Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway

Molecular Endocrinology

Volumn 14, Issue 1, 2000, Pages 40-51

  Liu, Jimin ^a   DeFranco, Donald B ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPORTIN 1; GLUCOCORTICOID RECEPTOR; LEPTOMYCIN B; LEUCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; GENE ACTIVITY; GENETIC TRANSFECTION; HORMONE RELEASE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STEROID METABOLISM; TRANSACTIVATION;

ANIMALIA; NES;

EID: 0034463835     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.1.0398     Document Type: Article

References (68)

1. Bidirectional transport of glucocorticoid receptors across the nuclear envelope
2. Nucleocytoplasmic shuttling of the progesterone receptor
3. Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons
4. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
5. Nucleocytoplasmic shuttling of steroid receptors
6. Intracellular localization of the glucocorticoid receptor: Evidence for cytoplasmic and nuclear localization
7. Signal transduction by steroid hormones: Nuclear localization is differentially regulated in estrogen and progesterone receptors
8. v-mos oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors
9. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera
10. The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor
11. Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking
12. Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor
13. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor
14. Mammary tumor virus DNA contains sequences required for its hormone-regulated transcription
15. Steroid receptor regulated transcription of genes and gene networks
16. In vivo protein-DNA interactions in a glucocorticoid response element require the presence of hormone
17. Hormonally induced alterations of chromatin structure in the polyadenylation and transcription termination regions of the chicken ovalbumin gene
18. Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: Induction leads to a reversible disruption of nucleosomes over an enhancer
19. Kinetics of glucocorticoid-receptor complexes in rat thymus cells
20. Subnuclear trafficking of glucocorticoid receptors in vitro: Chromatin recycling and nuclear export
21. Determinants of subcellular distribution of the glucocorticoid receptor
22. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
23. A nuclear export signal in hnRNPA1: A signal-mediated, temperature-dependent nuclear protein export pathway
24. The K nuclear shuttling domain: A novel signal for nuclear import and nuclear export in the hnRNP K protein
25. Identification of a signal for rapid export of proteins from the nucleus
26. Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm
27. Nuclear export signals and the fast track to the cytoplasm
28. Exportin (Crm1p) is an essential nuclear export factor
29. CMR1 is an export receptor for leucine-rich nuclear export signals
30. Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+, which encodes a 115-kD protein preferentially localized in the nucleus and its periphery
31. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type I (HIV-1) Rev protein and Rev-dependent mRNA
32. A cytosolic activity distinct from Drm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells
33. Export of importin a from the nucleus is mediated by a specific nuclear transport factor
34. β-subunit of nuclear pore-targeting complex (importin-β) can be exported from the nucleus in a Ran-independent manner
35. Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor
36. A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation and transrepression defects of a glucocorticoid receptor zinc finger mutant
37. Nuclear import-export: In search of signals and mechanisms
38. Nuclear localization signals also mediate the outward movement of proteins from the nucleus
39. Nuclear export of proteins: The role of nuclear retention
40. In vivo nuclear transport kinetics in Saccharomyces cerevisae: A role for heat shock protein 70 during targeting and translocation
41. Guiochon-Mantel 1998 mechanisms of progesterone receptor export from nuclei: Role of nuclear localization signal, nuclear export signal, and Ran guanosine triphosphate
42. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
43. Chromatin recycling of glucocorticoid receptors: Implications for multiple roles of heat shock protein 90
44. Nuclear retention of I κB α protects it from signal-induced degradation and inhibits nuclear factor κB transcriptional activation
45. Ligand-dependent down-regulation of stably transfected human glucocorticoid receptors is associated with the loss of functional glucocorticoid responsiveness
46. Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein
47. Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S3 cells
48. Regulation of the NF-κB/rel transcription factor and IκB inhibitor system
49. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
50. Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function
51. Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A
52. NF-AT activation requires suppression of Crm1-dependent export by calcineurin
53. The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain
54. Reconstitution of HIV-1 Rev nuclear export: Independent requirements for nuclear import and export
55. Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: A possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression
56. Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity
57. Localization of proteosomal antigens during different phases of the cell cycle in HeLa cells
58. Subpopulations of proteosomes in rat liver nuclei, microsomes and cytosol
59. Steroid receptor interactions with heat shock protein and immunophilin chaperones
60. Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors
61. Kinetics of glucocorticoid receptor phosphorylation in intact cells
62. Glucocorticoid receptors in ATP-depleted cells. Dephosphorylation, loss of hormone binding, Hsp90 dissociation and ATP-dependent cycling
63. Glucocorticoid receptor phosphorylation in v-mos transformed cells
64. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB
65. Activation of NF-κB requires proteolysis of the inhibitor IκB-α: Signal-induced phosphorylation of IκB-α alone does not release active NF-κB
66. Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus
67. Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor
68. Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen