Developmental patterns of bcl-2 and bcl-x polypeptide expression in the human spinal cord

Experimental Neurology

Volumn 150, Issue 1, 1998, Pages 82-97

  Yachnis, Anthony T ^a   Giovanini, Mark A ^a   Eskin, Thomas A ^a   Reier, Paul J ^a   Anderson, Douglas K ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Antigen retrieval; Apoptosis; Cell death; Immunohistochemistry; Motor neurons; Ontogeny

Indexed keywords

NEUROTROPHIC FACTOR; POLYPEPTIDE; PROTEIN BCL 2; PROTEIN BCL X; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FETUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOTOR NERVE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; NEUROMUSCULAR SYNAPSE; ONTOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; SPINAL CORD VENTRAL HORN;

EID: 0032031012     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6746     Document Type: Article

References (51)

1. Allsopp T. E., Wyatt S., Paterson H. F., Davies A. M. The protooncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell. 73:1993;295-307.
2. L/S. Cell Tissue Res. 288:1997;59-68.
3. Behl C., Hovey L., Krajewski S., Schubert D., Reed J. C. Bcl-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. Biochem. Biophys. Res. Commun. 197:1993;949-956.
4. Boise L. H., Gonzalez-Garcia M., Postema C. E., Ding L., Linsten T., Turka L. A., Mao X., Nunez G., Thompson C. B. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 74:1993;597-608.
5. Boise L. H., Gottschalk A. R., Quintans J., Thompson C. B. Bcl-2 and bcl-2-related proteins in apoptosis regulation. Curr. Top. Microbiol. Immunol. 200:1995;107-121.
6. Bothwell M. Functional interactions of neurotrophins and neurotrophin receptors. Annu. Rev. Neurosci. 18:1995;223-253.
7. Bredesen D. E. Neural apoptosis. Ann. Neurol. 38:1995;839-851.
8. Castren E., Ohga Y., Berzaghi M. P., Tzimagiorgis G., Thoenen H., Lindholm D. Bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain. Neuroscience. 61:1994;165-177.
9. Chen J., Graham S. H., Nakayama M., Zhu R. L., Jin K., Stetler A., Simon R. P. Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia. J. Cereb. Blood Flow Metab. 17:1997;2-10.
10. Davies A. M. Intrinsic programmes of growth and survival in developing vertebrate neurons. TINS. 17:1994;195-199.
11. Davies A. M. The bcl-1 family of proteins, and the regulation of neuronal survival. TINS. 18:1995;355-358.
12. Dubois-Dauphin M., Frankowski H., Tsujimoto Y., Huarte J., Martinou J. C. Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl. Acad. Sci. USA. 91:1994;3309-3313.
13. Farlie P. G., Dringen R., Rees S. M., Kannouralis G., Bernard O. Bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl. Acad. Sci. USA. 92:1995;4397-4401.
14. Forger N. G., Breedlove S. M. Motoneuronal death during human fetal development. J. Comp. Neurol. 264:1987;118-122.
15. Frankowski H., Missotten M., Fernandez P. A., Martinou I., Michel P., Sadoul R., Martinou J. C. Function and expression of the bcl-x gene in the developing and adult nervous system. NeuroReport. 6:1995;1917-1921.
16. Garcia I., Martinou I., Tsujimoto Y., Martinou J.-C. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science. 258:1992;302-304.
17. Gonzalez-Garcia M., Perez-Ballestero R., Ding L., Duan L., Boise L. H., Thompson C. B., Nunez G. Bcl-xL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development. 120:1994;3033-3042.
18. Gonzalez-Garcia M., Garcia I., Ding L., O'Shea S., Boise L. H., Thompson C. B., Nunez G. Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal death. Proc. Natl. Acad. Sci. USA. 92:1995;4304-4308.
19. Jacobson, M. 1991, Developmental Neurobiology, 311, 358, Plenum, New York.
20. Johnson E. M., Deckwerth T. L. Molecular mechanisms of developmental neuronal death. Annu. Rev. Neurosci. 16:1993;31-46.
21. Krajewski S., Krajewska M., Shabaik A., Wang H.-G., Irie S., Frong L., Reed J. C. Immunohistochemical analysis of in vivo patterns of bcl-X expression. Cancer Res. 54:1994;5501-5507.
22. Krajewski S., Mai J. K., Krajewska M., Sikorska M., Mossakowski M. J., Reed J. C. Upregulation of Bax protein levels in neurons following cerebral ischemia. J. Neurosci. 15:1995;6364-6376.
23. Lawrence M. S., Ho D. Y., Sun G. H., Steinberg G. K., Sapolsky R. M. Overexpression of bcl-2 with herpes simplex virus vectors protects CNS neurons against neurologic insultsin vitroin vivo. J. Neurosci. 16:1996;486-496.
24. LeBrun D. P., Warnke R. A., Cleary M. L. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am. J. Pathol. 142:1993;743-753.
