Embryonic stem cell differentiation: The role of extracellular factors

Differentiation

Volumn 68, Issue 4-5, 2001, Pages 167-174

  Czyz, Jaroslaw ^a   Wobus, Anna M ^a  

^a LEIBNIZ INSTITUTE OF PLANT GENETICS AND CROP PLANT RESEARCH IPK   (Germany)

Author keywords

BMP 4; Cardiogenesis; Embryonic stem cells; Extracellular matrix; Myogenesis; Neurogenesis; Wnt 1; 1 integrin

Indexed keywords

BETA1 INTEGRIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; ONCOPROTEIN; WNT PROTEIN; WNT1 PROTEIN; WNT1 PROTEIN, HUMAN; ZEBRAFISH PROTEIN;

ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; EMBRYO; GENE EXPRESSION REGULATION; HEART; HUMAN; NERVE CELL; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; STEM CELL;

ANIMALS; ANTIGENS, CD29; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HUMANS; NEURONS; PROTO-ONCOGENE PROTEINS; STEM CELLS; WNT PROTEINS; WNT1 PROTEIN; ZEBRAFISH PROTEINS;

EID: 0035495992     PISSN: 03014681     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-0436.2001.680404.x     Document Type: Review

References (72)

1. Ai, Z., Fischer, A., Spray, D.C., Brown, A.M. and Fishman, G.I. (2000) Wnt-1 regulation of connexin 43 in cardiac myocytes. J Clin Invest 105:161-171.
2. Angelov, D.N., Arnhold, S., Andressen, C., Grabsch, H., Puschmann, M., Hescheler, J. and Addicks, K. (1998) Temporospatial relationships between macroglia and microglia during in vitro differentiation of murine stem cells. Dev Neurosci 20:42-51.
3. Bagutti, C., Wobus, A.M., Fässler, R. and Watt, F.M. (1996) Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and beta 1 integrin-deficient cells. Dev Biol 179:184-196.
4. Bain, G., Kitchens, D., Yao, M., Huettner, J.E. and Gottlieb, D.I. (1995) Embryonic stem cells express neuronal properties in vitro. Dev Biol 168:342-357.
5. Baker, J.C., Beddington, R.S. and Harland, R.M. (1999) Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev 13:3149-3159.
6. Boheler, K. and Wobus, A.M. (2001) Myocardial aging and embryonic stem cell biology. Adv Cell Aging Gerontol (in press).
7. Boudreau, N.J. and Jones, P.L. (1999) Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 339:481-488.
8. Braun, T., Bober, E., Rudnicki, M.A., Jaenisch, R. and Arnold, H.H. (1994) MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Development 120:3083-3092.
9. Cadigan, K.M. and Nusse, R. (1997) Wnt signaling: a common theme in animal development. Genes Dev 11:3286-3305.
10. Dani, C. (1999) Embryonic stem cell-derived adipogenesis. Cells Tissues Organs 165:173-180.
11. Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W. and Kemler, R. (1985) The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87:27-45.
12. Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C. and Wobus, A.M. (1997) From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model. FASEB J 11:905-915.
13. Eastman, Q. and Grosschedl, R. (1999) Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 11:233-240.
14. Evans, M.J. and Kaufman, M.H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156.
15. Fässler, R., Georges-Labouesse, E. and Hirsch, E (1996a) Genetic analyses of integrin function in mice. Curr Opin Cell Biol 8:641-646.
16. Fässler, R. and Meyer, M. (1995) Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 9:1896-1908.
17. Fässler, R., Rohwedel, J., Maltsev, V., Bloch, W., Lentini, S., Guan, K., Gullberg, D., Hescheler, J., Addicks, K. and Wobus, A.M. (1996b) Differentiation and integrity of cardiac muscle cells are impaired in the absence of β1 integrin. J Cell Sci 109:2989-2999.
18. Finley, M.F., Kulkarni, N. and Huettner, J.E. (1996) Synapse formation and establishment of neuronal polarity by P19 embryonic carcinoma cells and embryonic stem cells. J Neurosci 16:1056-1065.
19. Fraichard, A., Chassande, O., Bilbaut, G., Dehay, C., Savatier, P., and Samarut, J. (1995) In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J Cell Sci 108:3181-3188.
20. Frisch, S.M. and Ruoslahti, E. (1997) Integrins and anoikis. Curr Opin Cell Biol 9:701-706.
21. Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Fujisawa, H., Kikuchi, A., and Kaibuchi, K. (1999) Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin. J Biol. Chem 274:26044-26050.
22. Gottlieb, D.I. and Huettner, J.E. (1999) An in vitro pathway from embryonic stem cells to neurons and glia. Cells Tissues Organs 165:165-172.
23. Gradl, D., Kuhl, M. and Wedlich, D. (1999) Keeping a close eye on Wnt-1/wg signaling in Xenopus. Mech Dev 86:3-15.
24. Guan, K., Czyz, J., Fürst, D.O. and Wobus, A.M. (2001) Expression and cellular distribution of αv integrins in β1 integrin-deficient embryonic stem cell-derived cardiac cells. J Mol Cell Cardiol 33:521-532.
25. Guan, K., Fürst, D.O. and Wobus, A.M. (1999a) Modulation of sarcomere organization during embryonic stem cell-derived cardiomyocyte differentiation. Eur J Cell Biol 78:813-823.
26. Guan, K., Chang, H., Rolletschek, A. and Wobus, A.M. (2001) Embryonic stem cell-derived neurogenesis: Retinoic acid induction and lineage selection of neuronal cells. Cell Tissue Res (in press).
27. Guan, K., Rohwedel, J. and Wobus, A.M. (1999b) Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogenesis, epithelial and vascular smooth muscle cell differentiation in vitro. Cytotechnology 30:211-226.
28. Hescheler, J., Fleischmann, B.K., Lentini, S., Maltsev, V.A., Rohwedel, J., Wobus, A.M. and Addicks, K. (1997) Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 36:149-162.
29. Hynes, R.O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25.
30. Johansson, B.M. and Wiles, M.V. (1995) Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 15:141-151.
31. Kramer, J., Hegert, C., Guan, K., Wobus, A.M., Müller, P.K. and Rohwedel, J. (2000) Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. Mech Dev 92:193-205.
32. Lee, S.H., Lumelsky, N., Studer, L., Auerbach, J.M. and McKay, R.D. (2000a) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nature Biotechnol 18:675-679.
33. Lee, S.M., Tole, S., Grove, E. and McMahon, A.P. (2000b) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127:457-467.
34. 2+ current in the early stages of cardiomyocyte development. Circ Res 84:136-145.
35. Maltsev, V.A., Rohwedel, J., Hescheler, J. and Wobus, A.M. (1993) Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 44:41-50.
36. Maltsev, V.A., Wobus, A.M., Rohwedel, J., Bader, M. and Hescheler, J. (1994) Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res 75:233-244.
37. McGrew, L.L., Takemaru, K., Bates, R. and Moon, R.T. (1999) Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus. Mech Dev 87:21-32.
38. McMahon, A.P. and Bradley, A. (1990) The Wnt-1 (int-1) protooncogene is required for development of a large region of the mouse brain. Cell 62:1073-1085.
39. Mishina, Y., Suzuki, A., Ueno, N. and Behringer, R.R. (1995) Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9:3027-3037.
40. Nishita, M., Hashimoto, M.K., Ogata, S., Laurent, M.N., Ueno, N., Shibuya, H. and Cho, K.W. (2000) Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature 403:781-785.
41. Nusse, R. (1999) WNT targets. Repression and activation. Trends Genet 15:1-3.
42. Okabe, S., Forsberg-Nilsson, K., Spiro, A.C., Segal, M. and McKay, R.D. (1996) Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev 59:89-102.
43. Prelle, K., Wobus, A.M., Krebs, O., Blum, W.F. and Wolf, E. (2000) Overexpression of insulin-like growth factor-II in mouse embryonic stem cells promotes myogenic differentiation. Biochem Biophys Res Commun 277:631-638.
44. Rathjen, P.D., Lake, J., Whyatt, L.M., Bettess, M.D. and Rathjen, J. (1998) Properties and uses of embryonic stem cells: prospects for application to human biology and gene therapy. Reprod. Fertil Dev 10:31-47.
45. Renoncourt, Y., Carroll, P., Filippi, P., Arce, V. and Alonso, S. (1998) Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons. Mech Dev 79:185-197.
46. Resnick, J.L., Bixler, L.S., Cheng, L. and Donovan, P.J. (1992) Long-term proliferation of mouse primordial germ cells in culture. Nature 359:550-551.
