Signal transduction by the lymphocyte-specific tyrosine protein kinasse p56lck

Current Topics in Microbiology and Immunology

Volumn 205, Issue , 1996, Pages 63-87

  Weil, R ^a   Veillette, A ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ENDOPLASMIC RETICULUM; HUMAN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0029655668     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (141)

1. ck. J Exp Med 173: 1421-1432
2. lck. Proc Natl Acad Sci USA 88: 3977-3981
3. lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation. Mol Cell Biol 10: 5197-5206
4. lck. Nature 350: 62-66
5. Adler HT, Reynolds PJ, Kelley CM, Sefton BM (1988) Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters. J Virol 62 4113-4122
6. ck, reveals its oncogenic potential in fibroblasts. Proc Natl Acad Sci USA 85. 4247-4251
7. ck mediates both intermolecular and intramolecular interactions. Proc Natl Acad Sci USA 90 10285-10289
8. lck EMBO J 13: 4877-4886
9. lck controls allelic exclusion of T-cell receptor β-chain genes. Nature 365: 552-554
10. + thymic selection in humans lacking Zap-70 kinase. Cell 76. 947-958
11. Bell GM, Bolen JB, Imboden JB (1992) Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Mol Cell Biol 12: 5548-5554
12. Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H (1994) Identification and characterization of novel tyrosine kinase from megakaryocytes J Biol Chem 369 1068-1074
13. lck at tyr-505 and down regulates its catalytic activity EMBO J 11: 2919-2924
14. + thymocytes influenced by CD4. Nature 344. 247-251
15. Brauninger A, Karn T, Strebhardt K, Rubsamen-Waigmann (1993) Characterization of the human CSK locus Oncogene 8: 1365-1369
16. Buday L, Egan SE, Viciana PR, Cantrell DA, Downward J (1994) A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells. J Biol Chem 269. 9091-9023
17. fyn. Proc Natl Acad Sci USA 8: 9311-9315
18. Burnett RC, David JC, Hardan AM, Le Beau MM, Rowley JD, Diaz MO (1991) The lck gene is involved in the t(1; 7)(p34, q34) in the T-cell acute lymphoblastic leukemia derived cell line HSB-2. Genes Chromosomes Cancer 3: 461-467
19. Bustelo XR, Ledbetter JA, Barbacid M (1992) Product of the vav proto-oncogene defines a new class of tyrosine protein kinase substrates Nature 356. 68-71
20. Cahir McFarland ED, Hurley TR, Pingel JT, Sefton BM, Shaw A, Thomas ML (1993) Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Proc Natl Acad Sci USA 90: 1402-1406
21. Cantley LC, Auger KR, Carpenter C, Duckworth A (1991) Oncogenes and signal transduction. Cell 64: 281-302
22. lck. Mol Cell Biol 6: 2720-2729
23. Casnellie JE, Harrison ML, Hellstrom KE, Krebs EG (1982) A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity. J Biol Chem 258: 10738-10742
24. lck is required for early T cell signaling events EMBO J 5: 1201-1207
25. Chan AC, Irving BA, Fraser JD, Weiss A (1991) The ζ chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci USA 88: 9166-9170
26. Chan AC, Iwashima M, Turck CW, Weiss A (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain Cell 71 649-662
27. Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A (1994) ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264: 1599-1601
28. Chow LML, Ratcliffe MJH, Veillette A (1992) tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Mol Cell Biol 12: 1226-1233
29. csx. Nature 365: 156-160
30. Chow LML, Jarvis C, Hu Q, Nye SH, Gervais FG, Veillette A, Matis LA (1994) Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T-lymphocytes Proc Natl Acad Sci USA 91: 4975-4979
31. Cooper JA (1990) The src family of protein-tyrosine kinases, p 85-113 In B E Kemp (ed), Peptides and protein phosphorylation CRC Press, Boca Raton
32. Deans JP, Kanner SB, Torres RM, Ledbetter JA (1992) Interaction of CD4: lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase. Eur J Immunol 22. 661-668
33. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA (1993) Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363: 45-51
34. lck modification in IL-2 or phorbol ester-activated human natural killer cells J Immunol 145 1490-1497
35. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG (1994) Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264. 1596-1599
36. Gacon G, Gisselbrecht S, Piau JP, Boissel JP, Tolle J, Fischer S (1982) High levels of tyrosine protein kinase in a murine lymphoma cell line induced by the Moloney leukemia virus. EMBO J 1: 1579-1582
37. Garvin AM, Pawar S, Marth JD, Perlmutter RM (1988) Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol Cell Biol 8: 3058-3064
38. ck at tyrosine 505, the negative regulatory site. Mol Cell Biol 13: 7112-7121
39. lck with CD4 in antigen-specific signal transduction in T cells Cell 64: 511-520
40. Groettrup M, Ungewiss K, Azogui O, Palacios R, Owen MJ, Hayday AC, von Boehmer H (1993) A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein Cell 75 283-294
41. Gulbins E, Coggeshall KM, Baier G, Katzav S, Burn P, Altman A (1993) Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 260: 822-825
42. lck identification of novel intermolecular association Science 252. 1523-1528
43. lck wrth CD4 inhibits the induction of growth through the αβ T-cell receptor Nature 358 328-331
44. lck. Proc Natl Acad Sci USA 88: 1996-2000
45. lck Science 245 407-409
46. Hurley TR, Hyman R, Sefton BM (1993) Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the Lck, Fyn, and c-Src tyrosine protein kinases. Mol Cell Biol 13 1651-1656
47. June CH, Fletcher MC, Ledbetter JA, Schieven GL, Siegel JN, Philipps AF, Samelson LE (1990) Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc Natl Acad Sci USA 87. 7722-7726
48. lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line Mol Cell Biol 10: 4521-4530
49. ck J Immunol 151: 1255-1262
50. Klages S, Adam D, Class K, Fargnoli J, Bolen JB, Penhallow RC (1994) Ctk a protein-tyrosine kinase related to Csk that defines an enzyme family Proc Natl Acad Sci USA 91: 2597-2601
51. Koch CA, Anderson D, Moran MF, Ellis C, Pawson T (1991) SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 25: 668-674
52. Koretzky GA, Picus J, Thomas ML, Weiss A (1990) A tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346: 66-68
53. Koretzky GA, Kohmetscher M, Ross S (1993) CD45-associated kinase activity requires Lck but not T cell receptor expression in Jurkat T cell line. J Biol Chem 268: 8958-8964
54. Letourneur F, Gabert J, Cosson P, Blanc D, Davoust J, Malissen B (1990) A signaling role for the cytoplasmic segment of the CD8 α chain detected under limiting stimulatory conditions Proc Natl Acad Sci USA 87. 2339-2343
55. Levin SD, Anderson SJ, Forbush KA, Perimutter RM (1993) Distinct intracellular localisation of Lck and Fyn protein tyrosine kinases in human T lymphocytes J Cell Biol 125: 639-649
56. Ley SC, Marsh M, Bebbington CR, Proudfoot K, Jordan P (1994) Distinct intracellular localisation of Lck and Fyn protein tyrosine kinases in human T lymphocytes. J Cell Biol 125 639-649
57. Luo K, Sefton BM (1990a) Cross-hnking of T cell surface molecules CD4 and CD8 stimulates phosphorylation of the Lck tyrosine protein kinase at the autophosphorylation site Mol Cell Biol 10: 5305-5313
58. lck whose phosphorylation is induced by tetradecanoyl phorbol acetate. Oncogene 5: 803-808
59. Luo K, Sefton BM (1992) Activated Lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells Mol Cell Biol 12: 4724-4732
60. Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J (1992) Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356 71-74
61. Marth JD, Peet R, Krebs EG, Perlmutter RM (1985) A lymphocyte-specific protein tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA Cell 43. 393-404
62. lck) Mol Cell Biol 8: 540-550
63. Marth JD, Overell RW, Meier KE, Krebs EG, Perlmutter RM (1988b) Translational activation of the lck proto-oncogene Nature 332. 171-173
64. McVicar DW, Lal BK, Lloyd A, Kawamura M, Chen YQ, Zhang X, Staples JE, Ortaldo JR, O'Shea JJ (1994) Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes Oncogene 9: 2037-2044
65. Miceli MC, von Hoegen P, Parnes JR (1991) Adhesion versus coreceptor function of CD4 and CD8 role of the cytoplasmic tail in coreceptor activity Proc Natl Acad Sci USA 88: 2623-2627
66. lck. Nature 357: 161-164
