • Anderson 1C, Supko J, Eder J, et al: Pilot pharmacokinetic study of marimastat (MAR) in combination with carboplatin (C)/Paclitaxel (T) in patients with metastatic or locally advanced inoperable non-small cell lung cancer (NSCLC). Proc Annu Meet Am Soc Clin Oncol 18:719A, 1999.
    • (1999) Proc Annu Meet Am Soc Clin Oncol , vol.18
    • Anderson, C.1    Supko, J.2    Eder, J.3
  • 42
    • 0032983844 scopus 로고    scopus 로고
    • Marimastat (BB2516): Current status and development
    • Steward WP: Marimastat (BB2516): Current status and development. Cancer Chemother Pharmacol 43:S56-S60, 1999.
    • (1999) Cancer Chemother Pharmacol , vol.43
    • Steward, W.P.1
  • 43
    • 33749406590 scopus 로고    scopus 로고
    • Phase I/II pharmacokinetic evaluation of marimastat in patients with advanced prostate cancer (PC): Identification of the biological active dose
    • Eisenberger M, Sinibaldi V, Laufer M, et al: Phase I/II pharmacokinetic evaluation of marimastat in patients with advanced prostate cancer (PC): Identification of the biological active dose. Proc Annu Meet Am Soc Clin Oncol 19:1321A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.19
    • Eisenberger, M.1    Sinibaldi, V.2    Laufer, M.3
  • 44
    • 14444284598 scopus 로고    scopus 로고
    • Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biological active and tolerable dose for long term studies
    • Nemunaitis J, Poole C, Primrose J, et al: Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biological active and tolerable dose for long term studies. Clin Cancer Res 4:1101-1109, 1998.
    • (1998) Clin Cancer Res , vol.4 , pp. 1101-1109
    • Nemunaitis, J.1    Poole, C.2    Primrose, J.3
  • 45
    • 0033999308 scopus 로고    scopus 로고
    • Matrix metalloproteinase: Biologic activity and clinical implications.
    • Nelson AR, Fingleton BM, Rothenberg ML, et al: Matrix metalloproteinase: Biologic activity and clinical implications. / Clin Oncol 18:1135-1149, 2000.
    • (2000) Clin Oncol , vol.18 , pp. 1135-1149
    • Nelson, A.R.1    Fingleton, B.M.2    Rothenberg, M.L.3
  • 46
    • 0000511054 scopus 로고    scopus 로고
    • : A randomized study comparing marimastat to gemcitabine as first line therapy in patients with non-resectable pancreatic cancer
    • Rosemurgy A, Buckels J, Charnley R: A randomized study comparing marimastat to gemcitabine as first line therapy in patients with non-resectable pancreatic cancer. ProcAnnu Meet Am Soc Clin Oncol 18:1005A, 1999.
    • (1999) ProcAnnu Meet Am Soc Clin Oncol , vol.18
    • Rosemurgy, A.1    Buckels, J.2    Charnley, R.3
  • 47
    • 0000407860 scopus 로고    scopus 로고
    • A randomized double-blind placebo controlled study of marimastat in patients with inoperable gastric adenocarcinoma
    • Fielding J, Scholefield J, Stuart P, et al: A randomized double-blind placebo controlled study of marimastat in patients with inoperable gastric adenocarcinoma. Proc Anna Meet Am Soc Clin Oncol 19:929A, 2000.
    • (2000) Proc Anna Meet Am Soc Clin Oncol , vol.19
    • Fielding, J.1    Scholefield, J.2    Stuart, P.3
  • 48
    • 0031882946 scopus 로고    scopus 로고
    • Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers
    • Millar A, Brown P, Moore J, et al: Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Br J Clin Pharmacol 45:21-26, 1998.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 21-26
    • Millar, A.1    Brown, P.2    Moore, J.3
  • 49
    • 0032837028 scopus 로고    scopus 로고
    • Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials
    • Shalinsky DR, Brekken J, Zou H, et al: Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sei 878:236-270, 1999.
    • (1999) Ann N Y Acad Sei , vol.878 , pp. 236-270
    • Shalinsky, D.R.1    Brekken, J.2    Zou, H.3
  • 50
    • 0030816454 scopus 로고    scopus 로고
    • Rodent pharmacokinetics and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases
    • Santos O, McDermott CD, Daniels R, et al: Rodent pharmacokinetics and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases. Clin Exp Metastasis 15:499-508, 1997.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 499-508
    • Santos, O.1    McDermott, C.D.2    Daniels, R.3
  • 51
    • 0032449008 scopus 로고    scopus 로고
    • Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations
    • Shalinsky DR, Brekken J, Zou H, et al: Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations. Invest New Drugs 16:303-313, 1998.
    • (1998) Invest New Drugs , vol.16 , pp. 303-313
    • Shalinsky, D.R.1    Brekken, J.2    Zou, H.3
  • 52
    • 0032791421 scopus 로고    scopus 로고
    • Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: Single agent and combination chemotherapy studies
    • Shalinsky D, Brekken J, Zou H, et al: Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: Single agent and combination chemotherapy studies. Clin Cancer Res 5:1905-1917, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 1905-1917
    • Shalinsky, D.1    Brekken, J.2    Zou, H.3
  • 53
    • 0002815897 scopus 로고    scopus 로고
    • A phase I study of AG3340, a matrix metalloproteinase (MMP) inhibitor in patients having advanced cancer
    • Hande K, Wilding G, Ripple G, et al: A phase I study of AG3340, a matrix metalloproteinase (MMP) inhibitor in patients having advanced cancer. Ann Oncol 9:279A, 1998.
    • (1998) Ann Oncol , vol.9
    • Hande, K.1    Wilding, G.2    Ripple, G.3
  • 54
    • 0002815897 scopus 로고    scopus 로고
    • Phase I study of AG3340, a matrix metalloproteinase inhibitor in combination with mitoxantrone/prednisone in patients having advanced prostate cancer
    • Wilding G, Small E, Ripple G, et al: Phase I study of AG3340, a matrix metalloproteinase inhibitor in combination with mitoxantrone/prednisone in patients having advanced prostate cancer. Ann Oncol 9:280A, 1998.
    • (1998) Ann Oncol , vol.9
    • Wilding, G.1    Small, E.2    Ripple, G.3
  • 55
    • 0000603394 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors
    • D'Olimpo J, Hande K, Collier M, et al: Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors. Proc Annu Meet Am Soc Clin Oncol 18:615A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.18
    • D'Olimpo, J.1    Hande, K.2    Collier, M.3
  • 57
    • 0032200444 scopus 로고    scopus 로고
    • Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms
    • Golub LM, Lee HM, Ryan ME, et al: Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 12:12-26, 1998.
    • (1998) Adv Dent Res , vol.12 , pp. 12-26
    • Golub, L.M.1    Lee, H.M.2    Ryan, M.E.3
  • 58
    • 0032864675 scopus 로고    scopus 로고
    • MMP inhibition in prostate cancer
    • Lokeshwar BL: MMP inhibition in prostate cancer. Ann N Y Acad Sei 878:271-289, 1999.
    • (1999) Ann N Y Acad Sei , vol.878 , pp. 271-289
    • Lokeshwar, B.L.1
  • 59
    • 0031281806 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells.
    • Fife RS, Rougraff BT, Proctor C, et al: Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells. / Lab Clin Med 130:530-534, 1997.
