Expression of cell death-associated proteins in neuronal apoptosis associated with pontosubicular neuron necrosis

Brain Pathology

Volumn 11, Issue 3, 2001, Pages 273-281

  Stadelmann, Christine ^a   Mews, Imke ^b   Srinivasan, Anu ^c   Deckwerth, Thomas L ^c   Lassmann, Hans ^d   Brück, Wolfgang ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c PFIZER INC   (United States)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CELL PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ADENOSINE DIPHOSPHATE RIBOSYLATION; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; BRAIN INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FETUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEWBORN; PERINATAL MORBIDITY; PROTEIN EXPRESSION; PROTEIN MODIFICATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL MARKERS; CASPASE 3; CASPASES; ENZYME ACTIVATION; ENZYME PRECURSORS; FEMALE; FETAL DEATH; FETAL HYPOXIA; FIXATIVES; FORMALDEHYDE; GENE EXPRESSION PROFILING; GENES, BCL-2; GENES, P53; HIPPOCAMPUS; HUMANS; INFANT, NEWBORN; MALE; NERVE TISSUE PROTEINS; NEURONS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; PONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034980176     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2000.tb00260.x     Document Type: Article

References (58)

1. Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis
2. High level calcineurin activity predisposes neuronal cells to apoptosis
3. Stroke-damaged neurons may commit cellular suicide
4. Poly(ADP-ribose) in the cellular response to DNA damage
5. Evidence for neuronal apoptosis in pontosubicular neuron necrosis
6. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
7. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
8. Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium
9. Bid-induced conformational change of bax is responsible for mitochondrial cytochrome C release during apoptosis
10. Pathobiology of ischaemic stroke: An integrated view
11. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
12. Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat
13. Ponto-subicular lesions in perinatal anoxia
14. Altered expression of bcl-2, bcl-x, bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
15. Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia
16. Up-regulation of bax and down regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
17. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques
18. bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
19. Calbindin-D28k immunoreactivity and selective vulnerability to ischemia in the dentate gyrus of the developing rat
20. Apoptotic pathways: The roads to ruin
21. The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: The potential role of apoptosis
22. HIF-1a and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia
23. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and exitotoxic neuronal damage
24. Hypocarbia as a pathogenetic factor in pontosubicular necrosis
25. Differential regulation of bax, bcl-2, and bcl-x proteins in focal cortical ischemia in the rat
26. Expression of bcl-2 and bax in the frontoparietal cortex of the rat following cardiac arrest
27. Activation of CPP32 during apoptosis of neurons and astrocytes
28. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
29. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
30. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
31. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
32. An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat
33. Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
34. Neuronal accumulation of poly(ADP-ribose) after brain ischaemia. Neuropathol
35. Neuronal death in brain infarcts in man
36. Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways
37. Roles of glutamate transporter and receptors, poly (ADPribose) polymerase, and transforming growth factor-β1 in pontosubicular neuron necrosis
38. BCL-2 gene family in the nervous system
39. Clinicopathological study of pontosubicular necrosis
40. Multiparametric staining to identify apoptotic human cells
41. Caspases: Killer proteases
42. L is an antiapoptotic regulator for postnatal CNS neurons
43. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia
44. Role of poly(ADP-ribose) formation in DNA repair
45. Caspases as treatment targets in stroke and neurodegenerative diseases
46. Cell death in perinatal hypoxicischaemic brain injury
47. Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat
48. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
49. Activation of caspase-3 in single neurons and autophagic vacuoles of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
50. Molecular characterization of mitochondrial apoptosis-inducing factor
51. Relationship between periventricular hemorrhage, leukomalacia and brainstem lesions in prematurely born infants
52. Caspases: Enemies within
53. The tumor suppressor p53 and its response gene p21 WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia
54. Affection of the hippocampal granule cells in pontosubicular neuron necrosis
55. Bcl-2 family: Life-or-death switch
56. The cellular response to p53: The decision between life and death
57. Developmental patterns of bcl-2 and bcl-x polypeptide expression in the human spinal cord
58. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity