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Volumn 14, Issue 4, 2000, Pages 567-572

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

Author keywords

6 Mercaptopurine; Childhood acute lymphoblastic leukemia; Pharmacogenetics; Thiopurine methytransferase

Indexed keywords

MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE;

EID: 0034034158     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401723     Document Type: Review
Times cited : (413)

References (34)
  • 1
    • 0033135738 scopus 로고    scopus 로고
    • Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
    • Relling MV, Hancock ML, Boyett JM, Pui CH, Evans WE. Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia. Blood 1999; 93: 2817-2823.
    • (1999) Blood , vol.93 , pp. 2817-2823
    • Relling, M.V.1    Hancock, M.L.2    Boyett, J.M.3    Pui, C.H.4    Evans, W.E.5
  • 3
    • 0032931005 scopus 로고    scopus 로고
    • Pharmacogenetics as a molecular basis for individualized drug therapy: The thiopurine S-methyltransferase paradigm
    • Krynetski EY, Evans WE. Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm. Pharmaceut Res 1999; 16: 342-349.
    • (1999) Pharmaceut Res , vol.16 , pp. 342-349
    • Krynetski, E.Y.1    Evans, W.E.2
  • 5
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukemia
    • Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukemia. Lancet 1990; 336: 225-229.
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 6
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects and dosage requirement in a thiopurine methyltranterase-deficient child with acute lymphoblastic leukemia
    • Evans WE, Horner M, Chu YO, Kalwinsky D, Roberts WM. Altered mercaptopurine metabolism, toxic effects and dosage requirement in a thiopurine methyltranterase-deficient child with acute lymphoblastic leukemia. J Pediatr 1991; 119: 985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.O.3    Kalwinsky, D.4    Roberts, W.M.5
  • 7
    • 0027285234 scopus 로고
    • Azathioprine induced myelosuppression in thiopurine methyltransferase deficient heart-transplant recipient
    • McLeod HL, Miller DR, Evans WE. Azathioprine induced myelosuppression in thiopurine methyltransferase deficient heart-transplant recipient. Lancet 1993; 341: 1151.
    • (1993) Lancet , vol.341 , pp. 1151
    • McLeod, H.L.1    Miller, D.R.2    Evans, W.E.3
  • 8
    • 0027401302 scopus 로고
    • Azathioprine induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
    • Schutz E, Gummert J, Mohr F, Oellerich M. Azathioprine induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993; 341: 436.
    • (1993) Lancet , vol.341 , pp. 436
    • Schutz, E.1    Gummert, J.2    Mohr, F.3    Oellerich, M.4
  • 9
    • 0028044714 scopus 로고
    • Thiopurine methyltransferase activity in American white subjects and black subjects
    • McLeod HL, Lin JS, Scott EP, Pui CH, Evans WE. Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharm Ther 1994; 55: 15-20.
    • (1994) Clin Pharm Ther , vol.55 , pp. 15-20
    • McLeod, H.L.1    Lin, J.S.2    Scott, E.P.3    Pui, C.H.4    Evans, W.E.5
  • 12
    • 0029919807 scopus 로고
    • Thiopurine S-methyltransterase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    • Tai HL, Krynetski EY, Yates CR, Loennechen T, Fessing MY, Krynetskaia NF, Evans WE. Thiopurine S-methyltransterase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am J Hum Genet 1993; 58: 694-702.
    • (1993) Am J Hum Genet , vol.58 , pp. 694-702
    • Tai, H.L.1    Krynetski, E.Y.2    Yates, C.R.3    Loennechen, T.4    Fessing, M.Y.5    Krynetskaia, N.F.6    Evans, W.E.7
  • 13
    • 0030986251 scopus 로고    scopus 로고
    • Enhanced proteolysis of thiopurine S-methyltransterase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
    • Tai HL, Krynetski EY, Schuetz EG, Yanishevski Y, Evans WE. Enhanced proteolysis of thiopurine S-methyltransterase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci USA 1997; 94: 6444-6449.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6444-6449
    • Tai, H.L.1    Krynetski, E.Y.2    Schuetz, E.G.3    Yanishevski, Y.4    Evans, W.E.5
  • 14
  • 15
    • 0032030953 scopus 로고    scopus 로고
    • Human thiopurine methyltransferase pharmacogenetics - Kindred with a terminal exon splice junction mutation that results in loss of activity
    • Otterness DM, Szumlanski CL, Wood TC, Weinshilboum RM. Human thiopurine methyltransferase pharmacogenetics - kindred with a terminal exon splice junction mutation that results in loss of activity. J Clin Invest 1998; 101: 1036-1044.
    • (1998) J Clin Invest , vol.101 , pp. 1036-1044
    • Otterness, D.M.1    Szumlanski, C.L.2    Wood, T.C.3    Weinshilboum, R.M.4
  • 17
    • 0032693405 scopus 로고    scopus 로고
    • Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: Mechanism for TPMT protein deficiency inherited by TPMT* 2, TPMT*3A, TPMT*3B or TPMT*3C
    • Tai HL, Fessing MY, Bonten EJ, Yanishevsky Y, d'Azzo A, Krynetski EY, Evans WE. Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT* 2, TPMT*3A, TPMT*3B or TPMT*3C. Pharmacogenetics 1999; 9: 641-650.
    • (1999) Pharmacogenetics , vol.9 , pp. 641-650
    • Tai, H.L.1    Fessing, M.Y.2    Bonten, E.J.3    Yanishevsky, Y.4    D'Azzo, A.5    Krynetski, E.Y.6    Evans, W.E.7
  • 18
    • 0031820555 scopus 로고    scopus 로고
    • Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
    • Loennechen T, Yates CR, Fessing MY, Relling MV, Krynestski EY, Evans WE. Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans. Clin Pharmacol Ther 1998; 64: 46-51.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 46-51
    • Loennechen, T.1    Yates, C.R.2    Fessing, M.Y.3    Relling, M.V.4    Krynestski, E.Y.5    Evans, W.E.6
  • 24
    • 0032532599 scopus 로고    scopus 로고
    • The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia
    • Coulthard SA, Howell C, Robson J, Hall AG. The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia. Blood 1998; 92: 2856-2862.
    • (1998) Blood , vol.92 , pp. 2856-2862
    • Coulthard, S.A.1    Howell, C.2    Robson, J.3    Hall, A.G.4
  • 27
    • 0028930908 scopus 로고
    • Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic-leukemia
    • McLeod HL, Relling MV, Liu Q, Pui CH, Evans WE. Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic-leukemia. Blood 1995; 85: 1897-1902.
    • (1995) Blood , vol.85 , pp. 1897-1902
    • McLeod, H.L.1    Relling, M.V.2    Liu, Q.3    Pui, Ch.4    Evans, W.E.5
  • 30
    • 0031884608 scopus 로고    scopus 로고
    • Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
    • Relling MV, Yanishevski Y, Nemec J, Evans WE, Boyett JM, Behn FG, Pui CH. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia 1998; 12: 346-352.
    • (1998) Leukemia , vol.12 , pp. 346-352
    • Relling, M.V.1    Yanishevski, Y.2    Nemec, J.3    Evans, W.E.4    Boyett, J.M.5    Behn, F.G.6    Pui, C.H.7
  • 32
    • 0032231751 scopus 로고    scopus 로고
    • Pharmacogenetics of cancer therapy: Getting personal
    • Krynetski EY, Evans WE. Pharmacogenetics of cancer therapy: getting personal. Am Hum Genet 1998; 63: 11-16.
    • (1998) Am Hum Genet , vol.63 , pp. 11-16
    • Krynetski, E.Y.1    Evans, W.E.2
  • 34
    • 0029073930 scopus 로고
    • Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase
    • Krynetski EY, Krynetskaia NF, Yanishevski Y, Evans WE. Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase. Mol Pharmacol 1995; 6: 1141-1147.
    • (1995) Mol Pharmacol , vol.6 , pp. 1141-1147
    • Krynetski, E.Y.1    Krynetskaia, N.F.2    Yanishevski, Y.3    Evans, W.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.