    • (1997) Lab Clin Med , vol.130 , pp. 530-534
    • Fife, R.S.1    Rougraff, B.T.2    Proctor, C.3
  • 60
    • 0031920784 scopus 로고    scopus 로고
    • Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis
    • Seftor RE, Seftor EA, De Larco JE, et al: Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis. Clin Exp Metastasis 16:217-225, 1998.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 217-225
    • Seftor, R.E.1    Seftor, E.A.2    De Larco, J.E.3
  • 61
    • 0031973365 scopus 로고    scopus 로고
    • In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: Relationship to bone and cartilage degradation
    • Greenwald RA, Golub LM, Ramamurthy NS, et al: In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: Relationship to bone and cartilage degradation. Bone 22:33-38, 1998.
    • (1998) Bone , vol.22 , pp. 33-38
    • Greenwald, R.A.1    Golub, L.M.2    Ramamurthy, N.S.3
  • 62
    • 0029688549 scopus 로고    scopus 로고
    • : Matrix metalloproteinases and their inhibition in periodontal treatment
    • Ryan ME, Ramamurthy S, Golub LM: Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontol 3:85-96, 1996.
    • (1996) Curr Opin Periodontol , vol.3 , pp. 85-96
    • Ryan, M.E.1    Ramamurthy, S.2    Golub, L.M.3
  • 63
    • 0000433329 scopus 로고    scopus 로고
    • Protracted daily treatment with Col-3, an oral tetracycline analog, matrix metalloproteinase (MMP) inhibitor, is feasible: A phase I pharmacokinetic and biological study
    • Rowinsky E, Eckhardt S, Rizzo J, et al: Protracted daily treatment with Col-3, an oral tetracycline analog, matrix metalloproteinase (MMP) inhibitor, is feasible: A phase I pharmacokinetic and biological study. Proc Annu Meet Am Soc Clin Oncol 19:700A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.19
    • Rowinsky, E.1    Eckhardt, S.2    Rizzo, J.3
  • 64
    • 0002566867 scopus 로고    scopus 로고
    • A phase I clinical trial of oral Col-3, a matrix metalloproteinase inhibitor, administered daily in patients.with refractory metastatic cancer
    • Rudek M, Figg W, Dyer V, et al: A phase I clinical trial of oral Col-3, a matrix metalloproteinase inhibitor, administered daily in patients .with refractory metastatic cancer. Proc Annu Meet Am Assoc Cancer Res 41:3894A, 2000.
    • (2000) Proc Annu Meet Am Assoc Cancer Res , vol.41
    • Rudek, M.1    Figg, W.2    Dyer, V.3
  • 65
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor.
    • Ferrara N: Molecular and biological properties of vascular endothelial growth factor. / Mol Med 77:527-543, 1999.
    • (1999) Mol Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 66
    • 0027751890 scopus 로고
    • : The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park JE, Keller GA, Ferrara N: The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 4:1317-1326, 1993.
    • (1993) Mol Biol Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, G.A.2    Ferrara, N.3
  • 67
    • 0033870727 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 a is a positive factor in solid tumor growth
    • Ryan HE, Poloni M, McNulty W, et al: Hypoxia-inducible factor-1 a is a positive factor in solid tumor growth. Cancer Res 60:4010-4015, 2000.
    • (2000) Cancer Res , vol.60 , pp. 4010-4015
    • Ryan, H.E.1    Poloni, M.2    McNulty, W.3
  • 68
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest FLK-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer B, Wizigmann-Voos S, Schnuren H, et al: High affinity VEGF binding and developmental expression suggest FLK-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835-846, 1993.
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnuren, H.3
  • 69
    • 0028899424 scopus 로고
    • Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.
    • Guo D, Jia Q, Song HY, et al: Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. / Biol Chem 270:6729-6733, 1995.
    • (1995) Biol Chem , vol.270 , pp. 6729-6733
    • Guo, D.1    Jia, Q.2    Song, H.Y.3
  • 70
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Fltl, two receptors for vascular endothelial growth factor
    • Waltenberger J, Claesson Welsh L, Siegbahn A, et al: Different signal transduction properties of KDR and Fltl, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-26995, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson Welsh, L.2    Siegbahn, A.3
  • 71
    • 0030453355 scopus 로고    scopus 로고
    • VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
    • Kukk E, Lymboussaki A, Taira S, et al: VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 122:3829-3837, 1996.
    • (1996) Development , vol.122 , pp. 3829-3837
    • Kukk, E.1    Lymboussaki, A.2    Taira, S.3
  • 72
    • 0033043733 scopus 로고    scopus 로고
    • : Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor
    • Asano M, Yukita A, Suzuki H: Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor. Jpn J Cancer Res 90:93-100, 1999.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 93-100
    • Asano, M.1    Yukita, A.2    Suzuki, H.3
  • 73
  • 74
    • 0031870765 scopus 로고    scopus 로고
    • Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice
    • Kanai T, Konno H, Tanaka T, et al: Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice. IntJ Cancer 77:933-936, 1998.
    • (1998) IntJ Cancer , vol.77 , pp. 933-936
    • Kanai, T.1    Konno, H.2    Tanaka, T.3
  • 75
    • 0031766832 scopus 로고    scopus 로고
    • Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm
    • Konno H, Arai T, Tanaka T, et al: Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm. Jpn J Cancer Res 89:933-939, 1998.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 933-939
    • Konno, H.1    Arai, T.2    Tanaka, T.3
  • 76
    • 0032779969 scopus 로고    scopus 로고
    • Antitumor effect on human gastric cancer and induction of apoptosis by vascular endothelial growth factor neutralizing antibody
    • Kamiya K, Konno H, Tanaka T, et al: Antitumor effect on human gastric cancer and induction of apoptosis by vascular endothelial growth factor neutralizing antibody. Jpn J Cancer Res 90:794-800, 1999.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 794-800
    • Kamiya, K.1    Konno, H.2    Tanaka, T.3
  • 77
    • 33749420909 scopus 로고    scopus 로고
    • Prevention of hepatic métastases after primary resection by a neutralizing anti-vascular endothelial growth factor (anti-VEGF) antibody
    • Tanaka T, Konno H, Kanai T, et al: Prevention of hepatic métastases after primary resection by a neutralizing anti-vascular endothelial growth factor (anti-VEGF) antibody. Proc Annu Meet Am Assoc Cancer Res 38:1388A, 1997.
    • (1997) Proc Annu Meet Am Assoc Cancer Res , vol.38
    • Tanaka, T.1    Konno, H.2    Kanai, T.3
  • 78
    • 33749394411 scopus 로고    scopus 로고
    • Enhanced antitumor activity of anti-VEGF antibody HuMV833 given in combination with gemcitabine in human pancreatic tumor xenografts
    • Burger AM, Hendriks HR, Tang T, et al: Enhanced antitumor activity of anti-VEGF antibody HuMV833 given in combination with gemcitabine in human pancreatic tumor xenografts. Clin Cancer Res 6:579A, 2000.
    • (2000) Clin Cancer Res , vol.6
    • Burger, A.M.1    Hendriks, H.R.2    Tang, T.3
  • 79
    • 0001123178 scopus 로고    scopus 로고
    • Phase I trial of recombinant humanized monoclonal anti-vascular endothelial growth factor (antiVEGF MAb) in patients with metastatic cancer
    • Gordon MS, Talpaz M, Margolin K, et al: Phase I trial of recombinant humanized monoclonal anti-vascular endothelial growth factor (antiVEGF MAb) in patients with metastatic cancer. Proc Annu Meet Am Soc Clin Oncol 17:809A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.17
    • Gordon, M.S.1    Talpaz, M.2    Margolin, K.3
  • 80
    • 0003348281 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody (MAb) to vascular endothelial growth factor (rhuMAb VEGF) in combination with chemotherapy (ChRx) in patients with advanced cancer (ÇA): Pharmacologie and long-term safety data
    • Margolin K, Gordon MS, Talpaz M, et al: Phase Ib trial of intravenous recombinant humanized monoclonal antibody (MAb) to vascular endothelial growth factor (rhuMAb VEGF) in combination with chemotherapy (ChRx) in patients with advanced cancer (ÇA): Pharmacologie and long-term safety data. Proc Ann u Meet Am Soc Clin Oncol 18:1678A, 1999.