25. Levine B., Goldman J. E., Jiang H. H., Griffin D. E., Hardwick J. M. Bcl-2 protects mice against fatal alphavirus encephalitis. Proc. Natl. Acad. Sci. USA. 93:1996;4810-4815.
26. Li G. L., Brodin G., Farooque M., Funa K., Holtz A., Wang W. L., Olsson Y. Apoptosis and expression of bcl-2 after compression trauma to the rat spinal cord. J. Neuropathol. Exp. Neurol. 55:1996;280-289.
27. Lindsay R. M., Wiegand S. J., Alter C. A., DiStefano P. S. Neurotrophic factors: From molecule to man. TINS. 17:1994;182-190.
28. Martinou J. C., Dubois-Dauphin M., Staple J. K., Rodriguez I., Frankowski H., Missotten M., Albertini P., Talabot D., Catsicas S., Pietra C., Huarte J. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 13:1994;1017-1030.
29. Merry D. E., Veis D. J., Hickey W. F., Korsmeyer S. J. Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development. 120:1994;301-311.
30. Michaelidis T. M., Sendtner M., Cooper J. D., Airaksinen M. S., Holtmann B., Meyer M., Thoenen H. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron. 17:1996;75-89.
31. Mizuguchi M., Sohma O., Takashima S., Ieda K., Yamada M., Shiraiwa N., Ohta S. Immunochemical and immunohistochemical localization of bcl-x protein in the rat central nervous system. Brain Res. 712:1996;281-286.
32. Moore K. L., Persaud T. V. N. The Developing Human: Clinically Oriented Embryology. 1993;Saunders, Philadelphia.
33. Motoyama N., Wang F., Roth K. A., Sawa H., Nakayama K.-I., Nakayama K., Negishi I., Senju S., Zhang Q., Fujii S., Loh D. Y. Massive cell death of immature hematopoetic cells and neurons in Bcl-x-deficient mice. Science. 267:1995;1506-1510.
34. Mu X., He J., Anderson D. W., Trojanowski J. Q., Springer J. E. Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons. Ann. Neurol. 40:1996;379-386.
35. Nakayama K., Nakayama K.-I., Negishi I., Kuida K., Sawa H., Loh D. Y. Targeted disruption of bcl-2 in mice: Occurrence of grey hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. USA. 91:1994;3700-3704.
36. Okazawa H., Shimizu J., Kamei M., Imafuku I., Hamada H. Bcl-2 inhibits retinoic acid-induced apoptosis during neural differentiation of embryonal stem cells. J. Cell Biol. 132:1996;955-968.
37. Oppenheim R. W. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14:1991;453-501.
38. Pezzella F., Tse A. G. D., Cordell J. L., Pulford K. A. F., Gatter K. C., Mason D. Y. Expression of the bcl-2 oncogene protein is not specific for the t(14;18) chromosomal translocation. Am. J. Pathol. 137:1990;225-232.
39. Raff M. C., Barres B. A., Burne J. F., Coles H. S., Ishizaki Y., Jacobson M. D. Programmed cell death and the control of cell survival: Lessons from the nervous system. Science. 262:1993;695-700.
40. Reed J. C. Bcl-2 and the regulation of programmed cell death. J. Cell. Biol. 124:1994;1-6.
41. Rouayrenc J.-F., Boise L. H., Thompson C. B., Privat A., Patey G. Presence of the long and short forms of bcl-x in several human and murine tissues. C.R. Acad. Sci. Paris. 318:1995;537-540.
42. Sadler, T. W. 1985, Langman's Medical Embryology, Williams & Wilkins, Baltimore.
43. Shi R.-S., Key M. E., Kalra K. L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39:1991;741-748.
44. Sohma O., Mizuguchi M., Takashima S., Yamada M., Ikeda K., Ohta S. High expression of bcl-x protein in the developing human cerebellar cortex. J. Neurosci. Res. 43:1996;175-182.
45. Tohyama T., Lee V. M.-Y., Rorke L. B., Trojanowski J. Q. Molecular milestones that signal axonal maturation and the commitment of human spinal cord precursor cells to the neuronal or glial phenotype in development. J. Comp. Neurol. 310:1991;285-299.
46. Veis D. J., Sorenson C. M., Shutter J. R., Korsmeyer S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 75:1993;229-240.
47. Veis-Novack D., Korsmeyer S. J. Bcl-2 protein expression during murine development. Am. J. Pathol. 145:1994;61-73.
48. Vekrellis K., McCarthy M. J., Watson A., Whitfield J., Rubin L. L., Ham J. Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development. 124:1997;1239-1249.
49. Yachnis A. T., Trojanowski J. Q. Studies of childhood brain tumors using immunohistochemistry and microwave technology: Methodological considerations. J. Neurosci. Methods. 55:1994;191-200.
50. Yachnis A. T., Powell S. Z., Olmsted J., Eskin T. A. Distinct neurodevelopmental patterns of Bcl-2 and Bcl-x expression are altered in glioneuronal hamartias of the human temporal lobe. J. Neuropathol. Exp. Neurol. 56:1997;186-198.
51. Zhoung L.-T., Sarafian T., Kane D. J., Charles A. C., Mah S. P., Edwards R. H., Bredesen D. E. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA. 90:1993;4533-4537.