Determinants of subcellular distribution of the glucocorticoid receptor

Molecular Endocrinology

Volumn 10, Issue 10, 1996, Pages 1191-1205

  Sackey, Faustina N A ^a   Haché, Robert J G ^a   Reich, Terry ^a   Kwast Welfeld, Joanna ^a   Lefebvre, Yvonne A ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOLOGY; CYTOPLASM; DNA BINDING; HORMONE RESPONSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; COS CELLS; CYTOPLASM; G0 PHASE; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0029777562     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.10.1191     Document Type: Article

References (78)

1. 1 cells. Evidence from dense amino acid labeling and whole cell studies for an equilibrium model explaining the influence of hormone on the intracellular distribution of receptor. J Biol Chem 258:417-428
2. Munck A, Holbrook NJ 1984 Glucocorticoid-receptor complexes in rat thymus cells. Rapid kinetic behavior and a cyclic model. J Biol Chem 259:820-831
3. Scherrer LC, Picard D, Massa E, Harmon JM, Simons SS, Yamamoto KR, Pratt WB 1993 Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein-90. Biochemistry 32:5381-5386
4. Urda LA, Yen PM, Simons SSJ, Harmon JM 1989 Region-specific antiglucocorticoid receptor antibodies selectively recognize the activated form of the ligand-occupied receptor and inhibit the binding of activated complexes to deoxyribonucleic acid. Mol Endocrinol 3:251-260
5. Picard D, Yamamoto KR 1987 Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6:3333-3340
6. Beato M, Herrlich P, Schütz G 1996 Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857
7. Pratt WB 1993 The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem 268:21455-21458
8. Guiochon-Mantel A, Lescop P, Christinmaitre S, Loosfelt H, Perrot-Applanat M, Milgrom E 1991 Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J 10:3851-3859
9. Madan AP, DeFranco DB 1993 Bidirectional transport of glucocorticoid receptors across the nuclear envelope. Proc Natl Acad Sci USA 90:3588-3592
10. Dauvois S, White R, Parker MG 1993 The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 106:1377-1388
11. Fischer U, Huber J, Boelens WC, Mattaj IW, Luhrmann R 1995 The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82:475-483
12. Meyer BE, Malim MH 1994 The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev 8:1538-1547
13. Wen W, Meinkoth JL, Tsien RY, Taylor SS 1995 Identification of a signal for rapid export of proteins from the nucleus. Cell 82:463-473
14. Lin YC, Brown K, Siebenlist U 1995 Activation of NF-kappa B requires proteolysis of the inhibitor I kappa-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. Proc Natl Acad Sci USA 92:552-556
15. Israel A 1995 A role for phosphorylation and degradation in the control of NF-kappa B activity. Trends Genet 11:203-205
16. Schindler C, Darnell JE 1995 Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-651
17. Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, Zajackaye M 1995 The N-terminal domain of c-myc associates with alpha-tubulin and microtubules in vivo and in vitro. Mol Cell Biol 15:5188-5195
18. Vandromme M, Carnac G, Gauthier-Rouviere C, Fesquet D, Lamb N, Fernandez A 1994 Nuclear import of the myogenic factor MyoD requires protein kinase activity but not the direct phosphorylation. J Cell Sci 107:613-620
19. Pines J, Hunter T 1994 The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J 13:3772-3781
20. Hutchison KA, Scherrer LC, Czar MJ, Stancato LF, Chow YH, Jove R, Pratt WB 1993 Regulation of glucocorticoid receptor function through assembly of a receptor heat shock protein complex. Ann NY Acad Sci 684:35-48
21. Czar MJ, Lyons RH, Welsh MJ, Renoir JM, Pratt WB 1995 Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus. Mol Endocrinol 9:1549-1560
22. Vancurova I, Jochova J, Lou W, Paine PL 1994 An NLS is sufficient to engage facilitated translocation by nuclear pore complex and subsequent intranuclear binding. Biochem Biophys Res Commun 205:529-536
23. Guiochon-Mantel A, Delabre K, Lescop P, Milgrom E 1994 Nuclear localization signals also mediate the outward movement of proteins from the nucleus. Proc Natl Acad Sci USA 91:7179-7183
