NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription

Molecular Cell

Volumn 2, Issue 2, 1998, Pages 213-222

  Sun, Xiaoqing ^a   Zhang, Yi ^a   Cho, Helen ^a   Rickert, Paula ^b   Lees, Emma ^b   Lane, William ^c   Reinberg, Danny ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE; FUNGAL PROTEIN; MED6 PROTEIN, HUMAN; REPRESSOR PROTEIN; RGR1 PROTEIN, S CEREVISIAE; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE PROTEIN; SSN8 PROTEIN, S CEREVISIAE; SURB7 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; GENETICS; HUMAN; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; SEQUENCE HOMOLOGY; TRANSACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CYCLIN-DEPENDENT KINASES; DNA, COMPLEMENTARY; FUNGAL PROTEINS; HUMANS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; REPRESSOR PROTEINS; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0032135274     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80131-8     Document Type: Article

References (51)

1. Akoulitchev, S., Mäkelä, T.P., Weinberg, R.A., and Reinberg, D. (1995). Requirement for TFIIH kinaseactivity in transcription by RNA polymerase II. Nature 377, 557-560.
2. Allison, L.A., Wong, J.K., Fitzpatrick, V.D., Moyle, M., and Ingles, C.J. (1988). The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function. Mol. Cell. Biol. 8, 321-329.
3. Carlson, M. (1997). Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD. Annu. Rev. Cell Dev. Biol. 13, 1-23.
4. Chang, M., and Jaehning, J. (1997). A multiplicity of mediators: alternative forms of transcription complexes communicate with transcription regulators. Nucleic Acid Res. 25, 4861-4865.
5. Chesnut, J., Stephens, J., and Dahmus, M. (1992). The interaction of RNA polymerase II with the Adenovirus-2 major late promoter is precluded by phosphorylation of the C-terminal domain of subunit IIa. J. Biol. Chem. 267, 10500-10506.
6. Cho, H., Maldonado, E., and Reinberg, D. (1997). Affinity purification of a human RNA polymerase II complex using monoclonal antibody against transcription factor IIF. J. Biol. Chem. 272, 11495-11502.
7. Cho, H., Orphanides, G., Sun, X., Yang, X.-J., Lees, E., Nakatani, Y., and Reinberg, D. (1998). Isolation of a human RNA polymerase II complex containing factors that modify chromatin structure. Mol. Cell. Biol., in press.
8. Dahmus, M. (1996). Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271, 19009-19012.
9. Eng, J.K., McCormick, A.L., and Yates, J.R. III (1994). An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J. Am. Soc. Mass Spectrom. 5, 976-989.
10. Flores, O., Lu, H., and Reinberg, D. (1992). Factors involved in specific transcription by mammalian RNA polymerase II. J. Biol. Chem. 267, 2786-2793.
11. Ge, H., and Roeder, R.G. (1994). Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78, 513-523.
12. Gebara, M.M., Sayre, M.N., and Cordon, J.L. (1997). Phosphorylation of the CTD of RNA polymerase II by Cyclin-dependent kinase is sufficient to inhibit transcription. J. Cell. Biochem. 64, 390-402.
13. Greenblatt, J., (1997). RNA polymerase II holoenzyme and transcriptional regulation. Curr. Opin. Cell Biol. 9, 310-319.
14. Guarente, L. (1995). Transcriptional coactivators in yeast and beyond. Trends Biochem. Sci. 20, 517-521.
15. Gustafsson, C., Myers, L., Li, Y., Redd, M., Lui, M., Erdjument-Bromage, H., Tempst, P., and Kornberg, R. (1997). Identification of Rox3 as a component of Mediator and RNA polymerase II holoenzyme. J. Biol. Chem. 272, 48-50.
16. Hampsey, M. (1998). Molecular genetics of the RNA polymerase II general transcription machinery. Microbiol. Mol. Biol. Rev. 62, 465-503.
17. Kaiser, K., and Meisterernst, M. (1996). The human general co-factors. Trends Biochem. Sci. 21, 342-345.
18. Kim, W.-Y., and Dahmus, M.E., (1988). Purification of RNA polymerase IIO from calf thymus. J. Biol. Chem. 263, 18880-18885.
19. Kim, Y.-J., Bjorklund, S., Li, Y., Sayre, M.H., and Kornberg, R.D. (1994). A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77, 599-608.
20. Koleske, A.J., and Young, R.A. (1994). An RNA polymerase II holoenzyme responsive to activators. Nature 368, 466-469.
21. Kuchin, S., Yeghiayan, P., and Carlson, M. (1995). Cyclin-dependent protein kinase and cyclin homologues SSN3 and SSN8 contribute to transcriptional control in yeast. Proc. Natl. Acad. Sci. USA 92, 4006-4010.
22. Lee, Y.-C., Min, S., Gim, B.-S., and Kim, Y.-J. (1997). A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. Mol. Cell. Biol. 17, 4622-4632.
23. LeRoy, G., Drapkin, R., Weiss, L., and Reinberg, D. (1998). Immunoaffinity purification of the human multisubunit transcription factor IIH. J. Biol. Chem. 273, 7134-7140.
