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Volumn 6, Issue 9, 1999, Pages 1565-1573

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

Author keywords

Adenovirus; Neutralizing antibody; Serotype; Vectors

Indexed keywords

NEUTRALIZING ANTIBODY; VIRUS DNA; VIRUS VECTOR;

EID: 0032827780     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300995     Document Type: Article
Times cited : (121)

References (74)
  • 1
    • 0030623809 scopus 로고    scopus 로고
    • Human adenovirus vectors for gene transfer into mammalian cells
    • Hitt MM, Addison CL, Graham FL. Human adenovirus vectors for gene transfer into mammalian cells. Adv Pharmacol 1997; 40: 137-206.
    • (1997) Adv Pharmacol , vol.40 , pp. 137-206
    • Hitt, M.M.1    Addison, C.L.2    Graham, F.L.3
  • 2
    • 0028328261 scopus 로고
    • Cellular immunity to viral antigens limits Eldeleted adenoviruses for gene therapy
    • Yang Y et al. Cellular immunity to viral antigens limits Eldeleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4407-4411
    • Yang, Y.1
  • 3
    • 0029028989 scopus 로고
    • Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo
    • Yang Y, Wilson JM. Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo. J Immunol 1995; 155: 2564-2570.
    • (1995) J Immunol , vol.155 , pp. 2564-2570
    • Yang, Y.1    Wilson, J.M.2
  • 4
    • 0029093070 scopus 로고
    • Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo
    • Yang Y et al. Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92: 7257-7261.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7257-7261
    • Yang, Y.1
  • 5
    • 0029836503 scopus 로고    scopus 로고
    • Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs
    • Yang Y, Su Q, Wilson JM. Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J Virol 1996; 70: 7209-7212.
    • (1996) J Virol , vol.70 , pp. 7209-7212
    • Yang, Y.1    Su, Q.2    Wilson, J.M.3
  • 6
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • Yang Y et al. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Therapy 1996; 3: 137-144.
    • (1996) Gene Therapy , vol.3 , pp. 137-144
    • Yang, Y.1
  • 7
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenovirual vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai Y et al. Cellular and humoral immune responses to adenovirual vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA 1995; 92: 1401-1405.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1401-1405
    • Dai, Y.1
  • 8
    • 0028832360 scopus 로고
    • Transient expression of genes transferred in vivo into heart using first-generation adenoviral vectors: Role of the immune response
    • Gilgenkrantz H et al. Transient expression of genes transferred in vivo into heart using first-generation adenoviral vectors: role of the immune response. Hum Gene Ther 1995; 6: 1265-1274.
    • (1995) Hum Gene Ther , vol.6 , pp. 1265-1274
    • Gilgenkrantz, H.1
  • 9
    • 0029612269 scopus 로고
    • Pulmonary inflammation induced by incomplete or inactivated adenoviral particles
    • McCoy RD et al. Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. Hum Gene Ther 1995; 6: 1553-1560.
    • (1995) Hum Gene Ther , vol.6 , pp. 1553-1560
    • McCoy, R.D.1
  • 10
    • 0030824640 scopus 로고    scopus 로고
    • Immune responses to reporter proteinsa nd high viral dose limit duration of expressiion with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors
    • Morral N et al. Immune responses to reporter proteinsa nd high viral dose limit duration of expressiion with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors. Hum Gene Ther 1997; 8: 1275-1286.
    • (1997) Hum Gene Ther , vol.8 , pp. 1275-1286
    • Morral, N.1
  • 11
    • 0030756821 scopus 로고    scopus 로고
    • Gene therapy with recombinant adenovirus vectors: Evaluation of the host immune response
    • Christ M et al. Gene therapy with recombinant adenovirus vectors: evaluation of the host immune response. Immunol Lett 1997; 57: 19-25.
    • (1997) Immunol Lett , vol.57 , pp. 19-25
    • Christ, M.1
  • 12
    • 0032530110 scopus 로고    scopus 로고
    • Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy
    • Kafri T et al. Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. Proc Natl Acad Sci USA 1998; 95: 11377-11382.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11377-11382
    • Kafri, T.1
  • 13
    • 0031570890 scopus 로고    scopus 로고
    • Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene
    • van Ginkel FW et al. Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene. J Immunol 1997; 159: 685-693.