24. Krohne G, Waizenegger I, Höger TH 1989 The conserved carboxy-terminal cysteine of nuclear lamins is essential for lamin association with the nuclear envelope. J Cell Biol 109:2003-2011
25. Hatanaka M 1990 Discovery of the nucleolar targeting signal. Bioessays 12:143-148
26. Nigg EA, Kitten GT, Vorburger K 1992 Targeting lamin proteins to the nuclear envelope: the role of CaaX box modifications. Biochem Soc Trans 20:500-504
27. Segil N, Roberts SB, Heintz N 1991 Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science 254:1814-1816
28. Cadepond F, Gasc JM, Delahaye F, Jibard N, Schweizergroyer G, Segardmaurel I, Evans R, Baulieu EE 1992 Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor. Exp Cell Res 201:99-108
29. Sanchez ER, Hirst M, Scherrer LC, Tang HY, Welsh MJ, Harmon JM, Simons SS, Ringold GM, Pratt WB 1990 Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90. J Biol Chem 265:20123-20130
30. Danielsen M, Northrop VP, Ringold GM 1986 The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins. EMBO J 5:2513-2522
31. Hsu S-c, Qi M, DeFranco DB 1992 Cell cycle regulation of glucocorticoid receptor function. EMBO J 11: 3457-3468
32. Aaronson SA 1991 Growth factors and cancer. Science 254:1146-1153
33. Pardee AB 1989 G1 events and regulation of cell proliferation. Science 246:603-607
34. Hoeck W, Rusconi S, Groner B 1989 Down-regulation and phosphorylation of glucocorticoid receptors in cultured cells. J Biol Chem 264:14396-14402
35. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PIB 1991 Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352:497-505
36. Hollenberg SM, Evans RM 1985 Multiple and cooperative transactivation domains of the human glucocorticoid receptor. Cell 55:899-906
37. Ylikomi T, Bocquel MT, Berry M, Gronemeyer H, Chambon P 1992 Cooperation of protosignals for nuclear accumulation of estrogen and progesterone receptors. EMBO J 11:3681-3694
38. Savouret JF, Perrot-Applanat M, Lescop P, Guiochon-Mantel A, Chauchereau A, Milgrom E 1993 Mechanisms controlling the cellular traffic and the concentration of the progesterone receptor. Ann NY Acad Sci 684:11-18
39. Izawa M, Satoh Y, Ichii S 1983 Receptor recycling: liberation of glucocorticoid receptors from liver nuclei in vitro. Endocrinol Jpn 30:475-484
40. Sanchez ER, Hu J-L, Zhong S, Shen P, Greene MJ, Housley PR 1994 Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock. Mol Endocrinol 8:408-421
41. Bresnick EH, Dalman FC, Sanchez ER, Pratt WB 1989 Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J Biol Chem 264:4992-4997
42. Chambraud B, Berry M, Redeuilh G, Chambon P, Baulieu EE 1990 Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein-90 complexes. J Biol Chem 265:20686-20691
43. Cadepond F, Schweizergroyer G, Segardmaurel I, Jibard N, Hollenberg SM, Giguere V, Evans RM, Baulieu EE 1991 Heat shock protein-90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state. J Biol Chem 266:5834-5841
44. Liu W, Hillmann AG, Harmon JM 1995 Hormone-independent repression of AP-1-inducible collagenase promoter activity by glucocorticoid receptors. Mol Cell Biol 15:1005-1013
45. Qi M, Hamilton BJ, DeFranco D 1989 v-mos Oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors. Mol Endocrinol 3:1279-1288
46. Qi M, Stasenko LJ, DeFranco DB 1990 Recycling and desensitization of glucocorticoid receptors in v-mos transformed cells depend on the ability of nuclear receptors to modulate gene expression. Mol Endocrinol 4:455-464
47. DeFranco DB, Qi M, Borror KC, Garabedian MJ, Brautigan DL 1991 Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol Endocrinol 5:1215-1228
48. Caamano CA, Morano MI, Watson SJJ, Dalman FC, Pratt WB, Akil H 1994 The functional relevance of the heteromeric structure of corticosteroid receptors. Ann NY Acad Sci 746:68-77
49. Baulieu EE 1994 RU486: A compound that gets itself talked about. Hum Reprod 9:1-6
50. Mao J, Regelson W, Kalimi M 1992 Molecular Mechanism of RU-486 Action - A Review. Mol Cell Biochem 109:1-8
51. Moguilewsky M, Philibert D 1984 RU38486: potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation. J Steroid Biochem 20:271-276
