T-cell tolerance and autoimmune diabetes

International Reviews of Immunology

Volumn 20, Issue 2, 2001, Pages 301-331

  Brumeanu, T D ^a   Bona, C A ^a   Casares, S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin dependent diabetes mellitus; Recombinant MHC II peptide chimera; T cell tolerance; TCR CD4 signaling

Indexed keywords

EID: 0035201533     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830180109043041     Document Type: Article

References (171)

1. Antigen activation of murine T-cells induces tyrosine phosphorylation of a polypeptide associated with the antigen receptor
2. Antigen receptor tail clue
3. Multiple components of the T-cell antigen receptor complexes become phosphorylated upon activation
4. A lymphocyte-specific protein tyrosine kinase gene is rearranged and overexpressed in the murine T-cell lymphoma LSTRA
5. Signal transduction by the lymphocyte-specific tyrosine protein kinase p561ck
6. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs
7. The protein product of the c-Cbl oncogene is the 120 kDa tyrosine phosphorylated protein in Jurkat cells activated via the T-cell receptor
8. Interaction of Shc with zeta chain of the T-cell receptor upon T-cell activation
9. T-cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane
10. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb-2 in T-cells
11. Vav and Slp-76 interact and functionally cooperate in IL-2 gene activation
12. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR
13. Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T-cells
14. VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T-cell antigen receptor activation
15. LAT: The ZAP-70 tyrosine kinase substrate that links T-cell receptor to cellular activation
16. Tyrosine kinase stimulated guanidine nucleotide exchange activity of Vav in T-cell activation
17. Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor
18. Defective antigen receptor mediated proliferation of B- and T-cells in the absence of Vav
19. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
20. Maintenance of human T-cell anergy: Blocking of IL-2 gene transcription by activated Rapl
21. The SRF accessory protein Elk-1 contains a growth-factor-regulated transcriptional activation domain
22. Straight and narrow or tortuous and intersecting?
23. The role of p21ras in CD28 signal transduction: Triggering of CD28 with antibodies but not the ligand B7-1 activates p21ras
24. Cell surface molecules and early events involved in human T lymphocyte activation
25. Potasium and calcium channels in lymphocytes
26. T-cell antigen receptor signal transduction pathways
27. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells
28. Transcription factors of the NFAT family: Regulation an function
29. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
30. Thomas, CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli
31. CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T-cells
32. Does co-aggregation of the CD45 and CD3 antigens inhibit T-cell antigen receptor complex-mediated activation of phospholipase C and protein kinase C?
33. Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p561ck
34. Differential effect of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the 1ck, fyn, and c-src tyrosine protein kinases
35. The human p50csk tyrosine kinase phosphorylates p561ck at Tyr-505 and down regulates its catalytic activity
36. Cole, Peptide and protein phosphorylation by protein tyrosine kinase Csk: Insights into specificity and mechanism
37. The linker phosphorylation site Tyr 292 mediates the negative regulatory effect of Cb1 on ZAP-70 in T-cells
38. Interaction between CD4 and class II MHC molecules mediates cell adhesion
39. CD4 molecules are associated with antigen receptor complex on activated but not resting T-cells
40. T-cell receptor-CD4 physical association in a murine T-cell hybridoma: Induction by antigen receptor ligation
41. Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies
42. Expression and function of CD4 in a murine T-cell hybridoma
43. Differential association of protein tyrosine kinases with the T-cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation
44. Stimulation and proliferation of CD4+ peripheral blood T lymphocytes induced by anti-CD4 monoclonal antibody
45. Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion
46. Distinct signaling properties identify functionally different CD4 epitopes
47. Gene activating and proapoptotic potential are independent properties of different CD4 epitopes
48. Ligation of CD4 surface antigen induces rapid tyrosine phosphorylation of the cytoskeletal protein erzin
49. LAT is required for TCR mediated activation of PLCgammal and the Ras pathway
50. Inhibition of CD4/p561ck signaling by a dominant negative mutant of the Shc adaptor protein
51. Cross-linking of T3(CD3) with T4(CD4) enhances the proliferation of resting T lymphocytes
52. Activation of T-cells by cross-linking an anti-CD3 antibody with a second anti-T-cell antibody: Mechanism and subset-specific activation
53. Cross-linking of the T-cell receptor complex with the subset-specific differentiation antigen stimulates interleukin-2 receptor expression in human CD4 and CD8 T-cells
54. Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytes in vitro and in vivo
55. CD4 regulation of TCR signaling and T-cell differentiation following stimulation with peptides of different affinities for the TCR
56. Impaired Th2 subset development in the absence of CD4
57. A role for CD4 in peripheral T-cell differentiation
58. Impaired Th2 subset development in the absence of CD4
59. Extensive CD4 cross-linking inhibits T-cell activation by anti-receptor antibody but not by antigen
60. Antigen-specific signaling by a soluble, dimeric peptide/MHC Class II/Fc chimera leading to Th2 differentiation
61. Models of T-cell anergy: Is there a common molecular mechanism?
62. Antigen presentation by chemically modified splenocytes induces antigen-specific T-cell unresponsiveness in vitro and in vivo
63. Stimulation of normal inducer T-cell clones with antigen presented by purified Ia molecules in planar lipid membranes: Specific induction of a long-lived state of proliferation nonresponsiveness
64. An accessory-cell derived costimulatory signal acts independently of protein kinase C activation to allow T-cell proliferation and prevent the induction of unresponsiveness
65. Inhibition of antigen-specific proliferation of type 1 murine T-cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
66. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance
67. Prevention of T-cell anergy by signaling through the gamma c chain of the IL-2 receptor
68. Transactivation by AP-1 is a molecular target of T-cell clonal anergy
69. Blocked ras activation in anergic CD4+ T-cells
70. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4-1- T-cells
71. Reversal of in vitro T-cell clonal anergy by IL-2 stimulation
72. Clonal anergy blocks the response to IL-4, as well as to the production of IL-2 in dual-producing helper T-cell clones
73. Th2 cell clonal anergy as a consequence of partial activation
74. Negative transcriptional regulation in anergic T-cells
75. Induction of T-cell anergy by altered T-cell receptor ligand on live antigen-presenting cells
76. Partial T-cell signaling: Altered phospho-zeta and lack of ZAP-70 recruitment in APL-induced T-cell anergy
77. IL-2 production, not the pattern of early TCR-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists
78. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
79. Clonal analysis of differential lymphokine production in peptide and superantigen induced T-cell anergy
80. T-cell anergy
81. Differential induction of the NFAT complex during restimulation and the induction of T-cell anergy
82. Tolerance of T-cells is associated with membrane changes
83. CD28 mRNA rapidly decays when activated T-cells are functionally anergized with specific peptide
84. Regulatory T-cells in autoimmunity
85. Regulatory CD4 T-cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
86. Peripheral autoantigen induces regulatory T-cells that prevent autoimmunity
87. Characterization of peripheral regulatory CD4+ T-cells that prevent diabetes onset in nonobese diabetic mice
88. Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice
89. Cell interactions in the induction of tolerance: The role of thymic lymphocytes
90. T-regulatory-1 cells: A novel subset of CD4 T cells with immunoregulatory properties
91. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
92. Suppressor effector function of CD4+CD25+ immunoregulatory T-cells is antigen non-specific
93. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
94. Tissue-specific suppressor T-cells involved in self-tolerance are activated extrathymically by self-antigens
95. Regulatory CD4 T-cells control the size of the peripheral activated/memory CD4 T-cell compartment
96. Regulatory T-cells in the control of autoimmunity: The essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4+CD45RC- cells and CD4+CD8- thymocytes
97. CD4+CD25+ regulatory T-cells down-regulate co-stimulatory molecules on antigen-presenting cells
98. Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on FAS-FASL interactions
99. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T-cells: Induction of autoimmune disease by breaking their anergic/suppressive state
100. Prevention of diabetes in NOD mouse: Implications for therapeutic interventions in human disease
101. Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: A longitudinal study
102. NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON) F1 mice
103. Transfer of autoimmune diabetes mellitus with splenocytes from non obese diabetic (NOD) mice
104. Islet-specific T-cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice
105. Peptide therapy for diabetes in NOD mice
106. Induction of tolerance to autoimmune diabetes with islet antigens
107. Immunotherapy of the non obese diabetic mouse: Treatment with an antibody to T-helper lymphocytes
108. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice
109. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes
110. Insulin-specific human T cells. Epitope specificity, major histocompatibility complex restriction, and alloreactivity to a diabetes-associated haplotype
111. The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2
112. Vaccination against autoimmune diabetes with a T-cell epitope of the human 65-kDa heat shock protein
