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Volumn 8, Issue 21, 2001, Pages 1593-1600

Genetically modified immunocompetent cells in HIV infection

Author keywords

Cell therapy; Gene therapy; HIV; Immunoreconstitution; Opportunistic pathogens; T cell repertoire

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; DNA; GANCICLOVIR; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYGROMYCIN; INTERLEUKIN 2; NERVE GROWTH FACTOR RECEPTOR; REV PROTEIN; THYMIDINE KINASE; TRANSFER RNA;

EID: 0035186203     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301569     Document Type: Review
Times cited : (5)

References (103)
  • 1
    • 0442268112 scopus 로고    scopus 로고
    • A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
    • AIDS Clinical Trial Group 320 Study Team.
    • (1997) N Engl J Med , vol.337 , pp. 725-733
    • Hammer, S.M.1
  • 2
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1
  • 3
    • 0032953920 scopus 로고    scopus 로고
    • + T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1
  • 4
    • 0033984045 scopus 로고    scopus 로고
    • The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
    • (2000) Nat Med , vol.1 , pp. 82-85
    • Ramratnam, B.1
  • 5
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 6
    • 0032546919 scopus 로고    scopus 로고
    • Toward HIV eradication or remission: The tasks ahead
    • (1998) Science , vol.280 , pp. 1866-1867
    • Ho, D.D.1
  • 8
    • 0035895295 scopus 로고    scopus 로고
    • + cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 597-602
    • Stranford, S.A.1
  • 10
    • 0034024560 scopus 로고    scopus 로고
    • Viral genetic heterogeneity in HIV-1-infected individuals is associated with increasing use of HAART and higher viraemia
    • (2000) AIDS , vol.14 , pp. 813-819
    • Ross, J.1
  • 12
    • 0034685037 scopus 로고    scopus 로고
    • Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society-USA Panel
    • (2000) JAMA , vol.283 , pp. 381-390
    • Carpenter, C.C.1
  • 13
    • 0343183245 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendations of an International AIDS Society-USA Panel
    • (2000) JAMA , vol.283 , pp. 2417-2426
    • Hirsch, M.S.1
  • 18
    • 0030976238 scopus 로고    scopus 로고
    • Protection of primary human T cells from HIV infection by Trev: A transdominant fusion gene
    • (1997) Hum Gene Ther , vol.8 , pp. 861-868
    • Chinen, J.1
  • 19
    • 8944232102 scopus 로고    scopus 로고
    • + T cell proliferation in HIV-positive patients as a result of CD28 costimulation
    • (1996) Science , vol.272 , pp. 1939-1943
    • Levine, B.L.1
  • 22
    • 0022326904 scopus 로고
    • T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex
    • (1985) Annu Rev Immunol , vol.3 , pp. 237-261
    • Schwartz, R.H.1
  • 23
    • 0030932983 scopus 로고    scopus 로고
    • + hematopoietic progenitor cells with an antitat gene protects T-cell and macrophage progeny from AIDS virus infection
    • (1997) J Virol , vol.71 , pp. 2740-2746
    • Rosenzweig, M.1
  • 25
    • 17344363485 scopus 로고    scopus 로고
    • Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression
    • (1999) J Virol , vol.73 , pp. 728-737
    • Shen, H.1
  • 26
    • 16944363303 scopus 로고    scopus 로고
    • Suitability of bone marrow from HIV-1-infected donors for retrovirus-mediated gene transfer
    • (1997) Hum Gene Ther , vol.8 , pp. 301-311
    • Kearns, K.1
  • 27
    • 0033015244 scopus 로고    scopus 로고
    • Mobilization of peripheral blood progenitor cells for human immunodeficiency virus-infected individuals
    • (1999) Exp Hematol , vol.27 , pp. 147-154
    • Law, P.1
  • 28
    • 0031440054 scopus 로고    scopus 로고
    • + hematopoietic cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection
    • (1997) Blood , vol.90 , pp. 4822-4831
    • Rosenzweig, M.1
  • 29
    • 0030919846 scopus 로고    scopus 로고
    • RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication
    • (1997) J Virol , vol.71 , pp. 4707-4716
    • Bonyhadi, M.L.1
  • 33
    • 0033606540 scopus 로고    scopus 로고
    • Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial
    • (1999) Lancet , vol.353 , pp. 2195-2199
    • Durant, J.1
  • 35
    • 0025363891 scopus 로고
    • Ribozymes as potential anti-HIV-1 therapeutic agents
    • (1990) Science , vol.247 , pp. 1222-1225
    • Sarver, N.1
  • 36
    • 0028220643 scopus 로고
    • Peripheral blood lymphocytes as target cells of retroviral vector-mediated gene transfer
    • (1994) Blood , vol.83 , pp. 1988-1997
    • Mavilio, F.1
