Presenilins in the genesis of Alzheimer's disease;Presenilinas en la génesis de la enfermedad de Alzheimer

Revista de Neurologia

Volumn 33, Issue 10, 2001, Pages 967-972

  Pérez Tur, Jordi ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Alzheimer's disease; Amyloid; Catenin; Notch; Presenilins.; secretase

Indexed keywords

CATENIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; APOPTOSIS; HUMAN; POINT MUTATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW;

EID: 0035713961     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3310.2001397     Document Type: Review

References (58)

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7. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene
8. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
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18. A pathogenic presenilin-1 deletion causes aberrant Abeta 42 production in the absence of congophilic amyloid plaques
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29. Presenilin 1 protein directly interacts with Bcl-2
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31. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
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33. The Notch1 receptor is cleaved constitutively by a furin-like convertase
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36. Presenilin is required for activity and nuclear access of Notch in Drosophila
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38. Evidence for a physical interaction between presenilin and Notch
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40. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities
41. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
42. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
43. Effects of PS1 deficiency on membrane protein trafficking in neurons
44. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
45. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
46. Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors
47. The discrepancy between presenilin subcellular localization and gamma- secretase processing of amyloid precursor protein
48. A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats
49. Interaction of presenilins with the filamin family of actin-binding proteins
50. Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport
51. A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment
52. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: No association between an exonic polymorphism and Alzheimer's disease
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54. Alzheimer's presenilin-1 mutation potentiates inositol 1, 4, 5- trisphosphatemediated calcium signaling in Xenopus oocytes
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56. Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor
57. Presenilin 1 interaction in the brain with a novel member of the Armadillo family
58. Direct association of presenilin-1 with beta-catenin