Molecular regulation of class switch recombination to IgE through ε germline transcription

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 56, Issue 4, 2001, Pages 270-278

  Monticelli, S ^a   Vercelli, D ^a,a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; ONCOPROTEIN; PROTEIN BCL 6; STAT6 PROTEIN;

CYTOKINE RESPONSIVE ELEMENT; DNA RECOMBINATION; HUMAN; IMMUNOGLOBULIN GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TRANSACTIVATION;

GENE EXPRESSION REGULATION; GERM CELLS; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN E; RECOMBINATION, GENETIC; TRANSCRIPTION, GENETIC;

EID: 0035103843     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1398-9995.2001.00129.x     Document Type: Review

References (65)

1. Molecular processes that regulate class switching
2. CD40 and IgE: Synergism between anti-CD40 mAb and IL-4 in the induction of IgE synthesis by highly purified human B cells
3. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function
4. Shutdown of class switch recombination by deletion of a switch region control element
5. Targeted mutation in the Iγ2b exon results in a selective Iγ2b deficiency in mice
6. Replacement of germ-line ε promoter by gene targeting alters control of immunoglobulin heavy chain class switching
7. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
8. Switch transcripts in immunoglobulin class switching
9. Processing of switch transcripts is required for targeting of antibody class switch recombination
10. Iα exon replacement mice synthesize a spliced HPRT-Cα transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice
11. Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein LR1
12. G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D: A role for G-G pairing in immunoglobulin switch recombination
13. Functions of the yeast meiotic recombination genes, MRE11 and MRE2
14. Frequent but biased class switch recombination in the S mu flanking regions
15. Unique and unprecedented recombination mechanisms in class switching
16. Sequential switching from μ to ε via γ4 in human B cells stimulated with IL-4 and hydrocortisone
17. A touch of antibody class
18. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
19. Transcription-dependent R-loop formation at mammalian class switch sequences
20. Stable RNA/DNA hybrids in the mammalian genome: Inducible intermediates in immunoglobulin class switch recombination
21. Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
22. Ku80 is required for immunoglobulin isotype switching
23. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
24. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
25. Synergistic activation of the germline promoter mediated by Stat6 and C/ EBPβ
26. STAT6 is required for IL-44nduced germline Ig gene transcription and switch recombination
27. STAT6, NF-κB and C/EBP in CD23 expression and IgE production
28. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
29. Essential role of Star6 in IL-4 signalling
30. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
31. Jaks and Stats in signaling by the cytokine receptor superfamily
32. Jaks and Stats: Biological implications
33. An interleukin-4-induced transcription factor: IL-4 Stat
34. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
35. Components of a Stat recognition code: Evidence for two layers of molecular selectivity
36. Cooperation of binding sites for STAT6 and NFκB/rel in the IL-4-induced upregulation of the human IgE germline promoter
37. Myb proteins in life, death and differentiation
38. Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: Potential role of Ets family members
39. Regulatory domains of the A-myb transcription factor and its interaction with the CBP/p300 adaptor molecules
40. B-Myb function can be markedly enhanced by cyclin-A dependent kinase and protein truncation
41. Linking Myb to the cell cycle: Cyclin-dependent phosphorylation and regulation of A-Myb activity
42. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb
43. Characterization and cell cycle-regulated expression of mouse B-Myb
44. p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
45. Cooperation of the transcriptional coactivators CBP and p300 with Star6
46. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
47. Control of inflammation: Cytokine expression and germinal center formation by BCL-6
48. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of Iε transcription and immunoglobulin E switching
49. A bifunctional control element in the human IgE germline promoter involved in repression and IL-4 activation
50. Independent pathways for de-repression of the mouse immunoglobulin heavy chain germ-line ε promoter: An IL-4 NAF/NF-IL4 site as a context-dependent negative element
51. Allergy-associated Iε and Fcε receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element
52. Characterization of an IL-4 responsive region in the immunoglobulin heavy chain germline g promoter: Regulation by NF-IL-4, a C/EBP family member, and NF-κB/p50
53. CD40 cross-linking induces Igε germline transcripts in B cells via activation of NF-κB: Synergy with IL-4 induction
54. Activation of NF-κB/Re by CD40 engagement induces the mouse germ line immunoglobulin Cγ1 promoter
55. Interaction of Star6 and NF-κB: Direct association and synergistic activation of interleukin-4-induced transcription
56. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
57. BSAP: A key regulator of B-cell development and differentiation
58. The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line s transcription
59. The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human a germline promoter
60. Functional synergism of STAT6 with either NF-κB or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription
61. Overexpression of BSAP/Pax5 inhibits switching to IgA and enhances switching to IgE in the 1.29μ B cell line
62. Pax5 (BSAP) regulates the murine immunoglobulin 3′α enhancer by suppressing binding of NF-αP, a protein that controls heavy chain transcription
63. B cell-specific activator protein prevents two activator factors from binding to the immunoglobulin J chain promoter until the antigen-driven stages of B cell development
64. Activation of the Ig germ-line γ1 promoter. Involvement of C/ enhancer-binding protein transcription factors and their possible interactions with an NF-IL-4 site
65. Regulation of human ε germline transcription: Role of B cell-specific activator protein (BSAP)