    • (1999) Proc Ann U Meet Am Soc Clin Oncol , vol.18
    • Margolin, K.1    Gordon, M.S.2    Talpaz, M.3
  • 81
    • 0003348278 scopus 로고    scopus 로고
    • A phase II trial of humanized monoclonal anti-vascular endothelial growth factor antibody (rhuMAb VEGF) in hormone-refractory prostate cancer (HRPC)
    • Reese D, Fröhlich M, Bok R, et al: A phase II trial of humanized monoclonal anti-vascular endothelial growth factor antibody (rhuMAb VEGF) in hormone-refractory prostate cancer (HRPC). Proc Annu Meet Am Soc Clin Oncol 18:1355A, 1999.
    • (1999) Proc Annu Meet Am Soc Clin Oncol , vol.18
    • Reese, D.1    Fröhlich, M.2    Bok, R.3
  • 83
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • Prewett M, Huber J, Li Y, et al: Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 59:5209-5218, 1999.
    • (1999) Cancer Res , vol.59 , pp. 5209-5218
    • Prewett, M.1    Huber, J.2    Li, Y.3
  • 84
    • 0031870832 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting the VEGF receptor-2 (Flkl/KDR) as an anti-angiogenic therapeutic strategy
    • Witte L, Hicklin DJ, Zhu Z, et al: Monoclonal antibodies targeting the VEGF receptor-2 (Flkl/KDR) as an anti-angiogenic therapeutic strategy. Cancer Metastasis Rev 17:155-161, 1998.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 155-161
    • Witte, L.1    Hicklin, D.J.2    Zhu, Z.3
  • 85
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/ KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, et al: SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/ KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 59:99-106, 1999.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3
  • 86
    • 0033229939 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas
    • Angelov L, Salhia B, Roncari L, et al: Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Cancer Res 59:5536-5541, 1999.
    • (1999) Cancer Res , vol.59 , pp. 5536-5541
    • Angelov, L.1    Salhia, B.2    Roncari, L.3
  • 87
    • 0033231069 scopus 로고    scopus 로고
    • Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
    • Shaheen RM, Davis DW, Liu W, et al: Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res 59:54125416, 1999.
    • (1999) Cancer Res , vol.59 , pp. 54125416
    • Shaheen, R.M.1    Davis, D.W.2    Liu, W.3
  • 88
    • 0000601929 scopus 로고    scopus 로고
    • Phase I dose-escalating trial of SU5416, a novel angiogenesis inhibitor in patients with advanced malignancies
    • Rosen L, Mulay M, Mayers A, et al: Phase I dose-escalating trial of SU5416, a novel angiogenesis inhibitor in patients with advanced malignancies. Proc Annu Meet Am Soc Clin Oncol 18:618A, 1999.
    • (1999) Proc Annu Meet Am Soc Clin Oncol , vol.18
    • Rosen, L.1    Mulay, M.2    Mayers, A.3
  • 89
    • 0000603698 scopus 로고    scopus 로고
    • A multicenter dose-escalating study of SU5416 in AIDS-related Kaposi's sarcoma
    • Miles S, Arasteh K, Gill P, et al: A multicenter dose-escalating study of SU5416 in AIDS-related Kaposi's sarcoma. Proc Annu Meet Am Soc Clin Oncol 19:683A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.19
    • Miles, S.1    Arasteh, K.2    Gill, P.3
  • 90
    • 0003037701 scopus 로고    scopus 로고
    • A Phase I/II study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer
    • Rosen PJ, Amado R, Hecht JR, et al: A Phase I/II study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer. Proc Annu Meet Am Soc Clin Oncol 19:5D, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.19
    • Rosen, P.J.1    Amado, R.2    Hecht, J.R.3
  • 91
    • 0001725212 scopus 로고    scopus 로고
    • VEGF receptor tyrosine kinase inhibitors as potential anti-tumor targets
    • Wedge SR, Ogilvie D], Dukes M, et al: VEGF receptor tyrosine kinase inhibitors as potential anti-tumor targets. Proc Annu Meet Am Assoc Cancer Res 41:3610A, 2000.
    • (2000) Proc Annu Meet Am Assoc Cancer Res , vol.41
    • Wedge, S.R.1    Ogilvie, D.2    Dukes, M.3
  • 92
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • Laird AD, Vajkoczy P, Shawver LK, et al: SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 60:4152-4160, 2000.
    • (2000) Cancer Res , vol.60 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3
  • 93
    • 0006277713 scopus 로고    scopus 로고
    • Phase I experience oral SU006668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies
    • Rosen L, Hannah A, Rosen P, et al: Phase I experience oral SU006668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies. Clin Cancer Res 6:581A, 2000
    • (2000) Clin Cancer Res , vol.6
    • Rosen, L.1    Hannah, A.2    Rosen, P.3
  • 94
    • 0033168947 scopus 로고    scopus 로고
    • Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA
    • Parry TJ, Cushman C, Gallegos AM, et al: Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res 27:25692577, 1999.
    • (1999) Nucleic Acids Res , vol.27 , pp. 25692577
    • Parry, T.J.1    Cushman, C.2    Gallegos, A.M.3
  • 95
    • 0034069028 scopus 로고    scopus 로고
    • Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
    • Pavco PA, Bouhana KS, Gallegos AM, et al: Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin Cancer Res 6:2094-2103, 2000.
    • (2000) Clin Cancer Res , vol.6 , pp. 2094-2103
    • Pavco, P.A.1    Bouhana, K.S.2    Gallegos, A.M.3
  • 96
    • 0001012263 scopus 로고    scopus 로고
    • A phase I/II study of repetitive dose Angiozyme, a ribozyme targeting the Flt-1 receptor for VEGF
    • Weng DE, Weiss P, Kellacky C, et al: A phase I/II study of repetitive dose Angiozyme, a ribozyme targeting the Flt-1 receptor for VEGF. Clin Cancer Res 6:267A, 2000.
    • (2000) Clin Cancer Res , vol.6
    • Weng, D.E.1    Weiss, P.2    Kellacky, C.3
  • 97
    • 0027474456 scopus 로고
    • How cancer cells evade chemotherapy: Sixteenth Hinda Rosenthal Foundation award (lecture)
    • Gottesman MM: How cancer cells evade chemotherapy: Sixteenth Hinda Rosenthal Foundation award (lecture). Cancer Res 53:747-754, 1993.
    • (1993) Cancer Res , vol.53 , pp. 747-754
    • Gottesman, M.M.1
  • 98
    • 0028263197 scopus 로고
    • : Does improved control of tumor growth require an anti-cancer therapy targeting both neoplastic and intratumoral endothelial cells?
    • Gasparini G, Harris AL: Does improved control of tumor growth require an anti-cancer therapy targeting both neoplastic and intratumoral endothelial cells? Eur J Cancer 30:201-206, 1994.
    • (1994) Eur J Cancer , vol.30 , pp. 201-206
    • Gasparini, G.1    Harris, A.L.2
  • 100
    • 0034048358 scopus 로고    scopus 로고
    • : Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D, Bergers G, Bergsland E: Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 105:1045-1047, 2000.
    • (2000) J Clin Invest , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 101
    • 0034131079 scopus 로고    scopus 로고
    • Accidental antiangiogenic drugs: Anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples
    • Kerbel RS, Viloria-Petit A, Klement G, et al: Accidental antiangiogenic drugs: Anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples. Eur J Cancer 36:1248-1257, 2000.