  • 37
    • 0030682167 scopus 로고    scopus 로고
    • + cells transduced with retroviral vectors containing an intracytoplasmatically truncated version of the human low-affinity nerve growth factor receptor (deltaLNGFR) gene
    • (1997) Hum Gene Ther , vol.8 , pp. 1815-1824
    • Fehse, B.1
  • 38
    • 0032477912 scopus 로고    scopus 로고
    • Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1201-1206
    • Ranga, U.1
  • 39
    • 0032211255 scopus 로고    scopus 로고
    • A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
    • (1998) Hum Gene Ther , vol.9 , pp. 2407-2425
    • Wong-Staal, F.1    Poeschla, E.M.2    Looney, D.J.3
  • 41
    • 0034652687 scopus 로고    scopus 로고
    • MLV-derived retroviral vectors selective for CD4-expressing cells and resistant to neutralization by sera from HIV-infected patients
    • (2000) Virology , vol.267 , pp. 229-236
    • Stitz, J.1
  • 44
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1
  • 45
    • 0028871397 scopus 로고
    • Activation of virus replication after vaccination of HIV-1-infected individuals
    • (1995) J Exp Med , vol.182 , pp. 1727-1737
    • Staprans, S.I.1
  • 48
    • 0035050963 scopus 로고    scopus 로고
    • Generation of HIV latency during thymopoiesis
    • (2001) Nat Med , vol.7 , pp. 459-464
    • Brooks, D.G.1
  • 51
    • 0032472840 scopus 로고    scopus 로고
    • + T helper type 1 cell responses to Candida albicans
    • (1998) J Exp Med , vol.187 , pp. 307-317
    • Mencacci, A.1
  • 53
    • 0032103038 scopus 로고    scopus 로고
    • + T cell response depending on the route of immunization
    • (1998) J Immunol , vol.160 , pp. 5522-5529
    • Bour, H.1
  • 55
    • 0030665257 scopus 로고    scopus 로고
    • + T cell responses associated with control of viremia
    • (1997) Science , vol.278 , pp. 1447-1450
    • Rosenberg, E.S.1
  • 57
    • 0028041344 scopus 로고
    • Virus-specific CD8 cytotoxic T lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • (1994) J Virol , vol.68 , pp. 6103-6110
    • Borrow, P.1
  • 58
    • 0030831656 scopus 로고    scopus 로고
    • Cytotoxic T-cell responses, viral load, and disease progression in early human immundeficiency virus type 1 infection
    • (1997) N Engl J Med , vol.337 , pp. 1267-1274
    • Musey, L.1
  • 60
    • 0029924619 scopus 로고    scopus 로고
    • Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes
    • (1996) Nat Med , vol.2 , pp. 551-555
    • Heslop, H.E.1
  • 61
    • 0032973455 scopus 로고    scopus 로고
    • In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
    • (1999) Nat Med , vol.5 , pp. 34-41
    • Brodie, S.J.1
  • 62
    • 16944367032 scopus 로고    scopus 로고
    • + T-cell repertoire that are not immediately restored by antiviral or immune-based therapies
    • (1997) Nat Med , vol.3 , pp. 533-540
    • Connors, M.1
  • 63
    • 0032970758 scopus 로고    scopus 로고
    • Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy
    • (1999) AIDS , vol.13 , pp. 185-194
    • Martinon, F.1
  • 64
    • 0031907427 scopus 로고    scopus 로고
    • Perturbation of CD4 and CD8 T cell repertoires during progression to AIDS and regulation of CD4 repertoire during antiretroviral therapy
    • (1998) Nat Med , vol.4 , pp. 215-220
    • Gorochov, G.1
  • 65
    • 0031849216 scopus 로고    scopus 로고
    • + T-cell regeneration in HIV-infected adults
    • (1998) Nat Med , vol.4 , pp. 852-856
    • Walker, R.E.1
  • 66
    • 0029054356 scopus 로고
    • + T lymphocyte lines from HIV-1 seropositive patients
    • (1995) J Infect Dis , vol.171 , pp. 1420-1430
    • Ratto, S.1
  • 67
    • 17344370006 scopus 로고    scopus 로고
    • Recognition of antigenic clusters of Candida albicans by T lymphocytes from human immunodeficiency virus-infected persons
    • (1998) J Infect Dis , vol.178 , pp. 488-496
    • Kunkl, A.1
  • 68
    • 0029060189 scopus 로고
    • Ex vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents
    • (1995) J Infect Dis , vol.172 , pp. 88-96
    • Wilson, C.C.1
  • 69
    • 0029887654 scopus 로고    scopus 로고
    • A new antisense tRNA construct for the genetic treatment of human immunodeficiency virus type 1 infection
    • (1996) J Virol , vol.70 , pp. 2154-2161
    • Biasolo, M.A.1
  • 70
    • 0030864267 scopus 로고    scopus 로고
    • Anti-HIV genetic treatment of antigen-specific human CD4 lymphocytes for adoptive immunotherapy of opportunistic infections in AIDS
    • (1997) Gene Therapy , vol.4 , pp. 1216-1224
    • Manca, F.1
  • 71
    • 0033053628 scopus 로고    scopus 로고
