CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1194-1203

  Leitenberg, David ^a   Boutin, Yvan ^a   Constant, Stephanie ^a   Bottomly, Kim ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD4 ANTIGEN; CYTOCHROME C; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; CELL DIFFERENTIATION; CROSSES, GENETIC; CYTOCHROME C GROUP; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MOTHS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 0032145326     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
2. Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259.
3. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
4. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of Zap 70 recruitment in APL-induced T cell anergy. Cell 79:913.
5. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζPhosphorylation without Zap-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
6. Sloan-Lancaster, J., T. H. Steinberg, and P. M. Allen. 1996. Selective activation of the calcium signaling pathway by altered peptide ligand. J. Exp. Med. 184: 1525.
7. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
8. Evavold, B. D., and P. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered TCR ligand. Science 252:1308.
9. Boutin, Y., D. Leitenberg, X. Tao, and K. Bottomly. 1997. Distinct biochemical signals characterize agonist and altered peptide ligand-induced differentiation of naive CD4 T cells into Th1 and Th2 subsets. J. Immunol. 159:5802.
10. Pfeiffer, C., J. Murray, J. Madri, and K. Bottomly. 1991. Selective activation of Th1 and Th2 like cells in vivo: response to human collagen IV. Immunol. Rev. 123:65.
11. Murray, J. S., C. Pfeiffer, J. Madri, and K. Bottomly. 1992. MHC control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. Eur. J. Immunol. 22:559.
12. Pfeiffer, C., K. Stein, S. Southwood, K. H, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
13. + T cells. J. Exp. Med.: 1591.
14. Kumar, V., V. Bhardwaj, L. Soares, J. Alexander, A. Sette, and E. Sercarz. 1995. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or IFN-γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510.
15. + T helper cell phenotype development in a TCR-αβ-transgenic model. J. Exp. Med. 182:1579.
16. Nicholson, L. B., J. M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
17. + T cells by antigenic peptides altered for TCR binding. J. Immunol. 158:4237.
18. Gaur, A., S. A. Boehme, D. Chalmers, P. D. Crowe, A. Pahuja, N. Ling, S. Brocke, L. Steinman, and P. J. Conlon. 1997. Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J. Neumimmunol. 74:149.
19. Germain, R. N., E. H. Levine, and J. Madrenas. 1995. The TCR as a diverse signal transduction machine. Immunologist 314:113.
20. Janeway Jr, C. A. 1995. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16:223.
21. Madrenas, J., L. A. Chau, J. Smith, J. A. Bluestone, and R. N. Germain. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/ partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185: 219.
22. a-reactive T cells. J. Exp. Med. 176:1459.
23. Vidal, K., B. L. Hsu, C. B. Williams, and P. M. Allen. 1996. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311.
24. Fowell, D. J., J. Magram, C. W. Turck, N. Killeen, and R. M. Locksley. 1997. Impaired Th2 subset development in the absence of CD4. Immunity 6:559.
25. Brown, D. R., N. H. Moskowitz, N. Killeen, and S. L. Reiner. 1997. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186:101.
26. + T cells in transgenic mice express a class II MHC restricted antigen receptor. Nature 341:746.
27. lck association. Nature 364:729.
28. +T lymphocytes to peptide antigen in vivo. J. Immunol. 151:6742.
29. + T lymphocytes different from unprimed cellś Eur. J. Immunol. 24:1073.
30. Farber, D., M. Luqman, O. Acuto, and K. Bottomly. 1995. Control of memory CD4 T cell activation: MHC class II molecules on antigen presenting cells and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity 2:249.
31. + T cells. Eur. J. Immunol. 25:2445.
32. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297.
33. Lyons, D. S., S. A. Lieberman, J. Hamp, J. J. Boniface, Y. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
34. Matechak, E. O., N. Killeen, S. M. Hedrick, and B. J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CDS lineage when CD4 is absent. Immunity 4:337.
35. Rabinowitz, J. D., C. Beeson, C. Wulfing, K. Tate, P. M. Allen, M. M. Davis, and H. M. McConnell. 1996. Altered TCR ligands trigger a subset of early T cell signals. Immunity 5:125.
36. Viola, A., M. Salio, L. Tuosto, S. Linken, O. Acuto, and A. Lanzavecchia. 1997. Quantitative contribution of CD4 and CDS to T cell antigen receptor serial triggering. J. Exp. Med. 186:1775.
37. Al-Ramadi, B. K., M. T. Jelonek, L. J. Boyd, D. H. Margulies, and A. L. M. Bothwell. 1995. Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR. J. Immunol. 155:662.
38. + T cells in the presence of a non-depleting monoclonal to CD4 induces a Th2-type response in vitro. J. Exp. Med. 182:5.
39. + T lymphocytes in vitro and in vivo. J. Immunol. 157:87.
40. + T cells from TCR transgenic mice. J. Exp. Med. 176:1091.