Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 9, 1997, Pages 4686-4691

  Kay, Mark A ^a,b   Meuse, Leonard ^a   Gown, Allen M ^b   Linsley, Peter ^c   Hollenbaugh, Diane ^c   Aruffo, Alejandro ^c   Ochs, Hans D ^a   Wilson, Christopher B ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

costimulation; factor IX; hepatic gene therapy; human alpha 1 antitrypsin; T cells

Indexed keywords

ALPHA 1 ANTITRYPSIN; BLOOD CLOTTING FACTOR 9; CD40 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MR 1; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; ANTIBODIES; ANTIBODIES, VIRAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION; CD40 LIGAND; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; IMMUNOCONJUGATES; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LIVER; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; T-LYMPHOCYTES;

EID: 0030984335     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.9.4686     Document Type: Article

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