Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen

Journal of Virology

Volumn 73, Issue 11, 1999, Pages 9266-9273

  Schüchner, Stefan ^a   Wintersberger, Erhard ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN E; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN P27; VIRUS LARGE T ANTIGEN; VIRUS SMALL T ANTIGEN;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CELL CYCLE S PHASE; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HOST CELL; MOUSE; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0344549384     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.11.9266-9273.1999     Document Type: Article

References (58)

1. cdk2. J. Virol. 67:6551-6557.
2. Campbell, K. S., K. R. Auger, B. A. Hemmings, T. M. Roberts, and D. C. Pallas. 1995. Identification of regions in polyomavirus middle T and small T antigens important for association with protein phosphatase 2A. J. Virol. 69: 3721-3728.
3. Campbell, K. S., K. P. Mullane, I. A. Aksoy, H. Stubdal, J. Zalvide, J. M. Pipas, P. A. Silver, T. M. Roberts, B. Schaffhausen, and J. A. DeCaprio. 1997. DNAJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 11:1098-1110.
4. Cannella, D., J. M. Roberts, and R. Fotedar. 1997. Association of cyclin A and cdk2 with SV40 DNA in replication initiation complexes is cell cycle dependent. Chromosoma 105:349-359.
5. Duronio, R. J., A. Brook, N. Dyson, and P. H. Farrell. 1996. E2F-induced S phase requires cyclin E. Genes Dev. 10:2505-2513.
6. Dyson, N. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245-2262.
7. Elledge, S. J., J. Winston, and J. W. Harper. 1996. A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. Trends Cell Biol. 6:388-392.
8. Ewen, M. E., B. Faha, E. Harlow, and D. M. Livingston. 1992. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science 255:85-87.
9. Fotedar, A., D. Cannella, P. Fitzgerald, T. Rousselle, S. Gupta, M. Doree, and R. Fotedar. 1996. Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts. J. Biol. Chem. 271:31627-31637.
10. Frost, J. A., A. S. Alberts, E. Sontag, K. Guan, M. C. Mumby, and J. R. Feramisco. 1994. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Mol. Cell. Biol. 14:6244-6252.
11. Girard, E., U. Strausfeld, A. Dernandez, and N. J. C. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian cells. Cell 67: 1169-1179.
12. Henglein, B., X. Chenivesse, J. Wang, D. Eick, and C. Brechot. 1994. Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc. Natl. Acad. Sci. USA 91:5490-5494.
13. Hiyama, H., A. Iavarone, and S. A. Reeves. 1998. Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F. Oncogene 16:1513-1523.
14. Huet, X., J. Rech, A. Plet, A. Vie, and J. M. Blanchard. 1996. Cyclin A expression is under negative transcriptional control during the cell cycle. Mol. Cell. Biol. 16:3789-3798.
15. kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15: 629-637.
16. Kelly, W., and C. Georgopoulos. 1997. The T/t common exon of simian virus 40, JC and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone. Proc. Natl. Acd. Sci. USA 94:3679-3684.
17. Kitigawa, M., H. Higashi, I. Suzuki-Takahashi, K. Segawa, S. K. Hanks, Y. Taya, S. Nishimura, and A. Okuyama. 1995. Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene 10:229-236.
18. Krek, W., M. E. Ewen, S. Shirodkar, Z. Arany, W. G. Kaelin Jr., and D. M. Livingston. 1994. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78: 161-172.
19. Krude, T., M. Jackman, J. Pines, and R. A. Laskey. 1997. Cyclin/cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88: 109-119.
20. LaBaer, J., M. D. Garrett, L. F. Stevenson, J. M. Slingerland, C. Sandhu, H. S. Chou, A. Fattaey, and E. Harlow. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847-862.
21. Lees, E., B. Faha, V. Dulic, S. I. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdks kinases associate with p 107 and E2F in a temporally distinct manner. Genes Dev. 6:1874-1885.
22. Moran, E. 1993. DNA tumorvirus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 3:63-70.
23. Mudrak, I., E. Ogris, H. Rotheneder, and E. Wintersberger. 1994. Coordinated trans activation of DNA synthesis-and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein. Mol. Cell. Biol. 14:1886-1892.
24. Mudryi, M., S. H. Devoto, S. W. Hiebert, T. Hunter, J. Pines, and J. R. Nevins. 1991. Cell cycle regulation of the E2F transcription factor involves interaction with cyclin A. Cell 65:1243-1253.
25. Newlon, C. S. 1997. Putting it all together: building a prereplicative complex. Cell 91:717-720.
26. Ogris, E., I. Mudrak, and E. Wintersberger. 1992. Polyomavirus large and small T antigens cooperate in induction of the S phase in serum-starved 3T3 mouse fibroblasts. J. Virol. 66:53-61.