52. Distelhorst CW, Howard KJ 1990 Evidence from pulse-chase labelling studies that the antiglucocorticoid hormone RU486 stabilizes the nonactivated form of the glucocorticoid receptor in mouse lymphoma cells. J Steroid Biochem Mol Biol 36:25-31
53. Archer TK, Hager GL, Omichinski JG 1990 Sequence-specific DNA binding by glucocorticoid receptor zinc finger peptides. Proc Natl Acad Sci USA 87:7560-7564
54. Beato M, Bruggemeier U, Chalepakis G, Hache RJG, Kalff M, Pina B, Slater E, Truss M 1990 Regulation of transcription by glucocorticoids. In: Foulkes G, Cohen P (eds) Molecular Aspects of Cellular Regulation. Elsevier Biomedical Press, Amsterdam, pp 287-298
55. Guiochon-Mantel A, Loosfelt H, Lescop P, Sar S, Atger M, Perrot-Applanat M, Milgrom E 1989 Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell 57:1147-1154
56. Dignam JD, Lebovitz RM, Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489
57. Scheidereit C, Geisse S, Westphal HM, Beato M 1983 The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus. Nature 304:749-752
58. van Steensel B, Jenster G, Damm K, Brinkmann AO, van Driel R 1995 Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix. J Cell Biochem 57:465-478
59. Howell GM, Gustafsson J-A, Lefebvre YA 1990 Glucocorticoid receptor identified on nuclear envelopes of male rat liver envelopes by affinity labelling and immunochemistry. Endocrinology 127:1087-1096
60. Wieland S, Dobbeling U, Rusconi S 1991 Interference and synergism of glucocorticoid receptor and octamer factors. EMBO J 10:2513-2521
61. Kutoh E, Stromstedt PE, Poellinger L 1992 Functional interference between the ubiquitous and constitutive octamer transcription factor-1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1. Mol Cell Biol 12:4960-4969
62. Muchardt C, Yaniv M 1993 A human homologue of Saccharomyces-cerevisiae SNF2/SWI2 and Drosophila-brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J 12:4279-4290
63. Willmann T, Beato M 1986 Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA. Nature 324:688-691
64. Hutchison KA, Dittmar KD, Pratt WB 1994 All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a "foldosome." J Biol Chem 269: 27894-27899
65. Stancato LF, Hutchison KA, Krishna P, Pratt WB 1996 Animal and plant cell lysates share a conserved chaperone that assembles the glucocorticoid receptor into a functional heterocomplex with Hsp90. Biochemistry 35:544-561
66. Beck CA, Estes PA, Bona BJ, Muro-Cacho CA, Nordeen SK, Edwards DP 1993 The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 133:728-740
67. Nordeen SK, Bona BJ, Moyer ML 1993 Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase-A. Mol Endocrinol 7:731-742
68. Renoir JM, Radanyi C, Jung-Testas I, Faber LE, Baulieu EE 1990 The nonactivated progesterone receptor is a nuclear heterooligomer. J Biol Chem 265:14402-14406
69. Smith DF, Toft DO 1993 Minireview: steroid receptors and their associated proteins. Mol Endocrinol 7:4-11
70. Parker MG 1993 Structure and function of the oestrogen receptor. J Neuroendocrinol 5:223-228
71. Feigner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM, Danielsen M 1987 Lipofection: a highly efficient, lipid mediated DNA/transfection procedure. Proc Natl Acad Sci USA 84:7413-7417
72. Godowski PJ, Rusconi S, Miesfeld R, Yamamoto KR 1987 Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325:365-368
73. Cato AC, Weinmann J 1988 Mineralocorticoid regulation of transcription of transfected mouse mammary tumor virus DNA in cultured kidney cells. J Cell Biol 106:2119-2125
74. Gorman CM, Moffat LF, Howard BH 1982 Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051
75. Pringle JR, Adams AE, Drubin DG, Haarer BK 1991 Immunofluorescence method for yeast. Methods Enzymol 194:565-602
76. Weil PA, Segall J, Harris B, Ng SY, Roeder RG 1979 Faithful transcription of eukaryotic genes by RNA polymerase III in systems reconstituted with purified DNA templates. J Biol Chem 254:6163-6173
77. Weil PA, Luse DS, Segall J, Roeder RG 1979 Selective and accurate initiation of transcription at the Ad2 major late promoter in a soluble system dependent on purified RNA polymerase II and DNA. Cell 18:469-484
78. Giffin W, Torrance H, Rodda DJ, Prefontaine GG, Pope L, Haché RJG 1996 Sequence-specific binding by Ku autoantigen and its effects on transcription. Nature 380: 265-268