The molecular weight ratio of monomethoxypolyethylene glycol (mPEG) to protein determines the immunotolerogenicity of mPEG proteins

Protein Engineering

Volumn 12, Issue 8, 1999, Pages 701-705

  So, Takanori ^a   Ito, Hiro O ^a,b   Tsujihata, Yoshiyuki ^a   Hirata, Masato ^a   Ueda, Tadashi ^a   Imoto, Taiji ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Chemical modification; Immunological tolerance; Monomethoxypolyethylene glycol; Neutralizing antibody; Protein pharmaceutics

Indexed keywords

BOVINE IMMUNOGLOBULIN; LYSOZYME; MACROGOL DERIVATIVE; OVALBUMIN; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DRUG CONJUGATION; IMMUNOLOGICAL TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0032834650     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/12.8.701     Document Type: Article

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