Engineered biosynthesis of novel polyenes: A pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis

Chemistry and Biology

Volumn 8, Issue 7, 2001, Pages 635-644

  Mendes, Marta V ^a   Recio, Eliseo ^a   Fouces, Roberto ^a   Luiten, Ruud ^b   Martín, Juan F ^a,c   Aparicio, Jesús F ^a,c  

^a Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

^b DSM RESOLVE   (Netherlands)

^c UNIVERSITY OF LEÓN   (Spain)

Author keywords

Cytochrome P450 monooxygenase; Epoxidase; Pimaricin; Polyene; Polyketide synthase

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450; DRUG DERIVATIVE; EPOXIDE HYDROLASE; NATAMYCIN; POLYENE;

ARTICLE; BACTERIAL GENE; COMBINATORIAL CHEMISTRY; ENZYMOLOGY; FERMENTATION; GENETICS; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING; STREPTOMYCES; SYNTHESIS;

ANTIBIOTICS, ANTIFUNGAL; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; EPOXIDE HYDROLASES; FERMENTATION; GENES, BACTERIAL; NATAMYCIN; POLYENES; PROTEIN ENGINEERING; STREPTOMYCES;

EID: 0034945645     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00033-3     Document Type: Article

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