    • (1997) J Immunol , vol.159 , pp. 685-693
    • Van Ginkel, F.W.1
  • 14
    • 0030023343 scopus 로고    scopus 로고
    • Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector
    • Dong JY et al. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Hum Gene Ther 1996; 7: 319-331.
    • (1996) Hum Gene Ther , vol.7 , pp. 319-331
    • Dong, J.Y.1
  • 15
    • 0029968303 scopus 로고    scopus 로고
    • Humoral and cellular immune responses of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2
    • Kaplan JM et al. Humoral and cellular immune responses of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2. Gene Therapy 1996; 3: 117-127.
    • (1996) Gene Therapy , vol.3 , pp. 117-127
    • Kaplan, J.M.1
  • 16
    • 0029873225 scopus 로고    scopus 로고
    • Biological response of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2
    • St George JA et al. Biological response of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2. Gene Therapy 1996; 3: 103-116.
    • (1996) Gene Therapy , vol.3 , pp. 103-116
    • St George, J.A.1
  • 17
    • 0031020458 scopus 로고    scopus 로고
    • Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity
    • Schulick AH et al. Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity. J Clin Invest 1997; 99: 209-219.
    • (1997) J Clin Invest , vol.99 , pp. 209-219
    • Schulick, A.H.1
  • 18
    • 0029030001 scopus 로고
    • The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- Adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector
    • Lee MG et al. The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector. Gene Therapy 1995; 2: 256-262.
    • (1995) Gene Therapy , vol.2 , pp. 256-262
    • Lee, M.G.1
  • 19
    • 0030005390 scopus 로고    scopus 로고
    • Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host
    • Poller W et al. Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Therapy 1996; 3: 521-530.
    • (1996) Gene Therapy , vol.3 , pp. 521-530
    • Poller, W.1
  • 20
    • 0030880893 scopus 로고    scopus 로고
    • Expressionof gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver
    • Bruder JT et al. Expressionof gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver. J Virol 1997; 71: 7623-7628.
    • (1997) J Virol , vol.71 , pp. 7623-7628
    • Bruder, J.T.1
  • 21
    • 0030988482 scopus 로고    scopus 로고
    • Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humorla and cellular immune responses and permits long-term gene expression
    • Ilan Y et al. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humorla and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci USA 1997; 94: 2587-2592.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2587-2592
    • Ilan, Y.1
  • 22
    • 0030943737 scopus 로고    scopus 로고
    • Heterologous expression of adenovirus E3-gp19K in an Ela-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expresssion in vivo
    • Schowalter DB et al. Heterologous expression of adenovirus E3-gp19K in an Ela-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expresssion in vivo. Gene Therapy 1997; 4: 351-360.
    • (1997) Gene Therapy , vol.4 , pp. 351-360
    • Schowalter, D.B.1
  • 23
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • Engelhardt JF et al. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 6196-6200.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1
  • 24
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrossis
    • Yang Y et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrossis. Nat Genet 1994; 7: 362-369.
    • (1994) Nat Genet , vol.7 , pp. 362-369
    • Yang, Y.1
  • 25
    • 0029091783 scopus 로고
    • Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: A preclinical toxicology study
    • Goldman MJ et al. Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study. Hum Gene Ther 1995; 6: 839-851.
    • (1995) Hum Gene Ther , vol.6 , pp. 839-851
    • Goldman, M.J.1
  • 26
    • 0029959867 scopus 로고    scopus 로고
    • Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy
    • Gao GP, Yang Y, Wilson JM. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J Virol 1996; 70: 8934-8943.
    • (1996) J Virol , vol.70 , pp. 8934-8943
    • Gao, G.P.1    Yang, Y.2    Wilson, J.M.3
  • 27
    • 0030923808 scopus 로고    scopus 로고
    • Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses
    • Dedieu JF et al. Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses. J Virol 1997; 71: 4626-4637.
