Nucleocytoplasmic shuttling of the thyroid hormone receptor α

Molecular Endocrinology

Volumn 15, Issue 4, 2001, Pages 512-533

  Bunn, Caroline F ^b   Neidig, Jessica A ^a   Freidinger, Kathryn E ^a   Stankiewicz, Tracy A ^a   Weaver, Brian S ^a   McGrew, Julie ^b   Allison, Lizabeth A ^a,b  

^a The College of William and Mary   (United States)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; LEPTOMYCIN B; ONCOPROTEIN; THYROID HORMONE; THYROID HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL NUCLEUS; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; GENE EXPRESSION; GENETIC TRANSCRIPTION; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOPUS;

ANIMALS; APYRASE; CARRIER PROTEINS; CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; FATTY ACIDS, UNSATURATED; FEMALE; GENES, DOMINANT; GREEN FLUORESCENT PROTEINS; HUMANS; KARYOPHERINS; LUMINESCENT PROTEINS; MAMMALS; MICE; MUTATION; NUCLEAR PROTEINS; ONCOGENE PROTEINS V-ERBA; OOCYTES; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, THYROID HORMONE; RIBOSOMAL PROTEINS; TEMPERATURE; XENOPUS;

ANIMALIA; MAMMALIA;

EID: 0035054747     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.15.4.512     Document Type: Article

References (72)

1. The mechanism of action of thyroid hormones
2. Thyroid hormone receptor, v-ErbA, and chromatin
3. Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway
4. Intracellular traffic of steroid hormone receptors
5. Subnuclear trafficking of steroid receptors
6. Association of the 3,5,3′-triiodo-L-thyronine nuclear receptor with the nuclear matrix of cultured growth hormone-producing rat pituitary tumor cells (GC cells)
7. Site-specific anti-c-erb A antibodies recognizing native thyroid hormone receptors: Their use to detect the expression and localization of α and β c-erb A proteins in rat liver
8. The D domain of the thyroid hormone receptor α1 specifies positive and negative transcriptional regulation functions
9. Chicken thyroid hormone receptor α requires the N-terminal amino acids for exclusive nuclear localization
10. Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus
11. Characterization of the domain structure of chick c-erbA by deletion mutation: In vitro translation and cell transfection studies
12. Hormone-induced translocation of thyroid hormone receptors in living cells visualized using a receptor green fluorescent protein chimera
13. Transport between the cell nucleus and the cytoplasm
14. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
15. The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1
16. Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion
17. Facilitated nuclear transport of calmodulin in tissue culture cells
18. Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus
19. Nuclear import of protein kinase C occurs by a mechanism distinct from the mechanism used by proteins with a classical nuclear localization signal
20. Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
21. 2+-dependent nuclear accumulation of calmodulin
22. Regulation of nuclear localization: A key to a door
23. Control of the nuclear localization of extradenticle by competing nuclear import and export signals
24. Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA
25. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals
26. Determinants of subcellular distribution of the glucocorticoid receptor
27. Constitutive transactivation by the thyroid hormone receptor and a novel pattern of activity of its oncogenic homolog v-ErbA in Xenopus oocytes
28. Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-ErbA yields a chromatin infrastructure-dependent transcriptional repression pathway
29. Quantitation of endogenous thyroid hormone receptors α and β during embryogenesis and metamorphosis in Xenopus laevis
30. Sequential binding of import ligands to distinct nucleopore regions during their nuclear import
31. A role for ribosomal protein L5 in the nuclear import of 5S rRNA in Xenopus oocytes
32. Functional modules in ribosomal protein L5 for ribonucleoprotein complex formation and nucleocytoplasmic transport
33. An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B″ spliceosome proteins
34. Nuclear import of IκBα is accomplished by a Ran-independent transport pathway
35. Use of the Xenopus oocyte system to study RNA transport
36. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin β-dependent nuclear localization signals
37. Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle
38. Importin β, transportin, RanBP5, and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
39. Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran
40. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera
41. Direct visualization of the human estrogen receptor reveals a role for ligand in the nuclear distribution of the receptor
42. Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells
43. Subcellular localization of mineralocorticoid receptors in living cells: Effects of receptor agonists and antagonists
44. Analysis of nucleocytoplasmic shuttling using transient interspecies heterokaryons
45. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
46. Mechanisms of progesterone export from nuclei: Role of nuclear localization signal, nuclear export signal, and Ran guanosine triphosphate
47. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
48. Functional analysis of the amino acids in the DNA recognition α-helix of the human thyroid hormone receptor
49. The c-erb-A protein is a high affinity receptor for thyroid hormone
50. The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations
51. ATP-dependent release of glucocorticoid receptors from the nuclear matrix
52. Nuclear and nucleolar targeting sequences of c-erbA, c-myb, N-myc, p53, HSP70, and HIV tat proteins
53. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
54. Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins
55. Differences between the silencing-related properties of the extreme carboxyl-terminal regions of thyroid hormone receptors α1 and β1
56. Ligand binding was acquired during evolution of nuclear receptors
57. Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons
58. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
59. Major nucleolar proteins shuttle between nucleus and cytoplasm
60. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm
61. Nucleocytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
62. A short region of its homeodomain is necessary for engrailed nuclear export and secretion
63. The Net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock
64. The glucocorticoid receptor: Rapid exchange with regulatory sites in living cells
65. Cross-talk between signal transducer and activator of transcription (Stat5) and thyroid hormone receptor-β1 (TRβ1) signaling pathways
66. Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
67. A subpopulation of the v-erbA oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90
68. The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors
69. A transcriptional co-repressor that interacts with nuclear hormone receptors
70. Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor
71. Analysis of structure and expression of the Xenopus thyroid hormone receptor-β gene to explain its autoinduction
72. v-erbA oncogene initiates ultrastructural changes characteristic of early and intermediate events of meiotic maturation in Xenopus oocytes