24. Li, Y., Bjorklund, S., Jiang, Y.W., Kim, Y.-J., Lane, W.S., Stillman, D.J., and Kornberg, R.D. (1995). Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 92, 10864-10868.
25. Liao, S., Zhang, J., Jeffery, D.A., Koleske, A.J., Thompson, C.M., Chao, D.M., Viljoen, M., van Vuuren, H.J.J., and Young, R.A. (1995). A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374, 193-196.
26. Lu, H., Flores, O., Weinmann, R., and Reinberg, D. (1991). The non-phosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex. Proc. Natl. Acad. Sci. USA 88, 10004-10008.
27. Lu, H., Zawel, L., Fisher, L., Egly, J.-M., and Reinberg, D. (1992). Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II. Nature 358, 641-645.
28. Ma, D., Olave, I., Merino, A., and Reinberg, D. (1996). Separation of the transcriptional coactivator and antirepression functions of transcription factor IIA. Proc. Natl. Acad. Sci. USA 93, 6583-6588.
29. Maldonado, E., Drapkin, R., and Reinberg, D. (1996a). Purification of human RNA polymerase II and general transcription factors. Methods Enzymol. 274, 72-100.
30. Maldonado, E., Sheikhattar, R., Sheldon, M., Cho, H., Drapkin, R., Rickert, P., Lees, E., Anderson, C.W., Linn, S., and Reinberg, D. (1996). A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature 381, 86-89.
31. Myers, L., Gustafsson, C., Bushnell, D., Lui, M., Erdjument-Bromage, H., Tempst, P., and Kornberg, R. (1998). The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev. 12, 45-54.
32. Nakajima, T., Uchida, C., Anderson, S., Lee, C.-G., Hurwitz, J., Parvin, J., and Montminy, M. (1997a). RNA helicase A mediates association of CBP with RNA polymerase II. Cell 90, 1107-1112.
33. Nakajima, T., Uchida, C., Anderson, S., Parvin, J., and Montminy, M. (1997b). Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcription induction via signal-dependent factors. Genes Dev. 11, 738-747.
34. Neigeborn, L., and Carlson, M. (1984). Gene affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics 108, 845-858.
35. Neugebauer, K., and Roth, M. (1997). Transcription units as RNA processing units. Genes Dev. 11, 3279-3285.
36. Nonet, M., and Young, R. (1989). Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics 123, 715-724.
37. O'Brien, T., Hardin, S., Greenleaf, A., and Lis, J.T. (1994). Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. Nature 370, 75-77.
38. Olave, I., Reinberg, D., and Vales, L.D. (1998). The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Genes Dev. 12, 1621-1637.
39. Orphanides, G., Lagrange, T., and Reinberg, D. (1996). The general transcription factors of RNA polymerase II. Genes Dev. 10, 2657-2683.
40. Pan, G., Aso, T., and Greenblatt, J. (1997). Interaction of elongation factors TFIIS and Elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. J. Biol. Chem. 272, 24563-24571.
41. Patturajan, M., Schulte, R.J., Sefton, B.M., Berezney, R., Vincent, M., Bensaude, O., Warren, S.L., and Corden, J.F. (1997). Growth-related changes in phosphorylation of yeast RNA polymerase II. J. Biol. Chem. 273, 4689-4694.
42. Payne, J., Laybourn, P., and Dahmus, M. (1989). The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa. J. Biol. Chem. 264, 19621-19629.
43. Rickert, P., Seghezzi, W., Shanahan, F., Cho, H., and Lees, E. (1996). Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. Oncogene 12, 2631-2640.
44. Roeder, R.G. (1996). The role of the general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21, 327-335.
45. Shi, X., Chang, M., Wolf, A., Chang, C., Frazer-Abel, A., Wade, P., Burton, Z., and Jaehning, J. (1997). Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex from the Srbp-containing holoenzyme. Mol. Cell. Biol. 17, 1160-1169.
46. Shuman, S. (1997). Origins of mRNA identity: capping enzymes bind to the phosphorylated C-terminal domain of the RNA polymerase II. Proc. Natl. Acad. Sci. USA 94, 12758-12760.
47. Song, W., Treich, I., Qian, N., Kuchin, S., and Carlson, M. (1996). SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II. Mol. Cell. Biol. 16, 115-120.
48. Sun, X., Ma, D., Sheldon, M., Yeung, K., and Reinberg, D. (1994). Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. Genes Dev. 8, 2336-2348.
49. Young, R.A. (1991). RNA polymerase II. Annu. Rev. Biochem. 60, 689-715.
50. Zehring, W.A., Lee, J.M., Weeks, J.R., Jokerst, R.S., and Greenleaf, A.L. (1988). The C-terminal repeat of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro. Proc. Natl. Acad. Sci. USA 85, 3698-3702.
51. Zhou, Q., Lieberman, P.M., Boyer, T.G., and Berk, A.J. (1992). Holo-TFIID supports transcriptional stimulation by diverse activators and from TATA-less promoters. Genes Dev. 6, 1964-1974.