    • (1997) J Virol , vol.71 , pp. 4626-4637
    • Dedieu, J.F.1
  • 28
    • 0031008929 scopus 로고    scopus 로고
    • Persistent transgene expression in mouse liver following in vivo gene transfer with a delta E1/delta E4 adenovirus vector
    • Wang Q et al. Persistent transgene expression in mouse liver following in vivo gene transfer with a delta E1/delta E4 adenovirus vector. Gene Therapy 1997; 4: 393-400.
    • (1997) Gene Therapy , vol.4 , pp. 393-400
    • Wang, Q.1
  • 29
    • 0031883829 scopus 로고    scopus 로고
    • Production and characterization of improved adenovirus vectors with El, E2b, and E3 genes deleted
    • Amalfitano A et al. Production and characterization of improved adenovirus vectors with El, E2b, and E3 genes deleted. J Virol 1998; 72: 926-933.
    • (1998) J Virol , vol.72 , pp. 926-933
    • Amalfitano, A.1
  • 30
    • 0029670374 scopus 로고    scopus 로고
    • Lack of persistence of E1- Recombinant adenoviral vectors containing a temperature-sensitive E2a mutation in immunocompetent mice and hemophilia B dogs
    • Fang B et al. Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. Gene Therapy 1996; 3: 217-222.
    • (1996) Gene Therapy , vol.3 , pp. 217-222
    • Fang, B.1
  • 31
    • 0031888263 scopus 로고    scopus 로고
    • In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1 /E2A, or E1 /E4 deleted
    • Lusky M et al. In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1 /E2A, or E1 /E4 deleted. J Virol 1998; 72: 2022-2032.
    • (1998) J Virol , vol.72 , pp. 2022-2032
    • Lusky, M.1
  • 32
    • 0029054932 scopus 로고
    • Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector
    • Mitani K et al. Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector. Prof Natl Acad Sci USA 1995; 92: 3854-3858.
    • (1995) Prof Natl Acad Sci USA , vol.92 , pp. 3854-3858
    • Mitani, K.1
  • 33
    • 0029966514 scopus 로고    scopus 로고
    • Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis
    • Fisher KJ et al. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology 1996; 217: 11-22.
    • (1996) Virology , vol.217 , pp. 11-22
    • Fisher, K.J.1
  • 34
    • 0029962474 scopus 로고    scopus 로고
    • In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes
    • Haecker SE et al. In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes. Hum Gene Ther 1996; 7: 1907-1914.
    • (1996) Hum Gene Ther , vol.7 , pp. 1907-1914
    • Haecker, S.E.1
  • 35
    • 0029943155 scopus 로고    scopus 로고
    • A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase
    • Kochanek S et al. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA 1996; 93: 5731-5736.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5731-5736
    • Kochanek, S.1
  • 36
    • 0030016358 scopus 로고    scopus 로고
    • Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNa to muscle cellss
    • Kumar-Singh R, Chamberlain JS. Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNA to muscle cellss. Hum Mol Genet 1996; 5: 913-921.
    • (1996) Hum Mol Genet , vol.5 , pp. 913-921
    • Kumar-Singh, R.1    Chamberlain, J.S.2
  • 37
    • 0029861452 scopus 로고    scopus 로고
    • Recombinant adenoviruses with large deleteions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo
    • Lieber A et al. Recombinant adenoviruses with large deleteions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 1996; 70: 8944-8960.
    • (1996) J Virol , vol.70 , pp. 8944-8960
    • Lieber, A.1
  • 38
    • 0031055468 scopus 로고    scopus 로고
    • Construction of adenovirus vectors through Crelox recombinations
    • Hardy S et al. Construction of adenovirus vectors through Crelox recombinations. J Virol 1997; 71: 1842-1849.
