Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 18, 1996, Pages 9736-9741

  Madrenas, Joaquín ^a,b   Schwartz, Ronald H ^a   Germain, Ronald N ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

antigen; major histocompatibility complex class II; receptor; T cell

Indexed keywords

INTERLEUKIN 2 RECEPTOR; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; DIAGNOSIS; ETIOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR OCCUPANCY; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL DIVISION; CLONAL ANERGY; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-2; L CELLS (CELL LINE); MICE; PHENOTYPE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH1 CELLS; TYROSINE;

EID: 0029792922     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.18.9736     Document Type: Article

References (47)

1. Marrack, P., Lo, D., Brinster, R., Palmiter, R., Burkly, L., Flavell, R. H. & Kappler, J. (1988) Cell 53, 627-634.
2. Webb, S., Morris, C. & Sprent, J. (1990) Cell 63, 1249-1256.
3. Lenardo, M. J. (1991) Nature (London) 353, 858-861.
4. Critchfield, J. M., Racke, M. K., Zuniga-Pflucker, J. C., Cannella, B., Raine, C. S., Goverman, J. & Lenardo, M. J. (1994) Science 263, 1139-1143.
5. Qin, S. X., Wise, M., Cobbold, S. P., Leong, L., Kong, Y. C., Parnes, J. R. & Waldmann, H. (1990) Eur. J. Immunol. 20, 2737-2745.
6. Schwartz, R. H. (1989) Cell 57, 1073-1081.
7. Burkly, L. C., Lo, D., Kanagawa, O., Brinster, R. L. & Flavell, R. A. (1989) Nature (London) 342, 564-566.
8. Dresser, D. W. (1962) Immunology 5, 378-388.
9. Lafferty, K. J. & Cunningham, A. J. (1975) Aust. J. Exp. Biol. Med. Sci. 53, 27-42.
10. Jenkins, M. K. & Schwartz, R. H. (1987) J. Exp. Med. 165, 302-319.
11. Mueller, D. L., Jenkins, M. K. & Schwartz, R. H. (1989) Annu. Rev. Immunol. 7, 445-480.
12. Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H. & Allison, J. P. (1992) Nature (London) 356, 607-609.
13. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Gray, G. & Nadler, L. M. (1993) Proc. Natl. Acad. Sci. USA 90, 6586-6590.
14. Sloan-Lancaster, J., Evavold, B. D. & Allen, P. M. (1993) Nature (London) 363, 156-159.
15. Sloan-Lancaster, J., Shaw, A. S., Rothbard, J. B. & Allen, P. M. (1994) Cell 79, 913-922.
16. Madrenas, J., Wange, R. L., Wang, J. L., Isakov, N., Samelson, L. E. & Germain, R. N. (1995) Science 267, 515-518.
17. DeSilva, D. R., Urdahl, K. B. & Jenkins, M. K. (1991) J. Immunol. 147, 3261-3267.
18. Beverly, B., Kang, S. M., Lenardo, M. J. & Schwartz, R. H. (1992) Int. Immunol. 4, 661-671.
19. Boussiotis, V. A., Barber, D. L., Nakarai, T., Freeman, G. J., Gribben, J. G., Bernstein, G. M., D'Andrea, A. D., Ritz, J. & Nadler, L. M. (1994) Science 266, 1039-1042.
20. Mueller, D. L., Jenkins, M. K. & Schwartz, R. H. (1989) J. Immunol. 142, 2617-2628.
21. Mueller, D. L., Jenkins, M. K., Chiodetti, L. & Schwartz, R. H. (1990) J Immunol. 144, 3701-3709.
22. Hecht, T. T., Longo, D. L. & Matis, L. A. (1983) J. Immunol. 131, 1049-1055.
23. Ronchese, F., Schwartz, R. H. & Germain, R. N. (1987) Nature (London) 329, 254-256.
24. Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N. & Shevach, E. M. (1993) J. Immunol. 151, 1224-1234.
25. Reis e Sousa, C. & Germain, R. N. (1995) J. Exp. Med. 182, 841-852.
26. Evavold, B. D., Sloan-Lancaster, J. & Allen, P. M. (1993) Immunol. Today 14, 602-609.
27. Sette, A., Alexander, J., Ruppert, J., Snoke, K., Franco, A., Ishioka, G. & Grey, H. M. (1994) Annu. Rev. Immunol. 12, 413-431.
28. Jameson, S. C. & Bevan, M. J. (1995) Immunity 2, 1-11.
29. Germain, R. N., Levine, E. H. & Madrenas, J. (1995) The Immunologist 3, 113-121.
30. Sloan-Lancaster, J. & Allen, P. M. (1995) Curr. Opin. Immunol. 7, 103-109.
31. Madrenas, J. & Germain, R. N. (1996) Semin. Immunol. 8, 83-101.
32. Linsley, P. S., Clark, E. A. & Ledbetter, J. A. (1990) Proc. Natl. Acad. Sci. USA 87, 5031-5035.
33. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Sugita, K., Freedman, A. S., Morimoto, C. & Nadler, L. M. (1991) Proc. Natl. Acad. Sci. USA 88, 6575-6579.
34. Hathcock, K. S., Laszlo, G., Dickler, H. B., Bradshaw, J., Linsley, P. & Hodes, R. J. (1993) Science 262, 905-907.
35. Freeman, G. J., Borriello, F., Hodes, R. J., Reiser, H., Gribben, J. G., Ng, J. W., Kim, J., Goldberg, J. M., Hathcock, K., Laszlo, G., Lombard, L. A., Wang, S., Gray, G. S., Nadler, L. M. & Sharpe, A. H. (1993) J. Exp. Med. 178, 2185-2192.
36. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. & Ben-Neriah, Y. (1994) Cell 77, 727-736.
37. Boussiotis, V. A., Freeman, G. J., Griffin, J. D., Gray, G. S., Gribben, J. G. & Nadler, L. M. (1994) J. Exp. Med. 180, 1665-1673.
38. Cho, E. A., Riley, M. P., Sillman, A. L. & Quill, H. (1993) J. Immunol. 151, 20-28.
39. Jenkins, M. K., Ashwell, J. D. & Schwartz, R. H. (1988) J. Immunol. 140, 3324-3330.
40. Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M. & Schwartz, R. H. (1987) Proc. Natl. Acad. Sci. USA 84, 5409-5413.
41. Gelfand, E. W., Weinberg, K., Mazer, B. D., Kadlecek, T. A. & Weiss, A. (1995) J. Exp. Med. 182, 1057-1065.
42. Matsui, K., Boniface, J. J., Steffner, P., Reay, P. A. & Davis, M. M. (1994) Proc. Natl. Acad. Sci. USA 91, 12862-12866.
43. Valitutti, S., Dessing, M., Aktories, K., Gallati, H. & Lanzavecchia, A. (1995) J. Exp. Med. 181, 577-584.
44. Fields, P. E., Gajewski, T. F. & Fitch, F. W. (1996) Science 271, 1276-1278.
45. Li, W., Waley, C. D., Mondino, A. & Mueller, D. L. (1996) Science 271, 1272-1276.
46. Salemi, S., Caporossi, A. P., Boffa, L., Longobardi, M. G. & Barnaba, V. (1995) J. Exp. Med. 181, 2253-2257.
47. Wucherpfennig, K. W. & Strominger, J. L. (1995) Cell 80, 695-705.