27. Ogris, E., H. Rotheneder, I. Mudrak, A. Pichler, and E. Wintersberger. 1993. A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene. J. Virol. 67:1765-1771.
28. 1-to-S phase transition. Mol. Cell. Biol. 15:2612-2624.
29. cdc2 and cyclin A levels by SV40 large T antigen. Oncogene 8:2987-2993.
30. Otzen Petersen, B., J. Lukas, C. Storgard Sorensen, J. Bartek, and K. Helin. 1999. Phosphorylation of mammalian CDC6 by cyclin A/cdk2 regulates its subcellular localization. EMBO J. 18:396-410.
31. Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11: 961-971.
32. Pagano, M., S. W. Tam, A. M. Theodoras, P. Beer-Romero, G. DelSal, V. Chau, P. R. Yew, G. F. Draetta, and M. Rolfe. 1995. A role of the ubiquitinproteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685.
33. Philips, A., X. Huet, A. Plet, L. Le Cam, A. Vie, and M. Blanchard. 1998. The retinoblastoma protein is essential for cyclin A repression in quiescent cells. Oncogene 16:1373-1381.
34. Porras, A., J. Bennett, A. Howe, K. Tokos, N. Bouck, B. Henglein, S. Sathyamangalam, B. Thimmapaya, and K. Rundell. 1996. A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays. J. Virol. 70:6902-6908.
35. Porras, A., S. Gaillard, and K. Rundell. 1999. The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts. J. Virol. 73:3102-3107.
36. kip1. Mol. Cell. Biol. 15:4347-4352.
37. Rosenberg, A. R., F. Zindy, F. Le Deist, H. Mouly, P. Metezeay, C. Brechot, and E. Lamas. 1995. Overexpression of human cyclin A advances entry into S phase. Oncogene 10:1501-1509.
38. Sala, A., M. Kundu, I. Casella, A. Engelhard, B. Calabretta, L. Grasso, M. G. Paggi. A. Giordano, R. J. Watson, K. Khalili, and C. Peschle. 1997. Activation of human B-myb by cyclins. Proc. Natl. Acad. Sci. USA 94:532-536.
39. Shanahan, F., W. Seghezzi, D. Parry, D. Mahony, and E. Lees. 1999. Cyclin E associates with BAF 155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol. Cell. Biol. 19:1460-1469.
40. kip1. Genes Dev. 11:1464-1478.
41. Sherr, C. J. 1996. Cancer cell cycles. Science 274:1672-1677.
42. Sherr, C. J., and J. M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
43. Shirodkar, S., M. Ewen, J. A. DeCaprio, J. Morgan, D. M. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retino-blastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68:157-166.
44. Sobczak-Thepot, J., F. Harper, Y. Florentin, F. Zindy, C. Brechot, and E. Puvion. 1993. Localization of cyclin A at the sites of cellular DNA replication. Exp. Cell Res. 206:43-48.
45. Sontag, E., J.-M. Sontag, and A. Garcia. 1997. Protein phosphatase 2A is a critical regulator of protein kinase C ξ signaling targeted by SV40 small t to promote cell growth and NF-KB activation. EMBO J. 16:5662-5671.
46. Sontag, E., S. Fedorov, C. Kambayashi, D. Robbins, M. Cobb, and M. C. Mumby. 1993. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the Map kinase pathway and induces cell proliferation. Cell 75:887-897.
47. Srinivasan, A., A. J. McClellan, J. Vartikar, I. Marks, P. Cantalupo, Y. Li, P. Whyte, K. Rundell, J. L. Brodsky, and J. M. Pipas. 1997 The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol. Cell. Biol. 17:4761-4773.
48. Stiegler, P., S. Schüchner, V. Lestou, and E. Wintersberger. 1997. Polyomavirus large T antigen-dependent DNA amplification. Oncogene 14:987-995.
49. Strausfeld, A. P., M. Howell, P. Descombes, S. Chevalier, R. E. Rempel, J. Adamczewski, J. L. Mailer, T. Hunt, and J. J. Blow. 1996. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J. Cell Sci. 109:1555-1563.
50. cdk2 and cyclin A. Oncogene 8: 195-202.
51. Kip1. EMBO J. 16: 5334-5344.
52. Voitenleitner, C., E. Fanning, and H.-P. Nasheuer. 1997. Phosphorylation of DNA polymerase α-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro. Oncogene 14:1611-1615.
53. Wang, E. H., S. Bhattacharyya, and C. Prives. 1993. The replication functions of polyomavirus large T antigen are regulated by phosphorylation. J. Virol. 67:6788-6796.
54. Zerfass, K., A. Schulze, D. Spitkovsky, V. Friedman, B. Henglein, and P. Jansen-Durr. 1995. Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J. Virol. 69:6389-6399.
55. Zerfass, K., D. Spitkovsky, A. Schulze, S. Joswig, B. Henglein, and P. Jansen-Dürr. 1996. Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. J. Virol. 70:2637-2642.
56. Zhang, H., J. Hannon, and D. Beach. 1994. P21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750-1758.
57. Zhao, J., B. Dynlacht, T. Imai, T.-A. Hori, and E. Harlow. 1998. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 12:456-461.
58. Ziebold, U., O. Bartsch, R. Marais, S. Ferrari, and K.-H. Klempnauer. 1997. Phosphorylation and activation of B-myb by cyclin A-cdk2. Curr. Biol. 7: 253-260.