    • (1997) J Virol , vol.71 , pp. 1842-1849
    • Hardy, S.1
  • 39
    • 0030462599 scopus 로고    scopus 로고
    • A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
    • Parks RJ et al. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA 1996; 93; 13565-13570.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13565-13570
    • Parks, R.J.1
  • 40
    • 0031049699 scopus 로고    scopus 로고
    • Persistence in muscle of an adenoviral vector that lacks all viral genes
    • Chen HH et al. Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc Natl Acad Sci USA 1997; 94: 1645-1650.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1645-1650
    • Chen, H.H.1
  • 41
    • 13144283616 scopus 로고    scopus 로고
    • An adenoviral vector deleted for all viral coding sequencces results in enhanced safety and extended expression of a leptin transgene
    • Morsy MA et al. An adenoviral vector deleted for all viral coding sequencces results in enhanced safety and extended expression of a leptin transgene. Proc Natl Acad Sci USA 1998; 95: 7866-7871.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7866-7871
    • Ma, M.1
  • 42
    • 0031916435 scopus 로고    scopus 로고
    • Genomic DNa transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
    • Schiedner G et al. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat Genet 1998; 18: 180-183.
    • (1998) Nat Genet , vol.18 , pp. 180-183
    • Schiedner, G.1
  • 43
    • 0032506791 scopus 로고    scopus 로고
    • High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alphal-antitrypsin with negligible toxicity
    • Morral N et al. High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alphal-antitrypsin with negligible toxicity. Hum Gene Ther 1998; 9: 2709-2716.
    • (1998) Hum Gene Ther , vol.9 , pp. 2709-2716
    • Morral, N.1
  • 44
    • 0028807696 scopus 로고
    • FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer
    • Vilquin JT et al. FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum Gene Ther 1995; 6: 1391-1401.
    • (1995) Hum Gene Ther , vol.6 , pp. 1391-1401
    • Vilquin, J.T.1
  • 45
    • 0029743163 scopus 로고    scopus 로고
    • Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung
    • Jooss K, Yang Y, Wilson JM. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum Gene Ther 1996; 7: 1555-1566.
    • (1996) Hum Gene Ther , vol.7 , pp. 1555-1566
    • Jooss, K.1    Yang, Y.2    Wilson, J.M.3
  • 46
    • 0029968305 scopus 로고    scopus 로고
    • Circumventing the immune response to adenovirus-mediated gene therapy
    • Kass-Eisler A et al. Circumventing the immune response to adenovirus-mediated gene therapy. Gene Therapy 1996; 3: 154-162.
    • (1996) Gene Therapy , vol.3 , pp. 154-162
    • Kass-Eisler, A.1
  • 47
    • 0029875608 scopus 로고    scopus 로고
    • Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors
    • Kolls JK et al. Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors. Hum Gene Ther 1996; 7: 489-497.
    • (1996) Hum Gene Ther , vol.7 , pp. 489-497
    • Kolls, J.K.1
  • 48
    • 0029741231 scopus 로고    scopus 로고
    • Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice
    • Lochmuller H et al. Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. Gene Therapy 1996; 3: 706-716.
    • (1996) Gene Therapy , vol.3 , pp. 706-716
    • Lochmuller, H.1
  • 49
    • 0029877620 scopus 로고    scopus 로고
    • Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium
    • Sawchuk SJ et al. Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium. Hum Gene Ther 1996; 7: 499-506.
    • (1996) Hum Gene Ther , vol.7 , pp. 499-506
    • Sawchuk, S.J.1
  • 50
    • 0029934048 scopus 로고    scopus 로고
    • Transient immunosuppresion permits successful repetitive intravenous administration of an adenovirus vector
    • Smith TA et al. Transient immunosuppresion permits successful repetitive intravenous administration of an adenovirus vector. Gene Therapy 1996; 3: 496-502.
    • (1996) Gene Therapy , vol.3 , pp. 496-502
    • Smith, T.A.1
  • 51
    • 0029944988 scopus 로고    scopus 로고
    • Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver
    • Yang Y, Greenough K, Wilson JM. Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Therapy 1996; 3: 412-420.
