Genes involved in initial steps of bile acid synthesis

Current Opinion in Lipidology

Volumn 12, Issue 2, 2001, Pages 97-103

  Björkhem, Ingemar ^a   Eggertsen, Gösta ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR;

BILE ACID SYNTHESIS; CHOLESTEROL METABOLISM; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

3-HYDROXYSTEROID DEHYDROGENASES; BILE ACIDS AND SALTS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS;

EID: 0035076216     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200104000-00002     Document Type: Review

References (39)

1. Regulation of bile acid synthesis
2. Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells
3. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans
4. Cholesterol homeostasis in human brain: Evidence for an age dependent flux of 24S-hydroxycholesterol from the brain into the circulation
5. 27-Hydroxycholesterol: Production rates in normal human subjects
6. CYP7b, a novel brain cytochrome P-450 catalyzes the synthesis of neurosteroids 7α-hydroxy DHEA and 7α-hydroxypregneneolone
7. Oxysterol 7α-hydroxylase activity by cholesterol 7α-hydrozylase (CYP7A)
8. 24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)
9. Expression cloning of an oxysterol 7α-hydroxylase selective for 24-hydroxycholesterol
10. On the mechanism of the enzymatic conversion of cholest-5-ene-3β,7α-diol into 7α-hydroxycholest-4-en-3-one
11. Mechanism of bile acid biosynthesis in mammalian liver
12. Mechanisms of degradation of the steroid side chain in the formation of bile acids
13. Identification of a nuclear receptor for bile acids
14. Bile acids: Natural ligands for an orphan nuclear receptor
15. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
16. Nuclear orphan receptors control cholesterol catabolism
17. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
18. A regulatory cascade of the nuclear receptors FXR, SHP, and LRH-1 represses bile acid biosynthesis
19. CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
20. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
21. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
22. Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids
23. Downregulation of the rat hepatic sterol 27-hydroxylase gene by bile acids in transfected primary hepatocytes: Possible role of hepatic nuclear factor 1a
24. Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic acid and cholestyramine
25. There is little or no coordinate regulation of sterol 27-hydroxylase and cholesterol 7α-hydroxylase in man
26. Removal of cholesterol from extrahepatic sources by oxidative mechanisms
27. Cholestenoic acid is a naturally occurring ligand for LXRα
28. Importance of a novel oxidative mechanism for elimination of brain cholesterol
29. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
30. Disruption of the oxysterol 7α-hydroxylase gene in mice
31. Role of oxysterols in the regulation of cholesterol homeostasis: A critical evaluation
32. Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1
33. Regulation of sterol 12α-hydroxylase and cholic acid biosynthesis in the rat
34. Structure and chromosomal assignment of the sterol 12α-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns
35. Thyroid hormone suppresses hepatic sterol 12α-hydroxylase (CYP8B1) activity and mRNA in rat liver: Failure to define known thyroid hormone response element in the gene
36. Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid mediated regulation of gene transcription
37. The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis
38. Studies on the formation and flux of oxysterols in vivo with stable isotopes. Evidence that the three major oxysterols in human circulation originate from functionally distinct pools of cholesterol
39. 27-steroid oxidoreductase gene of bile acid synthesis and its mutation in progressive intrahepatic cholestasis