    • (2000) Eur J Cancer , vol.36 , pp. 1248-1257
    • Kerbel, R.S.1    Viloria-Petit, A.2    Klement, G.3
  • 102
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present, and the near future
    • Kerbel RS: Tumor angiogenesis: Past, present, and the near future. Carcinogenesis 21:505-515, 2000.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 103
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drugresistant cancer
    • Browder T, Butterneid CE, Kraling BM, et al: Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drugresistant cancer. Cancer Res 60:1878-1886, 2000.
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterneid, C.E.2    Kraling, B.M.3
  • 104
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity.
    • Klement G, Baruchel S, Rak J, et al: Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. / Clin Invest 105:Rl5-R24, 2000.
    • (2000) Clin Invest , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 105
    • 0026444990 scopus 로고    scopus 로고
    • Angiostatic activity of anticancer agents in the chick embryo chorioallantoic membrane (CHE-CAM) assay
    • in Steiner R, Langer R (eds): Basel, Switzerland, Birkhauser Verlag
    • Steiner R: Angiostatic activity of anticancer agents in the chick embryo chorioallantoic membrane (CHE-CAM) assay, in Steiner R, Langer R (eds): Angiogenesis. Key Principles-Science-Technology-Medicine. Basel, Switzerland, Birkhauser Verlag, 1992, pp 449-454.
    • Angiogenesis. Key Principles-Science-Technology-Medicine. , vol.1992 , pp. 449-454
    • Steiner, R.1
  • 106
    • 0033563116 scopus 로고    scopus 로고
    • Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process
    • Presta M, Rusnati M, Belleri M, et al: Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process. Cancer Res 59:2417-2424, 1999.
    • (1999) Cancer Res , vol.59 , pp. 2417-2424
    • Presta, M.1    Rusnati, M.2    Belleri, M.3
  • 107
    • 0032795611 scopus 로고    scopus 로고
    • UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice
    • Yonekura K, Basaki Y, et al: UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice. Clin Cancer Res 5:2185-2191, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 2185-2191
    • Yonekura, K.1    Basaki, Y.2
  • 108
    • 0032956544 scopus 로고    scopus 로고
    • Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model
    • O'Leary JJ, Shapiro RL, et al: Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model. Clin Cancer Res 5:181-187, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 181-187
    • O'Leary, J.J.1    Shapiro, R.L.2
  • 109
    • 0032532391 scopus 로고    scopus 로고
    • Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4
    • lyer S, Chapin DJ, et al: Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4. Cancer Res 58:4510-4514, 1998.
    • (1998) Cancer Res , vol.58 , pp. 4510-4514
    • Lyer, S.1    Chapin, D.J.2
  • 110
    • 0032950870 scopus 로고    scopus 로고
    • Anti-vascular approaches to solid tumor therapy: Evaluation of combretastatin A4 phosphate
    • Chaplin DJ, Pettit GR, Hill S: Anti-vascular approaches to solid tumor therapy: Evaluation of combretastatin A4 phosphate. Anticancer Res 19:189-196, 1999.
    • (1999) Anticancer Res , vol.19 , pp. 189-196
    • Chaplin, D.J.1    Pettit, G.R.2    Hill, S.3
  • 111
    • 0031757277 scopus 로고    scopus 로고
    • Dose-dense therapy with weekly 1 hour paclitaxel infusions in the treatment of metastatic breast cancer.
    • Seidman AD, Hudis CA, Albane IJ, et al: Dose-dense therapy with weekly 1 hour paclitaxel infusions in the treatment of metastatic breast cancer. / Clin Oncol 16:3353-3361, 1998.
    • (1998) Clin Oncol , vol.16 , pp. 3353-3361
    • Seidman, A.D.1    Hudis, C.A.2    Albane, I.J.3
  • 112
    • 0030881725 scopus 로고    scopus 로고
    • Salvage weekly paclitaxel in recurrent ovarian cancer
    • Abu-Rustum NR, Aghajanian C, Barakat RR, et al: Salvage weekly paclitaxel in recurrent ovarian cancer. Semin Oncol 24:62-67, 1997.
    • (1997) Semin Oncol , vol.24 , pp. 62-67
    • Abu-Rustum, N.R.1    Aghajanian, C.2    Barakat, R.R.3
  • 113
    • 0030479075 scopus 로고    scopus 로고
    • Schedule- And dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: Results of a phase I/II trial
    • Loffler TM, Freund W, Lipke J, et al: Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: Results of a phase I/II trial. Semin Oncol 23:32-34, 1996.
    • (1996) Semin Oncol , vol.23 , pp. 32-34
    • Loffler, T.M.1    Freund, W.2    Lipke, J.3
  • 114
    • 0003252754 scopus 로고    scopus 로고
    • Weekly taxol in patients who had relapsed or remained stable with taxol in a 21 day schedule
    • Alvarez A, Mickiewicz E, Brosio C, et al: Weekly taxol in patients who had relapsed or remained stable with taxol in a 21 day schedule. Proc Annu Meet Am Soc Clin Oncol 17:726A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.17
    • Alvarez, A.1    Mickiewicz, E.2    Brosio, C.3
  • 115
    • 0001504902 scopus 로고    scopus 로고
    • Phase I study of the angiogenesis inhibitor TNP-70 in combination with paclitaxel in patients with solid tumors
    • Herbst RS, Tran HT, Madden TL, et al: Phase I study of the angiogenesis inhibitor TNP-70 in combination with paclitaxel in patients with solid tumors. Proc Annu Meet Am Soc Clin Oncol 20:707A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.20
    • Herbst, R.S.1    Tran, H.T.2    Madden, T.L.3
  • 116
    • 0024361471 scopus 로고
    • Catecholestrogens inhibit proliferation and DNA synthesis of porcine granulöse cells in vitro: Comparison with estradiol, 5 alpha-dihydrotestosterone, gonadotropins and catecholamines
    • Spicer LJ, Hammond JM: Catecholestrogens inhibit proliferation and DNA synthesis of porcine granulöse cells in vitro: Comparison with estradiol, 5 alpha-dihydrotestosterone, gonadotropins and catecholamines. Mol Cell Endocrinol 64:119-126, 1989.
    • (1989) Mol Cell Endocrinol , vol.64 , pp. 119-126
    • Spicer, L.J.1    Hammond, J.M.2
  • 117
    • 0028220858 scopus 로고
    • The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumour growth
    • Fotsis T, Zhang Y, Pepper MS, et al: The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumour growth. Nature 17:237-239, 1994.
    • (1994) Nature , vol.17 , pp. 237-239
    • Fotsis, T.1    Zhang, Y.2    Pepper, M.S.3
  • 118
    • 0031015504 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
    • Klauber N, Parangi S, Flynn E, et al: Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res 57:81-86, 1997.
    • (1997) Cancer Res , vol.57 , pp. 81-86
    • Klauber, N.1    Parangi, S.2    Flynn, E.3
  • 119
    • 0031037067 scopus 로고    scopus 로고
    • Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol
    • Mukhopadhyay T, Roth JA: Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol. Oncogene 14:379-384, 1997.
    • (1997) Oncogene , vol.14 , pp. 379-384
    • Mukhopadhyay, T.1    Roth, J.A.2
  • 120
    • 0029880479 scopus 로고    scopus 로고
    • The endogenous estrogen metabolite 2-methoxyestradiol induces apoptotic neuronal cell death in vitro
    • NakagawaYaki Y, Ogane N, Inoki Y, et al: The endogenous estrogen metabolite 2-methoxyestradiol induces apoptotic neuronal cell death in vitro. Life Sei 58:1461-1467, 1996.