47. Rohwedel, J., Guan, K., Hegert, K. and Wobus, A.M. (2001) Embryonic stem cells as in vitro model for mutagenicity and embryotoxicity studies - present state and future prospects. Toxicol in Vitro (in press).
48. Rohwedel, J., Guan, K., Zuschratter, W., Jin, S., Ahnert-Hilger, G., Fürst, D., Fässler, R. and Wobus, A.M. (1998) Loss of β1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro. Dev Biol 201:167-184.
49. Rohwedel, J., Horak, V., Hebrok, M., Füchtbauer, E.M. and Wobus, A.M. (1995) M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp Cell Res 220:92-100.
50. Rohwedel, J., Maltsev, V., Bober, E., Arnold, H.H., Hescheler, J. and Wobus, A.M. (1994) Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev Biol 164:87-101.
51. Rolletschek, A., Chang, H., Guan, K., Czyz, J., Meyer, M. and Wobus, A.M. (2001) Differentiation of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promoting factors. Mech Dev 105:93-104.
52. Sauer, H., Hofmann, C., Wartenberg, M., Wobus, A.M. and Hescheler, J. (1998) Spontaneous calcium oscillations in embryonic stem cell-derived primitive endodermal cells. Exp Cell Res 238:13-22.
53. Schlange, T., Andree, B., Arnold, H.H. and Brand, T. (2000) BMP2 is required for early heart development during a distinct time period. Mech Dev 91:259-270.
54. Schmitt, R.M., Bruyns, E. and Snodgrass, H.R. (1991) Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Genes Dev 5:728-740.
55. Schöler, H.R., Hatzopoulos, A.K., Balling, R., Suzuki, N. and Gruss, P. (1989) A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J 8:2543-2550.
56. Schneider, V.A. and Mercola, M. (2001) Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev 15:304-15.
57. Simon, M.C., Pevny, L., Wiles, M.V., Keller, G., Costantini, F. and Orkin, S.H. (1992) Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet 1:92-98.
58. Smith, W.C. (1999) TGF beta inhibitors. New and unexpected requirements in vertebrate development. Trends Genet 15:3-5.
59. Solter, D. and Knowles, B.B. (1978) Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci USA 75:5565-5569.
60. Soudais, C., Bielinska, M., Heikinheimo, M., MacArthur, C.A., Narita, N., Saffitz, J.E., Simon, M.C., Leiden, J.M. and Wilson, D.B. (1995) Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121:3877-3888.
61. Strübing, C., Ahnert-Hilger, G., Shan, J., Wiedenmann, B., Hescheler, J. and Wobus, A.M. (1995) Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech Dev 53:275-287.
62. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S. and Jones, J.M. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
63. Watt, F.M. and Hogan, B.L. (2000) Out of Eden: stem cells and their niches. Science 287:1427-1430.
64. Wiles, M.V. (1993) Embryonic stem cell differentiation in vitro. Methods Enzymol 225:900-918.
65. Willert, K. and Nusse, R. (1998) Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8:95-102.
66. Wobus, A.M. and Guan, K. (1998) Embryonic stem cell-derived cardiac differentiation: modulation of differentiation and 'loss-of-function' analysis in vitro. Trends Cardiovasc Med 8:64-74.
67. Wobus, A.M., Guan, K., Shan, J., Wellner, M.C., Rohwedel, J., Ji, G., Fleischmann, B., Katus, H.A., Hescheler, J. and Franz, W.M. (1997) Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes. J Mol Cell Cardiol 29:1525-1539.
68. Wobus, A.M., Guan, K. and Pich, U. (2001) In vitro differentiation of embryonic stem cells and analysis of cellular phenotypes. Meth Mol Biol Vol 158 In: Tymms, M.J. and Kola I. (Eds.) Gene Knockout Protocols, Humana Press, Totowa NJ, pp 263-286.
69. Wobus, A.M., Holzhausen, H., Jäkel, P. and Schöneich, J. (1984) Characterization of a pluripotent stem cell line derived from a mouse embryo. Exp Cell Res 152:212-219.
70. 2+ channel blockers. Differentiation 48:173-182.
71. Wodarz, A. and Nusse, R. (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
72. Yamaguchi, T.P., Takada, S., Yoshikawa, Y., Wu, N. and McMahon, A.P. (1999) T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13:3185-3190.