    • Rational reconstitution of the immune repertoire in AIDS with autologous, antigen-specific, in vitro-expanded CD4 lymphocytes
    • (1999) Immunol Lett , vol.66 , pp. 117-120
    • Manca, F.1
  • 72
    • 0028609662 scopus 로고
    • Consequences of stable transduction and antigen-inducible expression of the human interleukin-7 gene on tetanus-toxoid-specific T cells
    • (1994) Hum Gene Ther , vol.5 , pp. 1457-1466
    • Kim, J.H.1
  • 73
    • 0000575705 scopus 로고    scopus 로고
    • + cells transfected with IL-16 cDNA are resistant to HIV-1 infection: Inhibition of mRNA expression
    • (1997) Nat Med , vol.3 , pp. 659-664
    • Zhou, P.1
  • 74
    • 0030881882 scopus 로고    scopus 로고
    • Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11567-11572
    • Yang, A.G.1
  • 75
    • 0035019084 scopus 로고    scopus 로고
    • Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy
    • (2001) Eur J Immunol , vol.31 , pp. 1351-1360
    • Kovacs, J.A.1
  • 77
    • 0032550755 scopus 로고    scopus 로고
    • + cells by transdominant negative Rev-expressing retrovirus yields partial anti-HIV protection of progeny macrophages
    • (1998) Hum Gene Ther , vol.9 , pp. 1197-1207
    • Davis, B.R.1
  • 79
    • 0030854210 scopus 로고    scopus 로고
    • Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients
    • (1997) Blood , vol.90 , pp. 2196-2206
    • Lieberman, J.1
  • 80
    • 0033105536 scopus 로고    scopus 로고
    • Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
    • (1999) Blood , vol.93 , pp. 1506-1510
    • Tan, R.1
  • 81
    • 0028969816 scopus 로고
    • Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
    • (1995) Nat Med , vol.1 , pp. 330-336
    • Koenig, S.1
  • 82
    • 13344261952 scopus 로고    scopus 로고
    • T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
    • (1996) Nat Med , vol.2 , pp. 216-223
    • Riddell, S.R.1
  • 84
    • 0035077083 scopus 로고    scopus 로고
    • +) T cell expansions: Evidence for impaired CTL effector function
    • (2001) Eur J Immunol , vol.31 , pp. 677-686
    • Kostense, S.1
  • 85
    • 0028079896 scopus 로고
    • + T lymphocytes armed with universal T-cell receptors
    • (1994) Blood , vol.84 , pp. 2878-2889
    • Roberts, M.R.1
  • 86
    • 0030881697 scopus 로고    scopus 로고
    • Lysis of HIV-1 infected cells and inhibition of viral replication by universal receptor T cells
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11478-11483
    • Yang, O.O.1
  • 87
    • 0026083035 scopus 로고
    • Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
    • (1991) Cell , vol.64 , pp. 1037-1046
    • Romeo, C.1    Seed, B.2
  • 93
    • 0032032602 scopus 로고    scopus 로고
    • + T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat
    • (1998) Hum Gene Ther , vol.9 , pp. 487-496
    • Poznansky, M.C.1
  • 94
    • 16044372353 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
    • (1996) Nat Med , vol.2 , pp. 893-898
    • Huygen, K.1
  • 95
    • 0029012966 scopus 로고
    • + T cells can discriminate the molecular and structural context of T epitopes of HIV gp120 and HIV p66
    • (1995) J AIDS , vol.9 , pp. 227-237
    • Manca, F.1
  • 96
    • 0031942691 scopus 로고    scopus 로고
    • + T cells specific for HIV gp120 and p66 (primary antigens) or for PPD and tetanus toxoid (secondary antigens)
    • (1998) Hum Immunol , vol.59 , pp. 137-148
    • Li Pira, G.1
  • 97
    • 0028914941 scopus 로고
    • + T-cell lines from HTLV-1 seronegative individuals: Specificity and clonal heterogeneity
    • (1995) Blood , vol.85 , pp. 1547-1554
    • Manca, F.1
  • 99
    • 0028820386 scopus 로고
    • Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
    • (1995) N Engl J Med , vol.333 , pp. 1038-1044
    • Walter, E.A.1
  • 100
    • 0027409668 scopus 로고
    • + T lymphocytes in patients with acquired immunodeficiency syndrome (AIDS)-related complex or AIDS
    • (1993) Blood , vol.81 , pp. 2093-2101
    • Ho, M.1
  • 101
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and in HIV-1 infected humans
    • (1999) Nat Med , vol.5 , pp. 83-89
    • Hellerstein, M.1
  • 102
    • 0030891988 scopus 로고    scopus 로고
    • + T cell frequencies by flow-cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
    • (1997) J Clin Invest , vol.99 , pp. 1739-1750
    • Waldrop, S.L.1
  • 103
    • 7144227284 scopus 로고    scopus 로고
    • Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
    • (1998) Science , vol.279 , pp. 2103-2106
    • Ogg, G.S.1


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