    • (1996) Life Sei , vol.58 , pp. 1461-1467
    • Nakagawayaki, Y.1    Ogane, N.2    Inoki, Y.3
  • 121
    • 0033863030 scopus 로고    scopus 로고
    • 2-Methoxyestradiol blocks estrogen-induced rat pituitary tumor growth and angiogenesis: Possible role of vascular endothelial growth factor
    • Banerjeel SK, Zoubine MN, Sarkar DK, et al: 2-Methoxyestradiol blocks estrogen-induced rat pituitary tumor growth and angiogenesis: Possible role of vascular endothelial growth factor. Anticancer Res 20:2641-2645, 2000.
    • (2000) Anticancer Res , vol.20 , pp. 2641-2645
    • Banerjeel, S.K.1    Zoubine, M.N.2    Sarkar, D.K.3
  • 122
    • 0032994838 scopus 로고    scopus 로고
    • Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines
    • Schumacher G, Kataoka M, Roth JA, et al: Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines. Clin Cancer Res 5:493-499, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 493-499
    • Schumacher, G.1    Kataoka, M.2    Roth, J.A.3
  • 123
    • 0034283773 scopus 로고    scopus 로고
    • Comparison of 2-methoxyestradiolinduced, docetaxel-induced, and Paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species
    • Lin HL, Liu TY, Chau GY, et al: Comparison of 2-methoxyestradiolinduced, docetaxel-induced, and Paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species. Cancer 89:983-994, 2000.
    • (2000) Cancer , vol.89 , pp. 983-994
    • Lin, H.L.1    Liu, T.Y.2    Chau, G.Y.3
  • 124
    • 0031015504 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
    • Klauber N, Parangi S, Flynn E, et al: Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res 57:81-86, 1997.
    • (1997) Cancer Res , vol.57 , pp. 81-86
    • Klauber, N.1    Parangi, S.2    Flynn, E.3
  • 125
    • 0032211342 scopus 로고    scopus 로고
    • An agent that increases tumor suppressor-transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer
    • Kataoka M, Schumacher G, Cristiano RJ, et al: An agent that increases tumor suppressor-transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer in vivo. Cancer Res 58:4761-4765, 1999.
    • (1999) In Vivo. Cancer Res , vol.58 , pp. 4761-4765
    • Kataoka, M.1    Schumacher, G.2    Cristiano, R.J.3
  • 126
    • 33749403136 scopus 로고    scopus 로고
    • 2-Methoxyestradiol inhibits multiple métastases of human non-small cell lung cancer in nude mice with combination of systemic adenovims-p53. Proc
    • Kataoka M, Schumacher G, Roth JA, et al: 2-Methoxyestradiol inhibits multiple métastases of human non-small cell lung cancer in nude mice with combination of systemic adenovims-p53. Proc Annu Meet Am Assoc Cancer Res 39:2849A, 1998.
    • (1998) Annu Meet Am Assoc Cancer Res , vol.39
    • Kataoka, M.1    Schumacher, G.2    Roth, J.A.3
  • 127
    • 0031785593 scopus 로고    scopus 로고
    • Inhibition of normal and expérimental angiotumor endothelial cell proliferation and cell cycle progression by 2-methoxyestradiol
    • Reiser F, Way D, Berna M, et al: Inhibition of normal and expérimental angiotumor endothelial cell proliferation and cell cycle progression by 2-methoxyestradiol. Proc Soc Exp Biol Med 219:211-216, 1998.
    • (1998) Proc Soc Exp Biol Med , vol.219 , pp. 211-216
    • Reiser, F.1    Way, D.2    Berna, M.3
  • 128
    • 0030949341 scopus 로고    scopus 로고
    • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhib-its angiogenesis: Possible role for stress-activated protein kinase signaling pathway and Fas expression
    • Yue TL, Wang X, Louden CS, et al: 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhib-its angiogenesis: Possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol Pharmacol 51:951-962, 1997.
    • (1997) Mol Pharmacol , vol.51 , pp. 951-962
    • Yue, T.L.1    Wang, X.2    Louden, C.S.3
  • 129
    • 0032499891 scopus 로고    scopus 로고
    • 2-Methoxyestradiol, an endogenous metabolite of estrogen, enhances apoptosis and betagalactosidase expression in vascular endothelial cells
    • Tsukamoto A, Kaneko Y, Yoshida T, et al: 2-Methoxyestradiol, an endogenous metabolite of estrogen, enhances apoptosis and betagalactosidase expression in vascular endothelial cells. Biochem Biophys Res Commun 248:9-12, 1998.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 9-12
    • Tsukamoto, A.1    Kaneko, Y.2    Yoshida, T.3
  • 131
    • 0033918981 scopus 로고    scopus 로고
    • Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability. /Med
    • Wang Z, Yang D, Mohanakrishan AK, et al: Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability. /Med Chem 43:2419-2429, 2000.
    • (2000) Chem , vol.43 , pp. 2419-2429
    • Wang, Z.1    Yang, D.2    Mohanakrishan, A.K.3
  • 132
    • 0028331925 scopus 로고
    • 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site
    • D'Amato RJ, Lin CM, Flynn E, et al: 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc NatI Acad Sei USA 91:39643968, 1994.
    • (1994) Proc NatI Acad Sei USA , vol.91 , pp. 39643968
    • D'Amato, R.J.1    Lin, C.M.2    Flynn, E.3
  • 133
    • 0029008622 scopus 로고
    • Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicines binding site
    • Cushman M, He HM, Katzenellenbogen JA, et al: Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicines binding site. JMed Chem 38:2041-2049, 1995.
    • (1995) JMed Chem , vol.38 , pp. 2041-2049
    • Cushman, M.1    He, H.M.2    Katzenellenbogen, J.A.3
  • 134
    • 0034102108 scopus 로고    scopus 로고
    • Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen
    • Tsutsui T, Tamura Y, Hagiwara M, et al: Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen. Carcinogenesis 21:735-740, 2000.
    • (2000) Carcinogenesis , vol.21 , pp. 735-740
    • Tsutsui, T.1    Tamura, Y.2    Hagiwara, M.3
  • 135
    • 0031036011 scopus 로고    scopus 로고
    • Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol
    • Josefsson E, Tarkowski A: Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol. Arthritis Rheum 40:154-163, 1997.
    • (1997) Arthritis Rheum , vol.40 , pp. 154-163
    • Josefsson, E.1    Tarkowski, A.2
  • 136
    • 0018574156 scopus 로고
    • Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion
    • Martucci CP, Fishman J: Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion. Endocrinology 105:1288-1292, 1979.
    • (1979) Endocrinology , vol.105 , pp. 1288-1292
    • Martucci, C.P.1    Fishman, J.2
  • 137
    • 0031847271 scopus 로고    scopus 로고
    • An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats.
    • Liu D, Bachmann KA: An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats. / Pharmacol Exp Ther 286:561-568, 1998.
    • (1998) Pharmacol Exp Ther , vol.286 , pp. 561-568
    • Liu, D.1    Bachmann, K.A.2
  • 138
    • 0022568510 scopus 로고
    • Carcinogenicity of catechol estrogens in Syrian hamsters.
    • Liehr JG, Fang WF, Sirbasku DA, et al: Carcinogenicity of catechol estrogens in Syrian hamsters. / Steroid Biochem 24:353-356, 1986.
    • (1986) Steroid Biochem , vol.24 , pp. 353-356
    • Liehr, J.G.1    Fang, W.F.2    Sirbasku, D.A.3
  • 139
    • 47349113508 scopus 로고
    • Thalidomide and congenital abnormalities
    • McBride WG: Thalidomide and congenital abnormalities. Lancet 2:1358,1961.