    • (1996) Gene Therapy , vol.3 , pp. 412-420
    • Yang, Y.1    Greenough, K.2    Wilson, J.M.3
  • 52
    • 0029955391 scopus 로고    scopus 로고
    • Neonatal cotton rats do not exhibit dstructive immune responses to adenoviral vectors
    • Zepeda M, Wilson JM. Neonatal cotton rats do not exhibit dstructive immune responses to adenoviral vectors. Gene Therapy 1996; 3: 973-979.
    • (1996) Gene Therapy , vol.3 , pp. 973-979
    • Zepeda, M.1    Wilson, J.M.2
  • 53
    • 0030749713 scopus 로고    scopus 로고
    • Transient immunosuppression with deoxyspergualin improves longevity of transgene expression and ability to readminister adenoviral vector to the mouse lung
    • Kaplan JM, Smith AE. Transient immunosuppression with deoxyspergualin improves longevity of transgene expression and ability to readminister adenoviral vector to the mouse lung. Hum Gene Ther 1997; 8: 1095-1104.
    • (1997) Hum Gene Ther , vol.8 , pp. 1095-1104
    • Kaplan, J.M.1    Smith, A.E.2
  • 54
    • 0030943732 scopus 로고    scopus 로고
    • Macrophage depletion increasess the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo
    • Kuzmin AI, Finegold MJ, Eisensmith RC. Macrophage depletion increasess the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo. Gene Therapy 1997; 4: 309-316.
    • (1997) Gene Therapy , vol.4 , pp. 309-316
    • Kuzmin, A.I.1    Finegold, M.J.2    Eisensmith, R.C.3
  • 55
    • 0030756389 scopus 로고    scopus 로고
    • The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors
    • Lieber A et al. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J Virol 1997; 71: 8798-8807.
    • (1997) J Virol , vol.71 , pp. 8798-8807
    • Lieber, A.1
  • 56
    • 0030746543 scopus 로고    scopus 로고
    • Antibody to CD40 ligand inhibits both humoral and cellular immune responses to adenoviral vectors and facilitates repeated administration to mouse airway
    • Scaria A et al. Antibody to CD40 ligand inhibits both humoral and cellular immune responses to adenoviral vectors and facilitates repeated administration to mouse airway. Gene Therapy 1997; 4: 611-617.
    • (1997) Gene Therapy , vol.4 , pp. 611-617
    • Scaria, A.1
  • 57
    • 0031060294 scopus 로고    scopus 로고
    • Enhancement of in vivo adenovirus-mediated gene transfer and expresssion by prior depletion of tissue macrophages in the target organ
    • Wolff G et al. Enhancement of in vivo adenovirus-mediated gene transfer and expresssion by prior depletion of tissue macrophages in the target organ. J Virol 1997; 71: 624-629.
    • (1997) J Virol , vol.71 , pp. 624-629
    • Wolff, G.1
  • 58
    • 0030910938 scopus 로고    scopus 로고
    • Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer
    • Zsengeller ZK et al. Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer. Hum Gene Ther 1997; 8: 935-941.
    • (1997) Hum Gene Ther , vol.8 , pp. 935-941
    • Zsengeller, Z.K.1
  • 59
    • 0029983685 scopus 로고    scopus 로고
    • 'Sero-switch' adenovirus-mediated in vivo gene transfer: Circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype
    • Mastrangeli A et al. 'Sero-switch' adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum Gene Ther 1996; 7: 79-87.
    • (1996) Hum Gene Ther , vol.7 , pp. 79-87
    • Mastrangeli, A.1
  • 60
    • 16944367354 scopus 로고    scopus 로고
    • Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype
    • Mack CA et al. Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype. Hum Gene Ther 1997; 8: 99-109.
    • (1997) Hum Gene Ther , vol.8 , pp. 99-109
    • Mack, C.A.1
  • 61
    • 0031903186 scopus 로고    scopus 로고
    • Circumvention of immunity to the adenovirus major coat protein hexon
    • Roy S et al. Circumvention of immunity to the adenovirus major coat protein hexon. J Virol 1998; 72: 6875-6879.
