Natural biology of polyomavirus middle T antigen

Microbiology and Molecular Biology Reviews

Volumn 65, Issue 2, 2001, Pages 288-318

  Gottlieb, K A ^a   Villarreal, L P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE P60; PROTEIN P53; PROTEIN SHC; RAS PROTEIN; RHO KINASE; S6 KINASE; TRANSCRIPTION FACTOR; TYROSINE; VIRUS DNA; VIRUS MIDDLE T ANTIGEN; VIRUS PROTEIN;

APOPTOSIS; BREAST TUMOR; CELL GROWTH; CELLULAR DISTRIBUTION; DNA SYNTHESIS; ENZYME ACTIVATION; EVOLUTION; GENE CONTROL; GENETIC TRANSCRIPTION; HEMANGIOMA; HOST CELL; NONHUMAN; POLYOMA VIRUS; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; TUMOR; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; APOPTOSIS; CELL DIFFERENTIATION; CELL TRANSFORMATION, VIRAL; EUKARYOTIC CELLS; MICE; MICE, KNOCKOUT; POLYOMAVIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

DNA VIRUSES; POLYOMAVIRUS;

EID: 0034967608     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.65.2.288-318.2001     Document Type: Review

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249. The p53 cellular tumor antigen: Gene structure, expression and protein properties
250. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/ pp60c-src complexes, and PI3-kinase
251. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
252. The polyomavirus major capsid protein VP1 interacts with the nuclear matrix regulatory protein YY1
253. Association of polyomavirus middle tumor antigen with 14-3-3 proteins
254. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
255. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens
256. Expression in transgenic mice of the large T antigen of polyomavirus induces Sertoli cell tumours and allows the establishment of differentiated cell lines
257. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
258. Endothelial cells transformed by polyomavirus middle T oncogene: A model for haemangiomas and other vascular tumours
259. Mitosis-specific phosphorylation of polyomavirus middle-sized tumor antigen and its role during cell transformation
260. Domains in middle-T antigen that cooperate in polyomavirus-mediated oncogenic transformation
261. A study on the mechanism of polyoma-induced activation of the cellular DNA-synthesizing apparatus. Synchronization by FUdR of virus-induced DNA synthesis
262. Genetic diversity in twenty variants of the avian polyomavirus
263. Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells
264. Common and unique features of T antigens encoded by the polyomavirus group
265. Phosphorylation and activation of p70s6k by PDK1
266. Role of p53 mutation in polyomavirus-induced tumorigenesis
267. Polyoma virus middle T and small t antigens cooperate to antagonize p53-induced cell cycle arrest and apoptosis
268. Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
269. T antigens' role in polyomavirus transformation: c-myc but not c-fos or c-jun expression is a target for middle T
270. The role of phosphoinositide 3-kinase lipid products in cell function
271. Polyomavirus middle tumor antigen increases responsiveness to growth factors
272. Protein kinase C increases the activity of the polyoma virus middle T antigen-associated phosphatidylinositol kinase
273. Polyomavirus transforms rat F111 and mouse NIH 3T3 cells by different mechanisms
274. Protein kinase C promotes the phosphorylation of immunoprecipitated middle T antigen from polyoma-transformed cells
275. Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts
276. Cellular ras gene activity is required for full neoplastic transformation by polyomavirus
277. Transforming signals generated by the polyoma virus tumor antigens
278. Protein kinase C stimulation increases the transforming ability of the polyoma virus middle T antigen
279. A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family
280. The roles of individual polyoma virus early proteins in oncogenic transformation
281. The roles of 14-3-3 proteins in signal transduction
282. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
283. Phosphatidylinositol3-OH kinase as a direct target of Ras
284. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
285. The role of ovarian hormones, age and mammary gland development in polyomavirus mammary tumorigenesis
286. The genome of budgerigar fledgling disease virus, an avian polyomavirus
287. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha
288. The epidemiology of mouse polyoma virus infection
289. Observations on the spread of mouse polyoma virus infection
290. Ecology of a mouse tumor virus
291. Activation of phosphatidylinositol 3-kinase by insulin
292. Ultraviolet irradiation and c-jun over-expression regulates replication of polyoma sequences in WOP cells through a PEBP2 binding site
293. Induction of protooncogene c-jun by serum growth factors
294. cAMP stimulates protein kinase B in a Wortmannin-insensitive manner
295. Polyoma-induced stimulation of cellular RNA synthesis is paralleled by changed expression of the viral genome
296. Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro
297. Polyoma virus middle T antigen: Relationship to cell membranes and apparent lack of ATP-binding activity
298. Residual transforming activity of PY1178T, a mutant lacking the principal in vitro tyrosine phosphorylation site, is not affected by removal of the secondary tyrosine phosphorylation site at residue 322
299. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
300. Repression by Jun of the polyoma-virus enhancer overrides activation in a cell specific manner
301. Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen
302. Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen
303. Analysis of splice sites in the early region of bovine polyomavirus: Evidence for a unique pattern of large T mRNA splicing
304. Differential subcellular localization of in vivo-phosphorylated and nonphosphorylated middle-sized tumor antigen of polyoma virus and its relationship to middle-sized tumor antigen phosphorylating activity in vitro
305. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
306. Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family
307. Multimerization of polyomavirus middle-T antigen
308. Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen
309. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain
310. The evolution of small DNA viruses of eukaryotes: Past and present considerations