113. HLA-associated inverse correlation between T-cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus
114. Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice
115. Prevention of diabetes in non-obese diabetic I-Ak transgenic mice
116. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain
117. Insulin-dependent diabetes mellitus
118. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice
119. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
120. T helper cell subsets in insulin-dependent diabetes
121. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
122. Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent
123. Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma
124. Autoreactive and immunoregulatory T-cell subsets in insulin-dependent diabetes mellitus
125. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T-cells: Induction of autoimmune disease by breaking their anergic/suppressive state
126. CD4+CD25+ immunoregulatory T-cells suppress polyclonal T-cell activation in vitro by inhibiting interleukin 2 production
127. CD4+CDS- thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer
128. A new type of CD4+ T-cells completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice
129. A protective NOD islet-infiltrating CD8+ T-cell clone, I.S.2.15, has in vitro immunosuppressive properties
130. Molecular role of TGF-beta, secreted from a new type of CD4+ suppressor T-cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice
131. Prevention of insulitis and diabetes in beta 2-microglobulin-deficient non-obese diabetic mice
132. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
133. The winds of change
134. Testi, FAS-FASL interactions: A common pathogenic mechanism in organ-specific autoimmunity
135. The role of Fas in autoimmune diabetes
136. T-cell responses to autoantigens in IDDM. The search for the Holy Grail
137. The nature of autoantigens targeted in autoimmune endocrine diseases
138. Adoptive T-cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes
139. The diabetic BB rat. Neither Th1 nor Th2?
140. Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T-cell receptor (TCR)-zeta chain-Cb1 pathway mediate T-cell hyporesponsiveness in autoimmune nonobese diabetic mice
141. Thymic T-cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T-cell receptor regulation of the pathway of p21ras activation
142. Defective T-cell receptor/CD3 complex signaling in human type 1 diabetes
143. A cell culture model for T lymphocyte clonal anergy
144. Engineering and characterization of a murine MHC-immunoglobulin chimera expressing an immunodominant CD4 T viral epitope
145. Escape from natural self-tolerance leads to neonatal insulin-dependent diabetes mellitus
146. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
147. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
148. Modulating autoimmune responses to GAD inhibits disease progression and prolongs graft survival in diabetes-prone mice
149. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes mellitus
150. Modulating autoimmune responses to GAD inhibits disease progression and prolongs graft survival in diabetes-prone mice
151. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes mellitus
152. Regulatory Th2-type T-cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes
153. Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: Evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes
154. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freunds's adjuvant depends on route of administration
155. Intranasal administration of insulin peptide B9-23 protects NOD mice from diabetes
156. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B9-23
157. Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines
158. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
159. Naturally processed T-cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele DRB1*0401
160. Identification of naturally processed T-cells epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients
161. Identification of immunodominant T-cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101, β1*0401) transgenic mice
162. T-cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin
163. GAD T lymphocyte responses associated with susceptibility or resistance to type 1 diabetes: Analysis in disease-discordant human twins, nonobese diabetic mice and HLA-DQ transgenic mice
164. null NOD mice
165. NOD background genes influenza T-cells responses to GAD65 in HLA-DQ8 transgenic mice
166. Determination of glutamic acid decarboxylase 65 peptides presented by the type 1 diabetes-associated HLA-DQ8 class II molecules identifies an immunogenic peptide motif
167. T-cell recognition of human preproinsulin peptides depends on the polymorphism at the HLA-DQ locus: A study using HLA-DQ8 and DQ6 transgenic mice
168. Antigen presentation by dendritic cells following immunization with DNA encoding a MHC class-II restricted epitope
169. Efficient loading of identical peptide onto class II molecules by antigenized immunoglobulin and influenza virus
170. Derivatization with monomethoxypolyethylene glycol of Igs expressing viral epitopes obviates adjuvant requirements