    • (1998) J Virol , vol.72 , pp. 6875-6879
    • Roy, S.1
  • 62
    • 0032127610 scopus 로고    scopus 로고
    • Extensive cross-reactivity of adenovirus-specific cytotoxic T cells
    • Smith CA et al. Extensive cross-reactivity of adenovirus-specific cytotoxic T cells. Hum Gene Ther 1998; 9: 1419-1427.
    • (1998) Hum Gene Ther , vol.9 , pp. 1419-1427
    • Smith, C.A.1
  • 63
    • 0030426525 scopus 로고    scopus 로고
    • Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre
    • Chen L, Anton M, Graham FL. Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre. Somat Cell Mol Genet 1996; 22: 477-488.
    • (1996) Somat Cell Mol Genet , vol.22 , pp. 477-488
    • Chen, L.1    Anton, M.2    Graham, F.L.3
  • 64
    • 2642702620 scopus 로고    scopus 로고
    • Immune response to recombinant capsid proteins of adenovirus in humans: Antifiber and anti-penton base antibodies have a synergistic effect on neutralizing activity
    • Gahery-Segard H et al. Immune response to recombinant capsid proteins of adenovirus in humans: antifiber and anti-penton base antibodies have a synergistic effect on neutralizing activity. J Virol 1998; 72: 2388-2397.
    • (1998) J Virol , vol.72 , pp. 2388-2397
    • Gahery-Segard, H.1
  • 65
    • 0023908115 scopus 로고
    • Neutralization of adenoviruses: Kinetics, stoichiometry, and mechanisms
    • Wohlfart C. Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms. J Virol 1988; 62: 2321-2328.
    • (1988) J Virol , vol.62 , pp. 2321-2328
    • Wohlfart, C.1
  • 66
    • 0027260609 scopus 로고
    • Packaging capacity and stability of human adenovirus type 5 vectors
    • Bett AJ, prevec L, Graham FL. Packaging capacity and stability of human adenovirus type 5 vectors. J Virol 1993; 67: 5911-5921.
    • (1993) J Virol , vol.67 , pp. 5911-5921
    • Bett, A.J.1    Prevec, L.2    Graham, F.L.3
  • 67
    • 0030900511 scopus 로고    scopus 로고
    • A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNa packaging
    • Parks RJ, Graham FL. A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging. J Virol 1997; 71: 3293-3298.
    • (1997) J Virol , vol.71 , pp. 3293-3298
    • Parks, R.J.1    Graham, F.L.2
  • 69
    • 0030999469 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer: Influence of transgene, mouse strain and type of immune response on persistence of transgene expression
    • Michou AI et al. Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expression. Gene Therapy 1997; 4: 473-482.
    • (1997) Gene Therapy , vol.4 , pp. 473-482
    • Michou, A.I.1
  • 70
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • Tripathy SK et al. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nature Meet 1996; 2: 545-550.
    • (1996) Nature Meet , vol.2 , pp. 545-550
    • Tripathy, S.K.1
  • 71
    • 0017710978 scopus 로고    scopus 로고
    • Characteristics of a human cell line transformed by DNa from human adenovirus type 5
    • Graham FL et al. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gene Virol 1997; 36: 59-74.
    • (1997) J Gene Virol , vol.36 , pp. 59-74
    • Graham, F.L.1
  • 72
    • 77957042700 scopus 로고
    • Techniques for human adenovirus vector construction and characterization
    • Hitt M et al. Techniques for human adenovirus vector construction and characterization. Meth Mol Genet 1995; 7: 13-30.
    • (1995) Meth Mol Genet , vol.7 , pp. 13-30
    • Hitt, M.1
  • 73
    • 0344719899 scopus 로고
    • Construction and characterization of recombinant adenovirus type 5 vectors
    • McMaster: Hamilton
    • Bett AJ. Construction and characterization of recombinant adenovirus type 5 vectors. Biology. McMaster: Hamilton, 1995.
    • (1995) Biology
    • Bett, A.J.1
  • 74
    • 0030860068 scopus 로고    scopus 로고
    • Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors
    • Addison CL et al. Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J Gen Virol 1997; 78: 1653-1661.
    • (1997) J Gen Virol , vol.78 , pp. 1653-1661
    • Addison, C.L.1


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