Pharmacogenetics of cardiac K+ channels

European Journal of Pharmacology

Volumn 410, Issue 2-3, 2000, Pages 281-287

  Escande, Denis ^a  

^a HÔTEL DIEU   (France)

Author keywords

Heart; K+ channel; Long QT syndrome; Pharmacogenetics

Indexed keywords

AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; ASTEMIZOLE; BEPRIDIL; CHLORPROMAZINE; CISAPRIDE; CLARITHROMYCIN; CLEMASTINE; DESIPRAMINE; DIPHENHYDRAMINE; DOXEPIN; DROPERIDOL; ERYTHROMYCIN; FEXOFENADINE; GREPAFLOXACIN; HALOPERIDOL; HYDROXYZINE; IMIPRAMINE; INDAPAMIDE; KETANSERIN; MIBEFRADIL; PENTAMIDINE; PIMOZIDE; POTASSIUM CHANNEL; PROBUCOL; QUETIAPINE; RISPERIDONE; SERTINDOLE; SPARFLOXACIN; TAMOXIFEN; UNINDEXED DRUG;

ARTICLE; GENE MUTATION; GENETIC SUSCEPTIBILITY; HEART ARRHYTHMIA; HEART REPOLARIZATION; HUMAN; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; QT INTERVAL; SILENT GENE; SUDDEN DEATH; SYNCOPE; TORSADE DES POINTES;

ANIMALS; HEART; HUMANS; LONG QT SYNDROME; MYOCARDIUM; PHARMACOGENETICS; POTASSIUM CHANNELS;

EID: 0034723046     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00821-9     Document Type: Article

References (48)

1. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
2. + channel and its associated long QT diseases
3. Molecular mechanism for an inherited cardiac arrhythmia
4. Ketoconazole blocks potassium currents in feline heart
5. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
6. + channels involved in long-QT syndromes, are targets for calcium-channel blockers
7. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
8. A dominant negative isoform of the long QT syndrome 1 gene product
9. La tachycardie ventriculaire à deux foyers opposés variables
10. KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome
11. + channel-linked long-QT syndrome
12. Proarrhythmia with class III antiarrhythmic drugs: Types, risks, and management
13. Congenital deaf-mutism, functional heart disease with prolongation of Q-T interval and sudden death
14. Genetically uniform type of long QT1 syndrome: From molecular to QT analysis
15. Age-gender influence on the rate-corrected QT interval and the QT-heart rate relation in families with genotypically characterized long QT syndrome
16. Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: Findings from the International LQT syndrome Registry
17. Mutations in a dominant-negative isoform correlate with phenotype in inherited cardiac arrhythmias
18. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
19. Outward membrane currents activated in the plateau range of potential in cardiac Purkinje fibers
20. Low penetrance in the long-QT syndrome: Clinical impact
21. The antipsychotic agent sertindole is a high-affinity antagonist of the human cardiac potassium channel HERG
22. Sex differences in the evolution of the electrocardiographic QT interval with age
23. Antiarrhythmic drugs
24. The cardiac ion channels: Relevance to management of arrhythmias
25. Incidence and clinical features of the quinidine-associated long QT syndrome: Implications for patient care
26. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS
27. Assessi sincopali per fibrillaione ventricolare parossistics
28. Pharmacology of azimilide dihydrochloride (NE-10064), a class III antiarrhythmic agent
29. Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine
30. + current-differential sensitivity to block by class-III antiarrhythmic agents
31. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
32. +-channel dysfunction in an inherited cardiac arrhythmia
33. Mapping of a gene for long QT syndrome to chromosome 4q25-27
34. Quinidine syncope: Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias
35. Dominant-negative K nu LQT1 mutations underlie the LQT1 form of long QT syndrome
36. Mutations in hminK gene cause long-QT syndrome and suppress IKs function
37. Inhibition of the current of heterologously-expressed HERG potassium channels by imipramine and amitriptyline
38. Genome sequence of the nematode C. elegans: A platform for investigating biology
39. A classification of antiarrhythmic actions reassessed after a decade of new drugs
40. Long QT syndrome patients with normal to borderline prolonged QTc intervals are at risk for syncope, cardiac arrest and sudden death
41. Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: Affinity for open and inactivated states
42. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
43. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
44. A new familial cardiac syndrome in children
45. + channel mutations found in inherited cardiac arrhythmias
46. Block of potassium currents in rat isolated sympathetic neurones by tricyclic antidepressants and structurally related compounds
47. Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole