A new antisense tRNA construct for the genetic treatment of human immunodeficiency virus type 1 infection

Journal of Virology

Volumn 70, Issue 4, 1996, Pages 2154-2161

  Biasolo, Maria Angela ^a   Radaelli, Antonia ^b   Pup, Laura Del ^a   Franchin, Elisa ^a   De Giuli Morghen, Carlo ^b   Palú, Giorgio ^a,c  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Institute of Microbiology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; TRANSFER RNA; VIRUS VECTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTICODON; ARTICLE; BASE PAIRING; GENE EXPRESSION; GENE THERAPY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TARGET CELL;

EID: 0029887654     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.4.2154-2161.1996     Document Type: Article

References (58)

1. Agostini, C., R. Zambello, L. Trentin, A. Cerutti, C. Entammer, M. Faeco, A. Milani, R. Sancetta, S. Garbisa, and G. Semenzato. 1995. Expression of TNF receptor by T cells and membrane TNF-a by alveolar macrophages suggests a role for TNF-a in the regulation of the local immune responses in the lung of HIV-1-infected patients. J. Immunol. 155:2928-2938
2. Agrawal, S. 1992. Antisense oligonucleotides as antiviral agents Trends Biotechnol. 10:152-158.
3. Anderson, W. F. 1992. Human gene therapy. Science 256:808-813.
4. Baltimore, D. 1988. Intracellular immunization. Nature (London) 335:395-396.
5. Bevec, D., B. Volc-Platzner, K. Zimmermann, M. Dobrovnik, J. Hauber, G. Veres, and E. Böhnlein. 1994. Constitutive expression of chimeric neo-Rev response clement transcripts suppresses HIV-1 replication in human CD4+ lymphocytes. Hum. Gene Ther. 5:193-201.
6. Bozzini, R., C. Rossi, M. P. Grossi, P. C. Marconi, P. G. Balboni, G. Barbanti-Brodano, and A. Caputo. 1995. Effect of tat transdominant negative mutants on HIV-1 replication in Jurkat T cell lines. Minerva Biotecnol. 7:156-161.
7. Buchschacher, G. L. 1993. Molecular targets of gene transfer therapy for HIV infection. JAMA 269:2880-2886.
8. Ciampi, M. S., D. A. Melton, and R. Cortese. 1982. Site-directed mutagenesis of a tRNA gene, base alterations in the coding region affect transcription. Proc Natl Acad. Sci. USA 79:1388-1392
9. pro gene is composed of three noncontiguous reaions. Proc. Natl. Acad. Sci USA 79:1195-1199.
10. Cotten, M., and M. L. Birnstiel. 1989 Ribozyme mediated destruction of RNA in vivo. EMBO J. 8:3861-3866.
11. Crisell, P., S. Thompson, and W. James. 1993. Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro. Nucleic Acids Res. 21:5251-5255.
12. Cullen, B. R. 1990 The HIV-1 tat protein: an RNA sequence-specific processivity factor? Cell 63:655-657
13. Elangovan, B., T. Subramanian, and G. Chinnadurai. 1992. Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation. J. Virol. 66:2031-2036.
14. Gabrielsen, O. S., and A. Sentenac. 1992. RNA polymerase III (C) and its transcription factors. Trends Biochem. Sci. 16:412-416
15. Gait, M. J., and J. Karn. 1993. RNA recognition by the human immunodeficiency virus Tat and Rev proteins Trends Biochem Sci. 18:255-259
16. Galli, G., H. Hofstetter, and M. L. Birnstiel. 1981. Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements. Nature (London) 294:626-631.
17. Goodchild, J., S. Agrawal, M. P. Civeira, P. S. Sarin, D. Sun, and P. C. Zamecnik. 1988. Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides. Proc Natl. Acad. Sci. USA 85:5507-5551.
18. Gyotoku, J. I., M. A. El-Farrash, and S. Fujimoto. 1991. Inhibition of human immunodeficiency virus replication in human T cell line by antisense RNA expressed in the cells. Virus Genes 5:189-202.
19. Haseloff, J., and L. Gerlach. 1988. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature (London) 334:585-591.
20. Haseltine, W. A. 1991. Molecular biology of the human immunodeficiency virus type 1. FASEB J. 5:2349-2360.
21. Homann, M., K. Rittner, and G. Sczakiel. 1993 Complementary large loops determine the rate of RNA duplex formation in vitro in the case of an effective antisense RNA directed against the human immunodeficiency virus type 1. J. Mol. Biol. 233:7-15.
22. Joshi, S., A. Van Brunschot, S. Asad, I. Van Der Elst, S. E. Read, and A. Bernstein. 1991. Inhibition of human immunodeficiency virus type 1 multiplication by antisense and sense RNA expression. J. Virol. 65:5524-5530
23. Junker, U., K. Rittner, M. Homann, D. Bevec, E. Bohnlein, and G. Sczakiel. 1994. Reduction in replication of the human immunodeficiency virus type 1 in human T cell lines by polymerase III-driven transcription of chimeric tRNA-antisense RNA genes. Antisense Res Dev. 4:165-172
24. Lamb, J. W., and R. T. Hay. 1990. Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes. J. Gen. Virol. 71:2257-2264.
25. Leavitt, M. C., M. Yu, O. Yamada, G. Kraus, D. Looney, E. Poeschla, and F. Wong-Staal. 1994. Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes. Hum. Gene Ther. 5:1115-1120.
26. Lisziewicz, J., D. Sun, B. Trapnell, M. Thomson, H. K. Chang, B. Ensoli, and B. Peng. 1995 An autoregulated dual-function antitat gene for human immunodeficiency virus type 1 gene therapy. J. Virol. 69:206-212.
