Identification and molecular characterization of a natural mutant of the p50.2/KIR2DS2 activating NK receptor that fails to mediate NK cell triggering

European Journal of Immunology

Volumn 30, Issue 12, 2000, Pages 3569-3574

  Bottino, Cristina ^a   Falco, Michela ^b   Sivori, Simona ^a   Moretta, Lorenzo ^a,c   Moretta, Alessandro ^b   Biassoni, Roberto ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Activating receptors; cDNA; Killer Ig like receptor; NK cell

Indexed keywords

ADAPTOR PROTEIN; COMPLEMENTARY DNA; LYMPHOCYTE RECEPTOR;

ARTICLE; CODON; EXON; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CLONING, MOLECULAR; HLA-C ANTIGENS; HUMANS; KILLER CELLS, NATURAL; MOLECULAR SEQUENCE DATA; MUTATION; RECEPTORS, IMMUNOLOGIC;

EID: 0034532976     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200012)30:12<3569::AID-IMMU3569>3.0.CO;2-E     Document Type: Article

References (15)

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2. NK cell receptors
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4. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human Natural Killer cells
5. The HLA-C-specific 'activatory' or 'inhibitory' Natural Killer cell receptors display highly homologous extracellular domains but differ in their TM and intracytoplasmic portions
6. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human Natural Killer cells and induces both triggering of cell functions and proliferation
7. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells
8. Immunoreceptor DAP12 bearing a tyrosine-based activation motifs is involved in activating NK cells
9. NKp44, a triggering receptor involved in tumor cell lysis by activated human Natural Killer cells, is a novel member of the immunoglobulin superfamily
10. Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs
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12. Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103
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15. The natural killer cell receptor specific for HLA-A allotypes: A novel member of the p58/p70 family of inhibitory receptors which is characterized by three Ig-like domains and is expressed as a 140 kD disulphide-linked dimer