67. Mustelin T, Coggeshall KM, Isakov N, Altman A (1990) T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247. 1584-1587
68. c-src Nature 351 69-72
69. + cells by CD4. Science 249: 1558-1561
70. + thymocytes. Proc Natl Acad Sci USA 90 10534-10538
71. Nishibe S, Wahl MI, Hernández-Sotomayor SMT, Tonks NK, Rhee SG, Carpenter G (1990) Increase of the catalytic activity of phospholipase C-γ1 by tyrosine phosphorylation. Science 250 1253-1256
72. csk tyrosine kinase and engagement of its SH2 domain. Oncogene 9: 1625-1631
73. Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H (1991) CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem 266 24249-24252
74. ck. J Exp Med 172: 347-350
75. Ostergaard HL, Shackelford DA, Hurley TR, Johnson P, Hyman R, Sefton BM, Trowbridge IS (1989) Expression of CD45 alters phosphorylation of the Lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc Natl Acad Sci USA 86: 8959-8963
76. Park DJ, Rho YW, Rhee SG (1991) CD3 stimulation causes phosphorylation of phospholipase C on serine and tyrosine residues in a human T-cell line. Proc Natl Acad Sci USA 88: 5453-5456
77. src) Oncogene 6: 2013-2018
78. Pawson T, Gish GD (1992) SH2 and SH3 domains: from structure to function. Cell 71: 359-362
79. src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc Natl Acad Sci USA 90. 4902-4906
80. ck for thymic development of transgenic T cells Science 260. 358-361
81. lck with phosphotyrosine-containing proteins Oncogene 8: 2765-2772
82. Perlmutter RM, Levin SD, Appleby MW, Anderson SJ, Alberola-lla J (1993) Regulation of lymphocytes function by protein phosphorylation Annu Rev Biochem 11: 451-499
83. Pingel JT, Thomas ML (1989) Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation Cell 58: 1055-1065
84. lck SH3 domain binds to PI 3-kinase but not PI 4-kinase Mol Cell Biol 13: 7708-7717
85. Qian D, Griswold-Prenner I, Rosner MR, Fitch FW (1993) Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation. J Biol Chem 268.4488-4493
86. ck Mol Cell Biol 14 2862-2870
87. Ravichandran KS, Lee KK, Songyang Z, Cantley LC, Burn P, Burakoff SJ (1993) Interaction of Shc with the ζ chain of the T cell receptor upon T cell activation Science 262: 902-904
88. Reth M (1989) Antigen receptor tail clue Nature 338: 383
89. Reynolds PJ, Lesley J, Trotter J, Schulte R, Hyman R, Sefton BM (1990) Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development. Mol Cell Biol 10: 4266-4270
90. Reynolds PJ, Hurley TR, Sefton BM (1992) Functional analysis of the SH2 and SH3 domains of the Lck tyrosine protein kinase. Oncogene 7: 1949-1956
91. Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (1988) The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci USA 85 5190-5194
92. Ruzzene M, James P, Brunati AM, Donella-Deana A, Pinna LA (1994) Regulation of c-Fgr protein kinase by c-Src kinase (CSK) and by polycationic effectors J Biol Chem 269: 15885-15891
93. Sabe H, Okada M, Nakagawa H, Hanafusa H (1992) Activation of c-Src in cells bearing v-Crk and its suppression by Csk Mol Cell Biol 12: 4706-4713
94. Sakano S, Iwama A, Inazawa J, Ariyama T, Ohno M, Suda T (1994) Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). Oncogene 9: 1155-1161
95. Samelson LE, Klausner RD (1992) Tyrosine kinases and tyrosine-based activation motifs Current research on activation via the T cell antigen receptor. J Biol Chem 267: 24913-24916
96. Samelson LE, Patel MD, Weissman AM, Harford JB, Klausner RD (1986) Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the antigen receptor. Cell 46: 1083-1090
97. lck and pp32, a possible common substrate. Eur J Immunol 10. 2469-2477
98. Shaw AS, Amrein KE, Hammond C, Stern DF, Sefton BM, Rose JK (1989) The Lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain Cell 59 627-636
99. lck tyrosine protein kinase. Mol Cell Biol 10: 1853-1862
100. fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins Mol Cell Biol 13: 6385-6392
101. Shin S, Steffen DL (1993) Frequent activation of the lck gene by promoter insertion and aberrant splicing in murine leukemia virus-induced rat lymphomas. Oncogene 8 141-149
102. fyn couples T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx EMBO J 11 4887-4897
