Effect of the E4 region on the persistence of transgene expression from adenovirus vectors

Journal of Virology

Volumn 71, Issue 3, 1997, Pages 2408-2416

  Armentano, Donna ^a   Zabner, Joseph ^b   Sacks, Carol ^a   Sookdeo, Cathleen C ^a   Smith, Michael P ^a   St George, Judith A ^a   Wadsworth, Samuel C ^a   Smith, Alan E ^a   Gregory, Richard J ^a  

^a GENZYME CORPORATION   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CYTOMEGALOVIRUS; DOWN REGULATION; ENZYME ASSAY; FEMALE; GENE EXPRESSION REGULATION; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

EID: 0031041586     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.3.2408-2416.1997     Document Type: Article

References (36)

1. Armentano, D., C. C. Sookdeo, K. M. Hehir, R. J. Gregory, J. A. St. George, G. A. Prince, S. C. Wadsworth, and A. E. Smith. 1995. Characterization of an adenovirus gene transfer vector containing an E4 deletion. Hum. Gene Ther. 6:1343-1353.
2. Barr, D., J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. A. Kay. 1995. Strain related variations in adenoviral mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2:151-155.
3. Baskar, J. F., P. P. Smith, G. Nilaver, R. A. Jupp, S. Hoffmann, N. J. Peffer, D. J. Tenney, A. M. Colber-Poley, P. Ghazal, and J. A. Nelson. 1996. The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice. J. Virol. 70:3207-3214.
4. Berkner, K. L. 1988. Development of adenovirus vectors for the expression of heterologous genes. BioTechniques 6:616-627.
5. Berry, M. N., and D. S. Friend. 1969. High yield preparation of isolated rat liver parenchymal cells. J. Cell Biol. 43:506-520.
6. Bridge, E., S. Medghalchi, S. Ubol, M. Leesong, and G. Ketner. 1993. Adenovirus early region 4 and viral DNA synthesis. Virology 193:794-801.
7. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
8. Dobner, T., N. Horikoshi, S. Rubenwolf, and T. Shenk. 1996. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272:1470-1473.
9. Doucas, V., A. M. Ishov, A. Romo, H. Juguilon, M. D. Weitzman, R. M. Evans, and G. G. Maul. 1996. Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. Genes Dev. 10:196-207.
10. Engelhardt, J. F., L. Litsky, and J. M. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5:1217-1229.
11. Fang, B., R. C. Eisensmith, H. Wang, M. A. Kay, R. E. Cross, C. N. Landen, G. Gordon, D. A. Bellinger. M. S. Read, P. C. Hu, K. M. Brinkhous, and S. L. C. Woo. 1995. Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression. Hum. Gene Ther. 6:1039-1044.
12. - recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. Gene Ther. 3:217-222.
13. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
14. Goldman, M. J., L. A. Litzky, J. F. Engelhardt, and J. M. Wilson. 1995. Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study. Hum. Gene Ther. 6:839-851.
15. Gorziglia, M. I., M. J. Kadan, S. Yei, J. Lim, G. M. Lee, R. Luthra, and B. Trapnell. 1996. Elimination of both E1 and E2a from, adenovirus vectors further improves prospects for in vivo human gene therapy. J. Virol. 70: 4173-4178.
16. Guo, Z. S., L. H. Wang, R. C. Eisensmith, and S. L. C. Woo. 1996. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Ther. 3:802-810.
17. Hehir, K. M., D. Armentano, L. M. Cardoza, T. L. Choquette, P. B. Berthelette, G. A. White, L. A. Couture, M. B. Everton, J. Keegan, J. M. Martin, D. A. Pratt, M. P. Smith, A. E. Smith, and S. C. Wadsworth. 1996. Molecular characterization of replication competent variants of adenovirus vectors and genome modifications to prevent their occurrence. J. Virol. 70:8459-8467.
18. Imperiale, M. J., H.-T. Kao, L. T. Feldman, J. R. Nevins, and S. Strickland. 1984. Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol. Cell. Biol. 4:867-874.
19. Kaplan, J. M., D. Armentano, T. E. Sparer, S. G. Wynn, P. A. Peterson, S. C. Wadsworth, K. Couture, S. E. Pennington, J. A. St. George, L. R. Gooding, and A. E. Smith. Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung. Hum. Gene Ther., in press.
20. Kay, M. A., A. X. Holterman, L. Meuse, A. Gown, H. D. Ochs, P. S. Linsley, and C. B. Wilson. 1995. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nature Genet. 11:191-197.
21. Kleinberger, T., and T. Shenk. 1993. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription. J. Virol. 67:7556-7560.
22. Krougliak, V., and F. L. Graham. 1995. Development of cell lines capable of complementing E1, E4 and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6:1575-1586.
23. Lieber, A., C.-H. He, I. Kirillova, and M. A. Kay. 1996. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J. Virol. 70:8944-8960.
24. Marcellus, R. C., J. G. Teodoro, T. Wu, D. E. Brough, G. Ketner, G. C. Shore, and P. E. Branton. 1996. Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis. J. Virol. 70:6207-6215.
25. Marton, M. J., S. B. Baim, D. A. Ornelles, and T. Shenk. 1990. The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2f, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA. J. Virol. 64:2345-2359.
26. Müller, U., T. Kleinberger, and T. Shenk. 1993. Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1. J. Virol. 66:5867-5878.
27. Nietupski, J. Unpublished data.
28. Romanczuk, H. Personal communication.
29. Spergel, J. M., W. Hsu, S. Akira, B. Thimmappaya, T. Kishimoto, and S. Chen-Kiang. 1992. NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J. Virol. 66:1021-1030.
30. Tripathy, S. K., H. B. Black, E. Goldwasser, and J. M. Leiden. 1996. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat. Med. 2:545-550.
31. Wang, Q., X.-C. Xia, and M. Finer. 1995. A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions. Gene Ther. 2:775-783.
32. Yang, Y., Q. Li, H. C. J. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
33. Yang, Y., F. A. Nunes, K. Berencsi, E. E. Furth, Gönczöl, and J. M. Wilson. 1994. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407-4411.
34. Yei, P., J. F. Dedieu, C. Orsini, E. Vigne, P. Denefle, and M. Perricaudet. 1996. Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J. Virol. 70:559-565.
35. Zhou, H., W. O'Neal, N. Morral, and A. L. Beaudet. 1996. Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted. J. Virol. 70:7030-7038.
36. Zsengeller, Z. K., S. E. Wert, W. M. Hull, X. Hu, S. P. Yei, B. C. Trapnell, and J. A. Whitsett. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6:457-467.