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Volumn 118, Issue 38, 1996, Pages 9184-9185

Engineered biosynthesis of structurally diverse tetraketides by a trimodular polyketide synthase

Author keywords

[No Author keywords available]

Indexed keywords

POLYKETIDE; SYNTHETASE;

EID: 0029804299     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9617552     Document Type: Article
Times cited : (75)

References (25)
  • 10
    • 10244274340 scopus 로고    scopus 로고
    • note
    • III site of pCK7. An Spel site was engineered between L1466 and Q2891 so that the DNA sequence at the fusion is CTGACTAGTCAG.
  • 13
    • 10244266616 scopus 로고    scopus 로고
    • note
    • 13C NMR coupling patterns consistent with the derivation of 5 from four intact propionate units.
  • 14
    • 17344392088 scopus 로고    scopus 로고
    • Luo, G.; Pieper, R.; Rosa, A.; Khosla, C.; Cane, D. E. Bioora. Med. Chem. 1996, 4, 995-999. For a discussion on keto-enol equilibria in β-keto esters, see: March, J. Advanced Organic Chemistry, 3rd ed.; J. Wiley: New York, 1985: pp 66-68 and references cited.
    • (1996) Bioora. Med. Chem. , vol.4 , pp. 995-999
    • Luo, G.1    Pieper, R.2    Rosa, A.3    Khosla, C.4    Cane, D.E.5
  • 15
    • 17344392088 scopus 로고    scopus 로고
    • J. Wiley: New York
    • Luo, G.; Pieper, R.; Rosa, A.; Khosla, C.; Cane, D. E. Bioora. Med. Chem. 1996, 4, 995-999. For a discussion on keto-enol equilibria in β-keto esters, see: March, J. Advanced Organic Chemistry, 3rd ed.; J. Wiley: New York, 1985: pp 66-68 and references cited.
    • (1985) Advanced Organic Chemistry, 3rd Ed. , pp. 66-68
    • March, J.1
  • 16
    • 10244267786 scopus 로고    scopus 로고
    • note
    • A 10% NOE interaction was observed between H-2 and H-5.
  • 17
    • 0001924338 scopus 로고
    • Allinger, N. L., Eliel, E. L., Wilen, S. H., Eds.: Wiley: New York
    • (a) Evans, D. A.; Nelson, J. V.; Taber, T. R. In Topics in Stereochemistry: Allinger, N. L., Eliel, E. L., Wilen, S. H., Eds.: Wiley: New York, 1982; pp 1-115.
    • (1982) Topics in Stereochemistry , pp. 1-115
    • Evans, D.A.1    Nelson, J.V.2    Taber, T.R.3
  • 18
    • 0000584420 scopus 로고
    • Morrison, J. D., Ed.: Academic: New York
    • (b) Heathcock, C. H. In Asymmetric Synthesis; Morrison, J. D., Ed.: Academic: New York, 1984: Vol. III, pp 111-212.
    • (1984) Asymmetric Synthesis , vol.3 , pp. 111-212
    • Heathcock, C.H.1
  • 19
    • 10244260680 scopus 로고    scopus 로고
    • note
    • 12 gave 6 labeled at C-3, C-5, and C-7. The presence of only three enriched carbons in 6 is consistent with its formation by decarboxylation of the full-length acyclic tetraketide, followed by hemiketal formation between the C(7)-OH and C-3.
  • 20
    • 10244233155 scopus 로고    scopus 로고
    • note
    • + calcd 184.1463, found 184.1464.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.