Gene therapy targeting peripheral blood CD34+ hematopoietic stem cells of HIV-infected individuals

Human Gene Therapy

Volumn 8, Issue 18, 1997, Pages 2229-2238

  Gervaix, A ^a   Schwarz, L ^a   Law, P ^a   Ho, A D ^a   Looney, D ^a   Lane, T ^a   Wong Staal, F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; RIBOZYME;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENETIC ENGINEERING; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKAPHERESIS; MACROPHAGE; MALE; POLYMERASE CHAIN REACTION; TRANSGENE; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES;

EID: 0031564333     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.18-2229     Document Type: Article

References (6)

1. ABOULAFIA, D., MITSUYASU, R., and MILES, S. (1991). Bone marrow transplantation in an HIV positive thalassemic child following therapy with azidothymidine. Haematologica 75, 285-287.
2. BAUER, G., VALDEZ, P., KEARNS, K., BAHNER, I., WEN, S.F., ZAIA, J.A., and KOHN, D.D. (1997). Inhibition of human immuno-deficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34+ cells from HIV-1-infected donors using retroviral vectors containing anti-HIV-1 genes. Blood 89, 2259-2267.
3. BENDER, J., TO, L.B., WILLIAMS, S., and SCHWARTZBERG, L. (1992). Defining a therapeutic dose of peripheral blood stem cells. J. Hematother. 1, 329-335.
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5. BORDIGNON, C., NOTARANGELO, L.D., NOBILI, N., FERRARI, G., CASORATI, G., PANINA, P., MAZZOLARI, E., MAGGIONI, D., ROSSI, C., SERVIDA, P., UGAZIO, A.G., and MAVILIO, F. (1995). Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science 270, 470-475.
6. CHOMCZYNSKI, P., and SACCHI, N. (1987). Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Ann. Biochem. 162, 156-159.