A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: Induction of lymph node homing and apoptosis upon secondary signaling through homing receptors

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 268-276

  Wang, Liqiang ^a   Chen, Jenny J Y ^a   Gelman, Benjamin B ^a   Konig, Rolf ^a   Cloyd, Miles W ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; HERMES ANTIGEN; HOMING RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PADGEM PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LYMPHOCYTE DEPLETION; LYMPHOCYTE HOMING; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD44; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; HIV-1; HUMANS; INTERPHASE; L-SELECTIN; LYMPH NODES; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOCYTE SUBSETS; MICE; MICE, SCID; RECEPTORS, LYMPHOCYTE HOMING; SIGNAL TRANSDUCTION;

EID: 0032909114     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Bagnarelli, P., S. Menzo, A. Valenza, A. Manzin, M. Giaca, F. Ancarani, G. Scalise, P. E. Varaldo, and M. Clemente. 1992. Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS. J. Virol. 66:7328.
2. Gupta, P., J. Kingsley, J. Armstrong, M. Ding, M. Cottrill, and C. Rinaldo. 1993. Enhanced expression of human immunodeficiency virus type 1 correlates with development of AIDS. Virology 196:586.
3. Furtado, M. R., R. Murphy, J. Armstrong, M. Ding, M. Cottrill, and C. Rinaldo. 1993. Quantification of human immunodeficiency virus type 1 tat mRNA as a marker for assessing the efficacy of antiretroviral therapy. J. Infect. Dis. 167:213.
4. Bagnarelli, P., A. Valenza, S. Menzo, A. Manzin, G. Scalise, P. E. Varaldo, and M. Clementi. 1994. Dynamics of molecular parameters of human immunodeficiency virus type 1 activity in vivo. J. Virol. 68:2495.
5. Janossy, G., A. J. Pinching, M. Bofill, J. Weber, J. E. McLaughlin, M. Ornstein, K. Ivory, J. R. Harris, M. Favrot, and D. C. Macdonald-Burns. 1985. An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS. Clin. Exp. Immunol. 59:257.
6. + lymphocyte population in the blood of SIV-infected macaques is not reflected in lymph nodes. AIDS Res. Hum. Retroviruses 9:639.
7. Wang, L., C. W. Robb, and M. W. Cloyd. 1997. HIV induces homing of resting T lymphocytes to lymph nodes. Virology 228:141.
8. Embertson, J., M. Zupancic, J. Beneke, M. Till, S. Wolinsky, J. L. Ribas, A. Burke, and A. T. Haase. 1993. Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infection at single-cell resolution. Proc. Natl. Acad. Sci. USA 90:357.
9. Pantaleo, G., C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355.
10. Nuovo, G. J., J. Becker, M. W. Burk, M. Margiotta, J. Fuhrer, and R. T. Steigbigel. 1994. In situ detection of PCR-amplified HIV-1 nucleic acids in lymph nodes and peripheral blood in patients with asymptomatic HIV-1 infection and advanced-stage AIDS. J. Acquired Immune Defic. Syndr. 7:916.
11. Schmitz, J., J. Van Lunzen, K. Tenner-Racz, G. Grossschupff, P. Racz, H. Schmitz, M. Dietrich, and F. T. Hufert. 1994. Follicular dendritic cells retain HIV-1 particles on their plasma membrane but are not productively infected in asymptomatic patients with follicular hyperplasia. J. Immunol. 153:1352.
12. Harper, M. E., L. M. Marselle, R. C. Gallo, and F. Wong-Staal. 1986. Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc. Natl. Acad. Sci. USA 83:772.
13. Embertson, J., M. Zupancic, J. L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A. T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during incubation period of AIDS. Nature 362:359.
14. Chun, T. W., L. Carruth, D. Finzi, X. Shen, J. A. DiGiuseppe, H. Taylor, M. Hermankova, J. Chadwick, J. Margolick, T. C. Quinn, Y. H. Kuo, R. Bookmeyer, et al. 1997. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387:183.
15. Gougeon, M. L., S. Garcia, J. Heeney, R. T. Schopp, H. Lecoeur, D. Guetard, V. Rame, C. Dauguet, and L. Montagnier. 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retroviruses 9:553.
16. Li, C. J., D. J. Friedman, C. Wang, V. Metelev, and A. B. Pardec. 1995. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429.
17. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331.
18. Katsikis, P. D., E. S. Wunderlich, C. A. Smith, and L. A. Herzenberg. 1995. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J. Exp. Med. 181:2029.
19. Meyaard, L., S. A. Otto, R. R. Jonker, M. J. Mijnster, R. P. Keet, and F. Miedema. 1992. Programmed death of T cells in HIV-1 infection. Science 257:217.
20. Gougeon, M. L., H. Lecoeur, A. Dulioust, M. G. Enouf, M. Crouvoiser, C. Goujard, T. Debord, and L. Montagnier. 1996. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J. Immunol. 156:3509.
