Generation of HIV latency during thymopoiesis

Nature Medicine

Volumn 7, Issue 4, 2001, Pages 459-464

  Brooks, David G ^a   Kitchen, Scott G ^a   Kitchen, Christina M R ^b   Scripture Adams, Deirdre D ^a   Zack, Jerome A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; LATENT PERIOD; LATENT VIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; THYMUS; VIREMIA; VIRUS GENOME; VIRUS REACTIVATION; VIRUS REPLICATION;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CYTOKINES; DISEASE MODELS, ANIMAL; DNA PRIMERS; DNA, VIRAL; GENE EXPRESSION; HIV; HIV INFECTIONS; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, SCID; PROVIRUSES; RNA, VIRAL; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0035050963     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/86531     Document Type: Article

References (35)

1. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
2. Viral dynamics in human immunodeficiency virus type 1 infection
3. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
4. Identification of a reservoir for HIV-1 in patients on highly active anti-retroviral therapy
5. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
6. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
7. + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
8. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
9. A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children
10. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
11. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
12. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy
13. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
14. Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection
15. In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
16. Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1
17. CXCR4 expression during lymphopoiesis: Implications for human immunodeficiency virus type 1 infection of the thymus
18. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation
19. Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: Coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level
20. Thymic abnormalities in fetuses aborted from human immunodeficiency virus type 1 seropositive women
21. The SCID-hu mouse as a model for HIV-1 infection
22. HIV induces thymus depletion in vivo
23. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse
24. Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1
25. In vivo pathogenesis of a human immunodeficiency virus type 1 reporter virus
26. Nonproductive human immunodeficiency virus type 1 infection in nucleoside-treated G0 lymphocytes
27. In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates
28. Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle
29. - T cells using a combination of cytokines
30. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Edinburgh Heterosexual Transmission Study Group
31. - T cells
32. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes
33. Detection of cell cycle subcompartments by flow cytometric estimation of DNA-RNA content in combination with dual-color immunofluorescence
34. Dilution assay statistics
35. Analysis of rev gene function on human immunodeficiency virus type 1 replication in lymphoid cells by using a quantitative polymerase chain reaction method