Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression

Breast Cancer Research and Treatment

Volumn 61, Issue 3, 2000, Pages 249-259

  Zhou, Qing ^a   Sherwin, Russel P ^a   Parrish, Catherine ^a   Richters, Valda ^a   Groshen, Susan G ^b   Tsao Wei, Denice ^b   Markland, Francis S ^a  

^a Department of Biochemistry and Molecular Biology ^*  (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adhesion; Angiogenesis; Breast cancer; Disintegrin; Integrins; Invasion; Metastasis

Indexed keywords

CONTORTROSTATIN; DISINTEGRIN; FIBRONECTIN; INTEGRIN; LAMININ; MATRIGEL; SCLEROPROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG; VITRONECTIN;

AGKISTRODON; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASEMENT MEMBRANE; BINDING SITE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER INVASION; CELL ADHESION; CELL INVASION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG PROTEIN BINDING; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0033860870     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006457903545     Document Type: Article

References (51)

1. Integrins: Versatility modulation, and signaling in cell adhesion
2. Structural and biologic properties of integrin-mediated cell adhesion
3. Integrin-mediated adhesion and signaling in tumorgenesis
4. Adhesion molecules in cancer: The role of integrins
5. Signal transduction by integrins and its role in the regulation of tumor growth
6. Characterization of selected strongly and weakly invasive sublines of a primary human melanoma cell line and isolation of subtractive cDNA clones
7. Inhibitory effects of adhesion oligopeptides on the invasion of squamous carcinoma cells with special reference to implication of av integrins
8. Expression of αvβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas
9. Cooperative signaling by α5β1 and α4β1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
10. Role of the αvβ3 integrin in human melanoma cell invasion
11. The 72 kDa type IV collagenase is modulated via differential expression of αvβ3 and α5β1 integrins during human melanoma cell invasion
12. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin
13. Requirement of vascular integrin αvβ3 for angiogenesis
14. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
15. The cell attachment activity of fibronectin can be duplicated by small fragments of the molecule
16. Trigramin, an RGD-containing peptide from snake venom, inhibits cell-substratum adhesion of human melanoma cells
17. Contortrostatin, a snake venom disintegrin, inhibits β1 integrin-mediated human metastatic melanoma cell adhesion, and blocks experimental metastasis
18. Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid and recognition site(s) on platelet glycoprotein IIb/IIIa
19. Disintegrin interaction with αvβ3 integrin on human umbilical vein endothelial cells: Expression of ligand-induced binding site on β3 subunit
20. Platelet glycoprotein IIb/IIIa protein antagonists from snake venoms: Evidence for a family of platelet-aggregation inhibitors
21. Disintegrins: A family of integrin inhibitory proteins from viper venoms
22. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors
23. Viper venom disintegrins and related molecules [Review]
24. Purification and characterization of platelet aggregation inhibitors from snake venoms
25. Triflavin, an RGD-containing antiplatelet peptide, binds to GPIIIa of ADP-stimulated platelets
26. A novel disintegrin salmosin inhibits tumor angiogenesis
27. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice
28. A new in vitro assay for quantitating tumor cell invasion
29. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice
30. Prognostic significance of tumor vascularity
31. Hypothesis testing and goodness of fit
32. A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa
33. Platelet glycoprotein IIb-IIIa like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix
34. GP IIb-IIIa: The responsive integrin
35. Increased expression of αIIbβ3 integrin in subpopulations of murine melanoma cells with high lung-colonizing ability
36. Identification of the αIIbβ3 integrin in murine tumor cells
37. A murine monoclonal antibody that blocks fibrinogen binding to normal platelets also inhibits fibrinogen interactions with chymotrypsin-treated platelets
38. Tumor invasion and metastasis - Role of the extra-cellular matrix: Rhoads Memorial Award Lecture
39. Vitronectin and its receptors
40. Integrins αvβ3 and αvβ5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface
41. Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma
42. αv integrins mediate adhesion and migration of breast carcinoma cell lines
43. Regulation of cell motility by mitogen-activated protein kinase
44. Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin αvβ3 antagonist and inducing apoptosis
45. Editorial: Angiogenesis and breast cancer
46. Angiostatin induces and sustains dormancy of human primary tumors in mice
47. Endostatin: An endogenoits inhibitor of angiogenesis and tumor growth
48. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
49. Platelets and cancer metastasis: More than an epiphenomenon
50. Platelet-melanoma cell interaction is mediated by the glycoprotein IIb-IIIa complex
51. Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo