Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium

Journal of Neuroscience Research

Volumn 59, Issue 1, 2000, Pages 24-31

  D'Mello, Santosh R ^a   Kuan, Chia Yi ^b   Flavell, Richard A ^b   Rakic, Pasko ^b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caspase 3; Cerebellar granule neurons; CPP32; CPP32 deficient neurons; Neuronal survival; Tert butoxycarbonyl Asp.(O methyl).fluoromethyl ketone

Indexed keywords

CASPASE 3; DNA; POTASSIUM ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ACTIVITY; GRANULE CELL; MOUSE; NERVE CELL NECROSIS; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL CULTURE TECHNIQUES; DNA FRAGMENTATION; MICE; MICE, KNOCKOUT; NEURONS; POTASSIUM DEFICIENCY;

EID: 0033977687     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(20000101)59:1<24::AID-JNR4>3.0.CO;2-8     Document Type: Article

References (49)

1. Alnemri ES. 1997. Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases. J Cell Biochem 64:33-42.
2. Armstrong RC, Aja TJ, Hoang KD, Gaur S, Bai X, Alnemri ES, Litwack G, Karanewsky DS, Fritz LC, Tomaselli KJ. 1997. Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J Neurosci 17:553-562.
3. Bredesen DE. 1995. Neural apoptosis. Ann Neurol 38:839-851.
4. Caciola-Rosen L, Nicholson DW, Chong T, Rowan KR, Thornberry NA, Miller DK, Rosen A. 1996. Apopain/cpp32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med 183:1957-1964.
5. Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, Graham SH, Simon RP. 1998. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
6. Chinnaiyan A, Dixit V. 1996. The cell-death machine. Curr Biol 6:555-562.
7. D'Mello SR. 1998. Molecular regulation of neuronal apoptosis. Curr Top Dev Biol 39:187-213.
8. D'Mello SR, Galli C, Ciotti T, Calissano P. 1993. Induction of apoptosis in cerebellar granule neurons by lowering of extracellular potassium: inhibition of death by IGF-I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
9. + deprivation. J Neurochem 70:1809-1818.
10. Dodel RC, Du Y, Bales KR, Ling ZD, Carvey PM, Paul SM. 1998. Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neuroscience 86:701-707.
11. Dodel RC, Du Y, Bales KR, Ling Z, Carvey PM, Paul SM. 1999. Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death. Mol Brain Res 64:141-148.
12. Du Y, bales KR, Dodel RC, Hamilton-Byrd E, Horn JW, Czilli DL, Simmons LK, Ni B, Paul SM. 1997. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc Natl Acad Sci USA 94:11657-11662.
13. Eldadah BA, Yakolev AG, Faden AI. 1997. The role of ced-3 related cysteine proteases in apoptosis of cerebellar granule neurons. J Neurosci 17:6105-6113.
14. Enari M, Sakahira H, Yokoyama H, Iwamatsu A, Nagata S. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43-50.
15. Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA. 1998. Inhibition of human caspases by peptide-based and macromolecule inhibitors. J Biol Chem 273:32608-32613.
16. Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide NA, Vaillancourt JP, Hayden MR. 1996. Cleavage of huntington by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet 13:442-449.
17. Gregoli PA, Bondurant MC. 1999. Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J Cell Physiol 178:133-143.
18. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penmnger JM, Mak TW. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94:339-352.
19. Hara H, Friedlander RM, Gagliardinin V, Ayata C. Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA. 1997. Inhibition of interleukin-1 beta enzyme family proteases reduces ischemic and excito-toxic neuronal damage. Proc Natl Acad Sci USA 94:2007-2012.
20. Himi T, Ishizaki Y, Murota S. 1998. A caspase inhibitor blocks ischaemia-induced delayed neuronal death in the gerbil. Eur J Neurosci 10:777-781.
21. Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K, Sasada M. 1998. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med 187:587-600.
22. Kermer P, Klocker N, Labes M, Bahr M. 1998. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 18:4656-4662.
23. Kubo T, Nonomura T, Enokido Y, Hatanaka H. 1995. Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Brain Res Dev Brain Res 85:249-258.
24. Kuida K, Zheng TS, Songqing N, Kuan C-Y, Karasuyama H, Rakic P, Flavell R. 1996. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-372.
25. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H. Su MS, Rakic P, Flavell RA. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325-337.
26. Li L, Prevette D, Oppenheim RW, Milligan CE. 1998. Involvement of specific caspases in motoneuron cell death in vivo and in vitro following trophic factor deprivation. Mol Cell Neurosci 12:157-167.
27. Liu X, Zou H, Slaughter C, Wang X. 1997. DFF, a heterodimeric protein that functions downstream of caspoase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175-184.
28. Lynch T, Vasilakos JP, Raser K, Keane KM, Shivers BD. 1997. Inhibition of the interleukin-1 beta converting enzyme family rescues neurons from apoptotic death. Mol Psychiatr 2:227-238.
29. Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y, Livingston DJ. 1997. Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases. J Biol Chem 272:7223-7238.
30. Marks N, Berg MJ, Guidotti A, Saito M. 1998. Activation of caspase-3 and apoptosis in cerebellar granule cells. J Neurosci Res 52:334-341.
31. Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsnieyer SJ, Johnson EM Jr. 1997. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 139:205-217.
32. Namura S, Zhu J, Fink K, Endres M, Srinivasan A, Tomaselli KJ, Yuan J, Moskowitz MA. 1998. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 18:3659-3668.
33. Nach R, Probert A Jr, McGinnis KM, Wang KK. 1998. Evidence for activation of caspase-3-like protease in excitotoxin-and hypoxia/ hypoglycemia-injured neurons. J Neurochem 71:186-195.
34. Ni B, Wu X, Du Y, Su Y, Hamilton-Byrd E, Rockey PK, Rosteck PJ, Poirier GG, Paul SM. 1997. Cloning and expression of a rat brain interleukin-1 beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons. J Neurosci 17:1561-1569.
35. Oppenheim RW. 1991. Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501.
36. Packard BZ, Toptygin DD, Komoriya A, Brand L. 1996. Profluorescent protease substrates: intramolecular dimers described by the excitation model. Proc Nad Acad Sci USA 93:11640-11645.
37. Pike BR, Zhao X, Newcomb JK, Wang KK, Posmantur RM, Haves RL. 1998. Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures. J Neurosci Res 52:505-520.
38. Song Q, Lees-Miller SP, Kumar S, Zhang N, Chan DW, Smith GCM, Jackson SP, Khanna KK, Lavin MF. 1996. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J 15:3238-3246.
39. Tanabe H, Eguchi Y, Shimizu S, Martinou JC, Tsujimoto Y. 1998. Death-signalling cascade in mouse cerebellar granule neurons. Eur J Neurosci 10:1403-1411.
40. Taylor J, Gatchalian CL, Keen G, Rubin LL. 1997. Apoptosis in cerebellar granule neurones: involvement of interleukin-1 beta converting enzyme-like proteases. J Neurochem 68:1598-1605.
41. Tewari M, Quan LG, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesan GS, Dixit VM. 1995. Yama/CPP32, a mammalian homolog of CED-3, is a crmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81:801-809.
42. Thompson CB. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462.
43. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW. 1997. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272:17907-17911.
44. Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J. 1998. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501-509.
45. Wang Z-Q, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF. 1996. Cleavage of sterol regulatory element binding proteins (SREBPs) by cpp32 during apoptosis. EMBO J 15:1012-1020.
46. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW. 1998. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12:806-819.
47. Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R, Faden AI. 1997. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci 17:7415-7424.
48. Yan GM, Ni B, Weller M, Wood KA, Paul SM. 1994. Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res 656:43-51.
49. Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL, Flavell RA. 1998. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc Natl Acad Sci USA 95:13618-13623.