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This study describes the identification of an erythrocyte-specific SNF/Swi complex, E-RC1, which is required for ELKF-stimulated transcription of the β-globin promoter reconstituted into chromatin in a cell free system. Interestingly, E-RC1 purified from mouse erythroleukemia cells was unable to mediate TFE-3-stimulated transcription of the HIV-1 promoter. Thus ERC-1 is not a general cofactor for chromatin remodeling and may represent an activator- and/or gene-selective SNF/swi complex.
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Armstrong JA, Bieker JJ, Emerson BM A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell. 95:1998;93-104. This study describes the identification of an erythrocyte-specific SNF/Swi complex, E-RC1, which is required for ELKF-stimulated transcription of the β-globin promoter reconstituted into chromatin in a cell free system. Interestingly, E-RC1 purified from mouse erythroleukemia cells was unable to mediate TFE-3-stimulated transcription of the HIV-1 promoter. Thus ERC-1 is not a general cofactor for chromatin remodeling and may represent an activator- and/or gene-selective SNF/swi complex.
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Armstrong, J.A.1
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