    • (1961) Lancet , vol.2 , pp. 1358
    • McBride, W.G.1
  • 140
    • 49749219257 scopus 로고
    • Thalidomide and congenital abnormalities
    • Lenz W: Thalidomide and congenital abnormalities. Lancet 1:45,1962.
    • (1962) Lancet , vol.1 , pp. 45
    • Lenz, W.1
  • 141
    • 0023729816 scopus 로고
    • Proposed mechanisms of action in thalidomide embryopathy
    • Stephens TD: Proposed mechanisms of action in thalidomide embryopathy. Teratology 38:229-239, 1988.
    • (1988) Teratology , vol.38 , pp. 229-239
    • Stephens, T.D.1
  • 143
    • 0031171663 scopus 로고    scopus 로고
    • : Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
    • Kenyon BM, Browne F, D'Amato RJ: Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res 64:971-978, 1997.
    • (1997) Exp Eye Res , vol.64 , pp. 971-978
    • Kenyon, B.M.1    Browne, F.2    D'Amato, R.J.3
  • 144
    • 0033876198 scopus 로고    scopus 로고
    • Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals
    • Sauer H, Günther T, Hescheler J, et al: Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals. Am J Pathol 156:151-158, 2000.
    • (2000) Am J Pathol , vol.156 , pp. 151-158
    • Sauer, H.1    Günther, T.2    Hescheler, J.3
  • 145
    • 0028362802 scopus 로고
    • Bone marrow angiogenesis and progression in multiple myeloma
    • Vacca A, Ribatti D, Roncali L, et al: Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol 87:503-508, 1994.
    • (1994) Br J Haematol , vol.87 , pp. 503-508
    • Vacca, A.1    Ribatti, D.2    Roncali, L.3
  • 146
    • 0029146128 scopus 로고
    • Bone marrow of patients with active multiple myeloma: Angiogenesis and plasma cell adhesion molecules: LFA-1, VLA-4, LAM-1, and CD44
    • Vacca A, Di Loreto M, Ribatti D, et al: Bone marrow of patients with active multiple myeloma: Angiogenesis and plasma cell adhesion molecules: LFA-1, VLA-4, LAM-1, and CD44. Am f Hematol 50:9-14, 1995.
    • (1995) Am F Hematol , vol.50 , pp. 9-14
    • Vacca, A.1    Di Loreto, M.2    Ribatti, D.3
  • 147
    • 0029610669 scopus 로고
    • Angiogenesis in B-cell lymphoproliferative diseases: Biological and clinical studies
    • Vacca A, Ribatti D, Roncali L, et al: Angiogenesis in B-cell lymphoproliferative diseases: Biological and clinical studies. LeukLymphoma 20:27-38, 1995.
    • (1995) LeukLymphoma , vol.20 , pp. 27-38
    • Vacca, A.1    Ribatti, D.2    Roncali, L.3
  • 148
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
    • Vacca A, Ribbatti D, Presta M, et al: Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood 93:3064-3073, 1999.
    • (1999) Blood , vol.93 , pp. 3064-3073
    • Vacca, A.1    Ribbatti, D.2    Presta, M.3
  • 149
    • 0031059348 scopus 로고    scopus 로고
    • Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
    • Perez-Atayde AR, Sallan SE, Tedrow U, et al: Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol 150:815-820, 1997.
    • (1997) Am J Pathol , vol.150 , pp. 815-820
    • Perez-Atayde, A.R.1    Sallan, S.E.2    Tedrow, U.3
  • 150
    • 0033043613 scopus 로고    scopus 로고
    • Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma
    • Rajkumar SV, Fonseca R, Witzig TE, et al: Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma. Leukemia 13:469-472, 1999.
    • (1999) Leukemia , vol.13 , pp. 469-472
    • Rajkumar, S.V.1    Fonseca, R.2    Witzig, T.E.3
  • 151
    • 0002621260 scopus 로고    scopus 로고
    • Angiogenesis in newly diagnosed multiple myeloma: Poor prognosis with increased microvessel density (MVD) in bone marrow biopsies
    • Munshi N, Wilson CS, Penn J, et al: Angiogenesis in newly diagnosed multiple myeloma: Poor prognosis with increased microvessel density (MVD) in bone marrow biopsies. Blood 92:98A, 1998.
    • (1998) Blood , vol.92
    • Munshi, N.1    Wilson, C.S.2    Penn, J.3
  • 152
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al: Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 341:1565-1571, 1999.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 153
    • 0007458651 scopus 로고    scopus 로고
    • Thalidomide in the management of multiple myeloma: The Arkansas experience in > 300 patients with single agent and combined therapy
    • Barlogie B: Thalidomide in the management of multiple myeloma: The Arkansas experience in > 300 patients with single agent and combined therapy. Proc Annu Meet Am Soc Clin Oncol 20:28A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.20
    • Barlogie, B.1
  • 154
    • 0033942084 scopus 로고    scopus 로고
    • Phase II evaluation of thalidomide in patients with metastatic breast cancer.
    • Baidas SM, Winer EP, Flemming GF, et al: Phase II evaluation of thalidomide in patients with metastatic breast cancer. / Clin Oncol 18:2710-2717, 2000.
    • (2000) Clin Oncol , vol.18 , pp. 2710-2717
    • Baidas, S.M.1    Winer, E.P.2    Flemming, G.F.3
  • 155
    • 0033980850 scopus 로고    scopus 로고
    • Continuous low dose of thalidomide: A phase II study in advanced melanoma, renal cell, ovarian, and breast cancer
    • Eisen T, Boshoff C, Mak I, et al: Continuous low dose of thalidomide: A phase II study in advanced melanoma, renal cell, ovarian, and breast cancer. Br J Cancer 82:812-817, 2000.
    • (2000) Br J Cancer , vol.82 , pp. 812-817
    • Eisen, T.1    Boshoff, C.2    Mak, I.3
  • 156
    • 0003371767 scopus 로고    scopus 로고
    • Thalidomide treatment of metastatic renal cell cancer
    • Minor D, Elias L: Thalidomide treatment of metastatic renal cell cancer. Proc Annu Meet Am Soc Clin Oncol 20:1384A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.20
    • Minor, D.1    Elias, L.2
  • 157
    • 0033954292 scopus 로고    scopus 로고
    • Phase II trial of the anti-angiogenic agent thalidomide in patients with recurrent high-grade gliomas.
    • Fine HA, Figg WD, Jaeckle K, et al: Phase II trial of the anti-angiogenic agent thalidomide in patients with recurrent high-grade gliomas. / Clin Oncol 18:708-715, 2000.
    • (2000) Clin Oncol , vol.18 , pp. 708-715
    • Fine, H.A.1    Figg, W.D.2    Jaeckle, K.3
  • 158
    • 0000946318 scopus 로고    scopus 로고
    • Phase II study of thalidomide as an anti-angiogenic agent in the treatment of recurrent glioblastoma multiforme (GBM)
    • Marx GM, McCowatt S, Boyle F, et al: Phase II study of thalidomide as an anti-angiogenic agent in the treatment of recurrent glioblastoma multiforme (GBM). Proc Annu Meet Am Soc Clin Oncol 20:613A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.20
    • Marx, G.M.1    McCowatt, S.2    Boyle, F.3
  • 159
    • 0002215449 scopus 로고    scopus 로고
    • : Inhibitory effect of a primary tumor on metastatsis
    • in Day S, Myers P, Stansly PG, et al (eds): New York, Raven Press
    • Sugarbaker E, Thornwaite J, Ketcham A: Inhibitory effect of a primary tumor on metastatsis, in Day S, Myers P, Stansly PG, et al (eds): Progress in Cancer Research and Therapy. New York, Raven Press, 1977, pp 227-240.
