Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest

Journal of Virology

Volumn 73, Issue 9, 1999, Pages 7882-7885

  Doherty, Joanne ^b   Freund, Robert ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS MIDDLE T ANTIGEN;

ARTICLE; CELL CYCLE G1 PHASE; FIBROBLAST; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0032815931     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.9.7882-7885.1999     Document Type: Article

References (41)

1. Bates, S., and K. H. Vousden. 1996. p53 in signaling checkpoint arrest and apoptosis. Curr. Opin. Genet. Dev. 6:12-19.
2. Benjamin, T., and P. K. Vogt. 1990. Cell transformation by viruses, p. 345-367. In B. Fields (ed.), Virology. Raven Press, New York, N.Y.
3. Campbell, K. S., E. Ogris, B. Burke, W. Su, K. R. Auger, B. J. Druker, B. S. Schaffhausen, T. M. Roberts, and D. C. Pallas. 1994. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc. Natl. Acad. Sci. USA 91:6344-6348.
4. Deng, C., P. Zhang, J. W. Harper, S. J. Elledge, and P. Leder. 1995. Mice lacking p21/CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684.
5. Dilworth, S. M., C. E. P. Brewster, M. D. Jones, L. Lanfrancone, G. Pelicci, and P. G. Pelicci. 1994. Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature 367:87-90.
6. DiMaio, D., C. Lai, and O. Klein. 1998. Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu. Rev. Microbiol. 52:397-421.
7. Doherty, J., and R. Freund. 1997. Polyomavirus large T antigen overcomes p53 dependent growth arrest. Oncogene 14:1923-1931.
8. Donehower, L. A., and A. Bradley. 1993. The tumor suppressor p53. Biochim. Biophys. Acta 1155:181-205.
9. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
10. Eliyahu, D., D. Michalovitz, and M. Oren. 1985. Overproduction of p53 antigen makes established cells highly tumorigenic. Nature 316:158-160.
11. Freund, R., R. T. Bronson, and T. L. Benjamin. 1992. Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product. Oncogene 7:1979-1987.
12. Freund, R., A. Sotnikov, R. T. Bronson, and T. L. Benjamin. 1992. Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice. Virology 191:716-723.
13. Gutman, A., C. Wasylyk, and B. Wasylyk. 1991. Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter. Mol. Cell. Biol. 11: 5381-5387.
14. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
15. Harvey, M., A. T. Sands, R S. Weiss, M. E. Hegi, R. W. Wiseman, P. Pantazis, B. C. Giovanella, M. A. Tainsky, A. Bradley, and L. A. Donehower. 1993. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8:2457-2467.
16. Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris. 1991. p53 mutations in human cancers. Science 75:839-841.
17. Kaplan, D. R., D. C. Pallas, W. Morgan, B. Schaffhausen, and T. M. Roberts. 1989. Mechanisms of transformation by polyoma virus middle T antigen. Biochim. Biophys. Acta 948:345-364.
18. Karin, M., and T. Smeal. 1992. Control of transcription factors by signal transduction pathways: the beginning of the end. Trends Biochem. Sci. 17:418-422.
19. Land, H., L. F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304:596-602.
20. Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
21. Lin, D., M. T. Shields, S. J. Ullrich, E. Appella, and W. E. Mercer. 1992. Growth arrest induced by wild type p53 protein blocks cells prior to or near the restriction point in late G1 phase. Proc. Natl. Acad. Sci. USA 89:9210-9214.
22. Martinez, J., I. Georgoff, J. Martinez, and A. J. Levine. 1991. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev. 5:151-159.
23. Michalovitz, D., O. Halevy, and M. Oren. 1990. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62:671-680.
24. Nevins, J. R., and P. K. Vogt. 1996. Cell transformation by viruses, p. 301-343. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology. Lippincott-Raven Publishers, Philadelphia, Pa.
25. Oliveira, M. L. S., T. M. Roberts, B. J. Druker, and M. C. S. Armelin. 1998. Mapping of polyomavirus middle T domain that is responsible for AP-1 activation. Oncogene 16:2975-2982.
26. Pardee, A. B. 1989. G1 events and regulation of cell proliferation. Science 244:603-608.
27. Rameh, L. E., and M. C. S. Armelin. 1991. T antigens' role in polyomavirus transformation: c-myc but not c-fos or c-jun expression is a target for middle T. Oncogene 6:1049-1056.
28. Raptis, L., H. Lamfrom, and T. L. Benjamin. 1985. Regulation of cellular phenotype and expression of polyoma virus middle T antigen in rat fibroblasts. Mol. Cell. Biol. 5:2476-2485.
29. Rassoulzadegan, M., A. Cowie, A. Carr, N. Glaichenhaus, R. Kamen, and F. Cuzin. 1982. The roles of individual polyoma virus early proteins in oncogenic transformation. Nature 300:713-718.
30. Schonthal, A., S. Srinivas, and W. Eckhart. 1992. Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen. Proc. Natl. Acad. Sci. USA 89:4972-4976.
31. Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551-555.
32. Srinivas, S., A. Schonthal, and W. Eckhart. 1994. Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity. Proc. Natl. Acad. Sci. USA 91:10064-10068.
33. Su, W., W. Liu, B. S. Schaffhausen, and T. M. Roberts. 1995. Association of polyomavirus middle tumor antigen with phospholipase C-γ 1. J. Biol. Chem. 270:12331-12334.
34. c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis. Cell 59:55-64.
35. Talmage, D. A., and M. Listerud. 1994. Retinoic acid suppresses polyoma virus transformation by inhibiting transcription of the c-fos proto-oncogene. Oncogene 9:3557-3563.
36. Tooze, J. 1981. DNA tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
37. Treisman, R., U. Novak, J. Favaloro, and R. Kamen. 1981. Transformation of rat cells by an altered polyoma virus genome expressing only the middle T protein. Nature 292:595-600.
38. Wasylyk, C., J. L. Imler, and B. Wasylyk. 1988. Transforming but not immortalizing oncogenes activate the transcription factor PEA1. EMBO J. 7:2475-2483.
39. Whitman, M., D. R. Kaplan, B. S. Schaffhausen, L. Cantley, and T. M. Roberts. 1985. Association of phosphatidylinositol kinase activity and polyoma middle T competent for transformation. Nature 315:239-242.
40. Xiong, Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.
41. Zullo, J., C. D. Stiles, and R. L. Garcea. 1987. Regulation of c-myc and c-fos mRNA levels by polyomavirus: distinct roles for the capsid protein VP1 and the viral early proteins. Proc. Natl. Acad, Sci. USA 84:1210-1214.