Transcriptional coregulators of the nuclear receptor superfamily: Coactivators and corepressors

Cellular and Molecular Life Sciences

Volumn 58, Issue 2, 2001, Pages 289-297

  Lee, J W ^a   Lee, Y C ^a   Na, S Y ^a   Jung, D Ju ^a   Lee, S K ^a  

^a Chonnam National University   (South Korea)

Author keywords

Coactivator; Corepressor; Nuclear receptor; Transcription

Indexed keywords

CELL NUCLEUS RECEPTOR;

DNA SEQUENCE; GENE CONTROL; LIGAND BINDING; NONHUMAN; PROTEIN CONFORMATION; RECEPTOR BINDING; REVIEW; TRANSCRIPTION REGULATION;

EID: 0035099604     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000856     Document Type: Review

References (94)

1. The nuclear receptor superfamily: The second decade
2. Nuclear receptor coactivators and corepressors
3. Nuclear receptor coregulators: Cellular and molecular biology
4. The coregulator exchange in transcriptional functions of nuclear receptors
5. Nuclear hormone receptor coregulators in action: Diversity for shared tasks
6. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
7. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
8. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
9. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
10. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
11. Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2
12. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
13. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
14. Structure and specificity of nuclear receptor-coactivator interactions
15. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
16. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
17. Steroid receptor coactivator-1 is a histone acetyltransferase
18. Regulation of transcription by a protein methyltransferase
19. Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits
20. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations
21. Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations
22. SRC-1 and its family members differentially regulate transactivation by the tumor suppressor p53
23. Phosphorylated CREB binds specifically to the nuclear protein CBP
24. Molecular cloning and functional analysis of the adenovirus E1 A-associated 300-kd protein (p300) reveals a protein with properties of a transcriptional adaptor
25. The multifunctional role of the co-activator CBP in transcriptional regulation
26. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
27. p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin
28. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
29. The CBP co-activator is a histone acetyltransferase
30. The transcriptional coactivators p300 and CBP are histone acetyltransferases
31. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
32. Acetylation of general transcription factors by histone acetyltransferases
33. Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome
34. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
35. Regulation of activity of the transcription factor GATA-1 by acetylation
36. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases
37. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
38. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1a
39. The histone acetylase PCAF is a nuclear receptor coactivator
40. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
41. Histone-like TAFs within the PCAF histone acetylase complex
42. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
43. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
44. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
45. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes
46. Composite co-activator ARC mediates chromatin-directed transcriptional activation
47. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
48. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
49. ASC-1, as a novel transcription coactivator of nuclear receptors, and its cytosolic localization under serum-deprivation
50. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing
51. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha
52. RNA helicase A mediates association of CBP with RNA polymerase II
53. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
54. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
55. RNA polymerase II and the integration of nuclear events
56. ASC-2, a novel transcriptional coactivator of nuclear receptors and its amplification in human cancers
57. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator
58. Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR
59. Cloning and characterization of RAP250, a novel nuclear receptor coactivator
60. A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein
61. Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2
62. Distinct steady-state nuclear receptor coregulator complexes exist in vivo
63. Hybrid selection of transcribed sequences from microdissected DNA: Isolation of genes within amplified region at 20q11-q13.2 in breast cancer
64. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer
65. Activating protein-1, nuclear factor-κB and serum response factor, as novel target molecules of the cancer-amplified transcription coactivator ASC-2
66. A transcriptional co-repressor that interacts with nuclear hormone receptors
67. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor
68. Molecular determinants of nuclear receptor-corepressor interaction
69. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
70. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
71. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
72. The histone deacetylase-3 complex contains nuclear receptor corepressors
73. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
74. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
75. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
76. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
77. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
78. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
79. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
80. The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor
81. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
82. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
83. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
84. Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-κB and serum response factor
85. The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD
86. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
87. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins
88. Role of the histone deacetylase complex in acute promyelocytic leukemia
89. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
90. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation
91. Phosphorylation of steroid receptor coactivator-1: Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway
92. Regulation of CBP-mediated transcription by neuronal calcium signaling
93. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4
94. The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export