T cell proliferation and apoptosis in HIV-1-infected lymphoid tissue: Impact of highly active antiretroviral therapy

Clinical Immunology

Volumn 101, Issue 2, 2001, Pages 180-191

  Dyrhol Riise, Anne Ma ^a   Ohlsson, Maria ^a   Skarstein, Kathrine ^a   Nygaard, Svein J T ^a   Olofsson, Jan ^b   Jonsson, Roland ^a   Åsjö, Birgitta ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

CD4; CD8; HAART; HIV 1; Immune activation; Ki67; Lymphoid; Therapy; Tonsils; TUNEL; Turnover

Indexed keywords

ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; CD4 ANTIGEN; INDINAVIR; LAMIVUDINE; VIRUS RNA; ZIDOVUDINE;

APOPTOSIS; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TONSIL; VIRUS INFECTION;

EID: 0035178906     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2001.5102     Document Type: Article

References (70)

1. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
2. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
3. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques
4. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen
5. The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation: The impact of highly active antiretroviral therapy
6. + T cell repopulation of lymphoid tissues after treatment of HIV-1 infection
7. +T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy
8. + lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle
9. - T-cell activation in HIV infection is antigenic stimulation
10. Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
11. + T-cell pool during HIV-1 infection and triple combination therapy
12. - T cell turnover
13. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
14. + patients
15. Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection
16. + cells in blood and tonsillar tissue after highly active antiretroviral therapy in early HIV type-1 infection
17. T lymphocyte subset changes in human immunodeficiency virus infection
18. + T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis
19. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: The role of apoptosis in T cell memory
20. Anti-apoptotic strategies of lymphotropic viruses
21. Immunopathogenesis of HIV infection
22. Programmed death of T cells in HIV-1 infection
23. + lymphocyte depletion and human immunodeficiency virus replication
24. + T cells from human immunodeficiency virus-infected asymptomatic individuals
25. Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression
26. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
27. Analysis of apoptosis in lymph nodes of HIV-infected persons: Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden
28. + T-cells in tonsillar tissue in HIV type 1 infection
29. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
30. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection
31. Apoptosis and the CD95 system in HIV disease: Impact of highly active anti-retroviral therapy (HAART)
32. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis
33. In vivo analysis of Fas/FasL interactions in HIV-infected patients
34. The Fas death factor
35. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
36. Activation of CD8 T cells normalizes and correlates with the level of infectious provirus in tonsils during highly active antiretroviral therapy in early HIV-1 infection
37. Residual human immunodeficiency virus type 1 infection in lymphoid tissue during highly active antiretroviral therapy: Quantitation and virus characterization
38. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
39. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
40. Fas-induced apoptosis is a rare event in Sjogren's syndrome
41. Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA
42. Comparison of seven quantitative assays to assess lymphocyte cell death during HIV infection: Measurement of induced apoptosis in anti-Fas-treated Jurkat cells and spontaneous apoptosis in peripheral blood mononuclear cells from children infected with HIV
43. Measurement of T-cell kinetics: Recent methodologic advances
44. Early activation and proliferation of T cells in simian immunodeficiency virus-infected rhesus monkeys
45. + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
46. + T cells
47. T-cell-mediated immunopathology versus direct cytolysis by virus: Implications for HIV and AIDS
48. A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: Induction of lymph node homing and apoptosis upon secondary signaling through homing receptors
49. Autocrine feedback death and the regulation of mature T lymphocyte antigen responses
50. In vivo estimates of division and death rates of human T lymphocytes
51. + T cell responses associated with control of viremia
52. Normal CD4 T-cell receptor repertoire in tonsillar tissue despite perturbed repertoire in peripheral blood in HIV-1 infected individuals
53. T-cell dynamics of immunodeficiency
54. Changes in thymic function with age and during the treatment of HIV infection
55. Immunohistopathology of lymph nodes in HTLV-III infected homosexuals with persistent adenopathy or AIDS
56. + T-cells in lymphoid tissues of HIV-1-infected individuals in the absence of the high-affinity IL-2 receptor
57. - T cell subsets in HIV type 1-infected individuals
58. Programmed death of T cells in HIV infection: Result of immune activation?
59. A new look at T cells
60. + T cells during the primary immune response to Epstein-Barr virus in vivo
61. + T lymphocytes with changes in viral load: The RESTIM and COMET Study Groups
62. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
63. HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death
64. HIV-specific effector cytotoxic T lymphocytes and HIV-producing cells colocalize in white pulps and germinal centers from infected patients
65. + T cell subsets during acute Epstein-Barr and human immunodeficiency virus infections in humans
66. Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load
67. - T cell clones during primary HIV infection
68. Telomeres, telomerase and cancer
69. Patterns of T lymphocyte changes with human immunodeficiency virus infection: From seroconversion to the development of AIDS
70. The Fas/FasL system and T cell apoptosis in HIV-1-infected lymphoid tissue during highly active antiretroviral therapy