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Volumn 8, Issue 5, 1998, Pages 565-570

Regulatory targets in the RNA polymerase II holoenzyme

Author keywords

[No Author keywords available]

Indexed keywords

HOLOENZYME; RNA POLYMERASE II; UNCLASSIFIED DRUG;

EID: 0032192116     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(98)80012-9     Document Type: Article
Times cited : (49)

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    • BRCA1 physically associates with p53 and stimulates its transcriptional activity
    • of special interest. The functional comparison between BRCA1 and CBP is strengthened in this study as p53 is shown to bind to the former. The transcriptional activation domain of p53 is linked to CBP whereas a different domain of p53 is linked to BRCA1; it will be important to determine the situations under which the BRCA1-interacting domain regulates transcription.
    • Zhang H, Somasundaram K, Peng Y, Tian H, Zhang H, Bi D, Weber BL, El-Deiry WS. BRCA1 physically associates with p53 and stimulates its transcriptional activity. of special interest Oncogene. 16:1998;1713-1721 The functional comparison between BRCA1 and CBP is strengthened in this study as p53 is shown to bind to the former. The transcriptional activation domain of p53 is linked to CBP whereas a different domain of p53 is linked to BRCA1; it will be important to determine the situations under which the BRCA1-interacting domain regulates transcription.
    • (1998) Oncogene , vol.16 , pp. 1713-1721
    • Zhang, H.1    Somasundaram, K.2    Peng, Y.3    Tian, H.4    Zhang, H.5    Bi, D.6    Weber, B.L.7    El-Deiry, W.S.8
  • 56
    • 0032504104 scopus 로고    scopus 로고
    • A subset of TAFIIs are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulations
    • Grant PA, Schieltz D, Pray-Grant MG, Steger DJ, Reesse JC, Yates JR, Workman JL: A subset of TAFIIs are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulations. Cell 94:45-53.
    • Cell , vol.94 , pp. 45-53
    • Grant, P.A.1    Schieltz, D.2    Pray-Grant, M.G.3    Steger, D.J.4    Reesse, J.C.5    Yates, J.R.6    Workman, J.L.7
  • 57
    • 0000735813 scopus 로고    scopus 로고
    • Synergistic recruitment of TFIIB and CBP-RNA polymerase II complexes by an interferon-b enhanceosome in vitro
    • of outstanding interest
    • Kim TK, Kim TH, Maniatis T. Synergistic recruitment of TFIIB and CBP-RNA polymerase II complexes by an interferon-b enhanceosome in vitro. of outstanding interest Proc Natl Acad Sci USA. 1998; The regulation of transcription by the stereospecific assembly of five different transcriptional activator proteins and an architectural protein HMG I(Y) (Figure 1b) were reconstituted using purified factors and holoenzyme. The highly structured enhanceosome complex recruited TFIIB to a preassembled TFIID/TFIIA/USA complex, and the factors in the enhanceosome subsequently recruited the Pol II holoenzyme via CBP. The data reveal that the enhanceosome functions in generating synergy by combining multiple interactions into a powerful signal to TFIIB and to the holoenzyme.
    • (1998) Proc Natl Acad Sci USA
    • Kim, T.K.1    Kim, T.H.2    Maniatis, T.3
  • 58
    • 0031841947 scopus 로고    scopus 로고
    • A human RNA polymerase II complex containing factors that modify chromatin structure
    • of outstanding interest. The human holoenzyme complex was purified by conventional means, and upon gel filtration the SRB proteins were resolved into two peaks. One complex with an apparent molecular mass of ~4 MDa contained SRB proteins, Pol II. SWI/SNF, CBP/p300 and PCAF. The other complex, with a mass of about 1.5 MDa, contained SRB proteins, Pol II, and basal factors. The higher mass complex appeared to have two populations: one containing CBP/p300 and unphosphorylated Pol II and one containing PCAF and phosphorylated Pol II. As the phosphorylated Pol II is associated with the elongation stage of transcription, this study suggests that there exists an initiation form of holoenzyme containing CBP/p300 and an elongation form containing PCAF.
    • Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D. A human RNA polymerase II complex containing factors that modify chromatin structure. of outstanding interest Mol Cell Biol. 18:1998;5355-5363 The human holoenzyme complex was purified by conventional means, and upon gel filtration the SRB proteins were resolved into two peaks. One complex with an apparent molecular mass of ~4 MDa contained SRB proteins, Pol II. SWI/SNF, CBP/p300 and PCAF. The other complex, with a mass of about 1.5 MDa, contained SRB proteins, Pol II, and basal factors. The higher mass complex appeared to have two populations: one containing CBP/p300 and unphosphorylated Pol II and one containing PCAF and phosphorylated Pol II. As the phosphorylated Pol II is associated with the elongation stage of transcription, this study suggests that there exists an initiation form of holoenzyme containing CBP/p300 and an elongation form containing PCAF.
    • (1998) Mol Cell Biol , vol.18 , pp. 5355-5363
    • Cho, H.1    Orphanides, G.2    Sun, X.3    Yang, X.J.4    Ogryzko, V.5    Lees, E.6    Nakatani, Y.7    Reinberg, D.8


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