In vivo analysis of Fas/FasL interactions in HIV-infected patients

Journal of Clinical Investigation

Volumn 102, Issue 1, 1998, Pages 79-87

  Badley, Andrew D ^a,b,h   Dockrell, David H ^b   Algeciras, Alicia ^a   Ziesmer, Steve ^b   Landay, Alan ^c   Lederman, Michael M ^d   Connick, Elizabeth ^e   Kessler, Harold ^c   Kuritzkes, Daniel ^e   Lynch, David H ^f   Roche, Patrick ^b   Yagita, Hideo ^g   Paya, Carlos V ^a,b,d  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f AMGEN INC   (United States)

^g JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Apoptosis; CD4 T cells; FasL; Highly active retroviral therapy; HIV

Indexed keywords

APOPTOSIS; ARTICLE; CELL DEATH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VIVO STUDY; LYMPHOCYTE FUNCTION; LYMPHOID TISSUE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; VIRUS LOAD; VIRUS REPLICATION;

EID: 0032128437     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2691     Document Type: Article

References (42)

1. Perelson, A.S., A.U. Neumann, M. Markowitz, J.M. Leonard, and D.D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science. 271:1582-1586.
2. Badley, A.D., D.H. Dockrell, and C.V. Paya. 1997. Apoptosis in AIDS. In Apoptosis Pharmacological Implications and Therapeutic Opportunities. S.H. Kaufmann, editor. Academic Press, San Diego, CA. 41:271-289.
3. Dhein, J., H. Walczak, C. Baumler, K.-M. Debatin, and P.H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/Fas (CD95). Nature. 373: 438-441.
4. Brunner, T., R.J. Mogil, D. LaFace, N.J. Yoo, A. Mahboubi, F. Echeverri, S.J. Martin, W.R. Force, D.H. Lynch, C.F. Ware, and D.R. Green. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature. 373:441-444.
5. Alderson, R., T.W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K.A. Schooley, R.G. Goodwin, C.A. Smith, F. Ramdsdell, and D.H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71-77.
6. Sytwu, K., R.S. Liblau, and H.O. McDevitt. 1996. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity. 5:17-30.
7. Zheng, L., G. Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature. 377:348-351.
8. Boise, L.H., and C.B. Thompson. 1995. Hierarchical control of lymphocyte survival. Science. 274:67-68.
9. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331-340.
10. Meyaard, L., S.A. Otto, R.R. Jonker, M.J. Mijnster, R.P. Keet, and F. Miedema. 1992. Programmed death of T cells in HIV-1 infection. Science. 257: 217-219.
11. Oyaizu, N., T.W. McCloskey, M. Coronesi, N. Chirmule, V.S. Kalyanaraman, and S. Pahwa. 1993. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood. 82: 3392-3400.
12. Katsikis, P.D., E.S. Wunderlich, C.A. Smith, L.A. Herzenberg, and L.A. Herzenberg. 1995. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J. Exp. Med. 181:2029-2036.
13. + T lymphocyte activation in HIV infaction. Implications for immune pathogenesis and therapy. Adv. Exp. Med. Biol. 374:1-15.
14. + T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines. Proc. Natl. Acad. Sci. 93:14076-14081.
15. Lederman, M., E. Connick, A. Landay, H. Kessler, D. Kuritzkes, M. St. Clair, L. Fox, M. Heath-Chiozzi, F. Rousseau, and J. Spritzler. 1997. Partial immune reconstitution after 12 weeks of HAART (AZT, 3TC, Ritonavir) preliminary results of ACTG 315. 4th Conference on Retroviruses and Opportunistic Infections, Jan 22-26. Washington, D.C. (Abstr. LB13.)
16. Kayagaki, N., A. Kawasaki, T. Ebata, H. Ohmoto, S. Ikeda, S. Inoue, K. Yoshino, K. Okurmura, and H. Yagita. 1995. Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182:1777-1783.
17. + T lymphocytes from HIV-infected individuals mediated by FasL and tumor necrosis factor. J. Exp. Med. 185:55-64.
18. Dockrell, D.H., A.D. Badley, C.J. Heppelmann, S. Ziesmer, H. Yagita, D.H. Lynch, P.C. Roche, P.J. Leibson, and C.V. Paya. 1998. The expression of Fas ligand by differentiated macrophages and its upregulation by HIV infection. J. Clin. Invest. 101:2394-2405.
