Escape from self-tolerance leads to neonatal insulin-dependent diabetes mellitus

Autoimmunity

Volumn 30, Issue 4, 1999, Pages 199-207

  Radu, Dorel L ^a   Brumeanu, Teodor Doru ^a   McEvoy, Robert C ^a   Bona, Constantin A ^a   Casares, Sofia ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Hemagglutinin; IDDM; Neonatal tolerance; TCR

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; HYPERGLYCEMIA; HYPOINSULINEMIA; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; NEWBORN DISEASE; NONHUMAN; T LYMPHOCYTE;

EID: 0032824549     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908993801     Document Type: Article

References (17)

1. M. Blackman, J. Kappler and P. Marrack. The role of the T cell receptor in positive and negative selection of developing T cells. Science 1990: 248: 1335-1338.
2. A. Sarukhan, C. Garcia, A. Lanoue and H. von Boehmer. Allelic inclusion of T cells receptor α genes poses an autoimmune hazard due to low-level expression of autospecific receptors. Immunity 1998: 8: 563-570.
3. M.B.A. Oldstone, M. Nerenberg, P. Southern, J. Price and H. Lewicki. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: a role of anti-self (virus) immune response. Cell 1991: 65: 319-331.
4. P.S. Ohashi, S. Oehen, K. Buerki, H. Pircher, C.T. Ohashi, B. Odermatt et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991: 65: 305-317.
5. F. Ramsdell and B.J. Fowlkes. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 1990: 248: 1342-1348.
6. G. Schonrich, U. Kalinke, F. Momburg, M. Malissen, A.M. Schmitt-Verhulst, B. Malissen et al. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism from extrathymic tolerance induction. Cell 1990: 65: 293-304.
7. S. Webb, C. Morris and J. Sprent. Extrathymic tolerance induction of mature T cells: clonal elimination as a consequence of immunity. Cell 1990: 63: 1249-1255.
8. R. Billigham, L. Brent and P. Medawar. Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Proc. Roy. Soc. Lond. 1956: 239: 44-45.
9. S. Degermann, C. Reilly, B. Scott, L. Ogata, H. von Boehmer and D. Lo. On the various manifestations of autoimmune diabetes in rodent animals. Eur. J Immunol. 1994: 24: 3155-3160.
10. J. Kirberg, A. Baron, S. Jacob, A. Rolink, K. Karjalainen and H. von Boehmer. Thymic selection of CD8 single positive cells with a major histocompatibility complex-restricted receptor. J. Exp. Med. 1994: 180: 25-34.
11. T. Forsthuber, H.C. Yip and P.V. Lehmann. Induction of TH1 and TH2 immunity in neonatal mice. Science 1996: 271: 1728-1731.
12. R.R. Singh, B.H. Hahn and E.E. Sercarz. Neonatal peptide exposure can prime T cells and upon subsequent immunization induce their immune deviation: implications for antibody vs T-cell mediated autoimmunity. J Exp. Med. 1996: 183: 1613-1621.
13. + T cells. J. Immunol. 1998: 160: 4500-4507.
14. K. Sugamura, H. Asao, M. Kondo, N. Tanaka, N. Ishii, K. Ohbo et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Ann. Rev. Immunol. 1996: 14: 179-205.
15. M. Lopez-Cabrera, E. Munoz, M.V. Blazquez, M.A. Ursa, A.G. Santis and F. Sanchez-Madrid. Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. J. Biol. Chem. 1995: 270: 21 545-21 551.
16. A. Quinn and E.E. Sercarz. T cells with multiple fine specificities are used by non-obese diabetic (NOD) mice in the response to GAD (524-543). J. Autoimmu. 1996: 9: 365-370.
17. J. Tian, P.V. Lehmann and D.L. Kaufman. Determinant spreading of T helper cell 2 (TH2) responses to pancreatic islet autoantigens. J. Exp. Med. 1997: 186: 2039-2043.