Synergistic activation of the germline ε promoter mediated by Stat6 and C/EPBβ

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1822-1828

  Mikita, Thomas ^a,b   Kurama, Masae ^a   Schindler, Ulrike ^a  

^a AMGEN INC   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4;

ARTICLE; ENHANCER REGION; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; DNA; DNA-BINDING PROTEINS; DOWN-REGULATION; DRUG SYNERGISM; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN EPSILON-CHAINS; INTERLEUKIN-4; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0032529415     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
2. Abbas, A. K., K. M. Murphy, and A. Sher. 1996 Functional diversity of helper T lymphocytes. Nature 383:787.
3. Schindler, U., T. Hoey, and S. L. McKnight. 1996. Differentiation of T-helper lymphocytes: selective regulation by members of the Stat family of transcription factors. Genes Cells 1:507.
4. Schindler, C., and J. E. Darnell. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621.
5. Ihle, J.N. 1995. Cytokine receptor signaling. Nature 377:591.
6. O'Shea, J. J. 1997. Jaks, STATs, cytokine signal transduction, immunoregulation: are we there yet? Immunity 7:1.
7. Hou, J., U. Schindler, W. J. Henzel, T. Z. Ho, M. Brsseur, and S. L. McKnight. 1994. An interleukin-4 induced transcription factor: IL-4 Stat. Science 265:1701.
8. Kotanides, H., and N. C. Reich. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262:1265.
9. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4:313.
10. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K., K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signaling. Nature 380:627.
11. Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline c promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J. Exp. Med. 181: 181.
12. Lundgren, M., C. Larsson, A. Femino, M. Xu, J. Stavnezer, and E. Severinson. 1994. Activation of the Ig germline γ1 promoter: involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. J. Immunol. 153:2983.
13. Mikita, T., D. Campbell, P. Wu, K. Williamson, and U. Schindler. 1996. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16:5811.
14. Wang, N.-D., M. J. Finegold, A. Bradley, C. N. Ou, S. V. Abdelsayed, M. D. Wilde, L. R. Taylor, D. R. Wilson, and G. J. Darlington. 1995. Impaired energy homeostasis in C/EBP a knockout mice. Science 269:1108.
15. Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538.
16. Tanaka, T., S. Akira, K. Yoshida, M. Umemoto, Y. Yoneda, N. Shirafuji, H. Fujiwara, S. Suematsu, N. Yoshida, and T. Kishimoto. 1995. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353.
17. Antonson, P., B. Stellan, R. Yamanaka, and K. G. Xanthopoulos. 1996. A novel human CCAAT/enhancer binding protein gene, C/EBP∈, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus. Genomics 35:30.
18. Cooper, C., A. Henderson, S. Artandi, N. Avitahl, and K. Calame. 1995. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res. 23:4371.
19. Screpanti, I., L. Romani, P. Musiani, A. Modesti, E. Fattori, D. Lazzaro, C. Sellitto, S. Scarpa, D. Bellavia, G. Lattanzio, F. Bistoni, L. Frati, R. Cortese, A. Gulino, G. Ciliberto, F. Constanti, and V. Poli. 1995. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP β deficient mice. EMBO J. 14:1932.
20. Cooper, C. L., A. L. Berrier, C. Roman, and K. L. Calame. 1994. Limited expression of C/EBP family proteins during B lymphocyte development. J. Immunol. 153:5049.
21. Katz., S., E. Kowentz-Leutz, C. Muller, K. Meese, S. A. Ness, and A. Leutz. 1993. The NF-M transcription factor is related to C/EBPβ and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J. 12:1321.
22. Metz, R., and E. Ziff. 1991. cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev. 5:1754.
23. Wegner, M., Z. Cao, and M. G. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBP β. Science 256:370.
24. Tewari, M., and V. M. Dixit. 1995. Fas-and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270:3255.
25. Schindler, U., P. Wu, M. Rothe, M. Brasseur, and S. L. McKnight. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689.
26. Roman, C., J. S. Platero, J. Shuman, and K. Calame. 1990. Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterdimerizes with C/EBP. Genes Dev. 4:1404.
27. Ptashne, M., and A. Gann. 1997. Transcriptional activation by recruitment. Nature 386:569.
28. Herschlag, D., and F. B. Johnson. 1993. Synergism in transcriptional activation: a kinetic view. Genes Dev. 7:173.
29. Vinkemeier, U., S. L. Cohen, I. Moarefi, B. T. Chait, J. Kuriyan, and J. E. Darnell, Jr. 1996. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 15:5616.
30. Schaefer, T. S., L. K. Sanders, O. K. Park, and D. Nathans. 1997. Functional differences between Stat3 alpha and Stat3 beta. Mol. Cell Biol. 17:5307.
31. Darnell, J. E., Jr. 1997. Stats and gene regulation. Science 277:1630.
32. Caldenhaven, E., T. B. van Dijk, R. Solari, J. Armstrong, J. A. M. Raaijmchers, J. W. J. Lammers, L. Koenderman, and R. P. de Groot. 1996. Stat3β, a splice variant of transcription factor Stat3, is a dominant negative regulator of transcription. J. Biol. Chem. 271:13221.
33. Muller, M., C. Laxton, J Briscoe, C. Schindler, T. Improta, J. E. Darnell, G.R. Stark, and I. M. Kerr. 1993. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the IFN α and γ signal transduction pathways. EMBO J. 12:4221.
34. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical association belween NF-κB and C/EBP family members: a rel domain-bzip interaction. Mol. Cell. Biol. 13:3964.
35. Zhang, D. E., C. J. Hetherington, S. Meyers, K. L. Rhoades, C. J. Larson, H. M. Chen, S. W. Hiebert, and D. G. Tenen. 1996. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF α2) synergistically activate the macrophage colony stimulating factor receptor promoter. Mol. Cell. Biol. 16:1231.
36. Ness, S. C., E. Kowenz-Leutz, T. Casini, T. Graf, and A. Leutz. 1993. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7:749.
37. Nagulapalli, S., J. M. R. Pongubala, and M. L. Atchison. 1995. Multiple proteins physically interact with PU.1. J. Immunol. 155:4330.