A unifying purinergic hypothesis for the initiation of pain

Lancet

Volumn 347, Issue 9015, 1996, Pages 1604-1605

  Burnstock, Geoffrey ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PURINE DERIVATIVE; PURINE RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINE P2 RECEPTOR;

ADRENERGIC SYSTEM; ANGINA PECTORIS; ARTICLE; CANCER; CAUSALGIA; CLONING; ENDOTHELIUM CELL; HUMAN; MIGRAINE; NOCICEPTION; PAIN; PRIORITY JOURNAL; SENSORY NERVE CELL; TUMOR CELL; COMPLEX REGIONAL PAIN SYNDROME TYPE I; FEMALE; MALE; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR DISEASE;

ADENOSINE TRIPHOSPHATE; CAUSALGIA; FEMALE; HUMANS; MALE; NEOPLASMS; NEURONS, AFFERENT; PAIN; RECEPTORS, PURINERGIC P2; REFLEX SYMPATHETIC DYSTROPHY; VASCULAR DISEASES;

EID: 0029892771     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)91082-X     Document Type: Article

References (34)

1. Burnstock G. Physiological and pathological role of purines: an update. Drug Dev Res 1993; 28: 195-206.
2. Bleehen T. The effects of adenine nucleotides on cutaneous afferent nerve activity. Br J Pharmacol 1978; 62: 573-77.
3. Coutts AA, Jorizzo JL, Eady RAJ, Greaves MW, Burnstock G. Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action. Eur J Pharmacol 1981; 76: 391-401.
4. Bleehen T, Keele CA. Observations on the algogenic actions of adenosine compounds on human blister base preparation. Pain 1977; 3: 367-77.
5. Abbracchio M, Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 1994; 64: 445-75.
6. Chen C-C, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. A P2X purinoceptor expressed by a subset of sensory neurones. Nature 1995; 377: 428-31.
7. 3 receptor subunits can account for ATP-gated currents in sensory neurones. Nature 1995; 377: 432-35.
8. Krishtal OA, Marchenko SM, Obukhov AG, Volkova TM. Receptors for ATP in rat sensory neurones: the structure-function relationship for ligands. Br J Pharmacol 1988, 95: 1057-62.
9. Bouvier MM, Evans ML, Benham CD. Calcium influx induced by stimulation of ATP receptors on neurones cultured from dorsal root ganglia. Eur J Neurosci 1991; 3: 285-91.
10. McMahon SB. Mechanisms of sympathetic pain. Br Med Bull 1991; 47: 584-600.
11. Schott GD. Pain and the sympathetic nervous system. In: Autonomic failure. Bannister R, Mathias CJ, eds. Oxford: Oxford University Press, 1992:904-17.
12. Burnstock G. Noradrenaline and ATP as cotransmitters in sympathetic nerves. Neurochem Int 1990; 17: 357-68.
13. Hannington-Kiff JG. Intravenous regional sympathetic block with guanethidine. Lancet 1974; i: 1019-20.
14. Yasuda JM. Guanethidine for reflex sympathetic dystrophy. Ann Pharmacother 1994; 28: 338-41.
15. Levine JD, Goetzl EJ, Basbaum AI. Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthrides. Pathog Chronic Inflamm Arthritis 1987; 13: 369-83.
16. Needleman P, Minkes MS, Douglas JR. Stimulation of prostaglandin biosynthesis by adenine nucleotides. Circ Res 1974; 34: 455-60.
17. Levine JD, Fye K, Heller P, Basbaum AI, Whiting-O'Keefe Q. Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis. J Rheumatol 1986; 13: 1040-43.
18. Boulton AJM, Ward JD. Diabetic neuropathies and pain. Clin Endocrinol Metab 1986; 15: 917-31.
19. Wang Y-T, Takiguchi Y, Uematsu T, Nakashima M. Augmented responsiveness to sympathetic nerve stimulation of isolated vas deferens of diabetic rats. Arch Int Pharmacodyn Ther 1991; 309: 160-69.
20. Burnstock G. Pathophysiology of migraine: a new hypothesis. Lancet 1981; i: 1397-99.
21. Burnstock G. Dual control of local blood flow by purines. In: Dubyak GR, Fedan JA, eds. Biological actions of extracellular ATP. NY Acad Sci vol 603. New York Academy of Sciences, New York. 1990: 31-45.
22. Bodin P, Burnstock G. Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells. Experientia 1995; 51: 256-59.
23. Burnstock G. The role of adenosine triphosphate in migraine. Biomed Pharmacother 1989; 43: 727-36.
24. Hilton BP, Cumings JN. An assessment of platelet aggregation induced by 5-hydroxytryptamine. J Clin Pathol 1971; 24: 250.
25. Crea F, Pupita G, Galassi AR, et al. Role of adenosine in pathogenesis of anginal pain. Circulation 1990; 81: 164-72.
26. Sylvén C. Mechanisms of pain in angina pectoris - a critical review of the adenosine hypothesis. Cardiovasc Drugs Ther 1993; 7: 745-59.
27. Maehara Y, Kusumoto H, Anai H, Kusumoto T, Sugimachi K. Human tumor tissues have higher ATP contents than normal tissues. Clin Chem Acta 1987; 169: 341-44.
28. Siems WG, Grune T, Schmidt H, Tikhonov YV, Pimenov AM. Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor. Cancer Res 1993; 53: 5143-47.
29. Jänig W. Neurophysiological mechanisms of cancer pain. Recent Results Cancer Res 1984; 89: 45-58.
30. Trams EJ, Kauffman H, Burnstock G. A proposal for the role of ectoenzymes and adenylates in traumatic shock. J Theor Biol 1980; 87: 609-21.
31. 2-purinoceptor antagonists in rats. Brain Res 1994; 666: 182-88.
32. Khakh BS, Humphrey PPA, Surprenant A. Electrophysiological properties of P2X-purinoceptors in rat superior cervical nodose and guinea-pig coeliac neurones. J Physiol (Lond) 1995; 484: 385-95.
33. Fyffe REW, Perl E. Is ATP a central synaptic mediator for certain primary afferent fibers from mammalian skin? Proc Natl Acad Sci USA 1984; 81: 6890-93.
34. Sawynok J, Sweeney MI. The role of purines in nociception. Neuroscience 1989; 32: 557-69.