메뉴 건너뛰기




Volumn 64, Issue 2, 1997, Pages 182-195

Inhibition of MG-63 cell proliferation and PDGF-stimulated cellular processes by inhibitors of phosphatidylinositol 3-kinase

Author keywords

LY294002; mitogen; signal transduction; tyrosine kinase; wortmannin

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR;

EID: 0031023661     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(199702)64:2<182::AID-JCB2>3.0.CO;2-T     Document Type: Article
Times cited : (33)

References (39)
  • 3
    • 0023806904 scopus 로고
    • Tumor necrosis factor-α inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxyribonucleic acid synthesis in osteoblast-enriched bone cell cultures
    • Centrella M, McCarthy TL, Canalis E (1988): Tumor necrosis factor-α inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxyribonucleic acid synthesis in osteoblast-enriched bone cell cultures. Endocrinology 123:1442-1448.
    • (1988) Endocrinology , vol.123 , pp. 1442-1448
    • Centrella, M.1    McCarthy, T.L.2    Canalis, E.3
  • 4
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis and glucose transporter translocation
    • Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR (1994) Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis and glucose transporter translocation. Mol Cell Biol 14:4902-4911.
    • (1994) Mol Cell Biol , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 5
    • 0025727594 scopus 로고
    • cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF B-receptor
    • Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT (1991): cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF B-receptor. Cell 65:75-82.
    • (1991) Cell , vol.65 , pp. 75-82
    • Escobedo, J.A.1    Navankasattusas, S.2    Kavanaugh, W.M.3    Milfay, D.4    Fried, V.A.5    Williams, L.T.6
  • 6
    • 0026652899 scopus 로고
    • Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
    • Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams LT (1992): Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69:413-423.
    • (1992) Cell , vol.69 , pp. 413-423
    • Fantl, W.J.1    Escobedo, J.A.2    Martin, G.A.3    Turck, C.W.4    Del Rosario, M.5    McCormick, F.6    Williams, L.T.7
  • 7
    • 0024382926 scopus 로고
    • Phosphatidylinositol kinase type I activity associates with various oncogene products
    • Fukui Y, Kornbluth S, Jong S, Wang L, Hanafusa H (1989): Phosphatidylinositol kinase type I activity associates with various oncogene products. Oncogene Res 4:283-292.
    • (1989) Oncogene Res , vol.4 , pp. 283-292
    • Fukui, Y.1    Kornbluth, S.2    Jong, S.3    Wang, L.4    Hanafusa, H.5
  • 8
    • 0028120902 scopus 로고
    • Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
    • Holt KH, Olson AL, Moye-Rowley WS, Pessin JE (1994): Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits. Mol Cell Biol 14:42-49.
    • (1994) Mol Cell Biol , vol.14 , pp. 42-49
    • Holt, K.H.1    Olson, A.L.2    Moye-Rowley, W.S.3    Pessin, J.E.4
  • 9
    • 0026537450 scopus 로고
    • Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
    • Hu P, Margolis B, Skolnik EY, Lammers R, Ullrich A, Schlessinger J (1992): Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol Cell Biol 12:981-990.
    • (1992) Mol Cell Biol , vol.12 , pp. 981-990
    • Hu, P.1    Margolis, B.2    Skolnik, E.Y.3    Lammers, R.4    Ullrich, A.5    Schlessinger, J.6
  • 10
    • 0028351218 scopus 로고
    • Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites
    • Joly M, Kazlauskas A, Fay FS, Corvera S (1994): Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science 263:684-687.
    • (1994) Science , vol.263 , pp. 684-687
    • Joly, M.1    Kazlauskas, A.2    Fay, F.S.3    Corvera, S.4
  • 11
    • 0023013903 scopus 로고
    • Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells
    • Kadowaki T, Koyasu S, Nishida E, Sakai H, Takaku F, Yahara I, Kasuga M (1986): Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. J Biol Chem 261:16141-16147.
    • (1986) J Biol Chem , vol.261 , pp. 16141-16147
    • Kadowaki, T.1    Koyasu, S.2    Nishida, E.3    Sakai, H.4    Takaku, F.5    Yahara, I.6    Kasuga, M.7
  • 12
    • 0027442924 scopus 로고
    • Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3′ kinase complexes: Potential interactions with the microtubule cytoskeleton
    • Kapeller R, Chakrabarti R, Cantley L, Fay F, Corvera S (1993): Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3′ kinase complexes: potential interactions with the microtubule cytoskeleton. Mol Cell Biol 13:6052-6063.
    • (1993) Mol Cell Biol , vol.13 , pp. 6052-6063
    • Kapeller, R.1    Chakrabarti, R.2    Cantley, L.3    Fay, F.4    Corvera, S.5
  • 13
    • 0026557517 scopus 로고
    • Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI 3 kinase in vivo
    • Kashishian A, Kazlauskas A, Cooper JA (1992): Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI 3 kinase in vivo. EMBO J 11:1373-1382.
    • (1992) EMBO J , vol.11 , pp. 1373-1382
    • Kashishian, A.1    Kazlauskas, A.2    Cooper, J.A.3
  • 14
    • 0025042770 scopus 로고
    • Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase
    • Kazlauskas A, Cooper JA (1990): Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J 9:3279-3286.
    • (1990) EMBO J , vol.9 , pp. 3279-3286
    • Kazlauskas, A.1    Cooper, J.A.2
  • 16
    • 0027198412 scopus 로고
    • A region of the 85 kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo
    • Klippel A, Escobedo JA, Hu Q, Williams LT (1993): A region of the 85 kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo. Mol Cell Biol 13:5560-5566.
    • (1993) Mol Cell Biol , vol.13 , pp. 5560-5566
    • Klippel, A.1    Escobedo, J.A.2    Hu, Q.3    Williams, L.T.4
  • 17
    • 0028198330 scopus 로고
    • The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
    • Klippel A, Escobedo JA, Hirano M, Williams LT (1994): The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol Cell Biol 14:2675-2685.
    • (1994) Mol Cell Biol , vol.14 , pp. 2675-2685
    • Klippel, A.1    Escobedo, J.A.2    Hirano, M.3    Williams, L.T.4
  • 19
    • 0026726483 scopus 로고
    • The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
    • Matter WJ, Brown RF, Vlahos CJ (1992): The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun 186:624-631.
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 624-631
    • Matter, W.J.1    Brown, R.F.2    Vlahos, C.J.3
  • 21
    • 0023784627 scopus 로고
    • Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor
    • Mellstrom K, Heldin CH, Westermark B (1988): Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor. Exp Cell Res 177:347-359.
    • (1988) Exp Cell Res , vol.177 , pp. 347-359
    • Mellstrom, K.1    Heldin, C.H.2    Westermark, B.3
  • 22
    • 0024433529 scopus 로고
    • Protein kinase C-dependent and -independent pathways in the growth factor-induced cytoskeletal reorganization
    • Miyata Y, Nishida E, Koyasu S, Yahara I, Sakai H (1989): Protein kinase C-dependent and -independent pathways in the growth factor-induced cytoskeletal reorganization. J Biol Chem 264:15565-15568.
    • (1989) J Biol Chem , vol.264 , pp. 15565-15568
    • Miyata, Y.1    Nishida, E.2    Koyasu, S.3    Yahara, I.4    Sakai, H.5
  • 24
    • 0028146616 scopus 로고
    • Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
    • Okada T, Sakuma L, Fukui Y, Hazeki O, Michio U (1994): Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J Biol Chem 269:3563-3567.
    • (1994) J Biol Chem , vol.269 , pp. 3563-3567
    • Okada, T.1    Sakuma, L.2    Fukui, Y.3    Hazeki, O.4    Michio, U.5
  • 26
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A (1992): The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 28
    • 0025988995 scopus 로고
    • Identification and quantification of phosphatidylinositides produced in response to platelet-derived growth factor stimulation
    • Serunian LA, Auger KR, Cantley LC (1991): Identification and quantification of phosphatidylinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol 198:78-87.
    • (1991) Methods Enzymol , vol.198 , pp. 78-87
    • Serunian, L.A.1    Auger, K.R.2    Cantley, L.C.3
  • 29
    • 0028805707 scopus 로고
    • FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly
    • FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. J Biol Chem 270:24343-24351.
    • (1995) J Biol Chem , vol.270 , pp. 24343-24351
    • Seufferlein, T.1    Rozengurt, E.2
  • 30
    • 0027211693 scopus 로고
    • Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
    • Valius M, Kazlauskas A (1993): Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73:321-334.
    • (1993) Cell , vol.73 , pp. 321-334
    • Valius, M.1    Kazlauskas, A.2
  • 31
    • 0028933897 scopus 로고
    • Phosphatidylinositol 3-kinase inhibitors and their effects on cell signaling pathways
    • Vlahos CJ (1995): Phosphatidylinositol 3-kinase inhibitors and their effects on cell signaling pathways. Drugs Future 20:165-171.
    • (1995) Drugs Future , vol.20 , pp. 165-171
    • Vlahos, C.J.1
  • 32
    • 0026731135 scopus 로고
    • Signal transduction in neutrophil activation: Phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation
    • Vlahos CJ, Matter WF (1992): Signal transduction in neutrophil activation: Phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation. FEBS Lett 309:242-248.
    • (1992) FEBS Lett , vol.309 , pp. 242-248
    • Vlahos, C.J.1    Matter, W.F.2
  • 34
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF (1994): A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248.
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 37
    • 0028089005 scopus 로고
    • Membrane ruffling and chemotaxis transduced by the PDGF B-receptor require the binding site for phosphatidylinositol 3′ kinase
    • Wennstrom S, Siegbahn A, Yokote K, Arvidsson A, Heldin C, Mori S, Claesson-Welsh L (1994b): Membrane ruffling and chemotaxis transduced by the PDGF B-receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene 9:651-660.
    • (1994) Oncogene , vol.9 , pp. 651-660
    • Wennstrom, S.1    Siegbahn, A.2    Yokote, K.3    Arvidsson, A.4    Heldin, C.5    Mori, S.6    Claesson-Welsh, L.7
  • 38
    • 0028326907 scopus 로고
    • Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
    • Wymann M, Arcaro A (1994): Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts. Biochem. J. 298:517-520.
    • (1994) Biochem. J. , vol.298 , pp. 517-520
    • Wymann, M.1    Arcaro, A.2
  • 39
    • 0027374488 scopus 로고
    • Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
    • Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y (1993): Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846-25856.
    • (1993) J Biol Chem , vol.268 , pp. 25846-25856
    • Yano, H.1    Nakanishi, S.2    Kimura, K.3    Hanai, N.4    Saitoh, Y.5    Fukui, Y.6    Nonomura, Y.7    Matsuda, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.