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Biron CA, van den Elsen P, Tutt MM, Medveczky P, Kumar V, Terhorst C. Murine natural killer cells stimulated in vivo do not express the T cell receptor α, β, T3δ, or T3ε genes. J Immunol. 139:1987;1704-1710.
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A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3e gene
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Wang B, Biron C, She J, Higgins K, Sunshine M-J, Lacy E, Lonberg N, Terhorst C. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3e gene. Proc Natl Acad Sci USA. 91:1994;9402-9406.
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Kasaian MT, Biron CA. Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo. J Exp Med. 171:1990;745-762.
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McIntyre KW, Natuk RJ, Biron CA, Kase K, Greenberger J, Welsh RM. Blastogenesis of large granular lymphocytes in nonlymphoid organs. J Leuk Biol. 43:1988;492-501.
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Wiltrout RH, Pilaro AM, Gruys ME, Talmage JE, Longo DL, Ortaldo JR, Reynolds CW. Augmentation of mouse liver-associated natural killer activity by biologic response modifiers largely via recruitment of large granular lymphocytes from the bone marrow. J Immunol. 143:1989;373-378.
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NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction
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of outstanding interest. Demonstrates the role of VCAM-1/VLA-4 interactions in promoting NK cell migration to specific tissue sites after treatment with a chemical inducer of cytokines, polylCLC.
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Fogler WE, Volker K, McCormick KL, Watanabe M, Ortaldo JR, Wiltrout RH. NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. of outstanding interest J Immunol. 156:1996;1714-4707 Demonstrates the role of VCAM-1/VLA-4 interactions in promoting NK cell migration to specific tissue sites after treatment with a chemical inducer of cytokines, polylCLC.
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43
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Characterization of early IL-12, IFN-α/β, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection
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of outstanding interest. Characterizes the dichotomy of endogenous cytokine function for NK cell regulation during MCMV infection. NK cell cytotoxicity and blastogenesis are shown to be IFN-α/β-dependent but IL-12 independent, whereas NK cell IFN-γ production is shown to be IL-12 dependent but IFN-α/β-independent.
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Orange JS, Biron CA. Characterization of early IL-12, IFN-α/β, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. of outstanding interest J Immunol. 156:1996;4746-4756 Characterizes the dichotomy of endogenous cytokine function for NK cell regulation during MCMV infection. NK cell cytotoxicity and blastogenesis are shown to be IFN-α/β-dependent but IL-12 independent, whereas NK cell IFN-γ production is shown to be IL-12 dependent but IFN-α/β-independent.
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Ishikawa R, Biron CA. IFN induction and associated changes in splenic leukocyte distribution. J Immunol. 150:1993;3713-3727.
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of outstanding interest. Demonstrates dramatic leukocyte redistributions in spleen and unique NK-cell-dependent cell trafficking patterns to splenic marginal zones after endogenous IFN-α/β induction by treatment with polyl:C or after infections with MCMV or LCMV. Localization of NK cell IFN-γ mRNA expression is also shown.
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Salazar-Mather TP, Ishikawa R, Biron CA. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. of outstanding interest J Immunol. 157:1996;3054-3064 Demonstrates dramatic leukocyte redistributions in spleen and unique NK-cell-dependent cell trafficking patterns to splenic marginal zones after endogenous IFN-α/β induction by treatment with polyl:C or after infections with MCMV or LCMV. Localization of NK cell IFN-γ mRNA expression is also shown.
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Pilaro AM, Taub DD, McCormick KL, Williams HM, Sayers TJ, Fogler WE, Wiltrout RH. TNF-α is a principal cytokine involved in the recruitment of NK cells to liver parenchyma. J Immunol. 153:1994;333-342.
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Requirement for natural killer (NK) cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
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Presents the results of studies demonstrating NK cell IFN-γ production during MCMV infection and proving the role for this factor in NK-cell-mediated antiviral defense in the liver.
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Orange JS, Wang B, Terhorst C, Biron CA. Requirement for natural killer (NK) cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J Exp Med. 182:1995;1045-1056 Presents the results of studies demonstrating NK cell IFN-γ production during MCMV infection and proving the role for this factor in NK-cell-mediated antiviral defense in the liver.
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of outstanding interest. Demonstrates IFN-α/β induction of memory T cell blastogenesis in vivo.
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Tough DF, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. of outstanding interest Science. 272:1996;1947-1950 Demonstrates IFN-α/β induction of memory T cell blastogenesis in vivo.
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