Polymorphisms in UDP glucuronosyltransferase genes: Functional consequences and clinical relevance

Clinical Chemistry and Laboratory Medicine

Volumn 38, Issue 9, 2000, Pages 889-892

  Mackenzie, Peter I ^a   Miners, John O ^a   Mckinnon, Ross A ^b  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Glucuronidation; Polymorphism; UDP glucuronosyltransferase

Indexed keywords

ANDROGEN; BILIRUBIN; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; HYODEOXYCHOLIC ACID; IRINOTECAN; OXAZEPAM; PARACETAMOL; PREGNANE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ETHNIC GROUP; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GILBERT DISEASE; GLUCURONIDATION; HUMAN; MULTIGENE FAMILY; PRIORITY JOURNAL;

EID: 0033760290     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2000.129     Document Type: Article

References (32)

1. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
2. Drug glucuronidation in humans
3. Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
4. Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon
5. Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilberts syndrome
6. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
7. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilberts syndrome
8. (TA)(8) allele in the UGT1A1 gene promoter of a Caucasian with Gilbert's syndrome
9. Multiplicity of mutation in UDP-glucuronosyltransferase 1*1 gene in Gilberts syndrome
10. Gilbert- syndrome caused by a homozygous missense mutation (Tyr486asp) of bilirubin UDP-glucuronosyltransferase gene
11. Gilbert-syndrome accelerates development of neonatal jaundice
12. Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis
13. Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency - A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia
14. Co-inherited Gilbert's syndrome: A factor determining hyperbilirubinemia in homozygous beta-thalassemia
15. Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports
16. Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
17. Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome
18. Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate
19. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase - Pharmacological implications
20. UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: Relationships to serum bilirubin concentrations
21. Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture
22. CDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily
23. Characterization and substrate specificity of UGT2B4 (E-458): A UDP-glucuronosyltransferase encoded by a polymorphic gene
24. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates
25. Human UGT2B7 catalyzes morphine glucuronidation
26. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs
27. The regio- and stereo-selectivity of C19 and C21 hydroxysteroid glucuronidation by UGT2B7 and UGT2B11
28. 3'-Azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)
29. Interindividual variability in the glucuronidation of (S)oxazepam contrasted with that of (R)oxazepam
30. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
31. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates
32. Isolation and characterization of UGT2B15(Y85): A UDP-glucuronosyltransferase encoded by a polymorphic gene