311. The ETS-domain transcription factor family
312. Understanding Ras: 'It ain't over 'til it's over'
313. Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter
314. The A enhancer of polyomavirus: Protein-protein interactions for the differential early and late promoter function under nonreplicating conditions
315. T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication
316. Host-dependent evolution of three papova viruses
317. Phosphatidylinositol-3 kinase and growth regulation
318. Structural aspects of the p53 protein in relation to gene evolution
319. Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity
320. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
321. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
322. Association of polyomavirus middle tumor antigen with phospholipase C-gamma 1
323. Typing of urinary JC virus DNA offers a novel means of tracing human migrations
324. Characterization of cDNA clones for the human c-yes gene
325. Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner
326. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice
327. T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice
328. Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2
329. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus
330. fos/jun and octamer-binding protein interact with a common site in a negative element of the human c-myc gene
331. c-src-dependent and -independent pathways
332. Phosphorylation of middle T by pp60c-src: A switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis
333. Retinoic acid suppresses polyoma virus transformation by inhibiting transcription of the c-fos proto-oncogene
334. Nucleotides in the polyomavirus enhancer that control viral transcription and DNA replication
335. Mutation causing premature termination of the polyoma virus medium T antigen blocks cell transformation
336. Truncated forms of the polyomavirus middle T antigen can substitute for the small T antigen in lytic infection
337. Construction and expression of a recombinant DNA gene encoding a polyomavirus middle-size tumor antigen with the carboxyl terminus of the vesicular stomatitis virus glycoprotein G
338. Regulation of apoptosis by viral gene products
339. Proliferating cell nuclear antigen (PCNA/cyclin) immunocytochemistry as a labeling index in mouse lung tissues
340. Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src
341. Cellular functions regulated by Src family kinases
342. Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein
343. Small and middle T antigens contribute to lytic and abortive polyomavirus infection
344. Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression
345. A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication
346. Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase
347. Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen
348. Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on phosphatidylinositol 3-kinase
349. A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation
350. The PI3K-PDK1 connection: More than just a road to PKB
351. Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants
352. The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase
353. The elevation of cellular phosphatidic acid levels caused by polyomavirus transformation can be disassociated from the activation of phospholipase D
354. Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression
355. Acute and persistent viral life strategies and their relationship to emerging diseases
356. The hamster papovavirus: Evolutionary relationships with other polyomaviruses
357. Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion
358. Analysis of oncogene function in embryonal stem cells and chimeric mice
359. Association of protein phosphatase 2A with polyoma virus medium tumor antigen
360. The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen
361. The polyomavirus early region gene in transgenic mice causes vascular and bone tumors
362. Raf-1 physically interacts with Rb and regulates its function: A link between mitogenic signaling and cell cycle regulation
363. Ets transcription factors: Nuclear effectors of the Ras-MAP-kinase signaling pathway
364. The Ets family of transcription factors
365. Negative and positive factors determine the activity of the polyoma virus enhancer alpha domain in undifferentiated and differentiated cell types
366. The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
367. PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes
368. Transforming but not immortalizing oncogenes activate the transcription factor PEA1
369. Expression of raf oncogenes activates the PEA1 transcription factor motif
370. Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
371. The polyoma virus T antigen interferes with interferon-inducible gene expression
372. Polyoma "tumor antigen": An activator of chromosome replication?
373. Induction of cellular DNA synthesis by polyoma virus
374. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase
375. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
376. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
377. Tumour induction in fetal brain transplants exposed to the viral oncogenes polyoma middle T and v-src
378. Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene
379. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment
380. A frameshift at a mutational hotspot in the polyoma virus early region generates two new proteins that define T-antigen functional domains
381. Organ- and age-specific replication of polyomavirus in mice
382. AP-1: One switch for many signals
383. c-src is not required for complex formation with polyomavirus middle-T antigen
384. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells
385. Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene
386. lck
387. Deletion of proline-rich domain in polyomavirus T antigens results in virus partially defective in transformation and tumorigenesis
388. PEA1 and PEA3 enhancer elements are primary components of the polyomavirus late transcription initiator element
389. Viruses and apoptosis
390. At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes
391. Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin
392. Regulation of c-myc and c-fos mRNA levels by polyomavirus: Distinct roles for the capsid protein VP1 and the viral early proteins