21. Finkel, T. H., G. Tudor-Williams, N. K. Banda, M. F. Cotton, T. Curiel, C. Monks, T. W. Baba, R. M. Ruprecht, and A. Kupfer. 1995. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nat. Med. 1:129.
22. Gougeon, M. L., A. G. Laurent-Crawford, A. G. Hovanessian, and L. Montagnier. 1993. Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion. Semin. Immunol. 5:187.
23. Muro-Cacho, C. A., G. Pantaleo, and A. S. Fauci. 1995. Analysis of apoptosis in lymph nodes of HIV-infected persons: intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J. Immunol 154:5555.
24. Wacholtz, M. C., S. S. Patel, and P. E. Lipsky. 1989. Patterns of costimulation of T cell clones by crass-linking CD3, CD4/CD8, and class 1 MHC molecules. J. Immunol. 142:4201.
25. + T cells through CD26: the ADA-binding epitope is not essential for complete signaling. J. Leukocyte Biol. 58:325.
26. Lorenz, H. M., T. Harrer, A. S. Lagoo, A. Baur, G. Eger, and J. R. Kalden. 1993. CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1). Cell Immunol. 147:110.
27. McCallus, D. E., K. E. Ugen, A. I. Sato, W. V. Williams, and D. B. Weiner. 1992. Construction of a recombinant bacterial human CD4 expression system producing a bioactive CD4 molecule. Viral Immunol, 5:163.
28. Williams, L. M., and M. W. Cloyd. 1991. Polymorphic human gene(s) determines differential susceptibility of CD4 lymphocytes to infection of certain HIV-1 isolates. Virology 184:723.
29. Aruffo, A., I. Stamenkovic, M. Melnick, C. B. Underhill, and B. Seed. 1990. CD44 is the principal cell surface receptor for hyaluronate. Cell 61:1303.
30. Varki, A. 1994. Selectin ligands. Proc. Natl. Acad. Sci. USA 91:7390.
31. Oxley, S. M., and R. Sackstein. 1994. Detection of an L-selectin ligand on a hematopoietic progenitor cell line. Blood 84:3299.
32. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:494.
33. Zack, J. A., A. M. Haislip, P. Krogstad, and I. S. Y. Chen. 1992. Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle. J. Virol 66:1717.
34. Harris, H., and M. Miyasaka. 1995 Reversible stimulation of lymphocyte motility by cultured high endothelial cells: mediation by L-selectin. Immunology 84:47.
35. Van Nosel, C. J., R. A. Gruters, F. G. Terpstra, P. T. Schellekens, R. A. Van Lier, and F. Miedema. 1990. Functional and phenolypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men. J. Clin. Invest. 86:293.
36. Shearer, G. M., and M. Clerici. 1991. Early T-helper cell defects in HIV infection. AIDS 5:245.
37. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pet, J. E. Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: the role of apoptosis in T cell memory. J. Exp. Med. 178:427.
38. Picker, L. J., and E. C. Butcher. 1992. Physiological and molecular mechanisms of lymphocyte homing. Annu. Rev. Immunol. 10:561.
39. Stevenson, M., T. L. Stanwick, M. P. Dempsey, and C. A. Lamonica. 1990. HIV replication is controlled at the level of T-cell activation and proviral integration. EMBO J. 9:1551.
40. Pomerantz, R. J., D. Trono, M. B. Feinberg, and D. Baltimore 1990. Cells non-productively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency. Cell 61:1271.
41. Layne, S. P., M. J. Merges, J. L. Spouge, M. Dembo, and P. L. Nara. 1991. Blocking of human immunodeficiency virus infection depends on cell density and viral stock age. J. Virol. 65:3292.
42. Ford, W. L., and J. L. Gowans. 1969. The traffic of lymphocytes. Semin. Hematol. 6:67.
43. Smith, M. E., and W. L. Ford. 1969. The recirculating lymphocyte pool of the rat: a systemic description of the migratory behavior of recirculating lymphocytes. Immunology 49:83.
44. Kaneshima, H., C. C. Shih, R. Namikawa, L. Rabin, H. Outzen, S. G. Machado, and J. M. McCune. 1991. Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse. Proc. Natl. Acad. Sci. USA 88:4523.
45. + T cells in human-PBL-SC1D mice by noncytopathic HIV isolates. Science 260:689.
46. Picchio, G. R., R. J. Gulizia, K. Wehrly, B. Chesebro, and D. E. Mosier. 1998. The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SC1D mice reconstituted with human peripheral blood leukocytes. J. Virol. 72:2002.
47. Mosier, D., and H. Sieburg. 1994. Macrophage-tropic HIV: critical for AIDS pathogenesis? Immunol. Today 17:332.
48. Perelson, A. S., A. U. Neumann, M. Markowitz, J. M. Leonard, and D. D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582.
49. + cell counts, and HIV-1 production by cells. Science 271:670.
50. Tsai, W. P., S. R. Conley, H. F. Kung, R. R. Garrity, and P. L. Nara. 1996. Preliminary in vitro growth cycle and transmission studies of HIV-1 in an autologous primary cell assay of blood-derived macrophages and peripheral blood mononuclear cells. Virology 226:205.