    • Progress in Cancer Research and Therapy. , vol.1977 , pp. 227-240
    • Sugarbaker, E.1    Thornwaite, J.2    Ketcham, A.3
  • 160
    • 0000857281 scopus 로고
    • Heterologous, homologous, and autologous transplantation of human tumors
    • Koike A, Moore GE, Mendoza CB, et al: Heterologous, homologous, and autologous transplantation of human tumors. Cancer 16:1065.1071, 1963.
    • (1963) Cancer , vol.16 , pp. 1065-1071
    • Koike, A.1    Moore, G.E.2    Mendoza, C.B.3
  • 161
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of métastases by a Lewis lung carcinoma
    • O'Reilly M, Holgren L, Shing Y, et al: Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of métastases by a Lewis lung carcinoma. Cell 79:315-328, 1994.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.1    Holgren, L.2    Shing, Y.3
  • 162
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'Reilly M, Boehm T, Shing Y, et al: Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277-285, 1997.
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.1    Boehm, T.2    Shing, Y.3
  • 163
    • 0030935029 scopus 로고    scopus 로고
    • A recombinant human angiostatin inhibits experimental primary and metastatic cancer
    • Sim BKL, O'Reilly M, Liang H, et al: A recombinant human angiostatin inhibits experimental primary and metastatic cancer. Cancer Res 57:1329-1334, 1997.
    • (1997) Cancer Res , vol.57 , pp. 1329-1334
    • Sim, B.K.L.1    O'Reilly, M.2    Liang, H.3
  • 164
    • 18244419396 scopus 로고    scopus 로고
    • Combined effects of angiostatin and ionizing radiation in antitumor therapy
    • Mauceri HJ, Hanna N, Beckett MA, et al: Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature 394:287-291, 1998.
    • (1998) Nature , vol.394 , pp. 287-291
    • Mauceri, H.J.1    Hanna, N.2    Beckett, M.A.3
  • 165
    • 0033406794 scopus 로고    scopus 로고
    • Endothelial progenitor cells as putative targets for angiostatin
    • Ito H, Rovira I, Bloom M, et al: Endothelial progenitor cells as putative targets for angiostatin. Cancer Res 59:5875-5877, 1999.
    • (1999) Cancer Res , vol.59 , pp. 5875-5877
    • Ito, H.1    Rovira, I.2    Bloom, M.3
  • 166
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm T, Folkman J, Shing Y, et al: Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390:404-407, 1997.
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Shing, Y.3
  • 168
    • 0006631497 scopus 로고    scopus 로고
    • Recombinant endostatin demonstrates safety, linear pharmacokinetics and biological effects on tumor growth factors: Results of a phase I clinical study
    • Eder JP, Clark JW, Supko JG, et al: Recombinant endostatin demonstrates safety, linear pharmacokinetics and biological effects on tumor growth factors: Results of a phase I clinical study. Clin Cancer Res 6:258A, 2000.
    • (2000) Clin Cancer Res , vol.6
    • Eder, J.P.1    Clark, J.W.2    Supko, J.G.3
  • 169
    • 33749415957 scopus 로고    scopus 로고
    • A phase I clinical trial of recombinant human endostatin (rHE) in patients with solid tumors: Pharmacokinetic, safety, and efficacy analysis
    • Herbst R, Tran H, Hess T, et al: A phase I clinical trial of recombinant human endostatin (rHE) in patients with solid tumors: Pharmacokinetic, safety, and efficacy analysis. Clin Cancer Res 6:259A, 2000.
    • (2000) Clin Cancer Res , vol.6
    • Herbst, R.1    Tran, H.2    Hess, T.3
  • 170
    • 33749399536 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin
    • Thomas JP, Schiller J, Lee F, et al: A phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin. Clin Cancer Res 6:260A, 2000.
    • (2000) Clin Cancer Res , vol.6
    • Thomas, J.P.1    Schiller, J.2    Lee, F.3
  • 171
    • 0027464725 scopus 로고
    • Squalamine: An aminosterol antibiotic from the shark. Froc
    • Moore KS, Wehrli S, Roder H, et al: Squalamine: An aminosterol antibiotic from the shark. Froc Natl Acad Sei USA 90:1354-1358, 1993.
    • (1993) Natl Acad Sei USA , vol.90 , pp. 1354-1358
    • Moore, K.S.1    Wehrli, S.2    Roder, H.3
  • 172
    • 15644374381 scopus 로고    scopus 로고
    • Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature
    • Sills AK, Williams JI, Tyler BM, et al: Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res 58:2784-2792, 1998.
    • (1998) Cancer Res , vol.58 , pp. 2784-2792
    • Sills, A.K.1    Williams, J.I.2    Tyler, B.M.3
  • 173
    • 0031864882 scopus 로고    scopus 로고
    • Potential of the aminosterol, squalamine in combination therapy in the rat 13762 mammary carcinoma and the murine Lewis lung carcinoma
    • Teicher B A, Williams JI, Takeuchi H, et al: Potential of the aminosterol, squalamine in combination therapy in the rat 13762 mammary carcinoma and the murine Lewis lung carcinoma. Anticancer Res 18:25672574, 1998.
    • (1998) Anticancer Res , vol.18 , pp. 25672574
    • Teicher, B.A.1    Williams, J.I.2    Takeuchi, H.3
  • 174
    • 0008047898 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic (PK) study of the angiogenesis inhibitor, squalamine lactate (MSI-1256F)
    • Kalidas M, Hammond LA, Patnaik A, et al: A phase I and pharmacokinetic (PK) study of the angiogenesis inhibitor, squalamine lactate (MSI-1256F). Proc Annu Meet Am Soc Clin Oncol 19:698A, 2000.
    • (2000) Proc Annu Meet Am Soc Clin Oncol , vol.19
    • Kalidas, M.1    Hammond, L.A.2    Patnaik, A.3
  • 175
    • 0032216811 scopus 로고    scopus 로고
    • The role of av integrins during angiogenesis
    • Eliceiri BR, Cheresh DA: The role of av integrins during angiogenesis. Mol Med 4:741-750, 1998.
    • (1998) Mol Med , vol.4 , pp. 741-750
    • Eliceiri, B.R.1    Cheresh, D.A.2
  • 176
    • 0029998296 scopus 로고    scopus 로고
    • : Regulation of cell migration by the beta subunit ectodomain of ctv3.
    • Filardo EJ, Deming SL, Cheresh DA: Regulation of cell migration by the beta subunit ectodomain of ctv3. / Cell Sei 109:1615-1622, 1996.
    • (1996) Cell Sei , vol.109 , pp. 1615-1622
    • Filardo, E.J.1    Deming, S.L.2    Cheresh, D.A.3
  • 177
    • 0031856539 scopus 로고    scopus 로고
    • Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the av3 and avs integrins.
    • Sung V, Stubbs JT III, Fisher L, et al: Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the av3 and avs integrins. / Cell Physiol 176:482-494,1998.
    • (1998) Cell Physiol , vol.176 , pp. 482-494
    • Sung, V.1    Stubbs III, J.T.2    Fisher, L.3
  • 178
    • 0029808419 scopus 로고    scopus 로고
    • Up-regulated expression of the 3 integrin and the 92-kDa gelatinase in human HT-144 melanoma cell tumors grown in nude mice
    • Gouon V, Tucker GC, Kraus-Berthier L, et al: Up-regulated expression of the 3 integrin and the 92-kDa gelatinase in human HT-144 melanoma cell tumors grown in nude mice. Int J Cancer 68:650-662, 1996.