103. Sieh M, Bolen JB, Weiss A (1993) CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck EMBO J 12 315-321
104. Sleckman BP, Peterson A, Foran JA, Gorga JC, Kara CJ, Strominger JL, Burakoff SJ, Greenstein JL (1988) Functional analysis of cytoplasmic domain-deleted mutant of the CD4 molecule J Immunol 141 49-54
105. lck. J Biol Chem 268: 27420-27427
106. Strauss DB, Weiss A (1992) Genetic evidence for the involvement of the Lck tyrosine kinase in signal transduction through the T cell antigen receptor Cell 70: 585-593
107. Strauss DB, Weiss A (1993) The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation. J Exp Med 178: 1523-1530
108. lck kinase expression and control of DNA synthesis in activated human B lymphocytes. J Biol Chem 268. 9169-9171
109. ck T cell receptor complexes Science 254: 439-441
110. Trowbridge IS, Thomas ML (1994) CD45 an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development Annu Rev Immunol 12: 85-116
111. lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60 755-765
112. Tycko B, Smith SD, Sklar J (1991) Chromosomal translocation joining lck and TCR β loci in human T cell leukemia J Exp Med 174 867-873
113. Veillette A, Davidson D (1992) Src-related protein tyrosine kinases and T-cell receptor signaling Trends Genet 8: 61-66
114. lck. Eur J Immunol 21: 397-401
115. Veillette A, Foss FM, Sausville EA, Bolen JB, Rosen N (1987) Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res 1: 357-374
116. lck in response to activators of protein kinase C Oncogene Res 2. 385-401
117. ck Cell 55: 301-308
118. lck) during T-cell activation. Mol Cell Biol 8: 4353-4361
119. Veillette A, Bolen JB, Bookman MA (1989a) Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor on T-lymphocytes Mol Cell Biol 9: 4441-4446
120. lck. Nature 338: 257-259
121. Veillette A, Zuniga-Pflucker JC, Bolen JB, Kruisbeek AM (1989c) Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J Exp Med 170: 1671-1680
122. lck by the non-catalytic SH2 and SH3 domains. Oncogene 7: 971-980
123. 2+ oscillations. J Exp Med 176 835-844
124. lck is involved in binding to phosphatidylinositol 3′-kinase from T lymphocytes Mol Cell Biol 13. 7408-7417
125. von Boehmer H, Kisielow P (1993) Lymphocyte lineage commitment: instruction versus selection Cell 73 207-208
126. Voronova AF, Sefton BM (1986) Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature 319: 682-685
127. Voronova AF, Buss JE, Patchinsky T, Hunter T, Sefton BM (1985) Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. Mol Cell Biol 4 2705-2713
128. Wange RL, Tony Kong AN, Samelson LE (1992) A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor J Biol Chem 267 11685-11688
129. Wange RL, Malek SN, Desideno S, Sarnelson LE (1993) Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells. J Biol Chem 268 19797-19801
130. ck in activated T cells. J Biol Chem 258: 23275-23282
131. + T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli. Mol Cell Biol 11 4415-4422
132. lck in resting T-lymphocytes. J Biol Chem 269: 22830-22838
133. Weiss A, Littman DR (1994) Signal transduction by lymphocyte antigen receptors Cell 76: 263-294
134. Weiss A, Koretzky G, Schatzman RC, Kadlecek T (1991) Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ 1 Proc Natl Acad Sci USA 88: 5484-5488
135. lck tyrosine kinase basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J Exp Med 178 1701-1712
136. Wildin RS, Garvin AM, Pawar S, Lewis DB, Abraham KM, Forbush KA, Ziegler SF, Allen JM, Perlmutter RM (1991) Developmental regulation of lck gene expression in T lymphocytes J Exp Med 173: 383-393
137. lck. Proc Natl Acad Sci USA 90 5176-5180
138. Wright DD, Sefton BM, Kamps MP (1994) Oncogenic activation of the Lck protein accompanies translocation of the lck gene in the human HSB-2 T-cell leukemia. Mol Cell Biol 14 2429-2437
139. Xu H, Littman DR (1993) A kinase-independent function of Lck in potentiating antigen-speciftc T-cell activation. Cell 74 633-643
140. lck correlates with impaired function in vitro and lack of expression in vivo Nature 342: 278-281
141. ck association J Exp Med 179: 1973-1983