19. Kelleher, A., A. Carr, J. Zaunders, and D.A. Cooper. 1996. Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J. Infect. Dis. 173:321-329.
20. + T cells. Proc. Natl. Acad. Sci. 93:11014-11018.
21. Badley, A.D., J.A. McElhinny, P.J. Leibson, D.H. Lynch, M.R. Alderson, and C.V. Paya. 1996. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J. Virol. 70:199-206.
22. Laurent-Crawford, A.G., B. Krust, Y. Riviére, C. Desgranges, S. Muller, M.P. Kieny, C. Dauguet, A.G. Hovanessian. 1993. Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res. Hum. Retroviruses. 9:761-763.
23. Yang, Y., J. Bailey, M.S. Vacchio, R. Yarchoan, and J.D. Ashwell. 1995. Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells. Proc. Natl. Acad. Sci. 92:3051-3055.
24. Muro-Cacho, C.A., G. Pantaleo, and A.S. Fauci. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J. Immunol. 154:5555-5566.
25. Gougeon, M.L., S. Garcia, J. Heeney, R. Tschopp, H. Lecoeur, D. Guetard., V. Rame, C. Dauguet, and L. Montagnier. 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retroviruses. 9:553-563.
26. + donors by cysteine protease inhibitors. J. Immunol. 143:862.
27. Gougeon, M.-L., H. Lecour, A. Dulioust, M.-G. Enouf, M. Crouvoisier, C. Goujard, T. Debord, and L. Montagnier. 1996. Programmed cell death in peripheral lymphocytes from HIV-infected persons. J. Immunol. 156:3509-3520.
28. Estaquier, J., T. Idzoiorek, F. de Bels, F. Barré-Sinoussi, B. Hurtrel, A.M. Aubertin, A. Venet, M. Mehtali, E. Muchmore, P. Michel, Y. Mouton, M. Girard, and J.C. Ameisen. 1994. Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections. Proc. Natl. Acad Sci. 91:9431-9435.
29. Margolick, J.B., A. Munoz, A.D. Donnenberg, L.P. Park, N. Galai, J.V. Giorgi, M.R. O'Gorman, and J. Ferbas. 1995. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study. Nat. Med. 1:674-680.
30. Su, L., H. Kaneshima, M. Bonyhadi, S. Salimi, D. Kraft, L. Rabin, and J.M. McCune. 1995. HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity. 2:25-36.
31. + T cell turnover. Science. 274:1543-1547.
32. Lifson, J.D., G.R. Reyes, M.S. McGrath, B.S. Stein, and E.G. Engleman. 1986. AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science. 232:1123-1127.
33. Nixon, D.F., A.R. Townsend, J.G. Elvin, C.R. Rizza, J. Gallwey, and A.J. McMichael. 1988. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature. 336:484-487.
34. Haase, AT., K. Henry, M. Zupancic, G. Sedgewick, R.A. Faust, H. Melroe, W. Cavert, K. Gebhard, K. Staskus, Z.Q. Zhang, et al. 1996. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science. 274:985-989.
35. Walker, B.D., S. Chakrabarti, B. Moss, T.J. Paradis, T. Flynn, A.G. Durno, R.S. Blumberg, J.C. Kaplan, M.S. Hirsch, and R.T. Schooley. 1987. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature. 328: 345-348.
36. + T cell homeostasis and function in advanced HIV disease. Science. 277:112-116.
37. Embretson, J., M. Zupancic, J.L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, A.T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature. 362:359-362.
38. Chun, T.-W., L. Carruth, D. Finzi, X. Shen, J.A. DiGiuseppe, H. Taylor, M. Hermankova, K. Chadwick, J. Margolick, T.C. Quinn, Y.-H. Kuo, R. Brookmeyer, M.A. Zeiger, P. Barditch-Crovo, and R.F. Siliciano. 1997. Nature. 387: 183-188.
39. Cavert, W., S.D.W. Notermans, K. Staskus, S.W. Wietgrefe, M. Zupancic, K. Gebhard, K. Henry, Z.-Q. Zhang, R. Mills, H. McDade, J. Goudsmit, S.A. Danner. and A.T. Haase. 1997. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science. 276:960-964.
40. Pantaleo, G. 1997. How immune-based interventions can change HIV therapy. Nat. Med. 3:483-486.
41. Wong, J.K., M. Hezareh, H.F. Günthard, D.V. Havlir, C.C. Ignacio. C.A. Spina, and D.D. Richman. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 278:1291-1295.
42. Finzi, D., M. Hermankova, T. Pierson, L.M. Carruth, C. Buck, R.E. Chaisson, T.C. Quinn, K. Chadwick, J. Margolick, R. Brookmeyer, et al. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 278:1295-1300.