    • (1996) Int J Cancer , vol.68 , pp. 650-662
    • Gouon, V.1    Tucker, G.C.2    Kraus-Berthier, L.3
  • 179
    • 0029664423 scopus 로고    scopus 로고
    • Integrin c^j can promote adhesion and spreading of metastatic breast carcinoma cells on the lymph node stroma
    • Tawil NJ, Gowri V, Djoneidi M, et al: Integrin c^j can promote adhesion and spreading of metastatic breast carcinoma cells on the lymph node stroma. Int J Cancer 66:703-710, 1996.
    • (1996) Int J Cancer , vol.66 , pp. 703-710
    • Tawil, N.J.1    Gowri, V.2    Djoneidi, M.3
  • 180
    • 0031051662 scopus 로고    scopus 로고
    • Differential adhesion of metastatic RAW117 large-cell lymphoma cells under static or hydrodynamic conditions: Role of integrin av3
    • Yun Z, Smith TW, Menter DG, et al: Differential adhesion of metastatic RAW117 large-cell lymphoma cells under static or hydrodynamic conditions: Role of integrin av3. Clin Exp Metastasis 15:3-11, 1997.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 3-11
    • Yun, Z.1    Smith, T.W.2    Menter, D.G.3
  • 181
    • 0031426154 scopus 로고    scopus 로고
    • In vitro angiogenesis is modulated by the mechanical properties of fibrin gels and is related to av3 integrin localization
    • Vailhe B, Ronot X, Tracqui P, et al: In vitro angiogenesis is modulated by the mechanical properties of fibrin gels and is related to av3 integrin localization. In Vitro Cell Dev Biol Anim 33:763-773, 1997.
    • (1997) In Vitro Cell Dev Biol Anim , vol.33 , pp. 763-773
    • Vailhe, B.1    Ronot, X.2    Tracqui, P.3
  • 182
    • 0033624642 scopus 로고    scopus 로고
    • Av3 expression on blood vessels and melanoma cells in primary lesions: Differential association with tumor progression and clinical prognosis
    • Kageshita T, Hamby CV, Hirai S, et al: av3 expression on blood vessels and melanoma cells in primary lesions: Differential association with tumor progression and clinical prognosis. Cancer Immunol Immunother 49:314-318, 2000.
    • (2000) Cancer Immunol Immunother , vol.49 , pp. 314-318
    • Kageshita, T.1    Hamby, C.V.2    Hirai, S.3
  • 183
    • 0031724191 scopus 로고    scopus 로고
    • Vascular integrin av3: A new prognostic indicator in breast cancer
    • Gasparini G, Brooks PC, Biganzoli E, et al: Vascular integrin av3: A new prognostic indicator in breast cancer. Clin Cancer Res 4:26252634, 1998.
    • (1998) Clin Cancer Res , vol.4 , pp. 26252634
    • Gasparini, G.1    Brooks, P.C.2    Biganzoli, E.3
  • 184
    • 0030960689 scopus 로고    scopus 로고
    • Clinical significance of av3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions
    • Natali PG, Hamby CV, Felding-Habermann B, et al: Clinical significance of av3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions. Cancer Res 57:15541560, 1997.
    • (1997) Cancer Res , vol.57 , pp. 15541560
    • Natali, P.G.1    Hamby, C.V.2    Felding-Habermann, B.3
  • 185
    • 0033960562 scopus 로고    scopus 로고
    • Integrins av3 and avs are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide
    • Erdreich-Epstein A, Shimada H, Groshen S, et al: Integrins av3 and avs are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide. Cancer Res 60:712-721, 2000.
    • (2000) Cancer Res , vol.60 , pp. 712-721
    • Erdreich-Epstein, A.1    Shimada, H.2    Groshen, S.3
  • 186
    • 0033118450 scopus 로고    scopus 로고
    • Prostatic carcinoma cell migration via av3 integrin modulated by a focal adhesion kinase pathway
    • Zheng DQ, Woodard AS, Fornaro M, et al: Prostatic carcinoma cell migration via av3 integrin modulated by a focal adhesion kinase pathway. Cancer Res 59:1655-1664, 1999.
    • (1999) Cancer Res , vol.59 , pp. 1655-1664
    • Zheng, D.Q.1    Woodard, A.S.2    Fornaro, M.3
  • 188
    • 0002790798 scopus 로고    scopus 로고
    • Phase I study of Vitaxin, an anti-angiogenic humanized monoclonal antibody to vascular integrin vs
    • Gutheil JC, Campbell TN, Pierce PR, et al: Phase I study of Vitaxin, an anti-angiogenic humanized monoclonal antibody to vascular integrin vs- Proc Annu Meet Am Soc Clin Oncol 17:832A, 1998.
    • (1998) Proc Annu Meet Am Soc Clin Oncol , vol.17
    • Gutheil, J.C.1    Campbell, T.N.2    Pierce, P.R.3
  • 189
    • 0033870756 scopus 로고    scopus 로고
    • Targeted antiangiogenic therapy for cancer using Vitaxin: A humanized monoclonal antibody to the integrin av3
    • Guthiel JC, Campbell TN, Pierce PR, et al: Targeted antiangiogenic therapy for cancer using Vitaxin: A humanized monoclonal antibody to the integrin av3. Clin Cancer Res 6:3056-3061, 2000.
    • (2000) Clin Cancer Res , vol.6 , pp. 3056-3061
    • Guthiel, J.C.1    Campbell, T.N.2    Pierce, P.R.3
  • 190
    • 0003278163 scopus 로고    scopus 로고
    • A pilot study of an angiogenesis inhibitor Vitaxin in patients with advanced leiomyosarcomas
    • Patel SR, Jenkins J, Papadopoulos NE, et al: A pilot study of an angiogenesis inhibitor Vitaxin in patients with advanced leiomyosarcomas. Proc Anna Meet Am Soc Clin Oncol 19:2202A, 2000.
    • (2000) Proc Anna Meet Am Soc Clin Oncol , vol.19
    • Patel, S.R.1    Jenkins, J.2    Papadopoulos, N.E.3
  • 191
    • 33749371888 scopus 로고    scopus 로고
    • Human malignant glioma therapy using anti-av3 integrin agents.
    • Chatterjee S, Matsumura A, Schradermeier J, et al: Human malignant glioma therapy using anti-av3 integrin agents. / Neurooncol 46:135144, 2000.
    • (2000) Neurooncol , vol.46 , pp. 135144
    • Chatterjee, S.1    Matsumura, A.2    Schradermeier, J.3
  • 192
    • 0033862030 scopus 로고    scopus 로고
    • Av integrin antagonists induce the disassembly of focal contacts in melanoma cells
    • Castel S, Pagan R, Garcia R, et al: av integrin antagonists induce the disassembly of focal contacts in melanoma cells. EUT J Cell Biol 79:502-512, 2000.
    • (2000) EUT J Cell Biol , vol.79 , pp. 502-512
    • Castel, S.1    Pagan, R.2    Garcia, R.3
  • 193
    • 0003256224 scopus 로고    scopus 로고
    • Cilengitide (EMD 121974) inhibits angiogenesis by blocking av3 and otv5 integrins: Mature results of a phase I and pharmacological study
    • Eskens F, Dumez H, Verweij J, et al: Cilengitide (EMD 121974) inhibits angiogenesis by blocking av3 and otv5 integrins: Mature results of a phase I and pharmacological study. Clin Cancer Res 6:296A, 2000.
    • (2000) Clin Cancer Res , vol.6
    • Eskens, F.1    Dumez, H.2    Verweij, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.