27. Lo, K. M. S., M. A. Biasolo, G. Dehni, G. Palù, and W. A. Haseltine. 1992 Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA. Virology 190:176-183.
28. Marciniak, R. A., B. J. Calnan, A. D. Frankel, and P. A. Sharp. 1990. HIV-1 Tat protein trans-activates transcription in vitro. Cell 63:791-802.
29. Miller, A. D. 1992. Human gene therapy comes of age. Nature (London) 357:455-460.
30. Miller, A. D., and C. Battimore. 1986. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol. Cell. Biol 6:2895-2902.
31. Moffat, A.S. 1991. Making sense of antisense. Res. News Sci. 253:510-511.
32. Morsy, M. A., K. Mitani, P. Clemens, and T. Caskey. 1993. Proaress toward human gene therapy. JAMA 270:2338-2345
33. Ojwang, J. O., A. Hampel, D. J. Looney, F. Wong-Staal, and J. Rappaport, 1992. Inhibition of human immunodeficiency virus type 1 expression by hairpin ribozyme. Proc. Natl. Acad Sci. USA 89:10802-10806.
34. Pieken, W. A., D. B. Olsen, F. Benseler, H. Aurup, and F. Eckstein. 1991. Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes Science 253:314-317.
35. Ratner, L., W. A. Haseltine, R. Patarea, K. J. Livak, B. Starcich, S. F. Josephs, E. R. Doran, J. A. Rafalski, E. A. Whitehorn, K. Saumeister, L. Ivanoff, S. R. Petteway, Jr., M. L. Pearson, J. A. Lautenberger, T. S. Papas, J. Ghrayeb, N. T. Chang, R. C. Gallo, and F. Wong-Staal. 1985. Complete nucleotide sequence of the AIDS virus, HTLV III. Nature (London) 313:271-284.
36. Rho, H. M., B. Poiesz, F. Ruscetti, and R. C. Gallo. 1981. Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology 112:355-360.
37. Rhodes, A., and W. James. 1990. Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA. J. Gen Virol. 71:1965-1974.
38. Rhodes, A., and W. James. 1991. Inhibition of heterologous strain of HIV antisense RNA. AIDS 5:145-151
39. Rittner, K., C. Burmester, and G. Sczakiel. 1993. In vitro selection of fast-hybridizing and antisense RNAs directed against the human immunodeficiency virus type 1. Nucleic Acids Res. 21:1381-1387
40. Rossi, G. P., G. Albertin, A. Belloni, L. Zanin, M. A. Biasolo, T. Prayer-Galletti, M. Bader, G. G. Nussdorfer, G. Palù, and A. C. Pessina. 1994. Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex. J. Clin. Invest. 94:1226-1234.
41. Rossi, J. J., D. Elkins, and S. Sullivan. 1992. Ribozymes as anti-HIV-1 therapeutic agents: principles, application, and problems. AIDS Res. Hum. Retroviruses 8:183-189.
42. Ruben, S., A. Perkins, R. Purcell, K. Joung, R. Sia, R. Burghoff. W. A. Haseltine, and C. A. Rosen. 1989. Structural and functional characterization of human immunodeficiency virus tat protein. J. Virol. 63:1-8.
43. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y
44. Scatchard, G. 1949. The attractions of proteins for small molecules and ions Ann N. Y. Acad. Sci. 51:660-672.
45. Sczakiel, G., M. Oppenlander, K. Rittner, and M. Pawlita. 1992. Tat- and Rev-directed antisense RNA expression inhibits and abolishes replication of human immunodeficiency virus type 1: a temporal analysis. J. Virol. 66:5576-5581.
46. Sczakiel, G., and M. Pawlita. 1991. Inhibition of human immunodeficiency virus type 1 replication in human T cells expressing antisense RNA J. Virol. 65:468-472.
47. Stein, C. A., and Y. C. Cheng, 1993. Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science 261:1004-1012.
48. Stephenson, M. L., and P. C. Zamecnik. 1978 Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl. Acad Sci USA 75:285-288
49. Tomizawa, J. 1984. Control of ColE1 plasmid replication: the process of binding of RNA I to the primer transcript. Cell 38:861-870.
50. Trapnell, B. C. 1993. Quantitative evaluation of gene expression in freshly isolated human respiratory epithelial cells. Am J. Physiol. 264:L199-L212.
51. + lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme. J Virol. 65:5531-5534.
52. Wickstrom, E. 1992. Strategies for administering targeted therapeutic oligodeoxynucleotides. Trends Biotechnol. 10:281-287.
53. Yamada, O., G. Kraus, M. C. Leavitt, M. Yu, and F. Wong-Staal. 1994 Activity and cleavage site specificity of an anti-HIV-1 hairpin ribozyme in human T cells. Virology 205:121-126.
54. Yamada, O., M. Yu, J.-K. Yee, G. Kraus. D. Looney, and F. Wong-Staal. 1994. Intracellular immunization of human T-cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Ther. 1:38-45.
55. Yu, M., J. Ojwang, O. Yamada, A. Hampel, J. Rappaport, D. Looney, and F. Wong-Staal. 1993 A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90:6340-6344
56. Yu, M., E. Peschla, O. Yamada, P. Degrandis, M. C. Leavitt, M. Heusch, J.-K. Yees, F. Wong-Staal, and A. Hampel. 1995. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology 206:381-386.
57. Zamecnik, P. C., and M. L. Stephenson. 1978 Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad Sci. USA 75:230-284.
58. Zuker, M., and P. Stiegler. 1981. Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. Nucleic Acids Res 9:133-148.